Marijan Pušeljić, Borut Mohorko, Tadej Počivavšek, Florentine Moazedi-Fürst, Johannes Schmid, Michael Fuchsjäger, Emina Talakić
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引用次数: 0
Abstract
Introduction: High-resolution computed tomography (HRCT) is essential for evaluating interstitial lung disease (ILD). The effect of slice thickness on threshold-based quantification of individual ILD components remains underexplored. This study investigates the effect of slice thickness on ILD quantification using Lung CT Analyzer.
Methods: Retrospective analysis of 53 ILD patients (mean age 64.3 ± 14.1 years) who underwent chest CT scans with HRCT (slice thickness ≤ 1.25 mm) and conventional CT (CCT, ≥ 2.5 mm) reconstructions. Quantitative lung volumes, functional parenchyma, emphysema, ground-glass opacity (GGO), consolidation and affected parenchyma were assessed. The effects of contrast media (CM) application and ILD pattern was assessed separately.
Results: Emphysema volume was significantly higher in HRCT compared to CCT for the whole lung (766.9 ± 568.3 mL vs. 482.6 ± 454.4 mL, p < 0.001), the right lung (431.4 ± 314.6 mL vs. 270.2 ± 251.3 mL, p < 0.001), and the left lung (337.3 ± 259.9 mL vs. 228.0 ± 221.5 mL, p < 0.001). Consolidation volumes also differed significantly between HRCT and CCT for the whole lung (271.6 ± 128.4 mL vs. 252.0 ± 126.3 mL, p < 0.001), with similar findings for the right and left lung. Functional volume was underestimated in CCT reconstructions. No significant differences were observed for GGO volumes or overall affected parenchyma. CM application and ILD pattern had no significant interaction on the measurements.
Conclusion: Slice thickness significantly affects the quantification of functional parenchyma, emphysema and consolidation, whereas GGO and the overall ILD extent remain unaffected.
高分辨率计算机断层扫描（HRCT）对评估间质性肺疾病（ILD）至关重要。切片厚度对单个ILD成分的阈值定量的影响仍未得到充分探讨。本研究探讨了层厚对肺CT分析仪定量分析ILD的影响。方法：回顾性分析53例经HRCT（层厚≤1.25 mm）和常规CT（层厚≥2.5 mm）重建胸部CT扫描的ILD患者（平均年龄64.3±14.1岁）。定量评估肺体积、功能性实质、肺气肿、磨玻璃影（GGO）、实变和受影响实质。分别评估造影剂（CM）应用和ILD模式的影响。结果：HRCT显示全肺肺气肿体积明显高于CCT（766.9±568.3 mL vs 482.6±454.4 mL）。结论：肺层厚度显著影响功能性实质、肺气肿和实变的定量，而GGO和整体ILD程度不受影响。
期刊介绍：
Felice Perussia founded La radiologia medica in 1914. It is a peer-reviewed journal and serves as the official journal of the Italian Society of Medical and Interventional Radiology (SIRM). The primary purpose of the journal is to disseminate information related to Radiology, especially advancements in diagnostic imaging and related disciplines. La radiologia medica welcomes original research on both fundamental and clinical aspects of modern radiology, with a particular focus on diagnostic and interventional imaging techniques. It also covers topics such as radiotherapy, nuclear medicine, radiobiology, health physics, and artificial intelligence in the context of clinical implications. The journal includes various types of contributions such as original articles, review articles, editorials, short reports, and letters to the editor. With an esteemed Editorial Board and a selection of insightful reports, the journal is an indispensable resource for radiologists and professionals in related fields. Ultimately, La radiologia medica aims to serve as a platform for international collaboration and knowledge sharing within the radiological community.
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