Radiation and Environmental Biophysics最新文献

{"title":"Characteristic variation of organs at risk dose and biologically effective dose as a function of different α/β values for conventional, moderate, and ultrahypofractionated breast cancer radiotherapy.","authors":"Biplab Sarkar, Anirudh Pradhan","doi":"10.1007/s00411-025-01165-9","DOIUrl":"10.1007/s00411-025-01165-9","url":null,"abstract":"<p><p>This study aimed to establish reference dose-volume parameters for various organs at risk (OARs) across clinically relevant dose-fractionation regimens in breast cancer radiotherapy. It further evaluated the variation in biologically effective doses (BEDs) of OARs as functions of different α/β values and fractionation schedules. The regimens examined include conventional (50 Gy in 25 fractions), moderately hypofractionated (40 Gy in 15 fractions), and ultrahypofractionated (27 Gy-26 Gy in 5 fractions) approaches. Left-sided breast (Br) or chest wall (CW) cancer, with or without supraclavicular fossa involvement, were planned using five-field intensity-modulated radiotherapy (IMRT). Evaluation parameters included heart D0.2 cc, heart mean dose, and ipsilateral (left) lung mean dose. BEDs were calculated for six α/β values: 3.7, 3.0, 2.3, 2.0, 1.8, and 1.7 Gy. Variations between prescribed and achieved doses, along with their corresponding BEDs, were analyzed using one-way ANOVA. This study included 359 patients, with 50 in the ultrahypofractionated group and 309 in the combined moderately hypofractionated and conventional group. For the 50 Gy regimen, left lung mean BEDs ranged from 15.1 ± 4.2 Gy to 21.4 ± 6.2 Gy across different α/β values, suggesting potential risks of radiation pneumonitis or lung fibrosis. In contrast, the 26 Gy regimen yielded lower mean BEDs, ranging from 8.4 ± 1.8 Gy to 14.3 ± 3.3 Gy, indicating a more favourable risk-benefit profile. For the heart, mean BEDs were 6.1 ± 2.1 Gy to 8.6 ± 3.3 Gy with 50 Gy, compared with 3.3 ± 0.9 Gy to 5.7 ± 1.5 Gy with 26 Gy. Heart D0.2 cc BEDs were higher for 50 Gy (69.6 ± 11.6 Gy to 98.2 ± 15.8 Gy) than for 26 Gy (48.3 ± 11.7 Gy to 81.4 ± 18.7 Gy). All differences between prescription doses, OAR doses, and corresponding BEDs were statistically significant (p = 0.003-0.035). It is concluded that this study provided reference OAR dose-volume parameters and BED values across a range of α/β values for conventional, moderately hypofractionated, and ultrahypofractionated breast cancer radiotherapy in a large cohort of Asian women. Data presented here can guide treatment planning, support dose constraint selection, and aid interpretation of dosimetric data, particularly for ultrahypofractionated regimens, where evidence remains limited.</p>","PeriodicalId":21002,"journal":{"name":"Radiation and Environmental Biophysics","volume":" ","pages":"387-400"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145523767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment planning parameters in intensity modulated radiotherapy for prostate cancer and their dosimetric impact: a study using Monaco TPS.","authors":"Florentina Larisa Coc, Loredana G Marcu","doi":"10.1007/s00411-025-01190-8","DOIUrl":"10.1007/s00411-025-01190-8","url":null,"abstract":"<p><p>This study aimed to determine the most appropriate treatment planning solution for prostate cancer radiotherapy by analyzing the effect of planning parameters on dosimetric outcome. Four volumetric modulated arc therapy (VMAT) / intensity modulated radiation therapy (IMRT) plans were created for each of the 20 patients included in the study, using minimum segment width (MSW) of 0.5, 1.0, 1.5, and 2.0 cm. All prostate plans underwent \"Fluence Smoothing\" on \"High\", while plans using MSW = 1.0 were reoptimized with both \"Low\" and \"Medium\" settings. All plans met the planning objectives. MSW = 0.5 resulted in better tumour coverage (by over 0.3 Gy), enhanced conformity and better sparing for the majority of organs at risk (OARs). However, this small MSW was associated with a notable increase in monitor units (MUs) (by over 300), control points (CPs) (by over 83) and delivery time (DT) (by over 0.88 min). The most significant impact of reduced fluence smoothing was observed in parameters such as MUs (reduced by over 53) and DT (reduced by over 0.15 min), which improved gamma passing rate (GPR). In the context of dosimetric outcomes, variations in fluence smoothing had minimal effect on the dose distribution to the planning target volume and most OARs. It is concluded that clinically acceptable dose distributions were achieved across all segment widths and fluence smoothing levels. However, using a 1.0 cm MSW with medium-to-high fluence smoothing provided a favourable balance between plan quality, delivery accuracy and efficiency in prostate cancer, without compromising dosimetric outcomes.</p>","PeriodicalId":21002,"journal":{"name":"Radiation and Environmental Biophysics","volume":" ","pages":"473-489"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146150542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prolonged low-dose neutron irradiation induces late cellular and molecular impairments in the mice hippocampus and causes cognitive deficit.","authors":"Alla V Rodina, A S Zhirnik, O V Vysotskaya, O D Smirnova, I V Cheshigin, E Yu Moskaleva","doi":"10.1007/s00411-026-01208-9","DOIUrl":"10.1007/s00411-026-01208-9","url":null,"abstract":"<p><p>Late effects of prolonged low-dose neutron exposure on the brain function remain poorly studied. We analyzed the content of neural progenitor cells, microglia and astrocytes, the number of PSD-95 puncta, the expression level of pro- and anti-inflammatory cytokines in the hippocampus, and long-term spatial and recognition memory in conventional (CV) and specific pathogen-free (SPF) mice 2 months after prolonged neutron irradiation at doses of 0.05 (1 day) and 0.5 Gy (10 day). Neurogenesis was intact in all mice. The level of PSD-95 was increased only in CV mice irradiated at 0.05 Gy. In CV mice, an increase in the number of microglia was recorded at both doses and astrocytes at 0.05 Gy; in SPF mice, both microglia and astrocytes increased only after irradiation at 0.5 Gy. The expression of TNFα and IL-1β increased in all irradiated mice; the expression of TGFβ decreased in CV mice irradiated at 0.5 Gy. These findings suggest that the severity of neuroinflammation in irradiated CV mice was higher than in SPF mice. Conventional analysis of escape latencies in the Morris water maze (MWM) revealed an intact spatial memory in both groups, while analysis of the swimming strategies demonstrated spatial reference memory deficits in CV mice irradiated at 0.05 Gy and in SPF mice irradiated at 0.5 Gy. Novel object recognition (NOR) assay demonstrated decreased recognition index only in CV mice (both doses). Thus, the housing conditions of animal before expose affect the neuroinflammation level and cognitive impairment late after prolonged low-dose neutron irradiation.</p>","PeriodicalId":21002,"journal":{"name":"Radiation and Environmental Biophysics","volume":" ","pages":"197-209"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147356108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thyroid doses estimated for a cohort of people exposed to fallout from atmospheric nuclear weapons testing at the semipalatinsk nuclear test site, Kazakhstan.","authors":"Vladimir Drozdovitch, Alexandra Lipikhina, Kazbek Apsalikov, Yulia Brait, Alik Tokanov, Gani Yessilkanov, Rafail Rosenson, André Bouville, Evgenia Ostroumova","doi":"10.1007/s00411-025-01155-x","DOIUrl":"10.1007/s00411-025-01155-x","url":null,"abstract":"<p><p>Thyroid doses were estimated for a cohort of 3,183 individuals who were exposed to fallout from atmospheric nuclear weapons tests conducted at the Semipalatinsk Nuclear Test Site (SNTS), Kazakhstan, between 1949 and 1962. The study participants were mostly younger than 21 years of age at the time of their first exposure and lived in settlements near the SNTS. Individual thyroid doses from external irradiation from gamma-emitting radionuclides deposited on the ground as well as internal irradiation from intake of ¹³¹I and short-lived radiotellurium and radioiodine isotopes (¹³²Te+¹³²I, ¹³³I, and ¹³⁵I) with locally produced foodstuffs and inhalation of contaminated air during the passage of the radioactive cloud were reconstructed for the cohort. Estimated thyroid doses from external irradiation ranged from 4.9 × 10^-5 Gy to 0.58 Gy (arithmetic mean (AM) dose was 0.048 Gy, median dose was 0.023 Gy), internal thyroid doses from ingestion of ¹³¹I, ¹³²Te+¹³²I, ¹³³I and ¹³⁵I ranged from 0 to 13.3 Gy (AM: 0.34 Gy, median: 0.062 Gy), and internal thyroid doses from inhalation of ¹³¹I, ¹³²Te+¹³²I, ¹³³I and ¹³⁵I ranged from 0 to 0.28 Gy (AM: 0.046 Gy, median: 2.8 × 10^-3 Gy). The AM of thyroid doses from all exposure pathways was 0.43 Gy (range from 3.5 × 10^-4 Gy to 13.7 Gy) and the median was 0.13 Gy. The highest thyroid doses were received by cohort members after test #2 conducted on 24 September 1951 (AM: 1.1 Gy, geometric mean (GM): 0.70 Gy), followed by test #1 conducted on 29 August 1949 (AM: 0.49 Gy, GM: 0.047 Gy) and the thermonuclear test #4 conducted on 12 August 1953 (AM: 0.16 Gy, GM: 0.14 Gy). The predominant pathway of thyroid exposure in the cohort was intake of ¹³¹I with fresh milk from mares and cows, and dairy products made from these types of milk. Although the uncertainties in the dose estimates were not quantified, it was estimated that they are characterized by a geometric standard deviation from 2.0 to 4.0 for most individuals. The study cohort received quite high thyroid doses compared to other populations exposed to fallout from the Chernobyl accident and atmospheric nuclear weapons tests conducted elsewhere. The cohort included individuals exposed in utero, as children and as adolescents to high doses of radiation to the thyroid gland. Consequently, it provides a unique opportunity to assess radiation-related risks of thyroid cancer, thyroid nodules, and other structural and functional non-cancer thyroid diseases.</p>","PeriodicalId":21002,"journal":{"name":"Radiation and Environmental Biophysics","volume":" ","pages":"283-305"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12626414/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145542386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overview of naturally occurring radioactive materials (NORM) in mineral processing industries and consideration of ionising radiation in life cycle assessment (LCA) - PART II. NORM impact assessment.","authors":"Jelena Mrdakovic Popic, Alla Dvorzhak, Boguslaw Michalik, Gennaro Venoso, Raffaella Ugolini, Federica Leonardi, Rosabianca Trevisi, Nathalie Vanhoudt, Antti Kallio, Almudena Real, Alicia Escribano, Danyl Pérez-Sánchez, Cristina Nuccetelli, Flavio Trotti, Laureline Fevrier","doi":"10.1007/s00411-025-01171-x","DOIUrl":"10.1007/s00411-025-01171-x","url":null,"abstract":"<p><p>This work provides an overview of issues related to naturally occurring radioactive materials (NORM) in mineral processing industries across European countries, including the production of phosphoric acid and phosphate fertilisers, titanium dioxide (TiO₂), zircon and zirconium, and cement production industries. The study examines the impact of NORM from these industries on radiation exposure to workers, the public, and the environment. Relevant exposure scenarios are analysed, and effective radiation doses are evaluated. Potential treatments and final destinations of NORM residues are considered, with special attention to their possible valorisation and reuse. The aim of this work is to enhance overall knowledge of radiation protection in mineral processing industries, support the management of NORM-containing residues and waste, and assist regulatory decision-making. This is particularly important within the framework of Life Cycle Assessment (LCA) and the circular economy, which emphasizes optimal resource use, reduction of raw material extraction, waste minimization, and product life cycle extension. Current residues may be valorised as raw materials for future industrial applications. In such an economic strategy, the environmental impact of NORM and potential risks to the public can be significantly reduced—or even eliminated—at certain stages of the product life cycle. However, potential radiation exposure must always be considered. Therefore, further development of the LCA approach for NORM is important and requires substantial effort. An initial evaluation of the case of phosphoric acid production in the context of LCA is presented in this paper as an example of the broader development work needed in this area.</p>","PeriodicalId":21002,"journal":{"name":"Radiation and Environmental Biophysics","volume":" ","pages":"83-101"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13135523/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145763714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanistic trends and therapeutic targets in Radiation-Induced apoptosis: A bibliometric and translational mapping.","authors":"Xiangyu Chen, Yang Hu, Xinghai Yu, Ziwei Zhang, Pu Yang","doi":"10.1007/s00411-026-01194-y","DOIUrl":"10.1007/s00411-026-01194-y","url":null,"abstract":"<p><p>Apoptosis is a central mechanism by which ionizing radiation exerts both therapeutic and toxic biological effects. Despite its pivotal role in radiobiology, the evolving landscape of apoptosis-related radiation research has yet to be systematically mapped from a translational perspective.We conducted a bibliometric and thematic analysis of 4,372 English-language publications (2015–2025) retrieved from the Web of Science Core Collection using the search terms “radiation damage” and “apoptosis.” Co-authorship, keyword, and co-citation networks were visualized using VOSviewer and CiteSpace. Temporal bursts and clustering analysis were performed to identify mechanistic advances and emergent trends relevant to medicinal chemistry. Publications were additionally stratified by radiation modality (IR, UV and EMF).Annual publication volume increased by 15% from 2015 to 2025, with China emerging as the most prolific contributor. However, high-impact citations remained centered in North America and Europe. IR-related studies dominated overall output, while UV- and EMF-associated apoptosis research formed smaller but persistent niches. Research focus has shifted from oxidative stress and canonical DNA damage response pathways (ATM/ATR/PARP) to microenvironment mediated radiosensitivity and nano-enabled drug delivery. Citation-burst analysis highlights ongoing interest in tumor microenvironment modulation, extracellular vesicles, and nanoparticle radiosensitizers. Mechanistic hotspots include STING-mediated DNA sensing, ferroptosis driven mitochondrial destabilization, and DRP1/OPA1-regulated apoptotic commitment. Apoptosis-related radiation research is undergoing a mechanistic and translational shift, with growing relevance for drug discovery, radiosensitization, and biomarker-guided therapy. Cross-disciplinary collaboration and data integration are now critical to accelerating therapeutic innovation in precision radiotherapy.</p>","PeriodicalId":21002,"journal":{"name":"Radiation and Environmental Biophysics","volume":" ","pages":"221-235"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13135549/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146106953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Dosimetric Analysis of VMAT Treatment Plans for Stomach Cancer: A Study Using Halcyon™ and VitalBeam® Radiotherapy Machines.","authors":"Meriem Chenhaji, Morad El Kafhali, Marziyeh Tahmasbi, Driss Benchekroun, Dahbi Zineb, Fatima-Zohra Erradi","doi":"10.1007/s00411-025-01175-7","DOIUrl":"10.1007/s00411-025-01175-7","url":null,"abstract":"<p><p>This study aimed to compare the quality of radiotherapy treatment plans for stomach cancer on Halcyon™ and VitalBeam^® linacs. Treatment plans were created for 20 stomach cancer patients clinically treated with Halcyon™. The same plans were retrospectively generated for VitalBeam^® under identical planning conditions. Halcyon™ plans were generated with 6 MV FFF (flattening filter-free) beams (800 monitor units (MU)/min), while VitalBeam^® plans used 6 MV flattened beams (600 MU/min), reflecting routinely used configurations and enabling evaluation of FFF versus flattened beam delivery. Conformity index (CI), gradient index (GI), and homogeneity index (HI) for the planned target volume (PTV), and dose metrics for organs at risk (OARs) were assessed. Statistical comparisons were performed using paired tests, where significance was set at p < 0.05. VitalBeam^® achieved a higher CI for the PTV (0.70 ± 0.17) compared to Halcyon™ (0.64 ± 0.14, p = 0.048). GI values were slightly higher with VitalBeam^® (3.41 ± 0.39 vs. 3.26 ± 0.51) but not significantly (p = 0.058). HI values were similar (0.11 ± 0.04 vs. 0.10 ± 0.04, p = 0.308). For OARs, most dose metrics were comparable, while bowel V₁₅ was significantly higher with Halcyon™ (374.6 ± 215.8 cc vs. 346.6 ± 205.9 cc, p = 0.007). It is concluded that Halcyon™ and VitalBeam^® provide comparable VMAT quality for stomach cancer. VitalBeam^® achieved better target conformity and bowel sparing, while Halcyon™ maintained overall efficiency. These differences reflect the multi-leaf collimator (MLC) design and beam setup, highlighting clinical equivalence and tailoring machine choice to needs.</p>","PeriodicalId":21002,"journal":{"name":"Radiation and Environmental Biophysics","volume":" ","pages":"401-409"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145605573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A biokinetic model to assess radon uptake by the fetus during pregnancy.","authors":"Ä L Degenhardt, V Spielmann, A Giussani","doi":"10.1007/s00411-025-01187-3","DOIUrl":"10.1007/s00411-025-01187-3","url":null,"abstract":"<p><p>Epidemiological studies have shown a statistically significant increase in lung cancer risk from prolonged exposure to indoor radon. While current radiation protection efforts address the general population, including workers in radon-prone areas, pregnant individuals represent a vulnerable subgroup that requires specific consideration. Prenatal exposure to ionizing radiation, including radon and its progeny, raises concerns not only for maternal health but also for potential in-utero tissue reactions and/or cancer development in other life stages in the offspring. This study aimed to develop a comprehensive biokinetic model for radon to evaluate fetal uptake following maternal exposure through inhalation. The model was based on the latest ICRP age- and sex-specific biokinetic model for radon, adapted to include pregnancy-specific compartments such as the uterus, placenta, arterial and venous cord blood, and key fetal organs (lungs, brain, kidneys, thyroid, bone surface, liver, and adipose). Transfer rates were calculated using Fick's law of passive diffusion. Maternal and fetal physiological changes throughout pregnancy, including tissue masses and blood flows, were incorporated. Model simulations show that, despite radon gas being predominantly exhaled after inhalation, a fraction crosses the placenta, reaching fetal tissues-particularly those with higher fat content. Additionally, due to the chemical affinity of radon and fatty tissues, fetal adipose tissue receives a significant proportion of radon, resulting in the highest predicted uptake among fetal tissues. This biokinetic model provides an approach to estimate fetal uptake of radon from maternal exposures, supporting more accurate assessments for radiation protection of pregnant individuals and their developing fetuses.</p>","PeriodicalId":21002,"journal":{"name":"Radiation and Environmental Biophysics","volume":" ","pages":"135-145"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13135538/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145934797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Empowering communities: the impact of citizen science on radon measurement and mitigation.","authors":"Meritxell Martell, Tanja Perko","doi":"10.1007/s00411-025-01181-9","DOIUrl":"10.1007/s00411-025-01181-9","url":null,"abstract":"<p><p>Radon exposure poses a significant public health risk, yet authorities often struggle to engage residents in high-risk areas to test and mitigate radon levels. Traditional top-down approaches have shown limited success in motivating citizen engagement in radon mitigation. This study aims to assess the effectiveness of citizen science (CS) approaches in enhancing radon measurement and mitigation efforts across Europe, with a focus on citizen engagement and impact of the RadoNorm CS incubator. To evaluate the impact of CS projects, a mixed-methods approach was used, including computer-assisted web interviews with 231 citizen scientists, interviews with seven researchers, and group discussions with ten CS coordinators. The CS evaluation method developed by Hoedoafia et al. (2024) has been used. The RadoNorm CS Incubator engaged over 800 citizens and 57 research organizations across the EU. Pilot CS projects related to radon in France, Hungary, Ireland, and Norway informed the design of an open call, resulting in the selection and funding of six CS projects related to radon in Italy, Poland, Portugal, Slovakia, Slovenia, and Spain. The results show that these projects employed diverse methodologies to address specific community needs and improve radon awareness, measurement and mitigation strategies. The study highlights the successful outcomes of these projects, including the development of new radon dosimeters, innovative mitigation techniques, increased public awareness, improved local policies, and expanded school curricula. The findings demonstrate the potential of CS to enhance public engagement, improve risk communication, address research and scientific gaps and contribute to more effective radon protection strategies.</p>","PeriodicalId":21002,"journal":{"name":"Radiation and Environmental Biophysics","volume":" ","pages":"103-119"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13135579/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146087035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proteomic profiling of mouse lungs after radon inhalation and lipopolysaccharide administration.","authors":"Shota Naoe, Ayumi Tanaka, Reiju Takenaka, Fumiya Matoba, Takaaki Miyaji, Kiyonori Yamaoka, Takahiro Kataoka","doi":"10.1007/s00411-025-01189-1","DOIUrl":"10.1007/s00411-025-01189-1","url":null,"abstract":"<p><p>Radon therapy alleviates the symptoms of autoimmune diseases by enhancing antioxidant and anti-inflammatory effects. Although radon inhalation normalizes serum cytokine concentrations modulated by lipopolysaccharide (LPS) administration, it also increases pulmonary oxidative stress. Hence, its effects on lungs must be comprehensively evaluated; however, no study has reported the effects of short-term radon inhalation or the associated proteomic changes. In this study, we aimed to evaluate the state of protein expression in the lungs after radon inhalation and LPS administration and identified biomarkers that could be particularly affected. We performed shotgun proteomics and multivariate analyses and evaluated myeloperoxidase (MPO) activity. On examining the control, LPS-administration, and radon inhalation plus LPS-administered groups, the expression levels of cilia- and flagella-associated protein 61, segment polarity protein dishevelled homolog DVL-1, histone-lysine N-methyltransferase 2 A, and heat shock protein beta-1 varied and were identified as characteristic indicators. However, radon inhalation did not suppress MPO activity indicating an absence of anti-inflammatory effect in the lungs. Thus, although the combination of short-term continuous radon pre-inhalation and LPS administration cannot yet be considered effective against lung inflammation, we identified four key indicators for assessing the associated effects. Despite not clarifying the biological significance of these proteins, our findings provide useful information for applying radon therapy in systemic inflammation.</p>","PeriodicalId":21002,"journal":{"name":"Radiation and Environmental Biophysics","volume":" ","pages":"187-195"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145966747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}