Assessment of hypothalamic macrostructure in episodic cluster headache: a volumetric segmentation MRI study.

IF 9.7 1区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Radiologia Medica Pub Date : 2025-06-27 DOI:10.1007/s11547-025-02041-8

Davide Chiffi, Antonio Di Renzo, Giada Giuliani, Chiara Abagnale, Marta Altieri, Gabriele Sebastianelli, Francesco Casillo, Vittorio Di Piero, Gianluca Coppola, Francesca Caramia

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引用次数: 0

Abstract

Purpose: The functional involvement of the hypothalamus in the pathophysiology of episodic cluster headache (eCH) is well known, but its macrostructural involvement remains unclear. In this study, we investigated differences in the volumetry of the entire hypothalamus and its subunits in patients with in-bout eCH during headache-free periods.

Material and methods: We examined hypothalamic volumes in 26 eCH patients (scanned during bout periods but outside of active attacks and off prophylactic medications) and 20 age- and sex-matched healthy controls (HCs). Magnetic resonance imaging (MRI) with T1-weighted sequences was used to perform volumetric segmentation of hypothalamic subunits (anterior-inferior, anterior-superior, posterior, tubular inferior, and tubular superior) and total hypothalamic volume. General linear models were used to assess volumetric differences, adjusting for age, sex, and total intracranial volume.

Results: No statistically significant differences were found in either hypothalamic subunit volumes or total hypothalamic volumes between eCH patients and HCs (p > 0.05). Additionally, no correlations emerged between the hypothalamic volumes and CH clinical features.

Conclusion: These findings align with previous studies, suggesting that CH pathophysiology may involve network-level functional alterations rather than macrostructural hypothalamic changes.

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阵发性丛集性头痛的下丘脑宏观结构评估：体积分割MRI研究。

目的：下丘脑在阵发性丛集性头痛（eCH）病理生理中的功能参与是众所周知的，但其宏观结构的参与尚不清楚。在这项研究中，我们研究了发作期eCH患者在无头痛期间整个下丘脑及其亚单位的体积差异。材料和方法：我们检查了26例eCH患者的下丘脑体积（在发作期间扫描，但在主动发作和未服用预防性药物的情况下扫描）和20例年龄和性别匹配的健康对照（hc）。采用t1加权序列的磁共振成像（MRI）对下丘脑亚单位（前下、前上、后、下管状和上管状）和下丘脑总体积进行体积分割。一般线性模型用于评估容积差异，调整年龄、性别和总颅内容积。结果：eCH患者与hc患者的下丘脑亚基体积及下丘脑总体积均无统计学差异（p < 0.05）。此外，下丘脑体积与CH临床特征之间没有相关性。结论：这些发现与先前的研究一致，表明CH的病理生理可能涉及网络水平的功能改变，而不是下丘脑宏观结构的改变。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Radiologia Medica 医学-核医学

CiteScore

14.10

自引率

7.90%

发文量

133

审稿时长

4-8 weeks

期刊介绍： Felice Perussia founded La radiologia medica in 1914. It is a peer-reviewed journal and serves as the official journal of the Italian Society of Medical and Interventional Radiology (SIRM). The primary purpose of the journal is to disseminate information related to Radiology, especially advancements in diagnostic imaging and related disciplines. La radiologia medica welcomes original research on both fundamental and clinical aspects of modern radiology, with a particular focus on diagnostic and interventional imaging techniques. It also covers topics such as radiotherapy, nuclear medicine, radiobiology, health physics, and artificial intelligence in the context of clinical implications. The journal includes various types of contributions such as original articles, review articles, editorials, short reports, and letters to the editor. With an esteemed Editorial Board and a selection of insightful reports, the journal is an indispensable resource for radiologists and professionals in related fields. Ultimately, La radiologia medica aims to serve as a platform for international collaboration and knowledge sharing within the radiological community.