探索咪唑和2-巯基苯并咪唑衍生物的生物学和抗癫痫特性的双向作用。

Q3 Biochemistry, Genetics and Molecular Biology
Geetika Goel, Jannat Ul Firdous
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引用次数: 0

摘要

咪唑和2-巯基苯并咪唑类似物是一类具有多种生物活性的分子,在治疗癫痫方面具有良好的治疗潜力。本文就其生物学特性和抗癫痫作用作一综述。咪唑衍生物和2-巯基苯并咪唑具有一系列的生物活性,如抗真菌、抗氧化、抗炎和抗菌作用,除了治疗癫痫外,还具有治疗灵活性。咪唑衍生物通过机制调节γ -氨基丁酸(GABA)受体,抑制离子通道,并发挥神经保护作用,使其能够用于控制癫痫发作。它们的作用机制包括调节氧化应激途径以及提供抗癫痫的神经保护作用。在结构方面,咪唑和2-巯基苯并咪唑衍生物都经过了广泛的构效关系研究,以增强其生物学和药理学意义。然而,许多问题,如生物利用度、选择性和副作用,阻碍了它们在治疗各种疾病中的有效应用。展望未来,进一步研究新的衍生物和配方策略有望提高疗效和减少不良反应。本综述整合了现有的知识,强调咪唑和2-巯基苯并咪唑衍生物在生物系统中的多方面作用及其作为抗癫痫药物的潜力,从而为未来的研究和临床应用提供见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Exploring the Two-Way Role: Biological and Anti-Epileptic Properties of Imidazole and 2-Mercaptobenzimidazole Derivatives.

Imidazole and 2-mercapto benzimidazole analogues are a group of molecules that have various biological activities and good therapeutic potential in the treatment of epilepsy. This review explores their dual role, focusing on their biological properties and anti-epileptic effects. A spectrum of biological activities is displayed by imidazole derivatives and 2- mercaptobenzimidazole, such as antifungal, antioxidant, anti-inflammatory, and antimicrobial actions, leading to their therapeutic flexibility apart from epilepsy treatment. Imidazole derivatives mechanistically modulate Gamma-Aminobutyric Acid (GABA) receptors, inhibit ion channels, and exert neuroprotective effects, enabling them to be used for seizure control. Their mechanisms of action involve modulation of oxidative stress pathways as well as providing neuroprotective effects against epilepsy. In terms of structure, both imidazole and 2-mercaptobenzimidazole derivatives have gone through extensive structure-activity relationship studies to enhance their biological and pharmacological aspects. However, numerous concerns, such as bioavailability, selectivity, and side effects, hinder their effective application in the treatment of various diseases. Looking forward, further research into novel derivatives and formulation strategies holds promise for enhancing efficacy and reducing adverse effects. This review consolidates current knowledge, emphasizing the multifaceted roles of imidazole and 2-mercapto benzimidazole derivatives in biological systems and their potential as anti-epileptic agents, thus providing insights for future research and clinical applications.

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来源期刊
Recent patents on biotechnology
Recent patents on biotechnology Biochemistry, Genetics and Molecular Biology-Biotechnology
CiteScore
2.90
自引率
0.00%
发文量
51
期刊介绍: Recent Patents on Biotechnology publishes review articles by experts on recent patents on biotechnology. A selection of important and recent patents on biotechnology is also included in the journal. The journal is essential reading for all researchers involved in all fields of biotechnology.
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