The effects of acute and chronic administration of β-phenylethylamine on food intake and body weight in rats

Colin T. Dourish, Alan A. Boulton
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引用次数: 34

Abstract

  • 1.

    1. The food and water intake and diuresis of male Sprague-Dawley rats were monitored after a single injection of β-phenylethylamine (PEA), and thereafter, at 7 day intervals during 4 weeks of drug treatment.

  • 2.

    2. PEA reduced 24 hour food intake (maximal effect of 20% reduction at 50 mg/kg) after a single injection and tolerance did not develop to this effect during four weeks treatment. Similarly PEA caused a dose dependent reduction in body weight gain during this period.

  • 3.

    3. The anorectic effect of PEA appears to be behaviourally specific to feeding since there was no concurrent inhibition of water intake or diuresis.

急性和慢性给药β-苯乙胺对大鼠食物摄入和体重的影响
1.1. 观察雄性Sprague-Dawley大鼠单次注射β-苯乙胺(PEA)后的摄食、饮水及利尿情况,并在给药4周后每隔7天监测一次。单次注射后,PEA减少了24小时的食物摄入量(最大效果为50mg /kg时减少20%),在四周的治疗期间,耐受性没有达到这种效果。同样,在此期间,PEA引起了体重增加的剂量依赖性减少。PEA的厌食作用似乎是行为上特定于喂养的,因为它没有同时抑制水的摄入或利尿。
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