Progress in neuro-psychopharmacology最新文献_第5页

News and intercommunications in neuro-psychopharmacology 神经精神药理学的新闻与交流

Progress in neuro-psychopharmacology Pub Date : 1981-01-01 DOI: 10.1016/0364-7722(81)90083-7

引用次数: 0

The neuro- and cardiovascular pharmacology of RS-51324, a potential antidepressant RS-51324的神经和心血管药理学，一种潜在的抗抑郁药

Progress in neuro-psychopharmacology Pub Date : 1981-01-01 DOI: 10.1016/0364-7722(81)90098-9

Marshall B Wallach , Brian J Alps , A.Peter Roszkowski , L.David Waterbury

{"title":"The neuro- and cardiovascular pharmacology of RS-51324, a potential antidepressant","authors":"Marshall B Wallach , Brian J Alps , A.Peter Roszkowski , L.David Waterbury","doi":"10.1016/0364-7722(81)90098-9","DOIUrl":"10.1016/0364-7722(81)90098-9","url":null,"abstract":"<div><ul><li>1.1. The neuro- and cardiovascular effects of RS-51324 (DL-4(5)-(2,6dichlorophenyl)-2-methoxycarbonyl-amino-4,5 dihydroimidazole) have been explored in animals.</li><li>2.2. Antidepressant activities of RS-51324 were demonstrated by reserpine antagonism and L-DOPA potentiation.</li><li>3.3. Norepinephrine uptake was inhibited but MAO activity was not inhibited by RS-51324.</li><li>4.4. Peripheral vascular responses to serotonin were potentiated although central effects were not demonstrated.</li><li>5.5. Cardiovascular experiments indicated that RS-51324 lacked anticholinergic effects but had mild antihistaminic activity.</li><li>6.6. RS-51324 potentiated tyramine-induced pressor responses.</li><li>7.7. RS-51324 lacks centrally acting skeletal muscle relaxant activity.</li><li>8.8. The LD50 of RS-51324 was greater than 2 gm/kg.</li><li>9.9. RS-51324 appears to be a membrane-pump inhibiting compound with probable antidepressant activity.</li></ul></div>","PeriodicalId":20801,"journal":{"name":"Progress in neuro-psychopharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0364-7722(81)90098-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18235587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Reversal of learned helplessness by nortriptyline 去甲替林逆转习得性无助

Progress in neuro-psychopharmacology Pub Date : 1981-01-01 DOI: 10.1016/0364-7722(81)90052-7

J.I. Telner, R.L. Singhal, Y.D. Lapierre

{"title":"Reversal of learned helplessness by nortriptyline","authors":"J.I. Telner, R.L. Singhal, Y.D. Lapierre","doi":"10.1016/0364-7722(81)90052-7","DOIUrl":"10.1016/0364-7722(81)90052-7","url":null,"abstract":"<div><ul><li>1.1. Animals exposed to inescapable stress display avoidance and escape deficits when tested in a later task situation where successful responding results in stress offset, a phenomenon termed learned helplessness. This paradigm has been suggested as an animal model of depression as it shares many of the characteristics of the human disorder.</li><li>2.2. An escape delay procedure previously shown to reveal interference effects in mice was reproduced in rats.</li><li>3.3. Using this escape delay procedure, the effects of acute and sub-acute administration of nortriptyline on learned helplessness behavior were assessed.</li><li>4.4. Four and 6 days of drug treatment reversed the escape deficits produced in animals exposed to pre-shock whereas the 0 and 2 day drug regimens were without effect.</li><li>5.5. These findings support the utility of the learned helplessness model in evaluating the potential of antidepressant agents in experimental animals.</li></ul></div>","PeriodicalId":20801,"journal":{"name":"Progress in neuro-psychopharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0364-7722(81)90052-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18215412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

Ethanol as the negative reinforcer in an active avoidance paradigm 乙醇作为主动回避范式中的负强化物

Progress in neuro-psychopharmacology Pub Date : 1981-01-01 DOI: 10.1016/0364-7722(81)90075-8

Larry A. Grupp

引用次数: 8

The effects of ethanol, acetaldehyde, morphine and naloxone on histamine methyltransferase activity 乙醇、乙醛、吗啡和纳洛酮对组胺甲基转移酶活性的影响

Progress in neuro-psychopharmacology Pub Date : 1981-01-01 DOI: 10.1016/0364-7722(81)90051-5

George D. Prell, Irene M. Mazurkiewicz-Kwilecki

{"title":"The effects of ethanol, acetaldehyde, morphine and naloxone on histamine methyltransferase activity","authors":"George D. Prell, Irene M. Mazurkiewicz-Kwilecki","doi":"10.1016/0364-7722(81)90051-5","DOIUrl":"10.1016/0364-7722(81)90051-5","url":null,"abstract":"<div><ul><li>1.1. The microassay method of Taylor and Snyder for determining the activity of histamine N-methyltransferase (E.C.2.1.1.8) (HMT), the histamine metabolizing enzyme, was modifies to permit the simultaneous measurement of histamine and HMT activity in the same tissue sample under our experimental conditions.</li><li>2.2. The synthesis and purification of τ-methyl-[14C]-histamine was performed to assess the efficiency of extraction of methylhistamine which in this modified methodology is approximately 80 percent.</li><li>3.3. The influence of ethanol, acetaldehyde, morphine and naloxone alone and in combination on hypothalamic, thalamus-midbrain and cerebral cortical HMT activity was investigated at concentrations of 0.1 μM to 500 μM.</li><li>4.4. Ethanol, acetaldehyde and ethanol in the presence of 1 μM morphine failed to markedly influence HMT activity.</li><li>5.5. At high concentrations morphine strongly inhibited while naloxone enhanced enzyme activity. Morphine's effects on HMT remained unaltered by 1 μM naloxone.</li><li>6.6. In the present study low concentrations of ethanol and morphine have little effect on HMT activity ‘in vitro’. These observations suggest that changes in HMT activity may play a minor role in the alcohol and morphine-induced central histamine changes observed in our previous ‘in vivo’ studies.</li></ul></div>","PeriodicalId":20801,"journal":{"name":"Progress in neuro-psychopharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0364-7722(81)90051-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18351898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Neurotransmitter systems in aging and senile dementia 衰老和老年性痴呆的神经递质系统

Progress in neuro-psychopharmacology Pub Date : 1981-01-01 DOI: 10.1016/0364-7722(81)90025-4

Edith G. McGeer

{"title":"Neurotransmitter systems in aging and senile dementia","authors":"Edith G. McGeer","doi":"10.1016/0364-7722(81)90025-4","DOIUrl":"10.1016/0364-7722(81)90025-4","url":null,"abstract":"<div><ul><li>1.1. Reported changes in neurotransmitter systems with aging in human and animal brain are briefly reviewed. The effects of age appear to vary from region to region in brain, as well as from system to system. Considerable evidence is available that dopaminergic activity decreases with age, particularly in the striatum and nucleus accumbens; this loss may be important to age-related losses in agility and increases in the incidence and severity of tardive dyskinesia. Lesser, but still convincing, evidence indicates decreases with age in noradrenergic, GABAergic and cholinergic systems, with the most marked effects being found, respectively, in the hypothalamus, thalamus and cortex-hippocampus. The cortical and hippocampal losses in cholinergic activity are markedly accentuated in senile dementia of the Alzheimer type and are probably related to memory defects in aging and dementia.</li><li>2.2. Serotonin and met-enkephalin systems in the hypothalamus are probably relatively unchanged by age and little or no information is available on numerous other putative transmitters.</li><li>3.3. Brief consideration is also given to age-related changes in the density of specific binding sites, possible reasons for lack of therapeutic effect of choline analogs in senile dementia, and the question of whether cell death, loss of nerve endings and/or decreased neuronal vitality underlie the deficits found.</li></ul></div>","PeriodicalId":20801,"journal":{"name":"Progress in neuro-psychopharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0364-7722(81)90025-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17189418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 61

Role of serotonergic and adrenergic systems in alcohol tolerance 血清素和肾上腺素系统在酒精耐受性中的作用

Progress in neuro-psychopharmacology Pub Date : 1981-01-01 DOI: 10.1016/0364-7722(81)90027-8

J.M. Khanna, H. Kalant, A.D. Lê, A.E. LeBlanc

{"title":"Role of serotonergic and adrenergic systems in alcohol tolerance","authors":"J.M. Khanna, H. Kalant, A.D. Lê, A.E. LeBlanc","doi":"10.1016/0364-7722(81)90027-8","DOIUrl":"10.1016/0364-7722(81)90027-8","url":null,"abstract":"<div><ul><li>1.1. This paper attempts to provide an overview of our research which has led us to the concept of tolerance as adaptation to drug effects rather than adaptation to the drug itself.</li><li>2.2. This notion can be expanded to include drug tolerance as an example of a range of adaptive manifestations of neuroplasticity.</li><li>3.3. The suggestion that serotonin (5-HT) is involved in general adaptive processes gave impetus to exploration of its role in tolerance.</li><li>4.4. The paper focusses, therefore, primarily on the line of research that started with whole brain manipulation of brain 5-HT and evolved into a study of the effects of discrete and localized depletion of 5-HT.</li><li>5.5. The evidence for the role of median raphe nucleus, the limbic 5-HT, central norepinephrine (NE), and Des-Gly9 (Arg8) vasopressin (DGAVP) in ethanol tolerance is also provided, with the relationship between the median raphe nuclei and the limbic system most clearly delineated.</li></ul></div>","PeriodicalId":20801,"journal":{"name":"Progress in neuro-psychopharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0364-7722(81)90027-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17519191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Discriminative stimulus properties of cocaine related to an anxiogenic action 可卡因的鉴别刺激特性与焦虑作用有关

Progress in neuro-psychopharmacology Pub Date : 1981-01-01 DOI: 10.1016/0364-7722(81)90005-9

Gary T. Shearman, Harbans Lal

引用次数: 44

Communication from the viewpoint of the European Regional Reference Center 从欧洲区域参考中心的角度看交流

Progress in neuro-psychopharmacology Pub Date : 1981-01-01 DOI: 10.1016/0364-7722(81)90070-9

Hans Feer

引用次数: 0

Effects of a piperazine derivative, piribedil, on exploration, locomotor activity and social behaviour in the rat 哌嗪衍生物吡吡地尔对大鼠探索、运动活动和社会行为的影响

Progress in neuro-psychopharmacology Pub Date : 1981-01-01 DOI: 10.1016/0364-7722(81)90076-X

Sandra E. File

{"title":"Effects of a piperazine derivative, piribedil, on exploration, locomotor activity and social behaviour in the rat","authors":"Sandra E. File","doi":"10.1016/0364-7722(81)90076-X","DOIUrl":"10.1016/0364-7722(81)90076-X","url":null,"abstract":"<div><ul><li>1.1. The piperazine derivative, piribedil (ET495), in doses ranging from 10 to 100 mg/kg reduced locomotor activity and exploration in rats naive to the holeboard, but had less effect on exploration and was without effect on locomotor activity in rats familiar with the apparatus.</li><li>2.2. Doses of 5–100 mg/kg disrupted the usual between-day decrement in exploration and locomotor activity, but did not change the increase in head-dipping when novel objects were introduced on the second day.</li><li>3.3. ET495 and amphetamine counteracted each other's effects on locomotor activity, but had similar and additive effects on exploration.</li><li>4.4. Haloperidol did not antagonise the effects of ET495.</li><li>5.5. ET495 (0.5 & 1 mg/kg) increased social interaction between male rats when they were tested in an unfamiliar arena, but was without effect in a familiar one.</li><li>6.6. The effects of ET495 are dependent on the animal's familiarity with the test arena, but over the dose-range tested (0.5 to 100 mg/kg) there was no evidence of low doses acting on presynaptic receptors to produce stimulation of locomotor activity or exploration. The enhanced social interaction found after low doses might reflect a presynaptic action.</li></ul></div>","PeriodicalId":20801,"journal":{"name":"Progress in neuro-psychopharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0364-7722(81)90076-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18280703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12