Evaluating the biological impact of shelters on astronaut health during different solar particle events: a Geant4-DNA simulation study.

IF 1.5 4区环境科学与生态学 Q3 BIOLOGY

Radiation and Environmental Biophysics Pub Date : 2025-03-01 Epub Date: 2025-01-28 DOI:10.1007/s00411-025-01111-9

Hassan Vafapour, Payman Rafiepour, Javad Moradgholi, Smj Mortazavi

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引用次数: 0

Abstract

Mechanistic Monte Carlo simulations have proven invaluable in tackling complex challenges in radiobiology, for example for protecting astronauts from solar particle events (SPEs) during deep space missions which remains an underexplored area. In this study, the Geant4-DNA Monte Carlo code was used to assess the DNA damage caused by SPEs and evaluate the protective effectiveness of a multilayer shelter. By examining the February 1956 and October 1989 SPEs-two extreme cases-the results showed that the proposed shelter reduced DNA damage by up to 57.9% for the October 1989 SPE and 36.7% for the February 1956 SPE. Cell repair and survival modeling further revealed enhanced cell survival with the shelter, reducing lethal DNA damage by up to 64.3% and 88.2% for February 1956 and October 1989 SPEs, respectively. The results presented here highlight the crucial importance of developing effective radiation shielding to protect astronauts during solar storms and emphasizes the need to improve predictions of solar particle events to optimize shelter design.

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评估不同太阳粒子事件期间避难所对宇航员健康的生物影响：Geant4-DNA 模拟研究。

机械蒙特卡罗模拟已被证明在解决放射生物学的复杂挑战方面是无价的，例如在深空任务期间保护宇航员免受太阳粒子事件（spe）的影响，这仍然是一个未被充分探索的领域。本研究利用Geant4-DNA蒙特卡罗代码对spe造成的DNA损伤进行了评估，并对多层遮蔽物的防护效果进行了评估。通过对1956年2月和1989年10月两个极端案例的研究，结果表明，在1989年10月的SPE和1956年2月的SPE中，所提出的庇护减少了高达57.9%的DNA损伤和36.7%的DNA损伤。细胞修复和存活模型进一步揭示了遮荫条件下细胞存活率的提高，在1956年2月和1989年10月的SPEs中，致命DNA损伤分别减少了64.3%和88.2%。本文的研究结果强调了在太阳风暴期间开发有效的辐射屏蔽以保护宇航员的重要性，并强调了改进太阳粒子事件预测以优化遮蔽设计的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Radiation and Environmental Biophysics 环境科学-核医学

CiteScore

4.00

自引率

5.90%

发文量

审稿时长

>36 weeks

期刊介绍： This journal is devoted to fundamental and applied issues in radiation research and biophysics. The topics may include: Biophysics of ionizing radiation: radiation physics and chemistry, radiation dosimetry, radiobiology, radioecology, biophysical foundations of medical applications of radiation, and radiation protection. Biological effects of radiation: experimental or theoretical work on molecular or cellular effects; relevance of biological effects for risk assessment; biological effects of medical applications of radiation; relevance of radiation for biosphere and in space; modelling of ecosystems; modelling of transport processes of substances in biotic systems. Risk assessment: epidemiological studies of cancer and non-cancer effects; quantification of risk including exposures to radiation and confounding factors Contributions to these topics may include theoretical-mathematical and experimental material, as well as description of new techniques relevant for the study of these issues. They can range from complex radiobiological phenomena to issues in health physics and environmental protection.