Radiation and Environmental Biophysics最新文献_第5页

A novel paradigm in radiotherapy planning techniques comparison for dosimetric and secondary cancer risk assessment in right-sided modified radical mastectomy. 放射治疗计划技术在右侧改良乳房根治术中剂量学和继发性癌症风险评估的新范例。

IF 2.4 4区环境科学与生态学

Radiation and Environmental Biophysics Pub Date : 2026-05-01 Epub Date: 2026-04-24 DOI: 10.1007/s00411-026-01221-y

Amal Jose, Anju George, Abhishek Pratap Singh, Desh Deepak Ladia

{"title":"A novel paradigm in radiotherapy planning techniques comparison for dosimetric and secondary cancer risk assessment in right-sided modified radical mastectomy.","authors":"Amal Jose, Anju George, Abhishek Pratap Singh, Desh Deepak Ladia","doi":"10.1007/s00411-026-01221-y","DOIUrl":"10.1007/s00411-026-01221-y","url":null,"abstract":"Radiotherapy for right-sided modified radical mastectomy (MRM) patients carries a risk of secondary malignancies due to radiation exposure to nearby organs-at-risk (OARs). Techniques such as 3D-CRT, IMRT (sliding window), and VMAT differ in their dose distribution to these OARs. This retrospective study analyzed dose-volume histograms from 25 female patients with right-sided MRM to compare the three techniques in terms of dosimetric parameters, radiobiological outcomes, and secondary cancer risks. Mean doses to key OARs-the heart, contralateral lung, ipsilateral lung, and contralateral breast-were evaluated, and NTCP calculations were used to quantify radiation-induced secondary malignancy risks. 3D-CRT delivered lower mean doses to contralateral OARs, reducing secondary cancer risks compared to IMRT and VMAT, but was associated with higher NTCP in the ipsilateral lung. VMAT achieved superior target conformity but increased low-dose exposure to contralateral OARs, raising secondary cancer risks. These findings highlight the importance of individualized treatment planning for right-sided MRM patients. Overall, 3D-CRT appears favorable for minimizing secondary cancer risks in contralateral organs, despite higher ipsilateral lung NTCP. This study provides a framework for integrating dosimetric, radiobiological, and secondary cancer risk assessments in radiotherapy planning, supporting future strategies to optimize both efficacy and safety.","PeriodicalId":21002,"journal":{"name":"Radiation and Environmental Biophysics","volume":" ","pages":"771-780"},"PeriodicalIF":2.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147779052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polymeric tissue substitutes for In-vivo radionuclide monitoring phantoms: state of the art and future directions. 体内放射性核素监测幻影的聚合组织替代品：技术现状和未来方向。

IF 2.4 4区环境科学与生态学

Radiation and Environmental Biophysics Pub Date : 2026-05-01 Epub Date: 2026-04-15 DOI: 10.1007/s00411-026-01215-w

Vikash Nara, Shailesh Joshi, Madhusmita Panda, O Annalakshmi, C V Srinivas

引用次数: 0

Naturally occurring radionuclides (NOR) and rare earth elements (REE) in soil and cereals in a high background area, Fen complex, Norway. 挪威芬复合体高背景区土壤和谷物中的天然放射性核素（NOR）和稀土元素（REE）

IF 2.4 4区环境科学与生态学

Radiation and Environmental Biophysics Pub Date : 2026-05-01 Epub Date: 2026-05-04 DOI: 10.1007/s00411-026-01222-x

H Haanes, R Gjelsvik, J Hoftuft, J Brown

{"title":"Naturally occurring radionuclides (NOR) and rare earth elements (REE) in soil and cereals in a high background area, Fen complex, Norway.","authors":"H Haanes, R Gjelsvik, J Hoftuft, J Brown","doi":"10.1007/s00411-026-01222-x","DOIUrl":"10.1007/s00411-026-01222-x","url":null,"abstract":"Some areas of the world have high natural background levels of naturally occurring radionuclides (NOR) and/or rare earth elements (REE). With high background radiation risk, knowledge about, for example, uptake by crops is required in the process of assessing radiation doses to humans. In the Fen complex, in Norway, underlying bedrock has elevated levels of both NOR and REE. In Mining hill where these bedrocks surface and there are also legacy mines, soils also have high background levels. Most of Fen complex is, however, covered by thick Holocene deposits but some of its agricultural soils are situated near the areas of surfacing carbonatite bedrock and legacy mines. We assess whether there has been any influence on the levels in the agricultural soils within the Fen complex from the areas with high NOR and REE soil background. We also determine uptake from soils by cereals into grain or grain with hull, and present concentration ratios (CR) for NOR and REE in this high background area. In particular, the REE CRs are an important augmentation to existing sparse datasets. We furthermore assess whether uptake can be biased by any soil particles adhering to cereal grain or grain with hull. We investigate whether washing (or not washing) and use of different acids for dissolution may affect ICP-MS results on common elements. We also address soil mass in cereal samples using Scandium and Titanium as tracers for soil particles and assess the potential magnitude of bias CR.","PeriodicalId":21002,"journal":{"name":"Radiation and Environmental Biophysics","volume":" ","pages":"693-707"},"PeriodicalIF":2.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13303692/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147820042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Temporal and spatial patterns of γH2AX signaling in different human cells after exposure to X-rays and UV-C light. γ - h2ax信号在不同人体细胞暴露于x射线和UV-C光后的时空格局

IF 2.4 4区环境科学与生态学

Radiation and Environmental Biophysics Pub Date : 2026-05-01 Epub Date: 2026-05-22 DOI: 10.1007/s00411-026-01220-z

Isabella Guardamagna, Leonardo Lonati, Ombretta Iaria, Alice Mentana, Daniele Parodi, Giulia Peterlin, Rossella Semerano, Cecilia Riani, Andrea Previtali, Anna Tricarico, Paola Tabarelli de Fatis, Giovanni Battista Ivaldi, Paola Perucca, Ornella Cazzalini, Giorgio Baiocco

{"title":"Temporal and spatial patterns of γH2AX signaling in different human cells after exposure to X-rays and UV-C light.","authors":"Isabella Guardamagna, Leonardo Lonati, Ombretta Iaria, Alice Mentana, Daniele Parodi, Giulia Peterlin, Rossella Semerano, Cecilia Riani, Andrea Previtali, Anna Tricarico, Paola Tabarelli de Fatis, Giovanni Battista Ivaldi, Paola Perucca, Ornella Cazzalini, Giorgio Baiocco","doi":"10.1007/s00411-026-01220-z","DOIUrl":"10.1007/s00411-026-01220-z","url":null,"abstract":"The phosphorylation of H2AX at serine 139 (γH2AX) is a marker of DNA damage response, well characterized after ionizing radiation (IR) exposure. In this work we compared γH2AX activation in different human cell lines exposed to X-rays, up to 5 Gy, or UV-C light (below ionization threshold), up to 40 J/m2. We selected HeLa, Caco-2 and HaCaT cells as models with different origins and radiosensitivity, conventionally screened with the clonogenic assay. We integrated data from fluorescence microscopy and flow cytometry. Results highlight that γH2AX spatial pattern is determined by the genotoxic agent: X-rays induce discrete, countable foci (associated with DNA double-strand breaks), while UV-C leads to pan-nuclear signal distributions. Instead, dose-response curves are strongly dependent on the cell-line, showing linear or saturating trends, not attributable to the readout technique. After 5 Gy X-rays, γH2AX signal peaks within 1 hour. The residual intensity at 24 hours is compatible with the control for all cell lines; however, cells show different clonogenic survival fractions at 7 days. The kinetics of γH2AX positive cells following 20 J/m2 UV-C exposure is completely different, with a slower accumulation and persistent signaling from viable cells (not restricted to the S-phase) up to 24 hours, but with a loss of clonogenic potential in the long-term. These findings emphasize that γH2AX marker may be considered as a functional sensor of DNA damage response rather than a marker of specific DNA lesions, and that both radiation quality and cellular context must be considered for its correct interpretation.","PeriodicalId":21002,"journal":{"name":"Radiation and Environmental Biophysics","volume":" ","pages":"781-791"},"PeriodicalIF":2.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13303546/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147988858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of ionizing radiation on earthworms under long-term exposure: a review. 长期电离辐射对蚯蚓影响的研究进展。

IF 2.4 4区环境科学与生态学

Radiation and Environmental Biophysics Pub Date : 2026-05-01 Epub Date: 2026-04-27 DOI: 10.1007/s00411-026-01219-6

Tatiana Maystrenko, Anna Rybak

{"title":"Effects of ionizing radiation on earthworms under long-term exposure: a review.","authors":"Tatiana Maystrenko, Anna Rybak","doi":"10.1007/s00411-026-01219-6","DOIUrl":"10.1007/s00411-026-01219-6","url":null,"abstract":"Our review includes well-known works as well as relatively new experimental articles (published from 2015 to 2024) addressing the impact of prolonged exposure to soil with elevated radionuclide levels on earthworm populations, as well as organismal, cellular, and molecular parameters in individuals. It was shown that the negative influence of ionizing radiation on earthworms was not recorded in all studies. The reasons for this could be both the relatively high overall radioresistance of members of the taxon or non-ideal habitat conditions for earthworm populations in the studied areas (contaminated or reference). Yet, negative effects at individual and sub-individual levels in organisms from the contaminated areas or subjected to low-dose long-term radiation were often noted in the absence of any changes in population endpoints. Damages to tissues and cells were observed in earthworms inhabiting areas with enhanced concentrations of technologically enhanced natural radioactive materials (TENORM) in the soil. Overall, the results of studies on the effects of radionuclide-contaminated soil on soil invertebrates indicate a high potential for survival and maintenance of earthworm populations even with short-term disruptions to their age structure and reproductive capacity. The use of -omics technologies in such studies makes it possible to identify new biomarkers that respond to sub-chronic and chronic radiation exposure, to uncover complex mechanisms of radionuclide detoxification, radiation resistance, and adaptation to long-term radiation exposure, and to provide a more accurate assessment of the consequences for wildlife.","PeriodicalId":21002,"journal":{"name":"Radiation and Environmental Biophysics","volume":" ","pages":"635-656"},"PeriodicalIF":2.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147779133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the absorbed-dose response of EBT3, EBT4, HD-V2, MD-V3, and RTQA2 gafchromic films as a function of photon energy. 评价EBT3、EBT4、HD-V2、MD-V3和RTQA2变色膜的吸收剂量响应随光子能量的变化。

IF 2.4 4区环境科学与生态学

Radiation and Environmental Biophysics Pub Date : 2026-05-01 Epub Date: 2026-05-11 DOI: 10.1007/s00411-026-01223-w

Mohammad Khosravani, Hamid Reza Baghani, Reza Shamsabadi

{"title":"Evaluation of the absorbed-dose response of EBT3, EBT4, HD-V2, MD-V3, and RTQA2 gafchromic films as a function of photon energy.","authors":"Mohammad Khosravani, Hamid Reza Baghani, Reza Shamsabadi","doi":"10.1007/s00411-026-01223-w","DOIUrl":"10.1007/s00411-026-01223-w","url":null,"abstract":"The Energy dependence of the dose response is a primary characteristic of a radiation dosimeter. Although an ideal dosimeter should exhibit an independent energy response over the range of use, all types of dosimeters show some energy dependence. The current study aimed to evaluate this energy dependence of some gafchromic films in a photon field through Monte Carlo (MC) simulations using the MCNPX code. Five gafchromic films including EBT3, EBT4, HD-V2, MD-V3, and RTQA2 were considered and the energy dependence was evaluated for monochromatic and some polychromatic clinical photon beams. The results showed that all considered films show an energy dependent dose response. Specifically, the energy dependence was highly evident at photon energies below 60 keV. Among the studied films, the EBT4 and MD-V3 films showed the least and most energy dependence, respectively. Changing from monochromatic nature of photon beam to a polychromatic clinical beam changed film energy dependence response at keV energy range. Although considered gafchromic films are characterized as dosimeters with energy-independent response, all studied films showed a degree of absorbed-dose energy dependence. This observed energy dependence may be of concern in absorbed dose measurements, especially at low photon energies.","PeriodicalId":21002,"journal":{"name":"Radiation and Environmental Biophysics","volume":" ","pages":"819-829"},"PeriodicalIF":2.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147869471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biokinetic modelling of the exhalation of ²¹⁹Rn gas and its airborne progeny from patients undergoing treatment with ²²³Ra-dichloride and effective dose estimation for caregivers. 接受223ra -二氯化治疗的患者呼出219Rn气体及其空气传播后代的生物动力学模型和护理人员的有效剂量估计

IF 2.4 4区环境科学与生态学

Radiation and Environmental Biophysics Pub Date : 2026-05-01 Epub Date: 2026-05-18 DOI: 10.1007/s00411-025-01193-5

Lena Katzdobler, Astrid Delker, Augusto Giussani, Kerstin Hürkamp, Christina Kuttler, Oliver Meisenberg, Sibylle Ziegler, Wei Bo Li

{"title":"Biokinetic modelling of the exhalation of 219Rn gas and its airborne progeny from patients undergoing treatment with 223Ra-dichloride and effective dose estimation for caregivers.","authors":"Lena Katzdobler, Astrid Delker, Augusto Giussani, Kerstin Hürkamp, Christina Kuttler, Oliver Meisenberg, Sibylle Ziegler, Wei Bo Li","doi":"10.1007/s00411-025-01193-5","DOIUrl":"10.1007/s00411-025-01193-5","url":null,"abstract":"The radiopharmaceutical 223Ra-dichloride (Xofigo®) has been approved for palliative treatment of metastatic castration-resistant prostate cancer. During the treatment and caregiving, patients who received 223Ra-dichloride can exhale the progeny 219Rn, a radioactive gas. This causes a potential risk for medical staff and caregivers who might inhale the 219Rn gas and its airborne decay products. As an addition to the strategies of developing devices for measuring 219Rn gas and its daughter nuclides in treatment rooms, this work tried to estimate the amount of exhaled 219Rn and of its airborne progeny using biokinetic modelling. The biokinetic models and parameters for 223Ra and its progeny 219Rn, as published by the International Commission of Radiological Protection, were adopted for this analysis. Without consideration of room ventilation, the model predicted that the amount of 219Rn gas in the room air can reach a maximum activity of 5.8∙10− 2 Bq at approximately 1.5 min after infusion of one Bq of 223RaCl2. The summed activities of 219Rn and its airborne progeny do not exceed 1.2∙10− 1 Bq per infused Bq of 223RaCl2. In the breathing air of the patients, the activities at 1 and 5 min after the infusion were estimated to be approximately 2∙10− 2 Bq and 1.8∙10− 2 Bq per Bq of 223RaCl2, respectively. The values at 1 min are comparable to the measured results reported in the literature. The effective dose from inhalation of 219Rn gas and its airborne progeny due to a treatment of 4015 kBq of 223RaCl2, was estimated to be 232.6 nSv for medical staff and 7.5 µSv for caregivers.","PeriodicalId":21002,"journal":{"name":"Radiation and Environmental Biophysics","volume":" ","pages":"741-756"},"PeriodicalIF":2.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13303660/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147964545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dosimetric analysis of VMAT-TBI: measurement of organ and junction dose using a whole body anthropomorphic phantom. VMAT-TBI的剂量学分析：使用全身拟人模型测量器官和接点剂量。

IF 2.4 4区环境科学与生态学

Radiation and Environmental Biophysics Pub Date : 2026-05-01 Epub Date: 2026-04-15 DOI: 10.1007/s00411-026-01213-y

Nitin R Kakade, Rajesh Kumar, Mahendra More, Shatabdi Chakrabarty, S D Sharma, B K Sapra

{"title":"Dosimetric analysis of VMAT-TBI: measurement of organ and junction dose using a whole body anthropomorphic phantom.","authors":"Nitin R Kakade, Rajesh Kumar, Mahendra More, Shatabdi Chakrabarty, S D Sharma, B K Sapra","doi":"10.1007/s00411-026-01213-y","DOIUrl":"10.1007/s00411-026-01213-y","url":null,"abstract":"Total body irradiation (TBI) is an essential component of conditioning regimens for hematopoietic stem cell transplantation. Volumetric Modulated Arc Therapy-TBI (VMAT-TBI) has recently emerged as an innovative alternative to conventional TBI that offers improved dose conformity. However, VMAT-TBI introduces junction regions between adjacent fields, making dosimetric verification crucial for ensuring uniform dose delivery. In addition, measurement of organ dose in organs such as brain, eyes, heart, liver, lung, kidney, and spinal cord is important for minimizing acute and late toxicities. The present study aimed at measuring the organ and junction doses using a whole body anthropomorphic phantom (ATOM 701-D, CIRS, Norfolk, Virginia). This phantom includes capsule-containing thermoluminescence dosimeters (TLDs) at multiple positions within organ and field junction. Computed Tomography (CT) images of the phantom were acquired to delineate different organs and the TLD locations. A treatment plan comprising four sub-plans with three junction fields was generated using the Eclipse treatment planning system (Version 17.0, Varian Medical Systems, Palo Alto, CA) to deliver 95% of the prescription dose to 95% of the planning target volume (PTV). Conformal dose coverage of the PTV was achieved and organ doses were within acceptable tolerances. The percentage deviation between doses measured with the TLDs and those calculated with the treatment planning system (TPS) with respect to prescription dose was evaluated at 38 positions (26 within various organs and 12 within junction regions). Percentage deviations at the 12 positions in the junction regions and 21 positions within organs were within ± 5% with a slightly higher differences ranging from − 6.72% to 7.43% at remaining five positions. The results demonstrate the effectiveness of VMAT-TBI as a promising alternative to conventional TBI, for hematopoietic stem cell transplantation.","PeriodicalId":21002,"journal":{"name":"Radiation and Environmental Biophysics","volume":" ","pages":"793-801"},"PeriodicalIF":2.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147692120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimization radiation shielding for Bi₂O₃-based composites with artificial neural networks. 基于人工神经网络的Bi₂O₃基复合材料辐射屏蔽优化

IF 2.4 4区环境科学与生态学

Radiation and Environmental Biophysics Pub Date : 2026-05-01 Epub Date: 2026-04-20 DOI: 10.1007/s00411-026-01212-z

M R Alipoor, M Eshghi, R Razavi

{"title":"Optimization radiation shielding for Bi₂O₃-based composites with artificial neural networks.","authors":"M R Alipoor, M Eshghi, R Razavi","doi":"10.1007/s00411-026-01212-z","DOIUrl":"10.1007/s00411-026-01212-z","url":null,"abstract":"Lead-based shields are toxic, heavy, and inefficient for multi-spectrum radiation protection, creating a need for safer, lighter, and smarter materials. This study addresses this gap by developing novel bismuth oxide-based composites for broad-spectrum photon shielding. A series of composites were designed, and their performance was evaluated using Geant4 Monte Carlo simulations. An artificial neural network (ANN) model was trained over 120 epochs to predict linear attenuation coefficients (LACs) and validate the simulation data. The composites demonstrated effective shielding performance across an energy range of 0.015–10 MeV. The ANN model achieved high predictive accuracy, with over 95% of LAC predictions within ± 0.2 error units and relative deviations below 0.5% across most energies. The top-performing C-1 composite achieved a radiation protection efficiency of 62.35% at 1.4 MeV and exhibited the lowest half-value layer of less than 0.8 cm at 0.662 MeV and Compton-to-total interaction ratio among all designs. A critical performance enhancement was observed at bismuth’s K-edge (81 keV), where the tenth-value layer plummeted to less than 0.1 mm. In terms of broad-spectrum utility, the composites showed a high mass attenuation coefficient of up to 5.0 cm²/g at 0.1 MeV and maintained a competitive areal density of 824–889 g/cm² compared to lead at 567 g/cm². The findings indicate that these bismuth-based composites are a high-performance, non-toxic alternative to lead, offering effective protection against gamma rays. This work establishes a data-driven framework, combining simulation and machine learning, for the accelerated design of next-generation radiation shielding materials.","PeriodicalId":21002,"journal":{"name":"Radiation and Environmental Biophysics","volume":" ","pages":"803-817"},"PeriodicalIF":2.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147723470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Monte Carlo simulation of digestive and bladder positive contrast in pelvic CT scan examination: radiation dose and cancer risk assessment. 盆腔CT扫描检查中消化道和膀胱阳性对比的蒙特卡罗模拟：辐射剂量和癌症风险评估。

IF 2.4 4区环境科学与生态学

Radiation and Environmental Biophysics Pub Date : 2026-03-01 Epub Date: 2025-12-03 DOI: 10.1007/s00411-025-01179-3

Maroine Tahiri, Yassine Benameur, Mina Azeddou, Redouane El Baydaoui, Aziz Elkhatib, Noureddine Elamri, Mounir Mkimel

{"title":"Monte Carlo simulation of digestive and bladder positive contrast in pelvic CT scan examination: radiation dose and cancer risk assessment.","authors":"Maroine Tahiri, Yassine Benameur, Mina Azeddou, Redouane El Baydaoui, Aziz Elkhatib, Noureddine Elamri, Mounir Mkimel","doi":"10.1007/s00411-025-01179-3","DOIUrl":"10.1007/s00411-025-01179-3","url":null,"abstract":"This study aimed to evaluate the impact of digestive and bladder positive contrast agents (CA) on radiation dose and cancer risk during pelvic computed tomography (CT) scans using Monte Carlo simulation with the GATE platform and computational phantoms. The Siemens Emotion 16-slice CT scanner model was validated by comparing measured and simulated CTDIvol values using pelvic CT parameters. The densities and chemical compositions of CAs (Gastrografin® 30% and Utravist® 30%) were incorporated into the bladder and rectal cavities of Female Adult mesh (FASH) and Male Adult mesh (MASH) phantoms. Organ doses were simulated for scenarios using bladder CA (DU), digestive CA (DD), and both CAs (DDU). The dose enhancement factor (DEF) and lifetime attributable risk (LAR) were calculated using the Biological Effects of Ionizing Radiation (BEIR) VII model, considering a reference age of 30 years.The highest effective dose was observed in females (4.83 mSv) compared to males (2.61 mSv). The small intestine (22.35 mGy) and uterus (27.64 mGy) recorded the highest absorbed doses. Positive CAs significantly reduced radiation dose and cancer risk, with the greatest reductions achieved when both CAs were applied (mean DEFDU,male = 0.68, mean DEFD,male = 0.75, DEFU,male = 0.90). Specific reductions were noted for Organs containing CA, including the bladder (DEFDU,male = 0.41, DEFDU,female = 0.55) and small intestine (DEFDU,male = 0.52, DEFDU,female = 0.53). Cancer risk reductions ranged from 8.84% to 38.86% in females and 5.24% to 33.65% in males, with reductions of 19.59% for the uterus, 29.20% for the ovaries, and 40.84% for the prostate.The shadowing effect of enhanced cavities demonstrated a significant reduction in radiation dose and cancer risk, highlighting potential applications of CAs in clinical practice to improve safety.","PeriodicalId":21002,"journal":{"name":"Radiation and Environmental Biophysics","volume":" ","pages":"423-433"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145669442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0