Recent patents on biotechnology最新文献

{"title":"Emerging Methods in the Identification of Bacterial Respiratory Tract Pathogens.","authors":"Flora Kiaghobadi, Ali Dehshahri, Younes Ghasemi, Mohammad Hossein Morowvat","doi":"10.2174/0118722083309510240625085931","DOIUrl":"https://doi.org/10.2174/0118722083309510240625085931","url":null,"abstract":"<p><strong>Aims: </strong>Here, we will review different bacterial causes of respiratory tract infections and discuss the available diagnostic methods. Moreover, we will provide some recently published patents and newer techniques, such as respiratory panels and omics approaches, and express the challenges in this path.</p><p><strong>Background: </strong>Respiratory tract infections (RTIs) include those infections that can lead to the involvement of different respiratory parts, including the sinuses, throat, airways, and lungs. Acute respiratory tract infection is the leading cause of death from infectious illnesses worldwide. According to the World Health Organization, 1.6 to 2.2 million deaths have occurred due to acute respiratory infections in children under five years of age. About 4 million people die annually from respiratory infections, 98% of which are caused by lower respiratory infections.</p><p><strong>Results: </strong>Depending on the type of pathogen, the severity of the infection can vary from mild to severe and even cause death. The most important pathogens involved in respiratory tract infections include Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis. The symptoms are often similar, but the treatment can vary greatly. Therefore, correct diagnosis is so important. There are several methods for diagnosing respiratory infections. Traditional tests include the culture of respiratory samples, considered the primary tool for diagnosing respiratory infections in laboratories, and less common standard tests include rapid and antigenic tests. It is essential to think that the culture method is reliable. In the original method of diagnosing respiratory infections, some bacteria were challenging to grow successfully, and many clinical laboratories needed to be equipped for viral cultures. Another issue is the time to get the results, which may take up to 7 days. Rapid and antigenic tests are faster but need to be more accurate.</p><p><strong>Conclusion: </strong>The clinical laboratories are trying to be equipped with molecular methods for detecting respiratory pathogens and identifying the genetic material of the infectious agent in these new methods as the primary method in their agenda.</p>","PeriodicalId":21064,"journal":{"name":"Recent patents on biotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141535155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Acharas Sapota Linn in Traditional Medicine.","authors":"Ajay Ramdas Nannar","doi":"10.2174/0118722083304962240619101244","DOIUrl":"https://doi.org/10.2174/0118722083304962240619101244","url":null,"abstract":"<p><p>This article offers a thorough analysis of the contemporary application of Achras Sapota Linn, or sapodilla, in conventional medicine. Tropical fruit-bearing Achras Sapota Linn has long been used in many traditional medical systems. The study examines Achras Sapota Linn's phytochemical makeup and pharmacological characteristics with an emphasis on the plant's possible medical uses in the treatment of a range of illnesses. Moreover, it highlights the safety and efficacy characteristics of Achras Sapota Linn and talks about new research and clinical trials that back up its traditional applications. This study also discusses obstacles and potential avenues for further research and application of Achras Sapota Linn in contemporary medicine. All things considered, it emphasizes how important Achras Sapota Linn is to traditional medicine as a therapeutic resource.</p>","PeriodicalId":21064,"journal":{"name":"Recent patents on biotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141451394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Open Innovation or Traditional Patenting Strategies to Efficiently Address Health Emergencies? How Patent Information Was Used Towards Effective Treatments for COVID-19.","authors":"Tatiana Duque Martins Ertner de Almeida, Diéricon Sousa Cordeiro","doi":"10.2174/0118722083303431240528041945","DOIUrl":"https://doi.org/10.2174/0118722083303431240528041945","url":null,"abstract":"<p><strong>Introduction/objective: </strong>During the 1150 days of COVID-19 pandemic there were great efforts to develop efficient treatments for the disease. After this long time, some drugs emerged as treatment for COVID-19. Some of them are new drugs, most of them, known drugs. These developments were triggered by information already available in patent documents. Pharmaceutical companies, therefore, rushed to conduct drugs evaluations and trials in order to deliver to the world a reasonable treatment that could reach the majority of its population. However, it is not immediately clear how companies operated to reach their goals. The ability of open innovation to achieve results assertively and faster than closed innovation strategies is questioned and therefore, it is questioned whether pharmaceutical companies use open innovation to face COVID-19.</p><p><strong>Methods: </strong>In this work, data available on patent databases were mined to inform about the scientific and technological panorama of selected drugs tested for COVID-19 treatment and to understand the perspectives of such developments during the pandemic.</p><p><strong>Results: </strong>This study evidenced that most treatments were based on known drugs, that some of the initially promising drugs were abandoned during the pandemic, and that it was able to inform if open innovation and collaborations were explored strategies.</p><p><strong>Conclusion: </strong>This study evidenced that the developments during COVID-19 were not based on open innovation by revealing a patent race towards the treatment development, but with practically no collaborations or information exchange between companies, universities, and research facilities.</p>","PeriodicalId":21064,"journal":{"name":"Recent patents on biotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141443211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Actinobacteria: Smart Micro-Factories for The Health Sector.","authors":"Roohi Roohi, Naushin Bano","doi":"10.2174/0118722083300181240429072502","DOIUrl":"https://doi.org/10.2174/0118722083300181240429072502","url":null,"abstract":"<p><p>Antibiotics are considered \"wonder drugs\" due to the fact that they are the most extensively utilised medication in the world. They are used to cure a broad spectrum of diseases and lethal infections. A variety of bacteria and fungi produce antibiotics as a result of secondary metabolism; however, their production is dominated by a special class of bacteria, namely Actinobacteria. Actinobacteria are gram-positive bacteria with high G+C content and unparalleled antibiotic-producing ability. They produce numerous polyenes, tetracyclines, β-lactams, macrolides, and peptides. Actinobacteria are ubiquitous in nature and are isolated from various sources, such as marine and terrestrial endophytes of plants and air. They are studied for their relative antibiotic-producing ability along with the mechanism that the antibiotics follow to annihilate the pathogenic agents that include bacteria, fungi, protozoans, helminths, etc. Actinobacteria isolated from endophytes of medicinal plants have amassed significant attention as they interfere with the metabolism of medicinal plants and acquire enormous benefits from it in the form of conspicuous novel antibiotic-producing ability. Actinobacteria is not only an antibiotic but also a rich source of anticancer compounds that are widely used owing to its remarkable tumorigenic potential. Today, amongst Actinobacteria, class Streptomyces subjugates the area of antibiotic production, producing 70% of all known antibiotics. The uniqueness of bioactive Actinobacteria has turned the attention of scientists worldwide in order to explore its potentiality as effective \"micronanofactories\". This study provides a brief overview of the production of antibiotics from Actinobacteria inhabiting diverse environments and the methods involved in the screening of antibiotics.</p>","PeriodicalId":21064,"journal":{"name":"Recent patents on biotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140958030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospects of Plant Derived Bioactive Compounds as Nanoparticles for Biotechnological Applications.","authors":"N. Bano, Syed Khalida Izhar, Anamika Gupta, M. Zaheer, Roohi","doi":"10.2174/0118722083301253240417114400","DOIUrl":"https://doi.org/10.2174/0118722083301253240417114400","url":null,"abstract":"Nanoparticles bestow beneficial impacts on plants, specifically in increasing photosynthetic capacity and germination rate, pesticide delivery, managing pathogenicity and enhancing nutrient supply. The nanoparticles produced from the medicinal plant extracts are identified as an exceptional applicant in nanomedicine, cosmetics, and agriculture for the treatment of diseases as antimicrobial, antioxidant and anticancer agents, etc. Plant extracts actually have bioactive metabolites that provide therapeutic potential against a variety of diseases. Herein, we review the production of bioactive compounds from leaves, roots, seeds, flowers and stems. We further summarize the different methods for obtaining plant extracts and the green technologies for the synthesis of nanoparticles of plant derived bioactive compounds. Biotechnological aspects of these synthesized nanoparticles are also added here as highlights of this review. Overall, plant derived nanoparticles provide an alternative to conventional approaches for drug delivery as well and present exciting opportunities for future research on novel areas.","PeriodicalId":21064,"journal":{"name":"Recent patents on biotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140682560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decarbonizing the Transport of Microalgae-based Products - The Role of E-mobility.","authors":"R. R. Dias, Mariany C. Deprá, Victor Cesar Rodrigues Carvalho, Cristiano Ragagnin de Menezes, L. Q. Zepka, E. Jacob‐Lopes","doi":"10.2174/0118722083305025240409071630","DOIUrl":"https://doi.org/10.2174/0118722083305025240409071630","url":null,"abstract":"BACKGROUND\u0000The decarbonization of road transport is a precondition for achieving carbon neutrality. Battery-electric vehicle technology can make this a reality. In this bias, the objective of the article is to shed light on the ongoing debate about the potentially important role of the adoption of electric vehicles in the transport of microalgae- based products to help them advance to a cleaner life cycle.\u0000\u0000\u0000METHODS\u0000Five routes, including unimodal and multimodal conditions, were defined to assess the carbon emissions of the transport system and, more specifically, of road transport. The headquarters of market-leading microalgae manufacturers were selected as the origin of the routes and, as the destination, regions that sustain them.\u0000\u0000\u0000RESULTS\u0000The results reveal the supremacy of road transport of microalgae-based products using electric vehicles powered by nuclear, hydroelectric, and wind, followed by biomass and photovoltaic energy. They also show that the positive impact of wind, water, and photovoltaic energy on the climate, added to the lower battery charging costs and the greater opportunity to generate revenue from the sale of carbon credits, make their tradeoffs.\u0000\u0000\u0000CONCLUSION\u0000The exquisite results of this study convey key messages to decision-makers and stakeholders about the role of electromobility in building a zero-carbon delivery route.","PeriodicalId":21064,"journal":{"name":"Recent patents on biotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140700922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional Health Connection of Algae and its Pharmaceutical Value as Anticancer and Antioxidant Constituents of Drugs","authors":"S. Mirza, Sidra Akbar, Muhammad Umer Ijaz, Mohammad Hossein Morowvat, Ayesha Ishaque, Kalsoom Fatima","doi":"10.2174/0118722083287672240321081428","DOIUrl":"https://doi.org/10.2174/0118722083287672240321081428","url":null,"abstract":"\u0000\u0000The marine environment is one of the major biomass producers of algae and\u0000seaweed; it is rich in functional ingredients or active metabolites with valuable nutritional\u0000health effects. Algal Metabolites derived from the cultivation of both microalgae and\u0000macroalgae may positively impact human health, offering physiological, pharmaceutical\u0000and nutritional benefits. Microalgae have been widely used as novel sources of bioactive\u0000substances. Bioactive polymers extracted from algae, such as algal fucans, Galatians, alginates\u0000phenolics, carotenoids, vitamin B12, and peptides possess antioxidant, anticoagulant,\u0000antimicrobial, antiviral, anti-inflammatory, anti-allergy, anticancer, and hypocholesterolemic\u0000properties. It emphasizes that using marine-derived compounds with bioactive\u0000properties as functional food ingredients may help promote human health and prevent\u0000chronic diseases. Utilizing bioactive compounds has demonstrated notable advantages in\u0000terms of effectiveness more than conventional treatments and therapies currently in use.\u0000Despite the availability of numerous microalgae-derived products catering to human\u0000health and nutrition in the market, there remains a lack of social acceptance and awareness\u0000regarding the health benefits of microalgae. Hence, this review aims to offer a comprehensive\u0000account of the current knowledge on anticancers, antioxidants, commercially\u0000available edible algal products and therapeutics isolated from algae.\u0000","PeriodicalId":21064,"journal":{"name":"Recent patents on biotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140375069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Artificial Intelligence in Drug Discovery to Revolutionize\u0000the Pharmaceutical Industry: Resources, Methods and Applications","authors":"P. Singh, Kapil Sachan, Vishal Khandelwal, Sumita Singh, Smita Singh","doi":"10.2174/0118722083297406240313090140","DOIUrl":"https://doi.org/10.2174/0118722083297406240313090140","url":null,"abstract":"\u0000\u0000Traditional drug discovery methods such as wet-lab testing, validations, and\u0000synthetic techniques are time-consuming and expensive. Artificial Intelligence (AI) approaches\u0000have progressed to the point where they can have a significant impact on the\u0000drug discovery process. Using massive volumes of open data, artificial intelligence\u0000methods are revolutionizing the pharmaceutical industry. In the last few decades, many\u0000AI-based models have been developed and implemented in many areas of the drug development\u0000process. These models have been used as a supplement to conventional research\u0000to uncover superior pharmaceuticals expeditiously. Drug research and development\u0000to repurposing and productivity benefits in the pharmaceutical business through\u0000clinical trials. AI is studied in this article for its numerous potential uses. We have discussed\u0000how AI can be put to use in the pharmaceutical sector, specifically for predicting a\u0000drug's toxicity, bioactivity, and physicochemical characteristics, among other things. In\u0000this review article, we have discussed its application to a variety of problems, including\u0000de novo drug discovery, target structure prediction, interaction prediction, and binding affinity\u0000prediction. AI for predicting drug interactions and nanomedicines were also considered.\u0000","PeriodicalId":21064,"journal":{"name":"Recent patents on biotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140388110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a Novel Peptide with RGD Tumor Homing Motif: Evaluation of its Anticancer Potential in Hepatocellular Carcinoma and Colon Cancer Cells","authors":"Reda Abdallah Mohamed, Ohoud M. Marie, Dahlia I. Badran, O. Hammam, Hend Okasha","doi":"10.2174/0118722083300452240315035722","DOIUrl":"https://doi.org/10.2174/0118722083300452240315035722","url":null,"abstract":"\u0000\u0000Peptide-based therapy has emerged as a promising avenue for\u0000treating various disorders, and recent research has highlighted the potential of anti-cancer\u0000peptides (ACPs) in cancer treatment. In this context, this study aimed to design a novel\u0000peptide incorporating a tumor-homing peptide (RGD) and C-amidation to enhance its anticancer\u0000activity, particularly against liver (HepG2) and colon (HCT-116) cancer cell lines.\u0000\u0000\u0000\u0000The primary objective was to design a peptide with improved anticancer\u0000properties by leveraging the tumor-homing capabilities of RGD and enhancing its activity\u0000through C-amidation. The study sought to evaluate the cytotoxicity of the designed\u0000peptide against red blood cells (RBCs) and normal Vero cells. Furthermore, the anticancer\u0000efficacy of the peptide was assessed in hepatocellular carcinoma (HepG2) and colon\u0000cancer (HCT-116) cell lines. The specific objectives included examining the apoptotic\u0000induction and morphological changes in treated cells compared to untreated cells.\u0000\u0000\u0000\u0000The peptide was designed using the ACPred-FL bioinformatics tool, and its\u0000cytotoxicity was assessed through hemolysis assays against RBCs and normal Vero cells.\u0000Anticancer activity was evaluated against HepG2 and HCT-116 cell lines. The analysis\u0000of apoptotic induction involved measuring the relative gene expression of oncogenic\u0000marker BCL2 and apoptotic markers (BAX, BID, CAS-8). Additionally, Cytopathological\u0000examination and Western Blot analysis were employed to study morphological\u0000changes and confirm the quantification of relevant markers.\u0000\u0000\u0000\u0000The designed peptide, consisting of twelve amino acids with a molecular mass\u0000of 1230.6233 Da and an isoelectric point of 9.81, exhibited low erythrocyte lysis and\u0000minimal toxicity to normal cells. The IC50 values demonstrated significant anticancer\u0000activity against both HepG2 (36.49±2.6 μg/mL) and HCT-116 (11.03±2.5 μg/mL) cell\u0000lines. Treated cells exhibited a significant decrease in the oncogenic marker BCL2 and an\u0000upregulation of apoptotic markers (BAX, BID, CAS-8). Western Blot analysis confirmed\u0000these findings, and Cytopathological examination revealed scattered apoptotic and degenerative\u0000changes.\u0000\u0000\u0000\u0000The designed peptide displayed remarkable anticancer activity against\u0000hepatocellular carcinoma and colon cancer cell lines, effectively modulating apoptotic\u0000and oncogenic markers. These findings highlight the potential of the peptide as a therapeutic\u0000agent for cancer treatment, emphasizing its clinical significance in combating liver\u0000and colon cancers. Nonetheless, further research and development are warranted to explore\u0000the translational potential of this peptide in clinical settings.\u0000","PeriodicalId":21064,"journal":{"name":"Recent patents on biotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140389125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patents Selections","authors":"","doi":"10.2174/187220831801231013004218","DOIUrl":"https://doi.org/10.2174/187220831801231013004218","url":null,"abstract":"","PeriodicalId":21064,"journal":{"name":"Recent patents on biotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140085654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}