Hemodynamics and vascular oxygenation measured at the forehead during changes in respiration: A SPA-fNIRS study

IF 1.9 4区医学 Q3 PHYSIOLOGY

Respiratory Physiology & Neurobiology Pub Date : 2024-10-29 DOI:10.1016/j.resp.2024.104364

Sabino Guglielmini , Elena Wiggli , Felix Scholkmann , Martin Wolf

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引用次数: 0

Abstract

Significance

Cerebral blood flow is influenced by respiration, primarily through changes in the CO₂ concentration of arterial blood.

Aim

The objective of this study was to investigate the effect of changes in arterial CO₂ concentration induced by respiratory changes on oxygenation and hemodynamics in the cerebral and extracerebral tissue layers of the forehead.

Approach

We used systemic physiology augmented functional near-infrared spectroscopy (SPA-fNIRS) to assess changes in forehead hemodynamics and oxygenation as well as systemic physiology in 20 healthy subjects. All participants performed two respiratory tasks (breath-holding and hyperventilation).

Results

In our SPA-fNIRS study we found that changes in breathing affected hemodynamics and oxygenation in both the extracerebral and cerebral tissue layers of the forehead in characteristic ways, depending on the two respiratory tasks.

Conclusion

The results show that extracerebrovascular reactivity (ECVR) exists in parallel with the well-known cerebrovascular reactivity (CVR). CVR and ECVR must be considered when performing fNIRS neuroimaging studies involving changes in respiration.

查看原文本刊更多论文

呼吸变化时在前额测量血液动力学和血管氧合：SPA-fNIRS 研究。

意义：目的：本研究旨在探讨呼吸变化引起的动脉二氧化碳浓度变化对前额大脑和脑外组织层氧合和血液动力学的影响：方法：我们使用系统生理学增强功能近红外光谱（SPA-fNIRS）来评估 20 名健康受试者前额血液动力学和氧饱和度以及系统生理学的变化。所有受试者都完成了两项呼吸任务（屏气和过度换气）：结果：在我们的 SPA-fNIRS 研究中，我们发现呼吸的变化以特有的方式影响着前额脑外组织和脑组织层的血液动力学和氧合，这取决于两种呼吸任务：结果表明，脑外血管反应性（ECVR）与众所周知的脑血管反应性（CVR）同时存在：在进行涉及呼吸变化的 fNIRS 神经成像研究时，必须考虑 CVR 和 ECVR。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Respiratory Physiology & Neurobiology 医学-呼吸系统

CiteScore

4.80

自引率

8.70%

发文量

104

审稿时长

54 days

期刊介绍： Respiratory Physiology & Neurobiology (RESPNB) publishes original articles and invited reviews concerning physiology and pathophysiology of respiration in its broadest sense. Although a special focus is on topics in neurobiology, high quality papers in respiratory molecular and cellular biology are also welcome, as are high-quality papers in traditional areas, such as: -Mechanics of breathing- Gas exchange and acid-base balance- Respiration at rest and exercise- Respiration in unusual conditions, like high or low pressure or changes of temperature, low ambient oxygen- Embryonic and adult respiration- Comparative respiratory physiology. Papers on clinical aspects, original methods, as well as theoretical papers are also considered as long as they foster the understanding of respiratory physiology and pathophysiology.