DLNO和DLCO气体交换表面积的测量。

IF 1.9 4区医学 Q3 PHYSIOLOGY

Respiratory Physiology & Neurobiology Pub Date : 2025-02-13 DOI:10.1016/j.resp.2025.104403

Colin Borland

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引用次数: 0

摘要

估计的一氧化氮和一氧化碳在人血浆和红细胞中的扩散系数可以代入菲克第一定律和第二定律的方程中。肺泡膜的表面积和暴露的红细胞可以通过DLNO和DLCO（在高氧条件下）计算。通过DLNO，肺泡毛细血管膜表面积为2.2 m2，坐着休息时通过DLCO，红细胞表面积为19.6m2，膜氧合器为2.03m2。对于一个坐着的人来说，这个值基本上小于形态测量值。这可能是由于肺中有相当大的功能储备。

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Measurement of gas exchange surface area from DLNO and DLCO

The estimated diffusion coefficients for nitric oxide and carbon monoxide in human plasma and red cells can be inserted into the equations for Fick’s 1st and 2nd laws. The surface area of the alveolar membrane and exposed red cells can then be calculated from D_LNO and D_LCO (in hyperoxia). This yields a value of 18.7 m² for alveolar capillary membrane via D_LNO, 19.6 m² for red cell surface area via D_LCO in a seated human at rest and = 2.03m² for a membrane oxygenator. The values for a seated human are substantially less than morphometric values. This is likely due to a considerable functional reserve in the lung.

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来源期刊

Respiratory Physiology & Neurobiology 医学-呼吸系统

CiteScore

4.80

自引率

8.70%

发文量

104

审稿时长

54 days

期刊介绍： Respiratory Physiology & Neurobiology (RESPNB) publishes original articles and invited reviews concerning physiology and pathophysiology of respiration in its broadest sense. Although a special focus is on topics in neurobiology, high quality papers in respiratory molecular and cellular biology are also welcome, as are high-quality papers in traditional areas, such as: -Mechanics of breathing- Gas exchange and acid-base balance- Respiration at rest and exercise- Respiration in unusual conditions, like high or low pressure or changes of temperature, low ambient oxygen- Embryonic and adult respiration- Comparative respiratory physiology. Papers on clinical aspects, original methods, as well as theoretical papers are also considered as long as they foster the understanding of respiratory physiology and pathophysiology.