Phrenic motor output following acute hyperbaric oxygen exposure

IF 1.9 4区医学 Q3 PHYSIOLOGY

Respiratory Physiology & Neurobiology Pub Date : 2025-02-05 DOI:10.1016/j.resp.2025.104399

Prajwal P. Thakre , Kyle M. Deegan , David D. Fuller

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引用次数: 0

Abstract

We studied adult male rats to determine if phrenic motor output is altered following acute hyperbaric oxygen (HBO) pretreatment. Rats were treated with 1-h of 100 % O₂ at 2 atmospheres (HBO, n = 12) or 21 % O₂ at 1 atmosphere (normoxia, n = 12) and then anesthetized and ventilated to enable phrenic nerve recordings. Baseline phrenic output and blood pressure were similar between groups. Sixty minutes after exposure to acute intermittent hypoxia (AIH), inspiratory phrenic burst amplitude was +66 ± 47 (HBO) and +43 ± 13 % baseline (normoxia). Thus, both groups expressed phrenic long-term facilitation, pLTF (time effect, P = 0.008). The pLTF magnitude had a larger coefficient of variation after HBO (71 %) vs. normoxia (30 %). This resulted from a bimodal data distribution, with 4 of 12 HBO rats showing pLTF > +70 % baseline (vs. 0 of 12 normoxia). We conclude that acute HBO does not impact baseline phrenic output in this preparation, but further study of HBO and phrenic neuroplasticity is warranted.

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来源期刊

Respiratory Physiology & Neurobiology 医学-呼吸系统

CiteScore

4.80

自引率

8.70%

发文量

104

审稿时长

54 days

期刊介绍： Respiratory Physiology & Neurobiology (RESPNB) publishes original articles and invited reviews concerning physiology and pathophysiology of respiration in its broadest sense. Although a special focus is on topics in neurobiology, high quality papers in respiratory molecular and cellular biology are also welcome, as are high-quality papers in traditional areas, such as: -Mechanics of breathing- Gas exchange and acid-base balance- Respiration at rest and exercise- Respiration in unusual conditions, like high or low pressure or changes of temperature, low ambient oxygen- Embryonic and adult respiration- Comparative respiratory physiology. Papers on clinical aspects, original methods, as well as theoretical papers are also considered as long as they foster the understanding of respiratory physiology and pathophysiology.