Radiologia Medica最新文献

{"title":"How useful is contrast-enhanced ultrasound in rheumatoid arthritis? A systematic review with meta-analysis on the comparison between contrast-enhanced ultrasound and colour or power Doppler ultrasound.","authors":"Joaquim Polido-Pereira, Manuel Silvério António, Susana Oliveira Henriques, João Sabido, Ricardo M Fernandes, Elsa Vieira-Sousa, Maria Antonietta D'Agostino, João Eurico Fonseca","doi":"10.1007/s11547-025-02055-2","DOIUrl":"10.1007/s11547-025-02055-2","url":null,"abstract":"<p><strong>Objective: </strong>The primary objective was to evaluate the additional benefits of contrast-enhanced ultrasound (CEUS) compared to unenhanced Doppler ultrasound (DUS) for the identification of active synovitis in rheumatoid arthritis (RA).</p><p><strong>Methods: </strong>We searched PubMed/MEDLINE and EMBASE (February 2024) for all English-written published reports of human studies including the use of CEUS for the study of synovitis in RA. The risk of bias of included studies was evaluated using the QUADAS tool. DUS and CEUS semiquantitative scores were transformed in binomial, and these data were extracted for meta-analysis. Results that we were unable to quantitatively aggregate were summarised qualitatively.</p><p><strong>Results: </strong>Twenty-three studies using CEUS to evaluate 1117 joints from 827 subjects were included, of which 898 joints were from 669 RA patients. We performed a meta-analysis of 9 studies in active RA patients showing that from 474 joints evaluated by either PDUS/CDUS and CEUS, the synovitis detection was 49.2% and 83.8%, respectively, corresponding to a relative detection ratio (RDR) of 1.49 (95% CI 1.23-1.81) favouring CEUS. Heterogeneity of the data was moderate. In healthy subjects, CEUS detected no vascularisation in 4 studies.</p><p><strong>Discussion: </strong>CEUS detects more microvascularisation than PDUS in active RA with an RDR of 1.49.</p>","PeriodicalId":20817,"journal":{"name":"Radiologia Medica","volume":" ","pages":"1243-1253"},"PeriodicalIF":4.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-resolution quantitative mapping of extracellular pH by ratiometric MRI with iron chelates in a tumor mouse model.","authors":"Honglan Mi, Philipp Boehm-Sturm, Akvile Haeckel, Ying Li, Susanne Mueller, Fei Ni, Harald Kratz, Marco Foddis, Jing Xie, Eyk Schellenberger","doi":"10.1007/s11547-025-02020-z","DOIUrl":"10.1007/s11547-025-02020-z","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this study was to generate quantitative extracellular pH maps of tumors using a combination of a pH-sensitive iron chelate-based contrast agent (IBCA) and a pH-insensitive IBCA for concentration measurement, which we termed ratiometric pH magnetic resonance imaging (RpH-MRI).</p><p><strong>Methods: </strong>The pH-sensitive IBCA of ethylenediamine-trans-cyclohexane diamine tetraacetic acid (Fe-en-tCDTA) was synthesized, along with the pH-insensitive IBCAs of trans-cyclohexane diamine tetraacetic acid (Fe-tCDTA) and diethylenetriamine-N,N,N',N″,N″-pentaacetic acid (Fe-DTPA). The pH-dependent T1 contrast effects of these chelates were compared in water and serum phantoms at 0.94 T, 3 T and 7 T. For in vivo pH mapping of tumors at 7 T, 4T1 breast cancer cells were inoculated subcutaneously into the flanks of the BALB/c mice. RpH-MRI was performed with two sequential intravenous applications: first a pH-insensitive IBCA, followed by the pH-sensitive IBCA at the same dose (0.25 or 0.5 mmol/kg) with an interval of either 30 or 60 min. Quantitative pH maps were generated by calculating T1, S₀, and relative maximum enhancement maps of the two injections, together with pH-dependent T1-relaxivity parameters derived from in vitro measurements of the pH-sensitive IBCA and pH-insensitive control IBCA.</p><p><strong>Results: </strong>The T1 relaxivity (r1) of Fe-en-tCDTA was highly pH dependent, being approximately 2.7 times higher at pH 5.5 than at neutral pH, whereas Fe-DTPA and Fe-tCDTA showed stable r1 values between pH 5.5-7.4. In vivo, the time to maximum signal intensity (TMI) of the tumors of Fe-DTPA as control was comparable to that of Fe-en-tCDTA (2.57 ± 1.34 min vs. 2.683 ± 0.89 min, p = 0.7596, paired t test, 4 mice, 7 tumors) as well as for Fe-tCDTA as control versus Fe-en-tCDTA (3.30 ± 1.17 min vs. 3.627 ± 1.12 min, p = 0.2101, paired t test, 7 mice, 13 tumors), suggesting similar pharmacokinetics. The concentration distribution at TMI of the control chelates was assumed to be the same as that of the second injected Fe-en-tCDTA. The dynamic contrast enhanced MRI curve of the first injection of Fe-DTPA returned to baseline after 20-30 min, whereas Fe-tCDTA took 30-60 min to reach baseline. Calculated core and rim pH values were 6.512 ± 0.182 and 6.742 ± 0.121, respectively (p < 0.0001, paired t test, 11 mice, 20 tumors) with core areas showing lower chelate concentrations but higher T1 relaxivity; the mean tumor-wide pH value was 6.632 ± 0.140.</p><p><strong>Conclusion: </strong>Our results demonstrate the potential of high-resolution RpH-MRI based on pH-sensitive and pH-insensitive IBCAs for mapping tumor extracellular pH and concentration distribution.</p>","PeriodicalId":20817,"journal":{"name":"Radiologia Medica","volume":" ","pages":"1231-1242"},"PeriodicalIF":4.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12367910/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of slice thickness on quantitative analysis of interstitial lung disease: a retrospective volumetric chest CT study.","authors":"Marijan Pušeljić, Borut Mohorko, Tadej Počivavšek, Florentine Moazedi-Fürst, Johannes Schmid, Michael Fuchsjäger, Emina Talakić","doi":"10.1007/s11547-025-02023-w","DOIUrl":"10.1007/s11547-025-02023-w","url":null,"abstract":"<p><strong>Introduction: </strong>High-resolution computed tomography (HRCT) is essential for evaluating interstitial lung disease (ILD). The effect of slice thickness on threshold-based quantification of individual ILD components remains underexplored. This study investigates the effect of slice thickness on ILD quantification using Lung CT Analyzer.</p><p><strong>Methods: </strong>Retrospective analysis of 53 ILD patients (mean age 64.3 ± 14.1 years) who underwent chest CT scans with HRCT (slice thickness ≤ 1.25 mm) and conventional CT (CCT, ≥ 2.5 mm) reconstructions. Quantitative lung volumes, functional parenchyma, emphysema, ground-glass opacity (GGO), consolidation and affected parenchyma were assessed. The effects of contrast media (CM) application and ILD pattern was assessed separately.</p><p><strong>Results: </strong>Emphysema volume was significantly higher in HRCT compared to CCT for the whole lung (766.9 ± 568.3 mL vs. 482.6 ± 454.4 mL, p < 0.001), the right lung (431.4 ± 314.6 mL vs. 270.2 ± 251.3 mL, p < 0.001), and the left lung (337.3 ± 259.9 mL vs. 228.0 ± 221.5 mL, p < 0.001). Consolidation volumes also differed significantly between HRCT and CCT for the whole lung (271.6 ± 128.4 mL vs. 252.0 ± 126.3 mL, p < 0.001), with similar findings for the right and left lung. Functional volume was underestimated in CCT reconstructions. No significant differences were observed for GGO volumes or overall affected parenchyma. CM application and ILD pattern had no significant interaction on the measurements.</p><p><strong>Conclusion: </strong>Slice thickness significantly affects the quantification of functional parenchyma, emphysema and consolidation, whereas GGO and the overall ILD extent remain unaffected.</p>","PeriodicalId":20817,"journal":{"name":"Radiologia Medica","volume":" ","pages":"1172-1182"},"PeriodicalIF":4.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12367816/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144151271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combining MRI radiomics, hypoxia gene signature score and clinical variables for prediction of biochemical recurrence-free survival after radiotherapy in prostate cancer.","authors":"Jim Zhong, Angela Davey, Russell Frood, Alan McWilliam, Jane Shortall, Mark Reardon, Kimberley Reaves, Martin Swinton, Oliver Hulson, Catharine West, David Buckley, Sarah Brown, Ananya Choudhury, Peter Hoskin, Ann Henry, Andrew Scarsbrook","doi":"10.1007/s11547-025-02037-4","DOIUrl":"10.1007/s11547-025-02037-4","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the value of combining MRI radiomic and hypoxia-associated gene signature information with clinical data for predicting biochemical recurrence-free survival (BCRFS) after radiotherapy for prostate cancer.</p><p><strong>Methods: </strong>Patients with biopsy-proven prostate cancer, hypoxia-associated gene signature scores and pre-treatment MRI who received radiotherapy between 01/12/2007 and 31/08/2013 at two cancer centres were included in this retrospective cohort analysis. Prostate segmentation was performed on axial T2-weighted sequences using RayStation (v9.1). Histogram standardisation was applied prior to radiomic feature (RF) extraction. PyRadiomics (v3.0.1) was used to extract RFs for analysis. Four multivariable Cox proportional hazards BCRFS prediction models using clinical information alone and in combination with RFs and/or hypoxia scores were evaluated using concordance index (C-index) [confidence intervals (CI)]. Akaike Information Criterion (AIC) was used to assess model fit.</p><p><strong>Results: </strong>178 patients were included. The clinical-only model performance C-index score was 0.69 [0.64-0.7]. The combined clinical-radiomics model (C-index 0.70[0.66-0.73]) and clinical-radiomics-hypoxia model (C-index 0.70[0.65-0.73]) both had higher model performance. The clinical-hypoxia model (C-index 0.68 [0.63-0.7) had lower model performance. Based on AIC, addition of RFs to clinical variables alone improved model performance (p = 0.027), whereas adding hypoxia gene signature scores did not (p = 0.625). The selected features of the combined clinical-radiomics model included age, ISUP grade, tumour stage, and wavelet-derived grey level co-occurrence matrix (GLCM) RFs.</p><p><strong>Conclusion: </strong>Adding pre-treatment prostate MRI-derived radiomic features to a clinical model improves accuracy of predicting BCRFS after prostate radiotherapy, however addition of hypoxia gene signatures does not improve model accuracy.</p>","PeriodicalId":20817,"journal":{"name":"Radiologia Medica","volume":" ","pages":"1139-1148"},"PeriodicalIF":4.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12367909/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144541979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-dose ultrahigh-resolution PCCT enhances subsolid nodule characterization.","authors":"Qinqin Yan, Fuhua Yan, Qi Lin, Qiqi Cao, Yajie Zhang, Xiaoyan Chen, Bernhard Schmidt, Zhihan Xu, Wenjie Yang","doi":"10.1007/s11547-025-02057-0","DOIUrl":"10.1007/s11547-025-02057-0","url":null,"abstract":"<p><strong>Purpose: </strong>To characterize invasion-associated CT features in pulmonary subsolid nodules using low-dose ultrahigh-resolution (UHR) photon-counting CT (PCCT) images and evaluate UHR's diagnostic superiority over standard high-resolution (HR) images.</p><p><strong>Methods: </strong>Patients with subsolid lung adenocarcinoma were recruited for chest scan on PCCT to obtain UHR and standard HR images between November 2023 and May 2024. Nodule characteristics were visually assessed and histogram features were extracted from each nodule. Image quality and radiation dose at previous energy-integrating detector CT (EID-CT) of 30 patients were compared with those of PCCT. Differences between UHR and standard HR, PCCT and EID-CT were compared using paired McNemar-test or paired Wilcox-test.</p><p><strong>Results: </strong>One hundred and eighty-four patients with 203 subsolid nodules were collected including 77 precursors, 77 minimally invasive adenocarcinoma (MIA) and 49 IA. UHR significantly outperformed standard HR in revealing CT findings including larger nodular diameter and solid-component diameter, more frequency of heterogeneous attenuation, lobulation, bubble-like sign, air bronchogram, pleural indentation and vascular sign (all P < 0.05). Additionally, UHR images exhibited significantly greater value in histogram-derived parameters compared to standard HR images (all P < 0.05), except for \"Median,\" \"Minimum.\" Furthermore, the radiation dose in PCCT was half of that in EID-CT (effective dose: 1.32 ± 0.27 vs. 3.85 ± 1.65/mSv, P < 0.001. CDTI_vol: 2.97 ± 0.53 vs. 6.90 ± 2.97/mGy, P < 0.001), with image quality significantly better in PCCT.</p><p><strong>Conclusion: </strong>The UHR protocol on PCCT provides a magnified perspective to reveal CT characteristics of invasive growth in subsolid LUAD, previously undetectable on standard HR images, achieving halved radiation dose and better image quality than EID-CT.</p>","PeriodicalId":20817,"journal":{"name":"Radiologia Medica","volume":" ","pages":"1207-1220"},"PeriodicalIF":4.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12367857/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative analysis of myocardial strain and strain rate in cardiac computed tomography and magnetic resonance feature tracking.","authors":"Irene Del-Canto, María P López-Lereu, José V Monmeneu, Alicia Maceira, David Moratal","doi":"10.1007/s11547-025-02060-5","DOIUrl":"10.1007/s11547-025-02060-5","url":null,"abstract":"<p><strong>Purpose: </strong>This study investigated the feasibility of feature tracking cardiac computed tomography (CCT)-derived LV global and regional strain and its agreement with feature tracking cardiac magnetic resonance (CMR)-derived measurements.</p><p><strong>Methods: </strong>CMR images and CCT images were acquired from 15 adult patients (50% women, mean age: 65 ± 9 years). Cardiac LV global and segmental circumferential and longitudinal strain and strain rate were assessed on CCT and CMR using feature tracking (FT) technology. Agreement between the measurements from two different modalities was evaluated using Bland-Altman analysis and intraclass correlation coefficient (ICC).</p><p><strong>Results: </strong>Strain/strain rate analysis could be accomplished in every subject with both techniques. Agreement between CMR-FT and CCT-FT was strong for global circumferential strain (ICC > 0.75), while other global strain features displayed moderate inter-technique correlation (ICC > 0.50). On Bland-Altman analysis, strain analysis derived from CCT-FT showed a lower measurement of LV global longitudinal strain and strain rate in comparison with CMR-FT (mean difference: 5.32% and 0.71 s^-1, respectively). Additionally, reproducibility of segmental strain was better for myocardial and endocardial than epicardial walls.</p><p><strong>Conclusions: </strong>CCT-FT is a feasible technique, with good agreement with analogous CMR-FT-derived parameters, especially for global measurements, and could be an acceptable alternative for strain assessment.</p>","PeriodicalId":20817,"journal":{"name":"Radiologia Medica","volume":" ","pages":"1158-1171"},"PeriodicalIF":4.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12367947/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accelerated deep learning-based function assessment in cardiovascular magnetic resonance.","authors":"Domenico De Santis, Federica Fanelli, Luca Pugliese, Giovanna Grazia Bona, Tiziano Polidori, Curzio Santangeli, Michela Polici, Antonella Del Gaudio, Giuseppe Tremamunno, Marta Zerunian, Andrea Laghi, Damiano Caruso","doi":"10.1007/s11547-025-02019-6","DOIUrl":"10.1007/s11547-025-02019-6","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate diagnostic accuracy and image quality of deep learning (DL) cine sequences for LV and RV parameters compared to conventional balanced steady-state free precession (bSSFP) cine sequences in cardiovascular magnetic resonance (CMR).</p><p><strong>Material and methods: </strong>From January to April 2024, patients with clinically indicated CMR were prospectively included. LV and RV were segmented from short-axis bSSFP and DL cine sequences. LV and RV end-diastolic volume (EDV), end-systolic volume (EDV), stroke volume (SV), ejection fraction, and LV end-diastolic mass were calculated. The acquisition time of both sequences was registered. Results were compared with paired-samples t test or Wilcoxon signed-rank test. Agreement between DL cine and bSSFP was assessed using Bland-Altman plots. Image quality was graded by two readers based on blood-to-myocardium contrast, endocardial edge definition, and motion artifacts, using a 5-point Likert scale (1 = insufficient quality; 5 = excellent quality).</p><p><strong>Results: </strong>Sixty-two patients were included (mean age: 47 ± 17 years, 41 men). No significant differences between DL cine and bSSFP were found for all LV and RV parameters (P ≥ .176). DL cine was significantly faster (1.35 ± .55 m vs 2.83 ± .79 m; P < .001). The agreement between DL cine and bSSFP was strong, with bias ranging from 45 to 1.75% for LV and from - 0.38 to 2.43% for RV. Among LV parameters, the highest agreement was obtained for ESV and SV, which fell within the acceptable limit of agreement (LOA) in 84% of cases. EDV obtained the highest agreement among RV parameters, falling within the acceptable LOA in 90% of cases. Overall image quality was comparable (median: 5, IQR: 4-5; P = .330), while endocardial edge definition of DL cine (median: 4, IQR: 4-5) was lower than bSSFP (median: 5, IQR: 4-5; P = .002).</p><p><strong>Conclusion: </strong>DL cine allows fast and accurate quantification of LV and RV parameters and comparable image quality with conventional bSSFP.</p>","PeriodicalId":20817,"journal":{"name":"Radiologia Medica","volume":" ","pages":"1149-1157"},"PeriodicalIF":4.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12367930/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Quantification of progressive pulmonary fibrosis by visual scoring of HRCT images: recommendations from Italian chest radiology experts.","authors":"Elisa Baratella, Andrea Borghesi, Lucio Calandriello, Giancarlo Cortese, Giovanni Della Casa, Chiara Giraudo, Emanuele Grassedonio, Anna Rita Larici, Stefano Palmucci, Chiara Romei, Ubaldo Romeo Plastina, Nicola Sverzellati","doi":"10.1007/s11547-025-02036-5","DOIUrl":"10.1007/s11547-025-02036-5","url":null,"abstract":"","PeriodicalId":20817,"journal":{"name":"Radiologia Medica","volume":" ","pages":"1309"},"PeriodicalIF":4.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12367894/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144507966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review and meta-analysis on the concept of bone quality in dento-maxillofacial Cone Beam Computed Tomography.","authors":"Fabio Mistretta, Andrea Magnini, Lorenzo Cinci, Patrizio Zanobini, Maria Pisano, Eleonora Barcali, Leonardo Bocchi, Cosimo Nardi","doi":"10.1007/s11547-025-02052-5","DOIUrl":"10.1007/s11547-025-02052-5","url":null,"abstract":"<p><strong>Objectives: </strong>Bone quality is currently considered a set of intrinsic characteristics of the bone, among which macro- and microarchitecture of the trabecular bone tissue stands out. The investigation of bone quality is crucial in maxillofacial area and especially in dental implant planning. Nevertheless, there is currently no consensus about what bone quality really represents. The aim of this study was to investigate the role of CBCT in assessing bone quality of mandibular and maxillary bones.</p><p><strong>Methods: </strong>This systematic review included fourteen articles selected via PubMed, Embase, and Web of Science databases, with the following features: samples of maxillary or mandibular bones from living individuals or corpses; CBCT as diagnostic investigation tool; a reference standard in assessing bone quality. Ten studies using µCT as reference standard were included in the meta-analysis.</p><p><strong>Results: </strong>CBCT voxel size was from 80 to 400 µm. Only half of the studies evaluated a considerable number of morphometric parameters as described by the Society for Bone and Mineral Research. Meta-analysis was only possible for the 3D Accuitomo 170 CBCT scanner with a voxel size of 80 µm. Trabecular separation (Tb.Sp) and Degree of Anisotropy (DA) microstructural parameters showed moderate to low heterogeneity among studies without significative differences between CBCT and μCT.</p><p><strong>Conclusions: </strong>High-resolution CBCT with a voxel size down to 80 μm should be considered a suitable tool for the assessment of bone microarchitecture. Tb.Sp and DA showed similar values between CBCT and μCT and they could thus be considered as reliable tools for the assessment of bone quality with CBCT. Nevertheless, the high heterogeneity in several bone microstructural parameters and the lack of standardization both in imaging protocols and in image analysis software made CBCT not adequate to be currently deemed the gold standard technique for the assessment of jawbones quality.</p>","PeriodicalId":20817,"journal":{"name":"Radiologia Medica","volume":" ","pages":"1193-1206"},"PeriodicalIF":4.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144643259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Update on newer ultrasound systems to study the microvasculature.","authors":"Orlando Catalano, Antonio Pio Masciotra","doi":"10.1007/s11547-025-02035-6","DOIUrl":"10.1007/s11547-025-02035-6","url":null,"abstract":"<p><p>Color and power Doppler imaging has been employed for decades to analyze the presence, amount, and distribution of flow signals (i.e., blood vessels) in organs and abnormalities, representing a valuable adjunct to gray-scale morphostructural ultrasound. Conventional Doppler modalities, however, have the significant limitation of being insensitive to detect flow within vessels that are too thin and/or that contain blood flowing too slow. In this review article, we focus on the systems that the different companies have developed in the last decade to improve the ultrasound effectiveness in sensitively detecting microvascular flows.</p>","PeriodicalId":20817,"journal":{"name":"Radiologia Medica","volume":" ","pages":"1283-1296"},"PeriodicalIF":4.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144485687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}