Radiologia MedicaPub Date : 2024-10-01Epub Date: 2024-08-20DOI: 10.1007/s11547-024-01871-2
Davide Alaimo, Maria Chiara Terranova, Ettore Palizzolo, Manfredi De Angelis, Vittorio Avella, Giuseppe Paviglianiti, Giuseppe Lo Re, Domenica Matranga, Sergio Salerno
{"title":"Performance of two different artificial intelligence (AI) methods for assessing carpal bone age compared to the standard Greulich and Pyle method.","authors":"Davide Alaimo, Maria Chiara Terranova, Ettore Palizzolo, Manfredi De Angelis, Vittorio Avella, Giuseppe Paviglianiti, Giuseppe Lo Re, Domenica Matranga, Sergio Salerno","doi":"10.1007/s11547-024-01871-2","DOIUrl":"10.1007/s11547-024-01871-2","url":null,"abstract":"<p><strong>Purpose: </strong>Evaluate the agreement between bone age assessments conducted by two distinct machine learning system and standard Greulich and Pyle method.</p><p><strong>Materials and methods: </strong>Carpal radiographs of 225 patients (mean age 8 years and 10 months, SD = 3 years and 1 month) were retrospectively analysed at two separate institutions (October 2018 and May 2022) by both expert radiologists and radiologists in training as well as by two distinct AI software programmes, 16-bit AI<sup>tm</sup> and BoneXpert® in a blinded manner.</p><p><strong>Results: </strong>The bone age range estimated by the 16-bit AI<sup>tm</sup> system in our sample varied between 1 year and 1 month and 15 years and 8 months (mean bone age 9 years and 5 months SD = 3 years and 3 months). BoneXpert® estimated bone age ranged between 8 months and 15 years and 7 months (mean bone age 8 years and 11 months SD = 3 years and 3 months). The average bone age estimated by the Greulich and Pyle method was between 11 months and 14 years, 9 months (mean bone age 8 years and 4 months SD = 3 years and 3 months). Radiologists' assessments using the Greulich and Pyle method were significantly correlated (Pearson's r > 0.80, p < 0.001). There was no statistical difference between BoneXpert® and 16-bit AI<sup>tm</sup> (mean difference = - 0.19, 95%CI = (- 0.45; 0.08)), and the agreement between two measurements varies between - 3.45 (95%CI = (- 3.95; - 3.03) and 3.07 (95%CI - 3.03; 3.57).</p><p><strong>Conclusions: </strong>Both AI methods and GP provide correlated results, although the measurements made by AI were closer to each other compared to the GP method.</p>","PeriodicalId":20817,"journal":{"name":"Radiologia Medica","volume":" ","pages":"1507-1512"},"PeriodicalIF":9.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11480116/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142005100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Radiologia MedicaPub Date : 2024-10-01Epub Date: 2024-08-25DOI: 10.1007/s11547-024-01865-0
Tom Boeken, Olivier Pellerin, Camille Bourreau, Juliette Palle, Claire Gallois, Aziz Zaanan, Julien Taieb, Widad Lahlou, Alessandro Di Gaeta, Marc Al Ahmar, Xavier Guerra, Carole Dean, Pierre Laurent Puig, Marc Sapoval, Helena Pereira, Hélène Blons
{"title":"Clinical value of sequential circulating tumor DNA analysis using next-generation sequencing and epigenetic modifications for guiding thermal ablation for colorectal cancer metastases: a prospective study.","authors":"Tom Boeken, Olivier Pellerin, Camille Bourreau, Juliette Palle, Claire Gallois, Aziz Zaanan, Julien Taieb, Widad Lahlou, Alessandro Di Gaeta, Marc Al Ahmar, Xavier Guerra, Carole Dean, Pierre Laurent Puig, Marc Sapoval, Helena Pereira, Hélène Blons","doi":"10.1007/s11547-024-01865-0","DOIUrl":"10.1007/s11547-024-01865-0","url":null,"abstract":"<p><strong>Introduction: </strong>While thermal ablation is now a standard treatment option for oligometastatic colorectal cancer patients, selecting those who will benefit most from locoregional therapies remains challenging. This proof-of-concept study is the first to assess the feasibility of routine testing of ctDNA before and after thermal ablation with curative intent, analyzed by next-generation sequencing (NGS) and methylation specific digital droplet PCR (ddPCR). Our prospective study primary objective was to assess the prognostic value of ctDNA before thermal ablation.</p><p><strong>Methods: </strong>This single-center prospective study from November 2021 to June 2022 included colorectal cancer patients referred for curative-intent thermal ablation. Cell-free DNA was tested at different time points by next-generation sequencing and detection of WIF1 and NPY genes hypermethylation using ddPCR. The ctDNA was considered positive if either a tumor mutation or hypermethylation was detected; recurrence-free survival was used as the primary endpoint.</p><p><strong>Results: </strong>The study enrolled 15 patients, and a total of 60 samples were analyzed. The median follow-up after ablation was 316 days, and median recurrence-free survival was 250 days. CtDNA was positive for 33% of the samples collected during the first 24 h. The hazard ratio for progression according to the presence of baseline circulating tumor DNA was estimated at 0.14 (CI 95%: 0.03-0.65, p = 0.019). The dynamics are provided, and patients with no recurrence were all negative at H24 for ctDNA.</p><p><strong>Discussion: </strong>This study shows the feasibility of routine testing of ctDNA before and after thermal ablation with curative intent. We report that circulating tumor DNA is detectable in patients with low tumor burden using 2 techniques. This study emphasizes the potential of ctDNA for discerning patients who are likely to benefit from thermal ablation from those who may not, which could shape future referrals. The dynamics of ctDNA before and after ablation shed light on the need for further research and larger studies.</p>","PeriodicalId":20817,"journal":{"name":"Radiologia Medica","volume":" ","pages":"1530-1542"},"PeriodicalIF":9.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142056399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Radiologia MedicaPub Date : 2024-10-01Epub Date: 2024-08-09DOI: 10.1007/s11547-024-01867-y
Tommaso D'Angelo, Giuseppe M Bucolo, Tarek Kamareddine, Ibrahim Yel, Vitali Koch, Leon D Gruenewald, Simon Martin, Leona S Alizadeh, Silvio Mazziotti, Alfredo Blandino, Thomas J Vogl, Christian Booz
{"title":"Accuracy and time efficiency of a novel deep learning algorithm for Intracranial Hemorrhage detection in CT Scans.","authors":"Tommaso D'Angelo, Giuseppe M Bucolo, Tarek Kamareddine, Ibrahim Yel, Vitali Koch, Leon D Gruenewald, Simon Martin, Leona S Alizadeh, Silvio Mazziotti, Alfredo Blandino, Thomas J Vogl, Christian Booz","doi":"10.1007/s11547-024-01867-y","DOIUrl":"10.1007/s11547-024-01867-y","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate a deep learning-based pipeline using a Dense-UNet architecture for the assessment of acute intracranial hemorrhage (ICH) on non-contrast computed tomography (NCCT) head scans after traumatic brain injury (TBI).</p><p><strong>Materials and methods: </strong>This retrospective study was conducted using a prototype algorithm that evaluated 502 NCCT head scans with ICH in context of TBI. Four board-certified radiologists evaluated in consensus the CT scans to establish the standard of reference for hemorrhage presence and type of ICH. Consequently, all CT scans were independently analyzed by the algorithm and a board-certified radiologist to assess the presence and type of ICH. Additionally, the time to diagnosis was measured for both methods.</p><p><strong>Results: </strong>A total of 405/502 patients presented ICH classified in the following types: intraparenchymal (n = 172); intraventricular (n = 26); subarachnoid (n = 163); subdural (n = 178); and epidural (n = 15). The algorithm showed high diagnostic accuracy (91.24%) for the assessment of ICH with a sensitivity of 90.37% and specificity of 94.85%. To distinguish the different ICH types, the algorithm had a sensitivity of 93.47% and a specificity of 99.79%, with an accuracy of 98.54%. To detect midline shift, the algorithm had a sensitivity of 100%. In terms of processing time, the algorithm was significantly faster compared to the radiologist's time to first diagnosis (15.37 ± 1.85 vs 277 ± 14 s, p < 0.001).</p><p><strong>Conclusion: </strong>A novel deep learning algorithm can provide high diagnostic accuracy for the identification and classification of ICH from unenhanced CT scans, combined with short processing times. This has the potential to assist and improve radiologists' ICH assessment in NCCT scans, especially in emergency scenarios, when time efficiency is needed.</p>","PeriodicalId":20817,"journal":{"name":"Radiologia Medica","volume":" ","pages":"1499-1506"},"PeriodicalIF":9.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11480174/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141913756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Radiologia MedicaPub Date : 2024-10-01Epub Date: 2024-08-20DOI: 10.1007/s11547-024-01873-0
Riccardo Picasso, Andrea Cozzi, Virginia Picasso, Federico Zaottini, Federico Pistoia, Sara Perissi, Carlo Martinoli
{"title":"Fundamental misunderstandings and methodological flaws in \"exploring kappa statistics considerations between two raters\" by Yu et al.","authors":"Riccardo Picasso, Andrea Cozzi, Virginia Picasso, Federico Zaottini, Federico Pistoia, Sara Perissi, Carlo Martinoli","doi":"10.1007/s11547-024-01873-0","DOIUrl":"10.1007/s11547-024-01873-0","url":null,"abstract":"","PeriodicalId":20817,"journal":{"name":"Radiologia Medica","volume":" ","pages":"1557-1558"},"PeriodicalIF":9.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142005098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Radiologia MedicaPub Date : 2024-09-01Epub Date: 2024-08-18DOI: 10.1007/s11547-024-01855-2
Aaron Harman, Robert Toth, Zahra Mobley, Donnie Sartin, Ara Karamanian
{"title":"MRI-guided transrectal prostate laser ablation for benign prostatic hypertrophy: a retrospective cohort study.","authors":"Aaron Harman, Robert Toth, Zahra Mobley, Donnie Sartin, Ara Karamanian","doi":"10.1007/s11547-024-01855-2","DOIUrl":"10.1007/s11547-024-01855-2","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate whether MRI-guided transrectal laser ablation is safe and effective for the treatment of lower urinary tract symptoms caused by BPH.</p><p><strong>Materials and methods: </strong>This single-center retrospective cohort study evaluated men who underwent MRI-guided transrectal laser ablation for BPH between February 2017 and July 2021. Age, prostate-specific antigen, prostate volume, prior surgical BPH treatments if any, International Prostate Symptom Score (IPSS) and Sexual Health Inventory of Men (SHIM) were collected. The primary outcome measures assessed were change in IPSS and SHIM 6, 12 and 24 months after laser ablation and adverse events.</p><p><strong>Results: </strong>Fifty-two patients were included, having completed at least one follow-up survey. The mean patient age was 62.9 ± 5.7 years, and mean prostate volume was 80.2 ± 39.2 cc. Eighteen patients (34.6%) had received a prior BPH treatment. The IPSS scores dropped an average of 16.7 ± 7.0 (p < 0.001), 16.9 ± 7.5 (p < 0.001) and 17.1 ± 7.2 (p < 0.001) points from baseline at 6, 12 and 24 months, respectively. There was no statistically significant difference in IPSS score drop between patients who had received a prior BPH procedure and those who had not (p = 0.628). The SHIM scores showed a statistically insignificant increase at all time points. Nineteen patients (36.5%) reported a complication. There were 12 grade II complications (23%) and seven grade I complications (13.5%). There were no grade III or higher complications.</p><p><strong>Conclusion: </strong>Transrectal MRI-guided focal laser ablation is safe and effective for the treatment of lower urinary tract symptoms caused by BPH, with a significant improvement in symptom severity after 2 years.</p>","PeriodicalId":20817,"journal":{"name":"Radiologia Medica","volume":" ","pages":"1412-1423"},"PeriodicalIF":9.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141996338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Radiologia MedicaPub Date : 2024-09-01Epub Date: 2024-07-16DOI: 10.1007/s11547-024-01857-0
Sarah Alessi, Roberta Maggioni, Stefano Luzzago, Paul E Summers, Giuseppe Renne, Fabio Zugni, Maddalena Belmonte, Sara Raimondi, Silvano Vignati, Francesco A Mistretta, Letizia Di Meglio, Elisa D'Ascoli, Alice Scarabelli, Giulia Marvaso, Ottavio De Cobelli, Gennaro Musi, Barbara Alicja Jereczek-Fossa, Giuseppe Curigliano, Giuseppe Petralia
{"title":"Association between mpMRI detected tumor apparent diffusion coefficient and 5-year biochemical recurrence risk after radical prostatectomy.","authors":"Sarah Alessi, Roberta Maggioni, Stefano Luzzago, Paul E Summers, Giuseppe Renne, Fabio Zugni, Maddalena Belmonte, Sara Raimondi, Silvano Vignati, Francesco A Mistretta, Letizia Di Meglio, Elisa D'Ascoli, Alice Scarabelli, Giulia Marvaso, Ottavio De Cobelli, Gennaro Musi, Barbara Alicja Jereczek-Fossa, Giuseppe Curigliano, Giuseppe Petralia","doi":"10.1007/s11547-024-01857-0","DOIUrl":"10.1007/s11547-024-01857-0","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the ability of tumor apparent diffusion coefficient (ADC) values obtained from multiparametric magnetic resonance imaging (mpMRI) to predict the risk of 5-year biochemical recurrence (BCR) after radical prostatectomy (RP).</p><p><strong>Materials and methods: </strong>This retrospective analysis included 1207 peripheral and 232 non-peripheral zone prostate cancer (PCa) patients who underwent mpMRI before RP (2012-2015), with the outcome of interest being 5-year BCR. ADC was evaluated as a continuous variable and as categories: low (< 850 µm<sup>2</sup>/s), intermediate (850-1100 µm<sup>2</sup>/s), and high (> 1100 µm<sup>2</sup>/s). Kaplan-Meier curves with log-rank testing of BCR-free survival, multivariable Cox proportional hazard regression models were formed to estimate the risk of BCR.</p><p><strong>Results: </strong>Among the 1439 males with median age 63 (± 7) years, the median follow-up was 59 months, and 306 (25%) patients experienced BCR. Peripheral zone PCa patients with BCR had lower tumor ADC values than those without BCR (874 versus 1025 µm<sup>2</sup>/s, p < 0.001). Five-year BCR-free survival rates were 52.3%, 74.4%, and 87% for patients in the low, intermediate, and high ADC value categories, respectively (p < 0.0001). Lower ADC was associated with BCR, both as continuously coded variable (HR: 5.35; p < 0.001) and as ADC categories (intermediate versus high ADC-HR: 1.56, p = 0.017; low vs. high ADC-HR; 2.36, p < 0.001). In the non-peripheral zone PCa patients, no association between ADC and BCR was observed.</p><p><strong>Conclusion: </strong>Tumor ADC values and categories were found to be predictive of the 5-year BCR risk after RP in patients with peripheral zone PCa and may serve as a prognostic biomarker.</p>","PeriodicalId":20817,"journal":{"name":"Radiologia Medica","volume":" ","pages":"1394-1404"},"PeriodicalIF":9.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141627509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Investigation of abdominal artery delineation by photon-counting detector CT.","authors":"Takashi Ota, Hiromitsu Onishi, Toshihide Itoh, Hideyuki Fukui, Takahiro Tsuboyama, Atsushi Nakamoto, Yukihiro Enchi, Mitsuaki Tatsumi, Noriyuki Tomiyama","doi":"10.1007/s11547-024-01858-z","DOIUrl":"10.1007/s11547-024-01858-z","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the ability of 50-keV virtual monoenergetic images (VMI) to depict abdominal arteries in abdominal CT angiography (CTA) compared with 70-keV VMI with photon-counting detector CT (PCD-CT).</p><p><strong>Methods: </strong>Fifty consecutive patients who underwent multiphase abdominal scans between March and April 2023 were included. Signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were quantitatively assessed for the abdominal aorta (AA), celiac artery (CeA), superior mesenteric artery (SMA), renal artery (RA), and right hepatic artery (RHA) at both 50- and 70-keV VMI. In addition, 3D images from CTA were analyzed to measure arterial lengths and evaluate the visualization of distal branches.</p><p><strong>Results: </strong>Significantly higher SNR and CNR were observed at 50-keV compared to 70-keV VMI for all arteries: AA (36.54 and 48.28 vs. 25.70 and 28.46), CeA (22.39 and 48.38 vs. 19.09 and 29.15), SMA (23.34 and 49.34 vs. 19.67 and 29.71), RA (22.88 and 48.84 vs. 20.15 and 29.41), and RHA (14.38 and 44.41 vs. 13.45 and 27.18), all p < 0.05. Arterial lengths were also significantly longer at 50-keV: RHA (192.6 vs. 180.3 mm), SMA (230.9 vs. 216.5 mm), and RA (95.9 vs. 92.0 mm), all p < 0.001.</p><p><strong>Conclusion: </strong>In abdominal CTA with PCD-CT, 50-keV VMI demonstrated superior quantitative image quality compared to 70-keV VMI. In addition, 50-keV VMI 3D CTA allowed better visualization of abdominal artery branches, highlighting its potential clinical advantage for improved imaging and detailed assessment of abdominal arteries.</p>","PeriodicalId":20817,"journal":{"name":"Radiologia Medica","volume":" ","pages":"1265-1274"},"PeriodicalIF":9.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11379784/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141752520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Radiologia MedicaPub Date : 2024-09-01Epub Date: 2024-07-24DOI: 10.1007/s11547-024-01852-5
Lorenzo Cereser, Gaia Zussino, Carmelo Cicciò, Annarita Tullio, Chiara Montanaro, Mauro Driussi, Emma Di Poi, Vincenzo Patruno, Chiara Zuiani, Rossano Girometti
{"title":"Impact of an expert-derived, quick hands-on tool on classifying pulmonary hypertension in chest computed tomography: a study on inexperienced readers using RAPID-CT-PH.","authors":"Lorenzo Cereser, Gaia Zussino, Carmelo Cicciò, Annarita Tullio, Chiara Montanaro, Mauro Driussi, Emma Di Poi, Vincenzo Patruno, Chiara Zuiani, Rossano Girometti","doi":"10.1007/s11547-024-01852-5","DOIUrl":"10.1007/s11547-024-01852-5","url":null,"abstract":"<p><strong>Purpose: </strong>To test the inter-reader agreement in classifying pulmonary hypertension (PH) on chest contrast-enhanced computed tomography (CECT) between a consensus of two cardio-pulmonary-devoted radiologists (CRc) and inexperienced readers (radiology residents, RRs) when using a CECT-based quick hands-on tool built upon PH imaging literature, i.e., the \"Rapid Access and Practical Information Digest on Computed Tomography for PH-RAPID-CT-PH\".</p><p><strong>Material and methods: </strong>The observational study retrospectively included 60 PH patients who underwent CECT between 2015 and 2022. Four RRs independently reviewed all CECTs and classified each case into one of the five PH groups per the 2022 ESC/ERS guidelines. While RR3 and RR4 (RAPID-CT-PH group) used RAPID-CT-PH, RR1 and RR2 (control group) did not. RAPID-CT-PH and control groups' reports were compared with CRc using unweighted Cohen's Kappa (k) statistics. RRs' report completeness and reporting time were also compared using the Wilcoxon-Mann-Whitney test.</p><p><strong>Results: </strong>The inter-reader agreement in classifying PH between the RAPID-CT-PH group and CRc was substantial (k = 0.75 for RR3 and k = 0.65 for RR4); while, it was only moderate for the control group (k = 0.57 for RR1 and k = 0.49 for RR2). Using RAPID-CT-PH resulted in significantly higher report completeness (all p < 0.0001) and significantly lower reporting time (p < 0.0001) compared to the control group.</p><p><strong>Conclusion: </strong>RRs using RAPID-CT-PH showed a substantial agreement with CRc on CECT-based PH classification. RAPID-CT-PH improved report completeness and reduced reporting time. A quick hands-on tool for classifying PH on chest CECT may help inexperienced radiologists effectively contribute to the PH multidisciplinary team.</p>","PeriodicalId":20817,"journal":{"name":"Radiologia Medica","volume":" ","pages":"1313-1328"},"PeriodicalIF":9.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11379776/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141760603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Radiologia MedicaPub Date : 2024-09-01Epub Date: 2024-08-20DOI: 10.1007/s11547-024-01850-7
Olivera Djuric, Silvia Deandrea, Paola Mantellini, Francesco Sardanelli, Francesco Venturelli, Stefania Montemezzi, Riccardo Vecchio, Lauro Bucchi, Carlo Senore, Livia Giordano, Eugenio Paci, Adriana Bonifacino, Massimo Calabrese, Francesca Caumo, Flori Degrassi, Priscilla Sassoli De' Bianchi, Francesca Battisti, Marco Zappa, Pierpaolo Pattacini, Cinzia Campari, Andrea Nitrosi, Giovanni Di Leo, Alfonso Frigerio, Veronica Magni, Francesca Fornasa, Giovanna Romanucci, Patrizia Falini, Noemi Auzzi, Paola Armaroli, Paolo Giorgi Rossi
{"title":"Budget impact analysis of introducing digital breast tomosynthesis in breast cancer screening in Italy.","authors":"Olivera Djuric, Silvia Deandrea, Paola Mantellini, Francesco Sardanelli, Francesco Venturelli, Stefania Montemezzi, Riccardo Vecchio, Lauro Bucchi, Carlo Senore, Livia Giordano, Eugenio Paci, Adriana Bonifacino, Massimo Calabrese, Francesca Caumo, Flori Degrassi, Priscilla Sassoli De' Bianchi, Francesca Battisti, Marco Zappa, Pierpaolo Pattacini, Cinzia Campari, Andrea Nitrosi, Giovanni Di Leo, Alfonso Frigerio, Veronica Magni, Francesca Fornasa, Giovanna Romanucci, Patrizia Falini, Noemi Auzzi, Paola Armaroli, Paolo Giorgi Rossi","doi":"10.1007/s11547-024-01850-7","DOIUrl":"10.1007/s11547-024-01850-7","url":null,"abstract":"<p><strong>Purpose: </strong>This study quantifies the impact on budget and cost per health benefit of implementing digital breast tomosynthesis (DBT) in place of digital mammography (DM) for breast cancer screening among asymptomatic women in Italy.</p><p><strong>Methods: </strong>A budget impact analysis and a cost consequence analysis were conducted using parameters from the MAITA project and literature. The study considered four scenarios for DBT implementation, i.e., DBT for all women, DBT for women aged 45-49 years, DBT based on breast density (BI-RADS C + D or D only), and compared these to the current DM screening. Healthcare provider's perspective was adopted, including screening, diagnosis, and cancer treatment costs.</p><p><strong>Results: </strong>Introducing DBT for all women would increase overall screening costs by 20%. Targeting DBT to women aged 45-49 years or with dense breasts would result in smaller cost increases (3.2% for age-based and 1.4-10.7% for density-based scenarios). The cost per avoided interval cancer was significantly higher when DBT was applied to all women compared to targeted approaches. The cost per gained early-detected cancer slightly increases in targeted approaches, while the assumptions on the clinical significance and overdiagnosis of cancers detected by DBT and not by DM have a strong impact.</p><p><strong>Conclusions: </strong>Implementing DBT as a primary breast cancer test in screening programs in Italy would lead to a substantial increase in costs. Tailoring DBT use to women aged 45-49 or with dense breasts could enhance the feasibility and sustainability of the intervention. Further research is needed to clarify the impact of DBT on overdiagnosis and the long-term outcomes.</p>","PeriodicalId":20817,"journal":{"name":"Radiologia Medica","volume":" ","pages":"1288-1302"},"PeriodicalIF":9.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142005097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Radiologia MedicaPub Date : 2024-09-01Epub Date: 2024-06-19DOI: 10.1007/s11547-024-01834-7
Yang Yang, Kunhua Li
{"title":"Letter to editor on the article \"assessment of post-thrombectomy brain hemorrhage in acute ischemic stroke with dual-energy CT: how reliable is it in clinical practice?\" by Pacielli et al.","authors":"Yang Yang, Kunhua Li","doi":"10.1007/s11547-024-01834-7","DOIUrl":"10.1007/s11547-024-01834-7","url":null,"abstract":"","PeriodicalId":20817,"journal":{"name":"Radiologia Medica","volume":" ","pages":"1424-1425"},"PeriodicalIF":9.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141420517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}