Radiologia Medica最新文献

{"title":"Oncological outcomes after tailored PSMA-PET-guided treatment in biochemical relapse after prostatectomy (PSICHE Trial-NCT 05022914).","authors":"Giulio Francolini, Pietro Garlatti, Vanessa Di Cataldo, Saverio Caini, Mauro Loi, Gabriele Simontacchi, Isacco Desideri, Daniela Greto, Luca Burchini, Ilaria Bonaparte, Giulio Frosini, Sergio Serni, Riccardo Campi, Luca Vaggelli, Niccolò Bertini, Michele Aquilano, Nicola Simoni, Federico Colombo, Ciro Franzese, Marta Scorsetti, Arturo Chiti, Livia Ruffini, Maria Rosaria Raspollini, Mack Roach, Richard K Valicenti, Lorenzo Livi","doi":"10.1007/s11547-025-02107-7","DOIUrl":"https://doi.org/10.1007/s11547-025-02107-7","url":null,"abstract":"<p><strong>Background: </strong>Next-generation imaging (NGI) (68 Ga-prostate-specific membrane antigen (PSMA)-PET) represents a cornerstone in biochemical recurrent prostate cancer management. PSICHE is a multicentric prospective study, aimed to assess oncological outcomes of a predefined tailored imaging-guided treatment.</p><p><strong>Methods: </strong> Patients with biochemical recurrence (BCR) after surgery (prostate-specific antigen [PSA] > 0.2 ≤ 1 ng/mL) underwent staging with PSMA-PET. A predefined treatment algorithm was proposed to all patients: prostate bed salvage radiotherapy (SRT) in case of negative or positive PET within the prostate bed, stereotactic body radiotherapy (SBRT) if pelvic nodal recurrences or oligometastatic disease were detected, and androgen deprivation therapy (ADT) was proposed in widespread polymetastatic disease. Chi-square test was used to evaluate the relationship between baseline features and the rate of positive PSMA-PET/CT.</p><p><strong>Results: </strong>One hundred and fifty-nine patients were enrolled. One hundred and seven patients had a PSMA negative/positive in the prostate bed; pelvic nodal disease or oligometastatic metastatic disease was detected in 39 and 10 patients, respectively. Three patients had a polymetastatic disease. Seventeen patients underwent observation because of prior postoperative radiotherapy (RT)/treatment refusal. Eighty-eight patients were treated with SRT, and SBRT was performed in 49 patients with pelvic or extrapelvic oligometastatic disease. Stratifying patients according to EAU criteria (low risk: PSA doubling time > 12 months and Gleason score < 8; high risk: PSA doubling time ≤ 12 months or Gleason score ≥ 8) after a median follow-up of 19 months in the overall population, median BRFS and MFS were not significantly different between the two risk subgroups (p = 0.58 and p = 0.21, respectively). Median metastasis-free and ADT-free survival were not reached.</p><p><strong>Conclusions: </strong>A PSMA-targeted treatment strategy led to promising results, avoiding unnecessary toxicity from ADT or standard SRT administered in unselected patients. Analysis after longer follow-up is needed to clarify survival outcomes.</p>","PeriodicalId":20817,"journal":{"name":"Radiologia Medica","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145281079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of multidisciplinary discussion in diagnosis and management of interstitial lung diseases: a retrospective evaluation of a single-center 10 years' of experience.","authors":"Caterina Aida D'Amore, Laura Tavanti, Francesco Pistelli, Greta Ali, Giovanni Guglielmi, Alessandra Della Rossa, Fabio Falaschi, Annalisa De Liperi, Emanuele Neri, Chiara Romei","doi":"10.1007/s11547-025-02102-y","DOIUrl":"https://doi.org/10.1007/s11547-025-02102-y","url":null,"abstract":"<p><strong>Purpose: </strong>The importance of multidisciplinary discussion (MDD) in interstitial lung diseases (ILDs) is well known. The aim of this study was to describe the 10-year experience of the MDD at the Pisa University Hospital in diagnosis and management of ILDs.</p><p><strong>Material and methods: </strong>A single-center retrospective observational study was conducted at the Pisa University Hospital. A multidisciplinary group for ILDs diagnosis was instituted in 2012, and all patients referred till August 2022 were included.</p><p><strong>Results: </strong>Altogether 1240 patients were evaluated. At baseline assessment, 772 common multidisciplinary diagnoses were achieved, while in 458 cases it was not possible to obtain a definite diagnosis. Most frequent multidisciplinary diagnoses were idiopathic pulmonary fibrosis (IPF), non-specific interstitial pneumonia (NSIP), and smoking-related ILDs. In 9% of cases a histological evaluation was performed, leading to a diagnosis in 75% of cases. One-thousand and fourty-eight cases with at least one year of follow-up after the MDD were revised. Common diagnoses were confirmed or modified, while \"diagnostic hypotheses\" were changed into \"revised diagnoses\" or left as hypothesis as they still could not be confirmed. Among common diagnoses, 61% were confirmed, while 36% were not confirmed as patients did not perform further examinations or visits. Eighteen diagnoses were modified (3%). Among the \"diagnostic hypotheses,\" 57% changed into \"revised diagnoses.\" Only in 15% of cases a definite diagnosis was not achieved after the revision.</p><p><strong>Conclusion: </strong>The role of MDD in ILDs' assessment and diagnosis was confirmed. A multidisciplinary approach should be considered in the long-term follow-up of ILDs, as diagnosis may change on the basis of clinical course.</p>","PeriodicalId":20817,"journal":{"name":"Radiologia Medica","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of low-energy virtual monoenergetic imaging in photon-counting CT for pre-TAVI pelvic arteries visualization.","authors":"Leona S Alizadeh, Christian Booz, Thomas J Vogl, Ludovica R M Lanzafame, Simon S Martin, Ibrahim Yel, Leon D Gruenewald, Vitali Koch, Tommaso D'Angelo, Silvio Mazziotti, Kerstin Smolka, Grit Braunegger, Daniel Dillinger, Leonhard Kaatsch, Daniel Overhoff, Niklas Verloh, Stephan S Waldeck","doi":"10.1007/s11547-025-02113-9","DOIUrl":"https://doi.org/10.1007/s11547-025-02113-9","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to assess the impact of photon-counting computed tomography (PCCT) virtual monoenergetic images (VMI) on quantitative and qualitative parameters in abdominal and pelvic vascular imaging for transcatheter aortic valve implantation (TAVI) planning.</p><p><strong>Material and methods: </strong>A retrospective analysis of 125 patients undergoing dual-source PCCT scans before TAVI procedures was conducted. Reconstructions included polychromatic (T3D) images, leveraging multiple photon energy levels and VMI series spanning 40-100 keV in 15 keV increments. Quantitative parameters (signal-to-noise ratio [SNR] and contrast-to-noise ratio [CNR]) were evaluated. Qualitative assessments by three radiologists used clinically relevant five-point scales for overall image quality, TAVI access site suitability, and confidence in TAVI measurements.</p><p><strong>Results: </strong>VMI reconstructions, particularly at 40 and 55 keV, demonstrated significantly higher SNR and CNR than T3D reconstructions (p < 0.001). T3D reconstructions had a mean noise of 12.61 ± 6.12, comparable to 100 keV VMI reconstructions (14.77 ± 8.23, p > 0.05). In qualitative evaluation, 55 keV VMI images scored highest in overall image quality and TAVI access site assessability, followed by 70 keV VMI reconstructions.</p><p><strong>Conclusion: </strong>Low-keV PCCT VMI reconstructions provided superior quantitative and qualitative image quality for abdominal and pelvic vascular imaging in TAVI planning. Notably, 55 keV reconstructions showed an image quality reserve over T3D images, aiding confidence in TAVI-related measurements and enabling possible future reductions in contrast agent use, emphasizing the relevance of VMI techniques in optimizing TAVI imaging protocols.</p>","PeriodicalId":20817,"journal":{"name":"Radiologia Medica","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145239437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to the commentary on the article, entitled Post-vascular phase of contrast-enhanced ultrasound with perfluorobutane for preoperative evaluation of axillary lymph node status in early-stage breast cancer.","authors":"Yixin Hu, Qing Li, Lingling Li, Jianhua Zhou","doi":"10.1007/s11547-025-02106-8","DOIUrl":"https://doi.org/10.1007/s11547-025-02106-8","url":null,"abstract":"","PeriodicalId":20817,"journal":{"name":"Radiologia Medica","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145239443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microwave ablation for residual ground-glass nodule-like lung cancer after video-assisted thoracoscopic surgery: a retrospective, large-sample, multicenter study.","authors":"Yanting Hu, Dongyuan Li, Min Ding, Yuan Yan, Tiehong Zhang, Xia Yang, Zhengyu Lin, Jiachang Chi, Xiaoguang Li, Xin Ye","doi":"10.1007/s11547-025-02112-w","DOIUrl":"https://doi.org/10.1007/s11547-025-02112-w","url":null,"abstract":"<p><strong>Introduction: </strong>The management of residual or new ground-glass nodule (GGN)-like lung cancer after video-assisted thoracoscopic surgery (VATS) is challenging for patients who are not suitable for reoperation. This retrospective, large-sample, multicenter study aimed to evaluate the feasibility, safety, and preliminary efficacy of microwave ablation (MWA) for residual GGN-like lung cancer after VATS in early-stage lung cancer.</p><p><strong>Methods: </strong>A total of 216 patients with 216 residual GGN-like lung cancers who underwent 235 procedures of CT-guided percutaneous MWA after VATS (R0) of stage I-IIA lung adenocarcinoma from July 2016 to December 2023 were included in the study. The primary endpoints were technical success, complications, and pulmonary function test (PFT) variations after the MWA procedure. The secondary endpoints were local progression-free survival (LPFS) and overall survival (OS).</p><p><strong>Results: </strong>The rate of technical success was 100%. The major complications after MWA included pneumothorax (12.3%, 29/235), pleural effusion (5.5%, 13/235), pulmonary infection (2.6%, 6/235), hydropneumothorax (1.3%, 3/235), intrathoracic hemorrhage (0.4%, 1/235), and bronchopleural fistula (0.4%, 1/235). No MWA procedure-related death was observed. The PFT at 1-3 months after MWA was not significantly different from the baseline. The median follow-up duration was 58.5 months, and the 1-, 3- and 5-year OS rates were 100%, 99.1% and 96.3%, respectively. The median follow-up period after MWA was 33.8 months, and the 1-, 2- and 3-year LPFS rates were 100%, 97.7% and 96.3%, respectively.</p><p><strong>Conclusions: </strong>CT-guided percutaneous MWA is a safe, effective, and potentially curative approach for patients with residual GGN-like lung cancer after VATS.</p>","PeriodicalId":20817,"journal":{"name":"Radiologia Medica","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145225820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mining tumor and surrounding tissue information using artificial intelligence to predict responses to EGFR-targeted therapies and immunotherapy in lung cancer: a multicenter attribution analysis.","authors":"Xingping Zhang, Yuxin He, TianXiang Rao, Xingting Qiu, Qingwen Lai, Yanchun Zhang, Guijuan Zhang","doi":"10.1007/s11547-025-02077-w","DOIUrl":"https://doi.org/10.1007/s11547-025-02077-w","url":null,"abstract":"<p><strong>Purpose: </strong>In cancer therapy, tumor cell heterogeneity and dynamics influence gene sequencing and immunohistochemical staining. Importantly, patients treated with epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) have not demonstrated a favorable long-term prognosis. Therefore, this study proposes an integrated framework for artificial intelligence (IFAI) to explore new molecular detection methods.</p><p><strong>Materials and methods: </strong>Our study integrated data from 506 non-small cell lung cancer (NSCLC) patients across three institutions in China and the USA. To fuse radiomics scores and deep network features from both tumors and surrounding tissues, we developed the IFAI with an attention-based DenseNet 121 as the backbone network. We also explored the synergy between IFAI and clinical factors (IFAI-C). Additionally, we gained further insights into the biological mechanisms of IFAI by analyzing patient RNA sequencing data.</p><p><strong>Results: </strong>In independent test data, the IFAI-C demonstrated notable predictive performance, boasting an area under the curve of 0.912 for EGFR, 0.911 for exon 19 deletion (19Del), 0.905 for exon 21 mutation (L858R), 0.911 for T790M, and 0.904 for programmed cell death protein 1 (PD-1) or its ligand 1 (PD-L1). This capability is a crucial complement to traditional methods like gene sequencing and immunohistochemistry. Our analysis revealed that radiomics scores and deep network features in IFAI were significantly associated with EGFR genotypes, drug resistance mutations, and immune molecule expression. Furthermore, these features displayed robust connections with multiple genotypes associated with drug resistance and cancer progression mechanisms.</p><p><strong>Conclusion: </strong>IFAI-C introduces a novel method with performance advantages, accompanied by biological analyses demonstrating the extraction of genotypic and immunomolecular information from both tumors and surrounding tissues. This discovery holds potential value in guiding therapeutic decisions for lung cancer.</p>","PeriodicalId":20817,"journal":{"name":"Radiologia Medica","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145225793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CCM-ITALUNG2 pilot on lung cancer screening in Italy: recruitment, integration with smoking cessation and baseline results.","authors":"Giuseppe Gorini, Donella Puliti, Giulia Picozzi, Jasmine Giovannoli, Giulia Veronesi, Francesco Pistelli, Carlo Senore, Carlo Tessa, Edoardo Cavigli, Simonetta Bisanzi, Elisa Dieci, Piergiorgio Muriana, Annalisa Deliperi, Emanuela Romano, Cristiano Piccinelli, Paola Vivani, Eugenio Paci, Laura Carrozzi, Mario Mascalchi, Enrica Stancanelli, Marika Furuya, Guglielmo Bonaccorsi, Giuseppe Cavallo, Giulia Carreras, Cristina Sani, Jessica Viti, Carmen Visioli, Giovanna Masala, Paola Mantellini, Diletta Cozzi, Katia Ferrari, Amedeo Vannacci, Serena Checcacci, Olga Smorchkova, Luca Gozzi, Alessandra Bindi, Chiara Moroni, Silvia Luvarà, Maurizio Bartolucci, Ilaria Orlandi, Chiara Cruschelli, Chiara Romei, Zeno Falaschi, Valentina Bessi, Stefano Paoli, Elisabetta Casto, Giulia Marchi, Giacomo Guglielmi, Beatrice Vivaldi, Natascia Coltelli, Guido Marchi, Lucia Lupetti, Michela Zanetti, Ilaria Stellati, Maila Coltelli, Simona De Santis, Stefano Viscardi, Domenico Ghio, Paolo Fonio, Riccardo Faletti, Andrea Di Chio, Tiziana Vavalà, Roberto Albera, Silvia Novello, Paola Gollini, Sandra Anglesio, Fabio Beatrice, Pavilio Piccioni, Cristina Fanini, Guido Guidoni, Valentina Galli, Patrizia Gai, Antonella Manfredi, Anna Di Natale, Marzio Taddei, Laura Fallani, Michela Fioriti, Michele Di Francesco, Alessandro Guerrini, Niccolò Biancalani, Barbara Calistri, Lara Romagnani, Luca Puccetti, Gianluca Sassi, Marco Araldi, Pier Riccardo Rossi, Sabina Bianchi, Annalisa Cannatelli, Paolo Cataldi, Roberto Cernigliaro, Francesca D'Agostino, Cristina De Ambrogio, Francesca Di Valente, Giulia Durando, Alessandra Fracchia, Eleonora Giraudi, Patrizia Guerra, Massimo Massi, Laura Mondino, Cristina Nolli, Chiara Pugni, Enrica Zucchetti, Stefano Diciotti","doi":"10.1007/s11547-025-02109-5","DOIUrl":"https://doi.org/10.1007/s11547-025-02109-5","url":null,"abstract":"<p><strong>Background: </strong>The CCM-ITALUNG2 pilot was implemented to evaluate the feasibility of an organized lung cancer (LC) screening programme in five Italian centres.</p><p><strong>Methods: </strong>The screening pathway included invitation, recruitment, referral to Smoking Cessation Services (SCSs), and use of the Lung-RADS score for low-dose CT reading. Dedicated screening operators followed up participants from recruitment through the clinical follow-up established by multidisciplinary teams. Eligibility criteria included age 55-75 years, ever-smokers with ≥ 25 pack-years; quit within the past 10 years. Baseline round results are presented.</p><p><strong>Results: </strong>From November 2022 to May 2024, 1,144 of the 1,971 invited individuals (58.0%) were recruited following different strategies including in-person invitation by general practitioners (GPs; 356 subjects, 31.9%) or other healthcare personnel (18.1%), self-presentation (36.3%), and phone invitation using GPs' patient lists (13.7%). Among current smokers, 38.5% accepted referral to SCSs. Eighteen subjects (77.8% in stage I-II) were diagnosed with LC (prevalent LC rate 1.57%). The mean time to surgery was 147 days (standard deviation 73); the false-positive rate was 1.38% (15/1,085).</p><p><strong>Conclusions: </strong>By utilizing different organizational models, the pilot was tailored to the specific characteristics of each centre. Phone invitations from GPs' patient lists, in-person invitations by GPs and other healthcare personnel, and self-presentation might enhance equity of access in comparison with self-referral only. Dedicated screening operators, the use of the Lung-RADS scoring system, and a structured clinical follow-up supported participants throughout the screening pathway. Delivering brief advice for smoking cessation during recruitment and offering SCS referral were feasible within the screening pathway.</p>","PeriodicalId":20817,"journal":{"name":"Radiologia Medica","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145228579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low dose photon-counting digital breast tomosynthesis: comparison with a commercially available tomosynthesis unit in the detection and characterization of breast carcinomas.","authors":"Elena Venturini, Claudio Losio, Mariagrazia Rodighiero, Goffredo Ferrarese, Antonella Del Vecchio, Alessandro Loria, Jonas Rikard Rehn, Pietro Panizza","doi":"10.1007/s11547-025-02115-7","DOIUrl":"https://doi.org/10.1007/s11547-025-02115-7","url":null,"abstract":"<p><strong>Purpose: </strong>Digital Breast Tomosynthesis (DBT) has a diagnostic accuracy higher than 2D-FFDM, with a slightly higher Average Glandular Dose (AGD). Photon-counting technology was demonstrated to reduce AGD of 2D-FFDM, while preserving a high image quality; it therefore represents an interesting solution to significantly reduce the radiation dose of DBT. Our purpose is to compare the image quality and the AGD of a photon-counting DBT prototype with a conventional DBT unit in the detection of breast carcinoma.</p><p><strong>Materials and methods: </strong>In this preliminary prospective study, 17 women with a suspicious breast finding (BI-RADS 4c/5) were enrolled. Before biopsy, they underwent bilateral 2-view DBT with a conventional unit and a photon-counting prototype. The AGD delivered by the two DBT units were compared. Three readers independently reviewed and compared the images (DBT and synthesized 2D) giving a density, BI-RADS and conspicuity score focusing on suspicious findings. All women underwent core-needle biopsy with imaging guidance and histology was used as standard reference.</p><p><strong>Results: </strong>In 15 examinations at least one suspicious finding was detectable by both systems. Two exams were falsely negative with both units due to high density and small cancer size. All suspicious findings were histologically confirmed as malignant. There was no significant difference in density and BI-RADS scores. The conspicuity of findings was scored as equal or better for photon-counting DBT in 94% observations. The mean AGD delivered by photon-counting DBT was 55% lower than the conventional DBT.</p><p><strong>Conclusion: </strong>According to these preliminary data, photon-counting DBT provides a high image quality, like a conventional DBT unit, with a drastic reduction of the AGD delivered.</p><p><strong>Trial registration number: </strong>The clinical trial \"Low Dose Tomosynthesis Compared to Traditional Tomosynthesis\" has an identifier number NCT02771444 on the ClinicalTrials.gov website. It was first registered on 11.05.2016.</p>","PeriodicalId":20817,"journal":{"name":"Radiologia Medica","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145225790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripheral inflammation and central sensitization associated with postoperative pain following arthroscopy surgery in rotator cuff injury.","authors":"Xu Chu, Rui Zhao, Tao Wang, XuXu Chen, Hui Kang","doi":"10.1007/s11547-025-02079-8","DOIUrl":"https://doi.org/10.1007/s11547-025-02079-8","url":null,"abstract":"<p><strong>Purpose: </strong>Rotator cuff injury (RCI) is a prevalent cause of shoulder disability, with emerging evidence implicating localized inflammatory cascades as key mediators of nociceptive signaling. Recent studies suggest that preoperative central sensitization induced by exposure to inflammation serves as a predictor of persistent pain following surgery at one-year follow-up. However, the underlying mechanism between peripheral inflammation, central pain processing, and postsurgical pain remains poorly characterized in RCI. Therefore, we aim to characterize pain-elicited brain responses and identify brain mediators of pain hypersensitivity in RCI patients.</p><p><strong>Materials and methods: </strong>Utilizing a case-control design, twenty-eight patients with right/bilateral RCI and twenty healthy controls underwent functional MRI during pressure noxious stimuli, with pain intensity quantified via the visual analog scale. Comprehensive analyses of preoperative resting-state fMRI, serum cytokine profiles, and postoperative neuroimaging were conducted in RCI patients.</p><p><strong>Results: </strong>We found significantly higher level of pain sensitivity and IL-6 concentrations in RCI patients compared to controls. RCI patients exhibited higher activation within the left primary somatosensory cortex (S1), which mediated the relationship between IL-6 levels and pain sensitivity. Notably, preoperative S1 amplitude of low-frequency fluctuations (ALFF) exhibited a strong positive correlation with IL-6 concentrations (r = 0.62) and served as a robust predictor of postoperative pain reduction. These findings establish left S1 hyperactivation as a neuroplastic hub integrating peripheral inflammatory signaling (IL-6 elevation) and central pain sensitization in RCI.</p><p><strong>Conclusion: </strong>The observed preoperative associations between S1 function, cytokine profiles, and postoperative pain resolution provide translational evidence for S1 as a predictive biomarker of pain chronification risk.</p>","PeriodicalId":20817,"journal":{"name":"Radiologia Medica","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145225524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CMRO₂ (DSC-PW) perfusion parameter helps to distinguish between progression and pseudoprogression in patients with glioblastoma.","authors":"Emanuele Tommasino, François Ducray, Antoine Seyve, Thiebaud Picard, Anna Martin, Delphine Gamondes, Emilien Jupin Delevaux, Marc Hermier, Yves Berthezene, Alexandre Bani-Sadr","doi":"10.1007/s11547-025-02103-x","DOIUrl":"https://doi.org/10.1007/s11547-025-02103-x","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the diagnostic accuracy of CMRO₂ (cerebral metabolic rate of oxygen) in differentiating between pseudoprogression and true tumour progression in patients with glioblastoma (GB) following chemoradiotherapy and to compare its performance with rCBV (relative cerebral blood volume).</p><p><strong>Materials and methods: </strong>This diagnostic accuracy study included two cohorts: an analysis group (32 patients, 19 progression, 13 pseudoprogression) and a validation group (52 patients, 35 progression, 17 pseudoprogression). Patients underwent MRI (magnetic resonance imaging) with DSC (dynamic susceptibility contrast) and DCE (dynamic contrast-enhanced) perfusion imaging. CMRO₂ and rCBV thresholds were evaluated to calculate sensitivity, specificity, and area under the curve (AUC). Inclusion criteria were GB diagnosis, standard chemoradiotherapy, and new or enlarged enhancing lesions on MRI within one year.</p><p><strong>Results: </strong>In the analysis group (mean age, 60.8 ± 8 years), CMRO₂ showed superior performance with an AUC of 0.89 (95% CI 0.77-0.98), sensitivity of 84.2%, and specificity of 83.3%. rCBV achieved an AUC of 0.63 (95% CI 0.42-0.88). In the validation group (mean age, 63 ± 7 years), CMRO₂ maintained an AUC of 0.91 (95% CI 0.82-0.98), while rCBV reached an AUC of 0.79 (95% CI 0.65-0.91). The DeLong test confirmed CMRO₂'s significantly higher performance (p = 0.04).</p><p><strong>Conclusion: </strong>CMRO₂ demonstrates higher diagnostic performance than rCBV in distinguishing pseudoprogression from true progression in GB patients. Despite limitations, CMRO₂ shows promise as a non-invasive biomarker, warranting further multicentre validation.</p>","PeriodicalId":20817,"journal":{"name":"Radiologia Medica","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145213463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}