Progress in neuro-psychopharmacology最新文献_第5页

An EEG analysis of convulsive activity produced by cholinergic agents 胆碱能药物引起的惊厥活动的脑电图分析

Progress in neuro-psychopharmacology Pub Date : 1981-01-01 Epub Date: 2004-05-07 DOI: 10.1016/0364-7722(81)90089-8

Steven L. Cohen , Barbara J. Morley , O.Carter Snead

引用次数: 31

Reversal of learned helplessness by nortriptyline 去甲替林逆转习得性无助

Progress in neuro-psychopharmacology Pub Date : 1981-01-01 Epub Date: 2004-05-07 DOI: 10.1016/0364-7722(81)90052-7

J.I. Telner, R.L. Singhal, Y.D. Lapierre

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引用次数: 21

The effects of ethanol, acetaldehyde, morphine and naloxone on histamine methyltransferase activity 乙醇、乙醛、吗啡和纳洛酮对组胺甲基转移酶活性的影响

Progress in neuro-psychopharmacology Pub Date : 1981-01-01 Epub Date: 2004-05-07 DOI: 10.1016/0364-7722(81)90051-5

George D. Prell, Irene M. Mazurkiewicz-Kwilecki

{"title":"The effects of ethanol, acetaldehyde, morphine and naloxone on histamine methyltransferase activity","authors":"George D. Prell, Irene M. Mazurkiewicz-Kwilecki","doi":"10.1016/0364-7722(81)90051-5","DOIUrl":"10.1016/0364-7722(81)90051-5","url":null,"abstract":"<div><ul><li>1.1. The microassay method of Taylor and Snyder for determining the activity of histamine N-methyltransferase (E.C.2.1.1.8) (HMT), the histamine metabolizing enzyme, was modifies to permit the simultaneous measurement of histamine and HMT activity in the same tissue sample under our experimental conditions.</li><li>2.2. The synthesis and purification of τ-methyl-[14C]-histamine was performed to assess the efficiency of extraction of methylhistamine which in this modified methodology is approximately 80 percent.</li><li>3.3. The influence of ethanol, acetaldehyde, morphine and naloxone alone and in combination on hypothalamic, thalamus-midbrain and cerebral cortical HMT activity was investigated at concentrations of 0.1 μM to 500 μM.</li><li>4.4. Ethanol, acetaldehyde and ethanol in the presence of 1 μM morphine failed to markedly influence HMT activity.</li><li>5.5. At high concentrations morphine strongly inhibited while naloxone enhanced enzyme activity. Morphine's effects on HMT remained unaltered by 1 μM naloxone.</li><li>6.6. In the present study low concentrations of ethanol and morphine have little effect on HMT activity ‘in vitro’. These observations suggest that changes in HMT activity may play a minor role in the alcohol and morphine-induced central histamine changes observed in our previous ‘in vivo’ studies.</li></ul></div>","PeriodicalId":20801,"journal":{"name":"Progress in neuro-psychopharmacology","volume":"5 5","pages":"Pages 581-585"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0364-7722(81)90051-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18351898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Ethanol as the negative reinforcer in an active avoidance paradigm 乙醇作为主动回避范式中的负强化物

Progress in neuro-psychopharmacology Pub Date : 1981-01-01 Epub Date: 2004-05-07 DOI: 10.1016/0364-7722(81)90075-8

Larry A. Grupp

引用次数: 8

The neuro- and cardiovascular pharmacology of RS-51324, a potential antidepressant RS-51324的神经和心血管药理学，一种潜在的抗抑郁药

Progress in neuro-psychopharmacology Pub Date : 1981-01-01 Epub Date: 2004-07-14 DOI: 10.1016/0364-7722(81)90098-9

Marshall B Wallach , Brian J Alps , A.Peter Roszkowski , L.David Waterbury

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引用次数: 3

Communication from the viewpoint of the European Regional Reference Center 从欧洲区域参考中心的角度看交流

Progress in neuro-psychopharmacology Pub Date : 1981-01-01 Epub Date: 2004-05-07 DOI: 10.1016/0364-7722(81)90070-9

Hans Feer

引用次数: 0

Decreased tryptophan availability in endogenous depression caused by disturbed plasma leucine clearance 血浆亮氨酸清除紊乱引起的内源性抑郁症中色氨酸可用性降低

Progress in neuro-psychopharmacology Pub Date : 1981-01-01 Epub Date: 2004-05-07 DOI: 10.1016/0364-7722(81)90080-1

Svend E. Møller, Lars Kirk

引用次数: 8

Effects of a piperazine derivative, piribedil, on exploration, locomotor activity and social behaviour in the rat 哌嗪衍生物吡吡地尔对大鼠探索、运动活动和社会行为的影响

Progress in neuro-psychopharmacology Pub Date : 1981-01-01 Epub Date: 2004-05-07 DOI: 10.1016/0364-7722(81)90076-X

Sandra E. File

{"title":"Effects of a piperazine derivative, piribedil, on exploration, locomotor activity and social behaviour in the rat","authors":"Sandra E. File","doi":"10.1016/0364-7722(81)90076-X","DOIUrl":"10.1016/0364-7722(81)90076-X","url":null,"abstract":"<div><ul><li>1.1. The piperazine derivative, piribedil (ET495), in doses ranging from 10 to 100 mg/kg reduced locomotor activity and exploration in rats naive to the holeboard, but had less effect on exploration and was without effect on locomotor activity in rats familiar with the apparatus.</li><li>2.2. Doses of 5–100 mg/kg disrupted the usual between-day decrement in exploration and locomotor activity, but did not change the increase in head-dipping when novel objects were introduced on the second day.</li><li>3.3. ET495 and amphetamine counteracted each other's effects on locomotor activity, but had similar and additive effects on exploration.</li><li>4.4. Haloperidol did not antagonise the effects of ET495.</li><li>5.5. ET495 (0.5 & 1 mg/kg) increased social interaction between male rats when they were tested in an unfamiliar arena, but was without effect in a familiar one.</li><li>6.6. The effects of ET495 are dependent on the animal's familiarity with the test arena, but over the dose-range tested (0.5 to 100 mg/kg) there was no evidence of low doses acting on presynaptic receptors to produce stimulation of locomotor activity or exploration. The enhanced social interaction found after low doses might reflect a presynaptic action.</li></ul></div>","PeriodicalId":20801,"journal":{"name":"Progress in neuro-psychopharmacology","volume":"5 3","pages":"Pages 245-255"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0364-7722(81)90076-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18280703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Discriminative stimulus properties of cocaine related to an anxiogenic action 可卡因的鉴别刺激特性与焦虑作用有关

Progress in neuro-psychopharmacology Pub Date : 1981-01-01 Epub Date: 2004-04-26 DOI: 10.1016/0364-7722(81)90005-9

Gary T. Shearman, Harbans Lal

引用次数: 44

Regional redistribution of β-endorphin in the rat brain: The effect of stress 大鼠脑内β-内啡肽的区域再分配:应激的影响

Progress in neuro-psychopharmacology Pub Date : 1981-01-01 Epub Date: 2004-05-07 DOI: 10.1016/0364-7722(81)90054-0

Alice Barta, Kiran Yashpal

{"title":"Regional redistribution of β-endorphin in the rat brain: The effect of stress","authors":"Alice Barta, Kiran Yashpal","doi":"10.1016/0364-7722(81)90054-0","DOIUrl":"https://doi.org/10.1016/0364-7722(81)90054-0","url":null,"abstract":"<div><ul><li>1.1. After an acute mild swim (20°, 3 min), levels of β-endorphin-like immunoreactivity decreased in the anterior pituitary to 48% of controls and in the intermediate-posterior pituitary to 62%. In the brain, of the 14 regions examined, four showed remarkable increases: central n. of amygdala to 167%, n. interstitialis striae terminalis to 174%, n. raphe dorsalis to 170%, and n. paraventricularis to 136%.</li><li>2.2. An acute severe swim (4°, 3 min) caused a decrease of the opioid to 66% and 93% of controls in the anterior and intermediate-posterior pituitary, respectively, and an increase in central n. of amygdala to 227%, in n. interstitialis striae terminalis to 173%, in n. raphe magnus to 148%, in n. paraventricularis to 155%, and in periaqueductal gray (PAG) to 193%.</li><li>3.3. Mild swimmings applied chronically for 21 days resulted in return of the opioid levels nearly to control values as habituation developed.</li><li>4.4. After chronic swimmings of gradually increased severity during the 21 day period (water temperature gradually decreased from 20° to 4° and the time of swimming gradually increased from 3 to 9 min), no habituation occurred but further increases in β-endorphin-like immunoreactivity were observed.</li><li>5.5. The present results show that stress of swimming affects pituitary and brain levels of β-endorphin and that in brain, the most affected are areas of midbrain and limbic structures. These effects are reversed by repeated exposure to mild swimming conditions, but not when the conditions of swimming gradually increase in severity.</li></ul></div>","PeriodicalId":20801,"journal":{"name":"Progress in neuro-psychopharmacology","volume":"5 5","pages":"Pages 595-598"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0364-7722(81)90054-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91624154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 33