Recent patents on biotechnology最新文献

{"title":"Exploring the Therapeutic Potential of TROP2 Gene Silencing in Hepatocellular Carcinoma.","authors":"Fatma Yakoub, Hanem Hassan, Samah Mamdouh, Tarek Aboushousha, Fatma B Rashidi, Mohamed A El-Desouky","doi":"10.2174/0118722083352578241225130252","DOIUrl":"10.2174/0118722083352578241225130252","url":null,"abstract":"<p><strong>Background: </strong>Trophoblast Cell Surface Antigen 2 (Trop2) is a transmembrane glycoprotein that has been implicated in the progression and metastasis of various cancers, including hepatocellular carcinoma (HCC). Targeting Trop2 expression may represent a promising approach for the development of novel therapeutic strategies and patents.</p><p><strong>Objectives: </strong>This study aimed to investigate the effects of Trop2 knockdown using small interfering RNA (siRNA) on the phenotypic and molecular characteristics of the HepG2 liver cancer cell line.</p><p><strong>Methods: </strong>HepG2 cells were transfected with different concentrations of Trop2-targeting siRNA (3 nM, 5 nM, and 7 nM) at various time intervals (6, 24, and 48 hrs). The expression of Trop2 was assessed by real-time PCR before and after transfection. The impact of Trop2 knockdown on cell apoptosis, migration, morphology, histopathological features, wound-healing assays, and microscopic analysis was examined. Additionally, the expression of the TPM1 gene was evaluated using immunohistochemical analysis.</p><p><strong>Results: </strong>Trop2 mRNA level was significantly decreased in HepG2 cells in a time- and concentration-dependent manner following siRNA transfection. The downregulation of Trop2 resulted in a marked increase in apoptosis, a reduction in cell migration, and alterations in cell morphology and histopathological characteristics. Furthermore, the expression of the TPM1 gene was found to be upregulated in Trop2-knockdown HepG2 cells.</p><p><strong>Conclusion: </strong>These results highlight the potential of Trop2 as a therapeutic target for the management of hepatocellular carcinoma.</p>","PeriodicalId":21064,"journal":{"name":"Recent patents on biotechnology","volume":" ","pages":"166-179"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143010785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preface.","authors":"Nikolaos E Labrou","doi":"10.2174/0118722083417806250605092351","DOIUrl":"10.2174/0118722083417806250605092351","url":null,"abstract":"","PeriodicalId":21064,"journal":{"name":"Recent patents on biotechnology","volume":" ","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144286350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacological Applications of Fava d'anta: A Patent Review.","authors":"Willams Alves da Silva, Igor Lima Soares, Kristiana Cerqueira Mousinho, Afonso Leoncio Saraiva Junior, Isabelle Bruna Menezes Ferreira Alencar, Laisa Graziely Araujo Magalhaes, Gabriel da Silva Procopio, Gabriel Maia Menezes, Kellen Miranda Sa, Rafaela Gomes Bezerra, Mary Anne Medeiros Bandeira","doi":"10.2174/0118722083349741250325035323","DOIUrl":"10.2174/0118722083349741250325035323","url":null,"abstract":"<p><p>A significant portion of the population in low-income countries relies on medicinal plants for healthcare. Fava d'anta is an important species in Brazil due to its bioactive compounds like quercetin and rutin. These compounds have various pharmaceutical applications, but the sustainability of their exploitation is challenged by overharvesting, necessitating sustainable management practices and further biotechnological advancements. The study conducted a comprehensive review of fava d'anta patents and their applications in various pharmacological activities, which are crucial for the development of new medicines and formulations. Patents were searched in four specialized patent databases: The United States Patent and Trademark Office, the World Intellectual Property Organization (WIPO), Espacenet and the National Institute of Industrial Property (INPI). A total of 109 patents were identified through document collection, with 26 patents meeting the inclusion criteria. The analysis revealed a global concentration of innovation in regions like Europe and the United States. Fava d'anta has demonstrated a wide range of therapeutic properties, including antioxidant and anti-inflammatory effects, largely attributed to polyphenols. These bioactive components have shown potential in diverse applications, from nutraceuticals to cosmetics. Patent registrations highlight the significant potential of Dimorphandra species for phytoproducts, particularly due to compounds like quercetin and rutin, but further studies are needed to explore their mechanisms of action and enhance technological applications, especially in cosmetics.</p>","PeriodicalId":21064,"journal":{"name":"Recent patents on biotechnology","volume":" ","pages":"68-88"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current Status of Microalgae-based Food Products: Future Trends of Functional Ingredients.","authors":"Marcele Leal Nörnberg, Luisa Chitolina Schetinger, Tatiele Casagrande do Nascimento, Pricila Nass Pinheiro, Patricia Acosta Caetano, Eduardo Jacob-Lopes, Leila Queiroz Zepka","doi":"10.2174/0118722083380758250802021828","DOIUrl":"10.2174/0118722083380758250802021828","url":null,"abstract":"<p><p>The use of microalgae in food and beverages is becoming increasingly popular as a viable way to develop products with enhanced nutritional profiles, offering positive health effects. In parallel, the plant-based food market is expanding due to the growing vegan, vegetarian, and flexitarian populations, prompting manufacturers to create innovative foods and techniques, such as the addition of microalgae to products. These functional and/or nutraceutical foods present an attractive option for consumers seeking plantbased alternatives. Although some challenges remain, this is a growing market. Furthermore, biotechnological processes are being utilized to optimize the production of microalgae with even more robust nutritional characteristics, thereby increasing their added value. This review was based on a structured literature search across major databases, applying predefined keywords and selection criteria to identify recent advances, regulatory aspects, and biotechnological developments in the field. These innovations hold significant potential to meet the rising demand for bioactive products and to propel a new era in the commercialization of microalgae-based products, a segment still underexplored in the current market. Additionally, progress in this sector depends on the development and protection of biotechnological innovations through patents, ensuring greater security and competitiveness in the industry.</p>","PeriodicalId":21064,"journal":{"name":"Recent patents on biotechnology","volume":" ","pages":"307-324"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144856158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognition, Diagnosis, and Treatment of Alzheimer's Disease: A Review.","authors":"Yuping Qin, Xiangxia Deng, Shuang Zhang","doi":"10.2174/0118722083358924250606173812","DOIUrl":"10.2174/0118722083358924250606173812","url":null,"abstract":"<p><p>As the global population ages, the health of older adults has become a growing concern. Alzheimer's disease (AD) is a common ailment affecting older adults, but the diagnosis and treatment of AD are difficult given our insufficient understanding of the disease. This review article and patents aim to provide reliable information for patients and their families by presenting a detailed overview of the pathogenic factors, diagnostic methods, and clinical manifestation of AD, as well as advances in drug and physical therapies. The information presented here should help provide a more comprehensive understanding of AD for patients and their families and encourage family- or self-screening based on clinical manifestations, thus improving early AD detection. In addition, the current treatment methods for AD are summarized. Although a goldstandard treatment for AD is yet to be developed, controlled-release therapies and medications that slow disease progression or improve cognitive function are available. The appropriate treatment method depends on the patient's diagnosis and the local medical level, and the effectiveness of the treatments may vary. Therefore, improving our understanding of AD and cognition-related symptoms in the public is necessary to improve early AD diagnoses. This review provides information that will facilitate self-screening for AD based on clinical manifestations, which can improve the early clinical diagnosis rate.</p>","PeriodicalId":21064,"journal":{"name":"Recent patents on biotechnology","volume":" ","pages":"260-280"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Green-Synthesized Nanoparticles on Dental Caries-Causing Bacteria: A Systematic Review.","authors":"Asma Sepahdar, Behnoush Selahbarzin, Atoosa Vaez Naini, Samira Jafari, Mehrnaz Moradi, Pegah Shakib","doi":"10.2174/0118722083343723241204053839","DOIUrl":"10.2174/0118722083343723241204053839","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;The primary objective of this review was to investigate the therapeutic implications of green-synthesized metallic nanoparticles, such as silver and zinc nanoparticles, in addressing dental caries, with a focus on their antibacterial properties and potential to improve current treatment modalities.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Materials and methods: &lt;/strong&gt;In this study, a comprehensive search was conducted across multiple databases, including PubMed, Google Scholar, SID, Scopus, Medline, and Web of Science, as well as selected herbal medicine journals. The inclusion of herbal medicine journals was justified by the growing interest in green-synthesized nanoparticles derived from plant extracts, which are relevant to the focus of this review. Articles published between 2015 and 2023 were evaluated. To ensure a robust selection process, studies were assessed for quality using specific criteria beyond the AXIS checklist, including study design, sample size, and methodological rigor. Any discrepancies between reviewers were resolved through discussion or consultation with a third reviewer. This approach aimed to minimize bias and ensure the inclusion of high-quality studies that contribute meaningfully to the review's objectives.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;In this study, 22 clinical trials were reviewed, and the effectiveness of synthesized nanoparticles was demonstrated in nearly all of them. The nanoparticles found to be most effective against tooth decay-causing bacteria include silver, zinc, selenium, nickel, and copper nanoparticles. To provide greater clarity, key findings, such as nanoparticle size, minimum inhibitory concentration (MIC) values, and specific antibacterial effects, are presented in a table. Additionally, a more in-depth comparison was made between these nanoparticles, focusing on their relative effectiveness under different conditions. For example, silver nanoparticles were consistently effective across various trials due to their strong antimicrobial properties, while zinc and copper nanoparticles showed efficacy in specific concentrations and against particular bacterial strains. Furthermore, green-synthesized nanoparticles were compared with those produced using traditional methods, evaluating factors, such as effectiveness, scalability, and safety, to provide a comprehensive understanding of their potential in dental caries treatment.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;According to the literature review, nanoparticles with antibacterial properties have the potential to serve as an alternative or complement to conventional chemical treatments for combating tooth decay. Future research should focus on exploring specific types of nanoparticles, such as green-synthesized metallic nanoparticles (e.g., silver and zinc), which have shown promising antibacterial effects, Many of these ideas are patentable. Additionally, more emphasis should be placed on optimizing synthesis methods that enhance biocompatibili","PeriodicalId":21064,"journal":{"name":"Recent patents on biotechnology","volume":" ","pages":"108-121"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Pharmacognostical and Anti-Ulcer Potential of <i>Vernonia anthelmintica</i> (L.) Willd Seed in Aspirin-Induced Ulcer Rats.","authors":"Nidhi Bisht, Divya Jain, Neeraj Bainsal, Chandan Sharma","doi":"10.2174/0118722083376311250526075839","DOIUrl":"10.2174/0118722083376311250526075839","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Vernonia anthelmintica (L.) Willd., commonly known as Kalijiri, has been used for the treatment of different ailments, including stomach aches, skin diseases, asthma, and cough, and is popular as a powerful anthelmintic agent.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Aims: &lt;/strong&gt;This study aimed to evaluate the pharmacognostical, physicochemical, and phytochemical parameters along with the in-vivo antiulcer activity of the seeds of Vernonia anthelmintica (L.) Willd.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;The pharmacognostical evaluation included macroscopic and microscopic characterization of the seed and powder of &lt;i&gt;Vernonia anthelmintica&lt;/i&gt; (L.) Willd. Physicochemical parameters, such as moisture content, ash values, and extractive values, were evaluated, and fluorescence analysis was carried out. Phytochemical screening, including total flavonoid content (TFC) and total phenolic content (TPC), was conducted, along with antioxidant analysis. The anti-ulcer activity of ethanolic extract of V. anthelmintica seeds was also evaluated using an aspirin-induced ulcer model by employing multiple biochemical and histopathological assessment parameters.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The morphological characteristics of &lt;i&gt;V. anthelmintica&lt;/i&gt; seeds demonstrated that the seed was 0.8-1 cm in length and 0.1-0 in width, with a bitter taste, whereas microscopical findings revealed the presence of pericarp, endosperm, sclerenchymatous zone, parenchymatous zone, bundles of sclereids, seed coat, and prismatic crystals. Moisture content and ash values, including total ash, acid-insoluble ash, and water-soluble ash, were approximately 10.05%, 8.50%, 2.06%, and 4.35%, respectively. Extractive values of different solvents (petroleum ether, chloroform, benzene, ethanol, and water) were approximately 16.00%, 15.80%, 2.00%, 7.05%, and 1.06%, respectively. Moreover, fluorescence analysis revealed a characteristic brown colour. Preliminary phytochemical analysis showed the presence of phenolic, carbohydrates, proteins, flavonoids, saponins, diterpenes, steroids, and amino acids. The TFC and TPC revealed that the ethanolic extract contained more phenolic content, whereas the aqueous extract contained more flavonoids. The ethanolic extract exhibited 90% DPPH radical scavenging activity at a concentration of 100 μg/mL, while the aqueous extract showed 85.71% activity at the same concentration. In comparison, ascorbic acid demonstrated 94.32% scavenging activity at 40 μg/mL. The ethanolic extract of V. anthelmintica seeds at doses 200 and 400mg/kg showed a significant decrease in the ulcer index values, gastric volume, and total acidity levels, whereas an increase was observed in the SOD and GSH levels. The extract demonstrated a moderate effect on the levels of Hb and total protein when compared with the disease control group. The histopathological findings revealed the antiulcer potential of ethanolic extract of V. anthelmintica seeds at both doses.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Dis","PeriodicalId":21064,"journal":{"name":"Recent patents on biotechnology","volume":" ","pages":"372-386"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Blockchain Technology in the Improvement of Supply Chain Management in the Pharmaceutical Industry.","authors":"Dinesh Kumar, Rajni Tanwar, Debarshi Kar Mahapatra, Nisham Lohan, Geetanjali Dahiya, Divya Jain","doi":"10.2174/0118722083347810250711232759","DOIUrl":"10.2174/0118722083347810250711232759","url":null,"abstract":"<p><p>Blockchain technology has drawn a lot of interest in the healthcare industry in recent years. Efficient data management is crucial for pharmacies. Blockchain technology is a novel technology that has the potential to make many pharmaceutical processes safer and more transparent. In 2013, the US Congress created the Drug Supply Chain Security Act (DSCSA) to prevent the distribution of stolen, contaminated, or counterfeit drugs. Blockchain technology serves as an answer to this problem as it enables the tracking and tracing the product from manufacturer to patient through an electronic, immutable, digitized tracking record of all steps from inventory to consumer in the drug supply chain. To ensure the safety of a peer-to-peer network of transactions, blockchain technology employs cryptographic methods to create a distributed ledger that is not centralized. Incorporating it into a product ensures its safety and marketability. Blockchain technology offers solutions to enhance the validity, reliability, and efficiency of medication manufacturing by facilitating easy compliance with legislation. Additionally, it offers an opportunity to address a major problem: the proliferation of counterfeit drugs that enter the system and ultimately reach consumers. The pharmaceutical industry's deficient supply chain management results in counterfeit and fake drug entering the supply chain and negatively affecting patients' health, leading to serious complications or even death. Supply chain management may benefit from blockchain technology's transparency and immutability at every step of the process, which increases confidence, security, traceability, and transparency. Blockchain technology, designed to manage electronic data, holds promise for enhancing clarity. Every user of a computer network has access to the same immutable record of transactions known as a blockchain. Patent innovations have significant implications for pharmaceutical patent protection, supply chain transparency, and counterfeit prevention.</p>","PeriodicalId":21064,"journal":{"name":"Recent patents on biotechnology","volume":" ","pages":"242-259"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144744550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biosurfactants Used in the Bioremediation of Soils Contaminated with Hydrocarbons - Overview of the State of the Art and Future Perspectives.","authors":"Maria Auxiliadora de Oliveira, Vinícius Souza Tarabal, Felipe Ferreira Silva, Diego Fernandes Livio, Daniela Regiane da Silva, Adriano Guimaraes Parreira, Daniel Bonoto Goncalves, Jose Antonio da Silva, Pedro Pires Goulart Guimaraes, Paulo Afonso Granjeiro","doi":"10.2174/0118722083343490241130163344","DOIUrl":"10.2174/0118722083343490241130163344","url":null,"abstract":"<p><strong>Background: </strong>The increasing industrialization and hydrocarbon use have led to concerning soil contamination. Oil spills and improper disposal of oily waste pose threats to ecosystems and human health. The recovery of these environments is essential, but separating oily components from soil remains challenging. Current bioremediation strategies using synthetic surfactants can cause secondary contamination. Microbial biosurfactants, which are biodegradable and low in toxicity, emerge as promising solutions, and this study reviews methods for utilizing these biosurfactants in the environmental bioremediation of hydrocarbons.</p><p><strong>Objective: </strong>This study explores the efficient and eco-friendly use of biosurfactants for hydrocarbon- contaminated soil management, providing a market-oriented analysis of recent patents and trends, and highlighting the transition from academic research to industrial applications.</p><p><strong>Methods: </strong>The methodology involves an extensive literature review, careful selection of recent studies and patents on biosurfactants in hydrocarbon bioremediation, critical analysis of in-situ and ex-situ application methods, assessment of commercial viability, and synthesis of findings to contribute to sustainable solutions in contaminated environments.</p><p><strong>Conclusion: </strong>The present study demonstrates the extensive applicability of biosurfactants across various industrial sectors. The increasing interest in incorporating biosurfactants into industrial processes is driven by the pressing need for sustainable solutions to address tangible market challenges. Notably, the cosmetics industry exhibited the highest number of patents related to the use of biosurfactants, underscoring its significant role in advancing the adoption of these environmentally friendly agents. This trend highlights the critical demand for sustainable alternatives in product formulations and underscores the pivotal role of biosurfactants in fostering eco-innovation within the industry.</p>","PeriodicalId":21064,"journal":{"name":"Recent patents on biotechnology","volume":" ","pages":"3-24"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent Patents of Stent Grafts for Intravascular Aortic Repair.","authors":"Yiwen Wang, Yuxin Zhang","doi":"10.2174/0118722083355380250716073539","DOIUrl":"10.2174/0118722083355380250716073539","url":null,"abstract":"<p><strong>Introduction: </strong>Endovascular aortic repair involves the placement of stents through minimally invasive methods to seal rupture sites near the aortic inflow tract, thereby preventing blood entry into the false lumen and promoting thrombosis, which reduces the risk of aortic rupture. Endovascular stents typically consist of a metal framework and a flexible membrane graft designed to reopen obstructed aortic segments and maintain blood flow through the true lumen. Consequently, stents are widely used to treat aortic expansion diseases and aortic occlusive stenosis. However, traditional stents have limitations in terms of adaptability to complex anatomical structures, long-term durability, biomechanical stability, and reliance on radial support force for fixation, lacking active fixation mechanisms. These shortcomings remain the primary causes of postoperative complications, significantly impacting the quality of life for patients with aortic dissection.</p><p><strong>Methods: </strong>Integrating patent and academic literature, the research status of the endovascular stent was discussed in depth, and the main factors for the optimal design of the stent (geometry, pattern configuration, additional fixtures, and optimization methods) were analyzed and summarized according to the complications targeted by the repair device.</p><p><strong>Results: </strong>The composition structure, working principle, and development status of the stent grafts under review are elaborated in detail. Stent grafts attempt to alleviate postoperative complications through three approaches: enhancing the flexibility of the stent framework, improving the fit between the vessel wall and the stent, and reducing vascular injury. Blood flow guiding channels are established to alleviate the obstruction of branch blood flow. Additional self-anchoring devices are added to adapt to the dynamic remodeling of blood vessels.</p><p><strong>Discussion: </strong>The effects of various factors, including geometric parameters, structural design, and parameter optimization techniques, on the optimization of stent primary mechanical performance are discussed. The current research status of functional improvement methods for stents is also summarized.</p><p><strong>Conclusion: </strong>Refining the quantitative relationship between stent structural parameters and mechanical performance, as well as exploring the balance criteria between flexibility and radial support force, represent promising directions for future development. These objectives necessitate further in-depth analysis and research.</p>","PeriodicalId":21064,"journal":{"name":"Recent patents on biotechnology","volume":" ","pages":"325-341"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144708587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}