Respiratory Physiology & Neurobiology最新文献_第6页

Apnea behavior in early- and late-stage mouse models of Parkinson's disease: Cineradiographic analysis of spontaneous breathing, acute stress, and swallowing 帕金森病早期和晚期小鼠模型的呼吸暂停行为：自发呼吸、急性应激和吞咽的放射线分析。

IF 2.3 4区医学

Respiratory Physiology & Neurobiology Pub Date : 2024-02-22 DOI: 10.1016/j.resp.2024.104239

Lorena Roberta de Souza Mendes Kawamura , Max Sarmet , Priscila Sales de Campos , Sachiko Takehara , Yasuhiro Kumei , Jorge Luis Lopes Zeredo

{"title":"Apnea behavior in early- and late-stage mouse models of Parkinson's disease: Cineradiographic analysis of spontaneous breathing, acute stress, and swallowing","authors":"Lorena Roberta de Souza Mendes Kawamura , Max Sarmet , Priscila Sales de Campos , Sachiko Takehara , Yasuhiro Kumei , Jorge Luis Lopes Zeredo","doi":"10.1016/j.resp.2024.104239","DOIUrl":"10.1016/j.resp.2024.104239","url":null,"abstract":"<div><p>This study aimed to evaluate the timing and frequency of spontaneous apneas during breathing and swallowing by using cineradiography on mouse models of early/initial or late/advanced Parkinson’s disease (PD). C57BL/6 J mice received either 6-OHDA or vehicle injections into their right striatum, followed by respiratory movement recordings during spontaneous breathing and swallowing, and a stress challenge, two weeks later. Experimental group animals showed a significantly lower respiratory rate (158.66 ± 32.88 breaths/minute in late PD, 173.16 ± 25.19 in early PD versus 185.27 ± 25.36 in controls; p<0.001) and a significantly higher frequency of apneas (median 1 apnea/minute in both groups versus 0 in controls; p<0.001). Other changes included reduced food intake and the absence of swallow apneas in experimental mice. 6-OHDA-induced nigrostriatal degeneration in mice disrupted respiratory control, swallowing, stress responsiveness, and feeding behaviors, potentially hindering airway protection and elevating the risk of aspiration.</p></div>","PeriodicalId":20961,"journal":{"name":"Respiratory Physiology & Neurobiology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139940706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Skeletal muscle oxygenation and exercise intolerance in hemodialysis: Navigating toward promising horizons? 血液透析患者的骨骼肌氧合与运动不耐受：驶向充满希望的地平线？

IF 2.3 4区医学

Respiratory Physiology & Neurobiology Pub Date : 2024-02-20 DOI: 10.1016/j.resp.2024.104238

Marieta Theodorakopoulou , Afroditi Boutou , Pantelis Sarafidis

引用次数: 0

Stress stimulation promotes the injury repair process of airway epithelial cells through the [Cl−]i−FAK signaling axis 应激刺激通过[Cl-]i-FAK 信号轴促进气道上皮细胞的损伤修复过程。

IF 2.3 4区医学

Respiratory Physiology & Neurobiology Pub Date : 2024-02-12 DOI: 10.1016/j.resp.2024.104237

Jia Wang , Jinhua Luo , Yanjuan Liu , Yu Jiang , Xiangping Qu , Chi Liu , Yang Xiang , Xiaoqun Qin

{"title":"Stress stimulation promotes the injury repair process of airway epithelial cells through the [Cl−]i−FAK signaling axis","authors":"Jia Wang , Jinhua Luo , Yanjuan Liu , Yu Jiang , Xiangping Qu , Chi Liu , Yang Xiang , Xiaoqun Qin","doi":"10.1016/j.resp.2024.104237","DOIUrl":"10.1016/j.resp.2024.104237","url":null,"abstract":"<div><p>The airway epithelium serves as a critical interface with the external environment, making it vulnerable to various external stimuli. Airway epithelial stress acts as a catalyst for the onset of numerous pulmonary and systemic diseases. Our previous studies have highlighted the impact of acute stress stimuli, especially bacterial lipopolysaccharide (LPS) and hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>), on the continuous elevation of intracellular chloride concentration ([Cl<sup>−</sup>]<sub>i</sub>). However, the precise mechanism behind this [Cl−]<sub>i</sub> elevation and the consequential effects of such stress on the injury repair function of airway epithelial cells remain unclear. Our findings indicate that H<sub>2</sub>O<sub>2</sub> induces an elevation in [Cl<sup>−</sup>]<sub>i</sub> by modulating the expression of CF transmembrane conductance regulator (CFTR) and Ca-activated transmembrane protein 16 A (TMEM16A) in airway epithelial cells (BEAS-2B), whereas LPS achieves this solely through CFTR. Subsequently, the elevated [Cl<sup>−</sup>]<sub>i</sub> level facilitated the injury repair process of airway epithelial cells by activating focal adhesion kinase (FAK). In summary, the [Cl<sup>−</sup>]<sub>i</sub>−FAK axis appears to play a promoting effect on the injury repair process triggered by stress stimulation. Furthermore, our findings suggest that abnormalities in the [Cl<sup>−</sup>]<sub>i</sub>−FAK signaling axis may play a crucial role in the pathogenesis of chronic airway diseases. Therefore, controlling the structure and function of airway epithelial barriers through the modulation of [Cl<sup>−</sup>]<sub>i</sub> holds promising prospects for future applications in managing and treating such conditions.</p></div>","PeriodicalId":20961,"journal":{"name":"Respiratory Physiology & Neurobiology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139736012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pediatric patients diagnosed as overweight and obese have an elevated risk of dyspnea 被诊断为超重和肥胖的儿科患者出现呼吸困难的风险较高。

IF 2.3 4区医学

Respiratory Physiology & Neurobiology Pub Date : 2024-02-09 DOI: 10.1016/j.resp.2024.104230

Lydia S. Robson , Abidan Abulimiti , Jorge Z. Granados , Ayesha N. Zia , Bryce N. Balmain , James A. Pawelczyk , Tony G. Babb

{"title":"Pediatric patients diagnosed as overweight and obese have an elevated risk of dyspnea","authors":"Lydia S. Robson , Abidan Abulimiti , Jorge Z. Granados , Ayesha N. Zia , Bryce N. Balmain , James A. Pawelczyk , Tony G. Babb","doi":"10.1016/j.resp.2024.104230","DOIUrl":"10.1016/j.resp.2024.104230","url":null,"abstract":"<div><p>We investigated whether pediatric patients with overweight and obesity are more likely to have dyspnea compared with those who are non-overweight. We collected de-identified data from TriNetX, a global federated multicenter research database, using both the UT Southwestern Medical Center and multinational Research Networks. Our analysis focused on patients aged 8–12 years. We identified overweight and obesity using ICD-10-CM codes E66 and dyspnea using code R06.0. Patients with overweight and obesity had a significantly higher risk of dyspnea compared with those who were non-overweight. This association was observed in both the UT Southwestern Network (risk ratio: 1.81, p < 0.001) and the Research Network (risk ratio: 2.70, p < 0.001). Furthermore, within the UT Southwestern Network, the risk was found to be higher in females compared with males (risk ratio: 2.17 vs. 1.67). These results have significant clinical implications, suggesting that clinicians should consider overweight and obesity as independent risk factors for dyspnea in pediatric patients after excluding other possible contributing factors.</p></div>","PeriodicalId":20961,"journal":{"name":"Respiratory Physiology & Neurobiology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139716376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stress biomarker changes following a series of repeated static and dynamic apneas in non-divers 非潜水员在重复一系列静态和动态呼吸暂停后的压力生物标志物变化

IF 2.3 4区医学

Respiratory Physiology & Neurobiology Pub Date : 2024-02-01 DOI: 10.1016/j.resp.2024.104228

Antonis Elia , Matthew J. Barlow , Matthew J. Lees , Georgios Petri , Michail E. Keramidas

{"title":"Stress biomarker changes following a series of repeated static and dynamic apneas in non-divers","authors":"Antonis Elia , Matthew J. Barlow , Matthew J. Lees , Georgios Petri , Michail E. Keramidas","doi":"10.1016/j.resp.2024.104228","DOIUrl":"10.1016/j.resp.2024.104228","url":null,"abstract":"<div><h3>Purpose</h3><p>This study examined the magnitude of physiological strain imposed by repeated maximal static and dynamic apneas through assessing a panel of stress-related biomarkers.</p></div><div><h3>Methods</h3><p>Eleven healthy men performed on three separate occasions (≥72-h apart): a series of five repeated maximal (i) static (STA) or (ii) dynamic apneas (DYN) or (iii) a static eupneic protocol (CTL). Venous blood samples were drawn at 30, 90, and 180-min after each protocol to determine ischaemia modified albumin (IMA), neuron-specific enolase (NSE), myoglobin, and high sensitivity cardiac troponin T (hscTnT) concentrations.</p></div><div><h3>Results</h3><p>IMA was elevated after the apnoeic interventions (STA,+86%;DYN,+332%,p ≤ 0.047) but not CTL (p = 0.385). Myoglobin was higher than baseline (23.6 ± 3.9 ng/mL) 30-min post DYN (+70%,38.8 ± 13.3 ng/mL,p = 0.030). A greater myoglobin release was recorded in DYN compared with STA and CTL (p ≤ 0.035). No changes were observed in NSE (p = 0.207) or hscTnT (p = 0.274).</p></div><div><h3>Conclusions</h3><p>Five repeated maximal DYN led to a greater muscle injury compared with STA but neither elicited myocardial injury or neuronal-parenchymal damage.</p></div>","PeriodicalId":20961,"journal":{"name":"Respiratory Physiology & Neurobiology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1569904824000211/pdfft?md5=ef817c12d93152298a2659dd8a435fc9&pid=1-s2.0-S1569904824000211-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139664619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Respiratory activity during seizures induced by pentylenetetrazole 戊四唑诱发癫痫发作时的呼吸活动

IF 2.3 4区医学

Respiratory Physiology & Neurobiology Pub Date : 2024-02-01 DOI: 10.1016/j.resp.2024.104229

Hanna L. Umezu , Paloma G. Bittencourt-Silva , Flávio A.G. Mourão , Fabrício A. Moreira , Márcio Flávio D. Moraes , Victor R. Santos , Glauber S.F. da Silva

{"title":"Respiratory activity during seizures induced by pentylenetetrazole","authors":"Hanna L. Umezu , Paloma G. Bittencourt-Silva , Flávio A.G. Mourão , Fabrício A. Moreira , Márcio Flávio D. Moraes , Victor R. Santos , Glauber S.F. da Silva","doi":"10.1016/j.resp.2024.104229","DOIUrl":"10.1016/j.resp.2024.104229","url":null,"abstract":"<div><p>This study investigated the respiratory activity in adult Wistar rats across different behavioral seizure severity induced by pentylenetetrazole (PTZ). Animals underwent surgery for electrodes implantation, allowing simultaneous EEG and diaphragm EMG (DIA<sub>EMG</sub>) recordings and the respiratory frequency and DIA<sub>EMG</sub> amplitude were measured. Seizures were acutely induced through PTZ injection and classified based on a pre-established score, with absence-like seizures (spike wave discharge (SWD) events on EEG) representing the lowest score. The respiratory activity was grouped into the different seizure severities. During absence-like and myoclonic jerk seizures, the breathing frequency decreased significantly (∼50% decrease) compared to pre- and post-ictal periods. Pronounced changes occurred with more severe seizures (clonic and tonic) with periods of apnea, especially during tonic seizures. Apnea duration was significantly higher in tonic compared to clonic seizures. Notably, during PTZ-induced tonic seizures the apnea events were marked by tonic DIA<sub>EMG</sub> contraction (tonic-phase apnea). In the majority of animals (5 out of 7) this was a fatal event in which the seizure-induced respiratory arrest preceded the asystole. In conclusion, we provide an assessment of the respiratory activity in the PTZ-induced acute seizures and showed that breathing dysfunction is more pronounced in seizures with higher severity.</p></div>","PeriodicalId":20961,"journal":{"name":"Respiratory Physiology & Neurobiology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139664756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroanatomical frameworks for volitional control of breathing and orofacial behaviors 自主控制呼吸和口面部行为的神经解剖学框架

IF 2.3 4区医学

Respiratory Physiology & Neurobiology Pub Date : 2024-01-29 DOI: 10.1016/j.resp.2024.104227

Pedro Trevizan-Baú , Davor Stanić , Werner I. Furuya , Rishi R. Dhingra , Mathias Dutschmann

引用次数: 0

Obituary Fulvia Bongianni 1960–2023 讣告 Fulvia Bongianni 1960-2023

IF 2.3 4区医学

Respiratory Physiology & Neurobiology Pub Date : 2024-01-25 DOI: 10.1016/j.resp.2024.104226

Donatella Mutolo, Elenia Cinelli, Tito Pantaleo

引用次数: 0

Danshensu methyl ester attenuated LPS-induced acute lung injury by inhibiting TLR4/NF-κB pathway 丹参素甲酯通过抑制 TLR4/NF-κB 通路减轻 LPS 诱导的急性肺损伤

IF 2.3 4区医学

Respiratory Physiology & Neurobiology Pub Date : 2024-01-18 DOI: 10.1016/j.resp.2024.104219

Xuejia Han , Wensi Ding , Guiwu Qu , Youjie Li , Pingyu Wang , Jiahui Yu , Mingyue Liu , Xiulan Chen , Shuyang Xie , Jiankai Feng , Sen Xu

{"title":"Danshensu methyl ester attenuated LPS-induced acute lung injury by inhibiting TLR4/NF-κB pathway","authors":"Xuejia Han , Wensi Ding , Guiwu Qu , Youjie Li , Pingyu Wang , Jiahui Yu , Mingyue Liu , Xiulan Chen , Shuyang Xie , Jiankai Feng , Sen Xu","doi":"10.1016/j.resp.2024.104219","DOIUrl":"10.1016/j.resp.2024.104219","url":null,"abstract":"<div><p><span><span>Acute Lung Injury (ALI) manifests as an acute exacerbation of pulmonary inflammation with high mortality. The potential application of </span>Danshensu<span><span><span><span> methyl ester (DME, synthesized in our lab) in ameliorating ALI has not been elucidated. Our results demonstrated that DME led to a remarkable reduction in lung injury. DME promoted a marked increase in </span>antioxidant enzymes, like </span>superoxide dismutase<span> (SOD), and glutathione<span> (GSH), accompanied by a substantial decrease in reactive oxygen species<span> (ROS), myeloperoxidase (MPO), and </span></span></span></span>malondialdehyde (MDA). Moreover, DME decreased the production of IL-1β, TNF-α and IL-6, </span></span><em>in vitro</em> and <em>in vivo</em><span>. TLR4<span> and MyD88 expression is reduced in the DME-treated cells or tissues, which further leading to a decrease of p-p65 and p-IκBα. Meanwhile, DME effectively facilitated an elevation in cytoplasmic p65 expression. In summary, DME could ameliorate ALI by its antioxidant functionality and anti-inflammation effects through TLR4/NF-κB, which implied that DME may be a viable medicine for lung injury.</span></span></p></div>","PeriodicalId":20961,"journal":{"name":"Respiratory Physiology & Neurobiology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139500405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Longitudinal changes in respiratory reactance in patients with COPD: associations with longitudinal change in air-trapping, exacerbations, and mortality 慢性阻塞性肺病患者呼吸反应性的纵向变化：与空气捕获量、病情加重和死亡率的纵向变化相关。

IF 2.3 4区医学

Respiratory Physiology & Neurobiology Pub Date : 2024-01-17 DOI: 10.1016/j.resp.2024.104216

Yi Zhang , Naoya Tanabe , Susumu Sato , Yusuke Shiraishi , Tomoki Maetani , Ryo Sakamoto , Atsuyasu Sato , Shigeo Muro , Toyohiro Hirai

{"title":"Longitudinal changes in respiratory reactance in patients with COPD: associations with longitudinal change in air-trapping, exacerbations, and mortality","authors":"Yi Zhang , Naoya Tanabe , Susumu Sato , Yusuke Shiraishi , Tomoki Maetani , Ryo Sakamoto , Atsuyasu Sato , Shigeo Muro , Toyohiro Hirai","doi":"10.1016/j.resp.2024.104216","DOIUrl":"10.1016/j.resp.2024.104216","url":null,"abstract":"<div><h3>Introduction</h3><p><span>Air-trapping affects clinical outcomes in patients<span> with chronic obstructive pulmonary disease (COPD) and may be detected by reactance at 5 Hz (X5) on respiratory </span></span>oscillometry because X5 sensitively reflects the elasticity of the chest wall, airway and lung. However, the longitudinal association between X5 and air-trapping remains to be explored. This study aimed to test whether longitudinal changes in X5 could be associated with air-trapping progression, exacerbations, and mortality in patients with COPD.</p></div><div><h3>Methods</h3><p>In this prospective COPD observational study, the follow-up period consisted of the first 4 years to obtain longitudinal changes in X5 and residual volume (RV) and number of exacerbations and the remaining years (year 4 to 10) to test mortality. Patients were divided into large, middle, and small X5 decline groups based on the tertiles of longitudinal change in X5, and mortality after 4 years was compared between the groups.</p></div><div><h3>Results</h3><p><span>Patients with COPD (n = 114) were enrolled. The large X5 decline group (n = 38) showed a greater longitudinal change in RV and more exacerbations compared with the small X5 decline group (n = 39) in multivariable models adjusted for age, sex, body mass index, and smoking history. Long-term mortality after the 4-year follow-up was higher in the large X5 decline group than in the small X5 decline group (hazard ratio [95 % confidence interval] = 8.37[1.01, 69.0]) in the multivariable Cox </span>proportional hazard model.</p></div><div><h3>Conclusion</h3><p>Longitudinal changes in respiratory reactance could be associated with progressive air-trapping, exacerbation frequency, and increased mortality in patients with COPD.</p></div>","PeriodicalId":20961,"journal":{"name":"Respiratory Physiology & Neurobiology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139492004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0