Respiratory Physiology & Neurobiology最新文献_第7页

Isoproterenol modulates expiratory activities in the brainstem spinal cord preparation in neonatal mice in vitro 异丙肾上腺素调节新生小鼠体外脑干脊髓制备物的呼气活动。

IF 2.3 4区医学

Respiratory Physiology & Neurobiology Pub Date : 2024-02-26 DOI: 10.1016/j.resp.2024.104241

Jean-Charles Viemari

{"title":"Isoproterenol modulates expiratory activities in the brainstem spinal cord preparation in neonatal mice in vitro","authors":"Jean-Charles Viemari","doi":"10.1016/j.resp.2024.104241","DOIUrl":"10.1016/j.resp.2024.104241","url":null,"abstract":"<div><p>Motor behaviors such as breathing required temporal coordination of different muscle groups to insured efficient ventilation and provide oxygen to the body. This action is the result of interactions between neural networks located within the brainstem. Inspiration and expiration depend at least in part on interactions between two separate oscillators: inspiration is driven by a neural network located in the preBötzinger complex (PreBötC) and active expiration is driven by a network in the parafacial respiratory group (pFRG). Neurons of the pFRG are silent at rest and become active when the respiratory drive increased. This study investigated the temporal coordination between the brainstem respiratory network and the lumbar spinal network that generates spontaneous activities that is different of the induced fictive locomotion. The remaining question is how these activities coordinate early during the development. Results of this study show that brainstem networks contribute to the temporal coordination of the lumbar spontaneous activity during inspiration since lumbar motor activity occurs exclusively during the expiratory time. This study also investigated the role of the β-noradrenergic modulation on the respiratory activities. β-noradrenergic receptors activation increased the frequency of the double bursts and increased expiratory activity at the lumbar level. These results suggest interactions between brainstem and spinal networks and reveal a descending drive that may contribute to the coordination of the respiratory and lumbar spontaneous activities.</p></div>","PeriodicalId":20961,"journal":{"name":"Respiratory Physiology & Neurobiology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139990931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preventive effects of hesperidin in an experimental model ofs acute lung inflammation 橙皮甙对急性肺部炎症实验模型的预防作用

IF 2.3 4区医学

Respiratory Physiology & Neurobiology Pub Date : 2024-02-26 DOI: 10.1016/j.resp.2024.104240

Ana Beatriz Farias de Souza , Natália Alves de Matos , Thalles de Freitas Castro , Guilherme de Paula Costa , André Talvani , Akinori Cardozo Nagato , Rodrigo Cunha Alvim de Menezes , Frank Silva Bezerra

{"title":"Preventive effects of hesperidin in an experimental model ofs acute lung inflammation","authors":"Ana Beatriz Farias de Souza , Natália Alves de Matos , Thalles de Freitas Castro , Guilherme de Paula Costa , André Talvani , Akinori Cardozo Nagato , Rodrigo Cunha Alvim de Menezes , Frank Silva Bezerra","doi":"10.1016/j.resp.2024.104240","DOIUrl":"10.1016/j.resp.2024.104240","url":null,"abstract":"<div><p>In this study, we hypothesized that long-term administration of hesperidin can modulate the inflammatory response and oxidative stress in animals submitted to mechanical ventilation (MV). Twenty-five C57BL/6 male mice were divided into 5 groups: control, MV, animals receiving hesperidin in three doses 10, 25 and 50 mg/kg. The animals received the doses of hesperidin for 30 days via orogastric gavage, and at the end of the period the animals were submitted to MV. In animals submitted to MV, increased lymphocyte, neutrophil and monocyte/macrophage cell counts were observed in the blood and airways. Associated to this, MV promoted an increase in inflammatory cytokine levels such as CCL2, IL-12 and TNFα. The daily administration of hesperidin in the three doses prevented the effects caused by MV, which was observed by a lower influx of inflammatory cells into the airways, a reduction in inflammatory markers and less oxidative damage.</p></div>","PeriodicalId":20961,"journal":{"name":"Respiratory Physiology & Neurobiology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139990932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Apnea behavior in early- and late-stage mouse models of Parkinson's disease: Cineradiographic analysis of spontaneous breathing, acute stress, and swallowing 帕金森病早期和晚期小鼠模型的呼吸暂停行为：自发呼吸、急性应激和吞咽的放射线分析。

IF 2.3 4区医学

Respiratory Physiology & Neurobiology Pub Date : 2024-02-22 DOI: 10.1016/j.resp.2024.104239

Lorena Roberta de Souza Mendes Kawamura , Max Sarmet , Priscila Sales de Campos , Sachiko Takehara , Yasuhiro Kumei , Jorge Luis Lopes Zeredo

{"title":"Apnea behavior in early- and late-stage mouse models of Parkinson's disease: Cineradiographic analysis of spontaneous breathing, acute stress, and swallowing","authors":"Lorena Roberta de Souza Mendes Kawamura , Max Sarmet , Priscila Sales de Campos , Sachiko Takehara , Yasuhiro Kumei , Jorge Luis Lopes Zeredo","doi":"10.1016/j.resp.2024.104239","DOIUrl":"10.1016/j.resp.2024.104239","url":null,"abstract":"<div><p>This study aimed to evaluate the timing and frequency of spontaneous apneas during breathing and swallowing by using cineradiography on mouse models of early/initial or late/advanced Parkinson’s disease (PD). C57BL/6 J mice received either 6-OHDA or vehicle injections into their right striatum, followed by respiratory movement recordings during spontaneous breathing and swallowing, and a stress challenge, two weeks later. Experimental group animals showed a significantly lower respiratory rate (158.66 ± 32.88 breaths/minute in late PD, 173.16 ± 25.19 in early PD versus 185.27 ± 25.36 in controls; p<0.001) and a significantly higher frequency of apneas (median 1 apnea/minute in both groups versus 0 in controls; p<0.001). Other changes included reduced food intake and the absence of swallow apneas in experimental mice. 6-OHDA-induced nigrostriatal degeneration in mice disrupted respiratory control, swallowing, stress responsiveness, and feeding behaviors, potentially hindering airway protection and elevating the risk of aspiration.</p></div>","PeriodicalId":20961,"journal":{"name":"Respiratory Physiology & Neurobiology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139940706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Skeletal muscle oxygenation and exercise intolerance in hemodialysis: Navigating toward promising horizons? 血液透析患者的骨骼肌氧合与运动不耐受：驶向充满希望的地平线？

IF 2.3 4区医学

Respiratory Physiology & Neurobiology Pub Date : 2024-02-20 DOI: 10.1016/j.resp.2024.104238

Marieta Theodorakopoulou , Afroditi Boutou , Pantelis Sarafidis

引用次数: 0

Stress stimulation promotes the injury repair process of airway epithelial cells through the [Cl−]i−FAK signaling axis 应激刺激通过[Cl-]i-FAK 信号轴促进气道上皮细胞的损伤修复过程。

IF 2.3 4区医学

Respiratory Physiology & Neurobiology Pub Date : 2024-02-12 DOI: 10.1016/j.resp.2024.104237

Jia Wang , Jinhua Luo , Yanjuan Liu , Yu Jiang , Xiangping Qu , Chi Liu , Yang Xiang , Xiaoqun Qin

{"title":"Stress stimulation promotes the injury repair process of airway epithelial cells through the [Cl−]i−FAK signaling axis","authors":"Jia Wang , Jinhua Luo , Yanjuan Liu , Yu Jiang , Xiangping Qu , Chi Liu , Yang Xiang , Xiaoqun Qin","doi":"10.1016/j.resp.2024.104237","DOIUrl":"10.1016/j.resp.2024.104237","url":null,"abstract":"<div><p>The airway epithelium serves as a critical interface with the external environment, making it vulnerable to various external stimuli. Airway epithelial stress acts as a catalyst for the onset of numerous pulmonary and systemic diseases. Our previous studies have highlighted the impact of acute stress stimuli, especially bacterial lipopolysaccharide (LPS) and hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>), on the continuous elevation of intracellular chloride concentration ([Cl<sup>−</sup>]<sub>i</sub>). However, the precise mechanism behind this [Cl−]<sub>i</sub> elevation and the consequential effects of such stress on the injury repair function of airway epithelial cells remain unclear. Our findings indicate that H<sub>2</sub>O<sub>2</sub> induces an elevation in [Cl<sup>−</sup>]<sub>i</sub> by modulating the expression of CF transmembrane conductance regulator (CFTR) and Ca-activated transmembrane protein 16 A (TMEM16A) in airway epithelial cells (BEAS-2B), whereas LPS achieves this solely through CFTR. Subsequently, the elevated [Cl<sup>−</sup>]<sub>i</sub> level facilitated the injury repair process of airway epithelial cells by activating focal adhesion kinase (FAK). In summary, the [Cl<sup>−</sup>]<sub>i</sub>−FAK axis appears to play a promoting effect on the injury repair process triggered by stress stimulation. Furthermore, our findings suggest that abnormalities in the [Cl<sup>−</sup>]<sub>i</sub>−FAK signaling axis may play a crucial role in the pathogenesis of chronic airway diseases. Therefore, controlling the structure and function of airway epithelial barriers through the modulation of [Cl<sup>−</sup>]<sub>i</sub> holds promising prospects for future applications in managing and treating such conditions.</p></div>","PeriodicalId":20961,"journal":{"name":"Respiratory Physiology & Neurobiology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139736012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pediatric patients diagnosed as overweight and obese have an elevated risk of dyspnea 被诊断为超重和肥胖的儿科患者出现呼吸困难的风险较高。

IF 2.3 4区医学

Respiratory Physiology & Neurobiology Pub Date : 2024-02-09 DOI: 10.1016/j.resp.2024.104230

Lydia S. Robson , Abidan Abulimiti , Jorge Z. Granados , Ayesha N. Zia , Bryce N. Balmain , James A. Pawelczyk , Tony G. Babb

{"title":"Pediatric patients diagnosed as overweight and obese have an elevated risk of dyspnea","authors":"Lydia S. Robson , Abidan Abulimiti , Jorge Z. Granados , Ayesha N. Zia , Bryce N. Balmain , James A. Pawelczyk , Tony G. Babb","doi":"10.1016/j.resp.2024.104230","DOIUrl":"10.1016/j.resp.2024.104230","url":null,"abstract":"<div><p>We investigated whether pediatric patients with overweight and obesity are more likely to have dyspnea compared with those who are non-overweight. We collected de-identified data from TriNetX, a global federated multicenter research database, using both the UT Southwestern Medical Center and multinational Research Networks. Our analysis focused on patients aged 8–12 years. We identified overweight and obesity using ICD-10-CM codes E66 and dyspnea using code R06.0. Patients with overweight and obesity had a significantly higher risk of dyspnea compared with those who were non-overweight. This association was observed in both the UT Southwestern Network (risk ratio: 1.81, p < 0.001) and the Research Network (risk ratio: 2.70, p < 0.001). Furthermore, within the UT Southwestern Network, the risk was found to be higher in females compared with males (risk ratio: 2.17 vs. 1.67). These results have significant clinical implications, suggesting that clinicians should consider overweight and obesity as independent risk factors for dyspnea in pediatric patients after excluding other possible contributing factors.</p></div>","PeriodicalId":20961,"journal":{"name":"Respiratory Physiology & Neurobiology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139716376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stress biomarker changes following a series of repeated static and dynamic apneas in non-divers 非潜水员在重复一系列静态和动态呼吸暂停后的压力生物标志物变化

IF 2.3 4区医学

Respiratory Physiology & Neurobiology Pub Date : 2024-02-01 DOI: 10.1016/j.resp.2024.104228

Antonis Elia , Matthew J. Barlow , Matthew J. Lees , Georgios Petri , Michail E. Keramidas

{"title":"Stress biomarker changes following a series of repeated static and dynamic apneas in non-divers","authors":"Antonis Elia , Matthew J. Barlow , Matthew J. Lees , Georgios Petri , Michail E. Keramidas","doi":"10.1016/j.resp.2024.104228","DOIUrl":"10.1016/j.resp.2024.104228","url":null,"abstract":"<div><h3>Purpose</h3><p>This study examined the magnitude of physiological strain imposed by repeated maximal static and dynamic apneas through assessing a panel of stress-related biomarkers.</p></div><div><h3>Methods</h3><p>Eleven healthy men performed on three separate occasions (≥72-h apart): a series of five repeated maximal (i) static (STA) or (ii) dynamic apneas (DYN) or (iii) a static eupneic protocol (CTL). Venous blood samples were drawn at 30, 90, and 180-min after each protocol to determine ischaemia modified albumin (IMA), neuron-specific enolase (NSE), myoglobin, and high sensitivity cardiac troponin T (hscTnT) concentrations.</p></div><div><h3>Results</h3><p>IMA was elevated after the apnoeic interventions (STA,+86%;DYN,+332%,p ≤ 0.047) but not CTL (p = 0.385). Myoglobin was higher than baseline (23.6 ± 3.9 ng/mL) 30-min post DYN (+70%,38.8 ± 13.3 ng/mL,p = 0.030). A greater myoglobin release was recorded in DYN compared with STA and CTL (p ≤ 0.035). No changes were observed in NSE (p = 0.207) or hscTnT (p = 0.274).</p></div><div><h3>Conclusions</h3><p>Five repeated maximal DYN led to a greater muscle injury compared with STA but neither elicited myocardial injury or neuronal-parenchymal damage.</p></div>","PeriodicalId":20961,"journal":{"name":"Respiratory Physiology & Neurobiology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1569904824000211/pdfft?md5=ef817c12d93152298a2659dd8a435fc9&pid=1-s2.0-S1569904824000211-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139664619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Respiratory activity during seizures induced by pentylenetetrazole 戊四唑诱发癫痫发作时的呼吸活动

IF 2.3 4区医学

Respiratory Physiology & Neurobiology Pub Date : 2024-02-01 DOI: 10.1016/j.resp.2024.104229

Hanna L. Umezu , Paloma G. Bittencourt-Silva , Flávio A.G. Mourão , Fabrício A. Moreira , Márcio Flávio D. Moraes , Victor R. Santos , Glauber S.F. da Silva

{"title":"Respiratory activity during seizures induced by pentylenetetrazole","authors":"Hanna L. Umezu , Paloma G. Bittencourt-Silva , Flávio A.G. Mourão , Fabrício A. Moreira , Márcio Flávio D. Moraes , Victor R. Santos , Glauber S.F. da Silva","doi":"10.1016/j.resp.2024.104229","DOIUrl":"10.1016/j.resp.2024.104229","url":null,"abstract":"<div><p>This study investigated the respiratory activity in adult Wistar rats across different behavioral seizure severity induced by pentylenetetrazole (PTZ). Animals underwent surgery for electrodes implantation, allowing simultaneous EEG and diaphragm EMG (DIA<sub>EMG</sub>) recordings and the respiratory frequency and DIA<sub>EMG</sub> amplitude were measured. Seizures were acutely induced through PTZ injection and classified based on a pre-established score, with absence-like seizures (spike wave discharge (SWD) events on EEG) representing the lowest score. The respiratory activity was grouped into the different seizure severities. During absence-like and myoclonic jerk seizures, the breathing frequency decreased significantly (∼50% decrease) compared to pre- and post-ictal periods. Pronounced changes occurred with more severe seizures (clonic and tonic) with periods of apnea, especially during tonic seizures. Apnea duration was significantly higher in tonic compared to clonic seizures. Notably, during PTZ-induced tonic seizures the apnea events were marked by tonic DIA<sub>EMG</sub> contraction (tonic-phase apnea). In the majority of animals (5 out of 7) this was a fatal event in which the seizure-induced respiratory arrest preceded the asystole. In conclusion, we provide an assessment of the respiratory activity in the PTZ-induced acute seizures and showed that breathing dysfunction is more pronounced in seizures with higher severity.</p></div>","PeriodicalId":20961,"journal":{"name":"Respiratory Physiology & Neurobiology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139664756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroanatomical frameworks for volitional control of breathing and orofacial behaviors 自主控制呼吸和口面部行为的神经解剖学框架

IF 2.3 4区医学

Respiratory Physiology & Neurobiology Pub Date : 2024-01-29 DOI: 10.1016/j.resp.2024.104227

Pedro Trevizan-Baú , Davor Stanić , Werner I. Furuya , Rishi R. Dhingra , Mathias Dutschmann

引用次数: 0

Obituary Fulvia Bongianni 1960–2023 讣告 Fulvia Bongianni 1960-2023

IF 2.3 4区医学

Respiratory Physiology & Neurobiology Pub Date : 2024-01-25 DOI: 10.1016/j.resp.2024.104226

Donatella Mutolo, Elenia Cinelli, Tito Pantaleo

引用次数: 0