Recent patents on biotechnology最新文献

{"title":"The Patent Landscape of Polyhydroxyalkanoates Production by Algae and Cyanobacteria.","authors":"Dielle Pierotti Procópio,&nbsp;Letícia Oliveira Bispo Cardoso,&nbsp;Bruna Bacaro Borrego,&nbsp;Louise Hase Gracioso,&nbsp;Claudio Augusto Oller Nascimento,&nbsp;Elen Aquino Perpetuo,&nbsp;Cassius Vinicius Stevani,&nbsp;Renato Sanches Freire","doi":"10.2174/1872208317666221207145011","DOIUrl":"https://doi.org/10.2174/1872208317666221207145011","url":null,"abstract":"<p><strong>Background: </strong>As global awareness regarding climate change and environmental pollution outcomes arise, eco-friendly and negative emission technologies emerge.</p><p><strong>Methods: </strong>In this scenario, polyhydroxyalkanoate (PHA)-accumulating microorganisms play an important role in the transition from the petrochemical-based non-biodegradable polymer to renewable, eco-friendly, and biocompatible materials. More specifically, CO₂ can be converted to biopolymers through photosynthesis by cyanobacteria and algae, posing as a promising technology for renewable material, CO₂, and petroleum-dependence mitigations. However, although many microorganisms can accumulate PHA intracellularly, limitations persist, such as the elevated cost and limited market availability.</p><p><strong>Results: </strong>Herein is presented a patent-based mapping on technological trends of PHAs production, including its production by microalgae and cyanobacteria using the Questel Orbit Intelligence software (version 1.9.8) in complement with the Espacenet Patent Search database.</p><p><strong>Conclusion: </strong>The inquiry on PHAs retrieved 34,243 patents filed since 1912, whereas 156 are related to their specific production by photosynthetic microorganisms, evidencing a prospective market for intellectual property.</p>","PeriodicalId":21064,"journal":{"name":"Recent patents on biotechnology","volume":"17 3","pages":"271-288"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9818115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential Action of <i>Lactobacillus</i> Probiotics Against Fungi of the Genus <i>Candida</i>: A Bibliographic Review.","authors":"Milton Marcus Neves Sousa Carneiro Pimentel,&nbsp;Janaína de Carvalho Alves,&nbsp;Lúcio Henrique Sousa Pinheiro,&nbsp;Mariana Nougalli Roselino","doi":"10.2174/1872208317666221027093644","DOIUrl":"https://doi.org/10.2174/1872208317666221027093644","url":null,"abstract":"<p><strong>Background: </strong>The use of Lactobacillus probiotics may confer beneficial effects on an individual's health, such as the ability to act against fungi of the genus Candida. There are about 200 species of those yeasts, and they can develop candidiasis infections, which affect about 75% of adult women.</p><p><strong>Objective: </strong>This study aimed to raise articles that investigated the potential action of several Lactobacillus strains in front of Candida species.</p><p><strong>Methods: </strong>For this review, 15 articles published between 2015 and 2020 were studied.</p><p><strong>Results: </strong>The results showed the Lactobacillus species L. paracasei, L. acidophilus, L. helveticus, L. rhamnosus, L. reuteri, and L. gasseri have the potential action to inhibit the growth and quantity of colony-forming units of Candida species in vitro studies. Further, they can reduce the rate of candidiasis recurrence and increase the cure rate, mainly when associated with traditional pharmacotherapy, as observed in vivo studies.</p><p><strong>Conclusion: </strong>The time of use and the strain of Lactobacillus probiotics can also be determining factors for the efficiency in the treatment against Candida species, suggesting that a long time of use of Lactobacillus probiotics is directly associated with a better result.</p>","PeriodicalId":21064,"journal":{"name":"Recent patents on biotechnology","volume":"17 3","pages":"198-205"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9457061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Compact and Efficient Brine Shrimp Hatching Device.","authors":"Alexander Machado Cardoso","doi":"10.2174/1872208317666230119100522","DOIUrl":"https://doi.org/10.2174/1872208317666230119100522","url":null,"abstract":"<p><strong>Background: </strong>Artemia is considered an indispensable live food for rearing many fish and crustacean larvae and can be used in toxicity tests as a safe, practical, and economical method. It is straightforward to create and manipulate; however, many cysts do not hatch as expected.</p><p><strong>Methods: </strong>A new device was used to hatch Artemia salina. The device includes a tubularshaped reservoir, lid with a central hole, heater with a thermostat, air compressor, three porous stones, funnel-shaped bottom, light source, collection valve, switch, and electrical outlet, which permits better control of temperature and aeration in a single apparatus. Different patent devices were used for comparative analysis.</p><p><strong>Results: </strong>Hatched eggs of Artemia showed that the device was 97% efficient; in comparison, commercial and other devices hatched approximately less than 80% of the cysts. Although Artemia is an easy-to-handle animal, the device described here facilitates changes in the growth parameters and produces more nauplii larvae.</p><p><strong>Conclusion: </strong>This paper presents a new device that is effective, compact, and successful for hatching brine shrimp cysts, thereby improving Artemia production.</p>","PeriodicalId":21064,"journal":{"name":"Recent patents on biotechnology","volume":"17 3","pages":"289-292"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9519065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medicinal Plants Used for the Neutralization of Snake Venom in Northern Nigeria of West Africa.","authors":"Ameh Matthew Philip,&nbsp;Yusuf Peter Ofemile,&nbsp;Akefe Isaac Oluwatobi,&nbsp;Ada Gabriel,&nbsp;Ugwoke Peter Ejiofor,&nbsp;Omar Hosea Aske","doi":"10.2174/1872208316666220426120228","DOIUrl":"https://doi.org/10.2174/1872208316666220426120228","url":null,"abstract":"","PeriodicalId":21064,"journal":{"name":"Recent patents on biotechnology","volume":"17 1","pages":"3-8"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9147395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enzymatic Properties of Red Beet (<i>Beta vulgaris</i> L.) Leaf, Root Pulp, and Peel.","authors":"Tatek Sileshi,&nbsp;Zekeria Yusuf,&nbsp;Mulugeta Desta","doi":"10.2174/1872208317666230201091358","DOIUrl":"https://doi.org/10.2174/1872208317666230201091358","url":null,"abstract":"<p><strong>Background: </strong>Beetroot (Beta vulgaris</i> L.) is botanically classified as a herbaceous biennial belonging to the Chenopodiaceae family and has several varieties with bulb colors ranging from yellow to red. Peroxidases are widely occurring in organisms including microorganisms, plants, and animals, and have been involved in various physiological and biochemical functions.</p><p><strong>Objective: </strong>The study was conducted to investigate the characteristics of enzyme extracts from red beet leaves, root pulp, and peel.</p><p><strong>Methods: </strong>The enzyme extraction involved the homogenization of the sample and filtrate in cold acetone and then the filtrate was homogenized in 0.1M sodium acetate buffer, pH 7. The protein content was determined using the Lowry assay using bovine serum albumin (BSA) as a standard protein. Then, enzymatic activity was determined by peroxidase, polyphenol oxidase, and catalase assays. The patent for biological activity of enzymes was obtained from the Office of Career Development, Haramaya University. The antioxidant activities of the enzyme extract were conducted by using DPPH and hydrogen peroxide free radical scavenging activities.</p><p><strong>Results: </strong>The result indicated that the Enzymatic activity of crude enzyme extract of red beet leaf, root pulp and peel indicated that significantly the highest total soluble protein (16.68 mg/ml), peroxidase activity (PODA, 111.50 U/ml), polyphenol oxidase activity (PPOA, 170.90 U/ml), polyphenol oxidase specific activity (PPOspa, 10.25 U/mg), catalase activity (CATA, 180.50 U/ml) and catalase specific activity (CATspa, 10.82 U/mg), were recorded for red beet leaf enzyme extract. The antioxidant activity of the enzyme extracts demonstrated that significantly higher DPPH radical scavenging activity of leaf extract (59.16) and peel extract (61.92) were recorded. The Pearson correlation coefficient of enzyme activity parameters and free radical scavenging activities presented that protein content was significantly and positively correlated with CATA, PPOA, and PPOspa. Catalase- specific activity (CATspa) was significant and positively correlated only with HPSA. Peroxidase-specific activity (PODspa) was significant and positively correlated with PODA and DPPH. Based on the plot for principal component PC2 vs. PC1 for D statistics DPPH, PODA, and PODspa have close PC1 and PC2 scores (with vector angle < 90° showing similar/correlated effects.</p><p><strong>Conclusion: </strong>In this study, B. vulgaris</i> has shown promising peroxidase enzyme activity. Beetroot peel contained higher antioxidant compounds thus promising a more intense utilization of the peels in food and nutraceuticals.</p>","PeriodicalId":21064,"journal":{"name":"Recent patents on biotechnology","volume":"17 4","pages":"395-404"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9533325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current Status and Medicinal Prominence of <i>Arnebia euchroma</i> (Ratanjot): A Critically Endangered Plant of Trans-Himalayan Region.","authors":"Sunita Devi,&nbsp;Pooja Sharma,&nbsp;Rohini Sharma,&nbsp;Meena Thakur","doi":"10.2174/1872208316666220718154341","DOIUrl":"https://doi.org/10.2174/1872208316666220718154341","url":null,"abstract":"<p><p>Trans-Himalayan region has been a major component of the India's opulent medicinal plant heritage that encompasses numerous critically endangered plant species. Arnebia euchroma (Royle ex Benth.) Johnston (common name: Ratanjot), a Trans- Himalayan native, is amongst them, and it belongs to the family Boraginaceae. Ratanjot has long been used as a colourant in food and cosmetics besides a major ingredient of traditional remedies prescribed for curing mild constipation, dermatitis, frostbite, and eczema like health disorders. Though principally harvested for its roots, almost all the parts of this plant have been used in pharmaceutical products, food, dyes and beverages since prehistoric times. Its roots are a rich source of naphthoquinone pigment(s) mainly shikonin, acetylshikonin and deoxyshikonin, accountable for its medicinal value as antimicrobial, wound healing, anti-inflammatory, anticancer, and antioxidant agent(s). Considering the medicinal importance and critically endangered status of this taxon, the need of the hour is to conserve and propagate it for supplying sufficient raw materials for its commercial exploitation.</p>","PeriodicalId":21064,"journal":{"name":"Recent patents on biotechnology","volume":"17 1","pages":"92-102"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9434213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Levothyroxine Sodium - Thyroid Hormone Replacement Therapy for Hypothyroidism: A Review of Patent Literature.","authors":"Uddeshya Upadhyay,&nbsp;Pratik Ashwinbhai Vora,&nbsp;Rakesh Patel,&nbsp;Bijal Prajapati","doi":"10.2174/1872208317666221212124113","DOIUrl":"https://doi.org/10.2174/1872208317666221212124113","url":null,"abstract":"<p><strong>Background: </strong>Levothyroxine Sodium is a thyroid hormone replacement therapy for Hypothyroidism. Levothyroxine Sodium is approved to treat Hypothyroidisim, to suppress thyroid hormone release from cancerous thyroid nodules, and to prevent the growth of goiters. In addition, it is also used to treat conditions such as myxedema, cretinism, and obesity.</p><p><strong>Objective: </strong>This assessment highlights the overview of the recent patents of Levothyroxine Sodium. This review includes patents grouped in sections like product patents, process patents, and composition-related patents, along with the treatment methodology. The objective of this article is to impel pseudoscientists to all existing patents in a solitary place.</p><p><strong>Methods: </strong>Data were gathered from various internet-based resources, including Patentscope ® (WIPO), Worldwide Espacenet® (EPO), Google Patents, and InPASS (Indian patent database).</p><p><strong>Results: </strong>Several new processes and composition-related patents of Levothyroxine Sodium have been reported. Further, due to the problem of photosensitivity, oxidation during development, and stability of Levothyroxine Sodium formulation, several excipients are tried in these patents to stabilize the same. However, the formulation of Levothyroxine Sodium with better characteristics needs to be developed.</p><p><strong>Conclusion: </strong>Extensive exposure has been carried out towards various processes for the preparation of Levothyroxine Sodium and the composition of the same. This sort of dynamic exploration will clear the path for many generic players, which will lead to the reduction of the expense of the composition and accordingly enhance global health care at a less expensive cost.</p>","PeriodicalId":21064,"journal":{"name":"Recent patents on biotechnology","volume":"17 3","pages":"245-256"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9466156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using Bacteria and Fungi as Plant Biostimulants for Sustainable Agricultural Production Systems.","authors":"Mohamad Hesam Shahrajabian,&nbsp;Wenli Sun,&nbsp;Qi Cheng","doi":"10.2174/1872208316666220513093021","DOIUrl":"https://doi.org/10.2174/1872208316666220513093021","url":null,"abstract":"<p><p>Different compounds with bioactive constituents can be applied as biostimulants to increase plant growth and development under both normal and stressful conditions. Biostimulant utilization can be considered a sustainable and beneficial nutritional crop management, and may decrease the negative impacts of excessive chemical fertilization. Google scholar, Science Direct, CAB Direct, Springer Link, Scopus, Web of Science, Taylor and Francis, and Wiley Online Library have been checked. The search was done to all manuscript sections according to the terms \"Glomus intraradices\", \"Trichoderma atroviride\", \"Trichoderma reesei\", \"Heteroconium chaetospira\", \"Arthrobacter spp.\", \"Acintobacter spp.\", \"Enterobacer spp.\", \"Pseudomonas spp.\", \"Ochrobactrum spp.\", \"Bacilus spp.\", \"Rhodococcus spp.\", \"Biostimulants\", and \"Plant growth promotion\". On the basis of the initial check, Titles and Abstracts were reviewed based on online literature, and then articles were read carefully. Within the framework of sustainable crop management, this review article aimed to provide an overview of the application of the most common fungi and bacteria as plant biostimulants on various crops.</p>","PeriodicalId":21064,"journal":{"name":"Recent patents on biotechnology","volume":"17 3","pages":"206-244"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9468742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patent and Marketing Exclusivities 101 for Drug Developers.","authors":"Bryan Oronsky,&nbsp;Scott Caroen,&nbsp;Franck Brinkhaus,&nbsp;Tony Reid,&nbsp;Meaghan Stirn,&nbsp;Raj Kumar","doi":"10.2174/1872208317666230111105223","DOIUrl":"https://doi.org/10.2174/1872208317666230111105223","url":null,"abstract":"<p><p>Despite an ever-increasing need for newer, safer, more effective, and more affordable therapies to treat a multitude of diseases and conditions, drug development takes too long, costs too much, and is too uncertain to be undertaken without the conferment of exclusionary rights or entry barriers to motivate and sustain investment in it. These entry barriers take the form of patents that protect intellectual property and marketing exclusivity provisions that are provided by statute. This review focuses on the basic ins and outs of regulatory and patent exclusivities for which new chemical entities (NCEs), referring to never-before approved drugs with an entirely new active ingredient, are eligible and uses RRx-001, a small molecule aerospace-derived NCE in development for the treatment of cancer, radiation toxicity, and diseases of the NLR family pyrin domain containing 3 (NLRP3) inflammasome, as a \"real world\" example. This is intended as a '101-type' of primer; its aim is to help developers of original pharmaceuticals navigate the maze of patents, other IP regulations, and statutory exclusivities in major markets so that they can make proper use of them.</p>","PeriodicalId":21064,"journal":{"name":"Recent patents on biotechnology","volume":"17 3","pages":"257-270"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10242760/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9592079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patented Keratinolytic Enzymes for Industrial Application: An Overview.","authors":"Shestakova Anna,&nbsp;Lyamina Veronika,&nbsp;Timorshina Svetlana,&nbsp;Osmolovskiy Alexander","doi":"10.2174/1872208317666221212122656","DOIUrl":"https://doi.org/10.2174/1872208317666221212122656","url":null,"abstract":"<p><p>Proteases that perform keratin hydrolysis (keratinases) have great potential in biotechnology. After investigation, the next step to an industrial application is protecting intellectual property by patenting. There are many fields of discovered keratinase implementation dictated by features of the molecule and its producer. This article provides an overview of existing patents on keratinases. Among the patents found using terms related to 'keratinase', only those that contain data on the structure and features of the enzyme to provide a sufficient overview of the current situation are covered. It includes information on publication timelines of patents, as well as their origin; features of cultivation process and producers, such as fermentation type and pathogenicity; and features of enzymes, such as their classes, pH, and temperature optima. This article summarizes information about proprietary keratinases and reflects trends and dependencies in their production and application development. It is also the first review of existing patents on keratinases, which emphasizes the uniqueness and novelty of this article.</p>","PeriodicalId":21064,"journal":{"name":"Recent patents on biotechnology","volume":"17 4","pages":"346-363"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9689610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}