Breathing pattern alteration from weanling to old age in male Sprague-Dawley rats

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-10-01 DOI:10.1016/j.resp.2024.104357

Mehdi Eslami-Behroozi, Payam Shahsavar, Reyhaneh Vali, Mohammad Reza Raoufy

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Abstract

Respiratory patterns were investigated in male Sprague-Dawley rats throughout their lifespan, from weanling (1 month) to old age (24 months), under natural conditions. Both inter-breath interval (IBI) and respiratory volume (RV) were examined. Sample entropy suggested increasing irregularity in IBI but decreasing irregularity in RV until 12 months. According to detrended fluctuation analysis, alpha exponent of the IBI showed a bimodal pattern around the value 0.7. From 1–15 months, the alpha exponent for RV generally decreased to the value 0.5, but it increased again as the animals neared the end of their lifespan. Cross-sample entropy revealed increasing synchronization between IBI and RV until 12 months, then plateauing. Many measures demonstrated a transition around 12 months, potentially reflecting maturation of respiratory control mechanisms. The findings characterize complex dynamics of respiratory patterns across the rat lifespan, providing a normative foundation to identify deviations indicative of dysfunction or disease.

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雄性 Sprague-Dawley 大鼠从断奶到老年呼吸模式的改变

在自然条件下，对雄性 Sprague-Dawley 大鼠从断奶（1 个月）到老年（24 个月）的整个生命周期的呼吸模式进行了研究。对呼吸间歇（IBI）和呼吸量（RV）进行了研究。样本熵表明，在 12 个月之前，IBI 的不规则性不断增加，而 RV 的不规则性则不断减少。根据去趋势波动分析，IBI 的α指数在 0.7 值附近呈现双峰模式。从1个月到15个月，RV的α指数普遍下降到0.5，但随着动物寿命接近尾声，α指数又再次上升。跨样本熵显示，在12个月之前，IBI和RV之间的同步性不断提高，然后趋于平稳。许多测量指标在 12 个月左右出现转变，这可能反映了呼吸控制机制的成熟。这些发现描述了大鼠整个生命周期呼吸模式的复杂动态，为识别表明功能障碍或疾病的偏差提供了规范基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.