Progress in neuro-psychopharmacology最新文献_第6页

Decreased tryptophan availability in endogenous depression caused by disturbed plasma leucine clearance 血浆亮氨酸清除紊乱引起的内源性抑郁症中色氨酸可用性降低

Progress in neuro-psychopharmacology Pub Date : 1981-01-01 DOI: 10.1016/0364-7722(81)90080-1

Svend E. Møller, Lars Kirk

引用次数: 8

Radioimmunoassay of melatonin in rat serum 大鼠血清中褪黑素的放射免疫测定

Progress in neuro-psychopharmacology Pub Date : 1981-01-01 DOI: 10.1016/0364-7722(81)90039-4

Lee J. Grota , Victor Snieckus , S.Osmond De Silva , Hing W. Tsui , William R. Holloway , Alfred J. Lewy , Gregory M. Brown

{"title":"Radioimmunoassay of melatonin in rat serum","authors":"Lee J. Grota , Victor Snieckus , S.Osmond De Silva , Hing W. Tsui , William R. Holloway , Alfred J. Lewy , Gregory M. Brown","doi":"10.1016/0364-7722(81)90039-4","DOIUrl":"10.1016/0364-7722(81)90039-4","url":null,"abstract":"<div><ul><li>1.1. Melatonin was coupled to albumin by means of a Na-p-carboxybenzyl, a Na-propionic acid, methylene, or a diazotized p-aminobenzoic acid bridge and injected into rabbits or sheep.</li><li>2.2. All coupling procedures stimulated antisera which bound melatonin with the greatest affinity; N-acetylserotonin and 6-hydroxymelatonin cross-reacted with the antisera at 3–5%. Other naturally occurring indolealkylamine derivatives showed less cross-reactivity.</li><li>3.3. Coupling the hapten melatonin to protein through a bridge at or near the indole N can stimulate antisera which are relatively specific to melatonin and suggest that antisera which bind specifically to any other individual indolealkylamine derivative could be produced using these coupling procedures.</li><li>4.4. Using the methylene bridged antisera, a radioimmunoassay for melatonin was developed and validated for rat serum. In addition to tests for reliability and parallelism, serum estimates of melatonin by radioimmunoassay correlated .98 with gas chromatography-mass spectrometry.</li><li>5.5. Serum melatonin levels have a characteristic 24-hour rhythm with a crest late in the dark period (L:D 12:12). Following the injection of 50 ug of melatonin, serum levels reach 5–20 fold higher concentrations than physiological levels.</li></ul></div>","PeriodicalId":20801,"journal":{"name":"Progress in neuro-psychopharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0364-7722(81)90039-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18351891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 50

3, 4 dihydroxyphenylethyleneglycol (DHPG) formation: The major route of rat brain norepinephrine metabolism 3,4二羟基苯乙二醇(DHPG)的形成:大鼠脑去甲肾上腺素代谢的主要途径

Progress in neuro-psychopharmacology Pub Date : 1981-01-01 DOI: 10.1016/0364-7722(81)90041-2

Peter P. Li, Jerry J. Warsh, Damodar D. Godse

引用次数: 13

Determination of brain regional normetanephrine levels by liquid chromatography with electrochemical detection (LC-EC) 液相色谱-电化学检测(LC-EC)测定脑区去甲肾上腺素水平

Progress in neuro-psychopharmacology Pub Date : 1981-01-01 DOI: 10.1016/0364-7722(81)90046-1

Andrew S. Chiu , Damodar D. Godse, Jerry J. Warsh

引用次数: 4

Regional redistribution of β-endorphin in the rat brain: The effect of stress 大鼠脑内β-内啡肽的区域再分配:应激的影响

Progress in neuro-psychopharmacology Pub Date : 1981-01-01 DOI: 10.1016/0364-7722(81)90054-0

Alice Barta, Kiran Yashpal

{"title":"Regional redistribution of β-endorphin in the rat brain: The effect of stress","authors":"Alice Barta, Kiran Yashpal","doi":"10.1016/0364-7722(81)90054-0","DOIUrl":"https://doi.org/10.1016/0364-7722(81)90054-0","url":null,"abstract":"<div><ul><li>1.1. After an acute mild swim (20°, 3 min), levels of β-endorphin-like immunoreactivity decreased in the anterior pituitary to 48% of controls and in the intermediate-posterior pituitary to 62%. In the brain, of the 14 regions examined, four showed remarkable increases: central n. of amygdala to 167%, n. interstitialis striae terminalis to 174%, n. raphe dorsalis to 170%, and n. paraventricularis to 136%.</li><li>2.2. An acute severe swim (4°, 3 min) caused a decrease of the opioid to 66% and 93% of controls in the anterior and intermediate-posterior pituitary, respectively, and an increase in central n. of amygdala to 227%, in n. interstitialis striae terminalis to 173%, in n. raphe magnus to 148%, in n. paraventricularis to 155%, and in periaqueductal gray (PAG) to 193%.</li><li>3.3. Mild swimmings applied chronically for 21 days resulted in return of the opioid levels nearly to control values as habituation developed.</li><li>4.4. After chronic swimmings of gradually increased severity during the 21 day period (water temperature gradually decreased from 20° to 4° and the time of swimming gradually increased from 3 to 9 min), no habituation occurred but further increases in β-endorphin-like immunoreactivity were observed.</li><li>5.5. The present results show that stress of swimming affects pituitary and brain levels of β-endorphin and that in brain, the most affected are areas of midbrain and limbic structures. These effects are reversed by repeated exposure to mild swimming conditions, but not when the conditions of swimming gradually increase in severity.</li></ul></div>","PeriodicalId":20801,"journal":{"name":"Progress in neuro-psychopharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0364-7722(81)90054-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91624154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 33

Dextro-propranolol in schizophrenia 右心得安治疗精神分裂症

Progress in neuro-psychopharmacology Pub Date : 1981-01-01 DOI: 10.1016/0364-7722(81)90106-5

Steven R Hirsch , Rahul Manchanda , Malcolm P.I Weller

引用次数: 12

Theoretical and practical importance of plasma levels of haloperidol. correlations with clinical and computerized EEG data 氟哌啶醇血浆水平的理论和实践重要性。与临床和计算机脑电图数据的相关性

Progress in neuro-psychopharmacology Pub Date : 1981-01-01 DOI: 10.1016/0364-7722(81)90033-3

Rene P. De Buck , Norberto Zelaschi , Christian Gilles , Jacques Durdu , Henri Brauman

{"title":"Theoretical and practical importance of plasma levels of haloperidol. correlations with clinical and computerized EEG data","authors":"Rene P. De Buck , Norberto Zelaschi , Christian Gilles , Jacques Durdu , Henri Brauman","doi":"10.1016/0364-7722(81)90033-3","DOIUrl":"10.1016/0364-7722(81)90033-3","url":null,"abstract":"<div><ul><li>1.1. Haloperidol plasma levels, after long acting haloperidol i.m. injection, are analyzed and compared with clinical evolution and EEG modifications.</li><li>2.2. Haloperidol plasma levels were determined by radioimmunoassay. Clinical status was assessed weekly and computerized EEG were performed daily from day 3 to 7 after haloperidol decanoate injection.</li><li>3.3. The plasma level-dose relationship during oral treatment and 4 weeks after haloperidol decanoate injection are very similar. After injection, the plasma level attains its highest value within 3 to 10 days and decreases along a logarithmic curve. An inverse relationship with B.P.R.S.scores is found in many patients. EEG changes are related to clinical status rather than to plasma levels.</li><li>4.4. The results obtained by these three methods are proposed as criteria for the assessment of the reinjection time.</li></ul></div>","PeriodicalId":20801,"journal":{"name":"Progress in neuro-psychopharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0364-7722(81)90033-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18351885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Panic induced by sodium lactate: Electrophysiological correlates 乳酸钠引起的恐慌:电生理相关

Progress in neuro-psychopharmacology Pub Date : 1981-01-01 DOI: 10.1016/0364-7722(81)90036-9

Verner Knott, Rajnish Chaudhry, Yvon D. Lapierre

引用次数: 25

Extra-focal catecholamine levels in ‘kindled’ rat forebrains 点燃的大鼠前脑的焦外儿茶酚胺水平

Progress in neuro-psychopharmacology Pub Date : 1981-01-01 DOI: 10.1016/0364-7722(81)90042-4

W. McIntyre Burnham, Gary A. King , Kenneth G. Lloyd

引用次数: 17

Antidepressant action of lithium: Proposed mechanism based upon behavioral analysis in the mouse 锂的抗抑郁作用:基于小鼠行为分析提出的机制

Progress in neuro-psychopharmacology Pub Date : 1981-01-01 DOI: 10.1016/0364-7722(81)90086-2

Henriette Frances, Marie-Hélène Marion, Pierre Simon

引用次数: 2