{"title":"急性和慢性给药β-苯乙胺对大鼠食物摄入和体重的影响","authors":"Colin T. Dourish, Alan A. Boulton","doi":"10.1016/0364-7722(81)90093-X","DOIUrl":null,"url":null,"abstract":"<div><p></p><ul><li><span>1.</span><span><p>1. The food and water intake and diuresis of male Sprague-Dawley rats were monitored after a single injection of <em>β</em>-phenylethylamine (PEA), and thereafter, at 7 day intervals during 4 weeks of drug treatment.</p></span></li><li><span>2.</span><span><p>2. PEA reduced 24 hour food intake (maximal effect of 20% reduction at 50 mg/kg) after a single injection and tolerance did not develop to this effect during four weeks treatment. Similarly PEA caused a dose dependent reduction in body weight gain during this period.</p></span></li><li><span>3.</span><span><p>3. The anorectic effect of PEA appears to be behaviourally specific to feeding since there was no concurrent inhibition of water intake or diuresis.</p></span></li></ul></div>","PeriodicalId":20801,"journal":{"name":"Progress in neuro-psychopharmacology","volume":"5 4","pages":"Pages 411-414"},"PeriodicalIF":0.0000,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0364-7722(81)90093-X","citationCount":"34","resultStr":"{\"title\":\"The effects of acute and chronic administration of β-phenylethylamine on food intake and body weight in rats\",\"authors\":\"Colin T. Dourish, Alan A. Boulton\",\"doi\":\"10.1016/0364-7722(81)90093-X\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p></p><ul><li><span>1.</span><span><p>1. The food and water intake and diuresis of male Sprague-Dawley rats were monitored after a single injection of <em>β</em>-phenylethylamine (PEA), and thereafter, at 7 day intervals during 4 weeks of drug treatment.</p></span></li><li><span>2.</span><span><p>2. PEA reduced 24 hour food intake (maximal effect of 20% reduction at 50 mg/kg) after a single injection and tolerance did not develop to this effect during four weeks treatment. Similarly PEA caused a dose dependent reduction in body weight gain during this period.</p></span></li><li><span>3.</span><span><p>3. The anorectic effect of PEA appears to be behaviourally specific to feeding since there was no concurrent inhibition of water intake or diuresis.</p></span></li></ul></div>\",\"PeriodicalId\":20801,\"journal\":{\"name\":\"Progress in neuro-psychopharmacology\",\"volume\":\"5 4\",\"pages\":\"Pages 411-414\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1981-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0364-7722(81)90093-X\",\"citationCount\":\"34\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Progress in neuro-psychopharmacology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/036477228190093X\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Progress in neuro-psychopharmacology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/036477228190093X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The effects of acute and chronic administration of β-phenylethylamine on food intake and body weight in rats
1.
1. The food and water intake and diuresis of male Sprague-Dawley rats were monitored after a single injection of β-phenylethylamine (PEA), and thereafter, at 7 day intervals during 4 weeks of drug treatment.
2.
2. PEA reduced 24 hour food intake (maximal effect of 20% reduction at 50 mg/kg) after a single injection and tolerance did not develop to this effect during four weeks treatment. Similarly PEA caused a dose dependent reduction in body weight gain during this period.
3.
3. The anorectic effect of PEA appears to be behaviourally specific to feeding since there was no concurrent inhibition of water intake or diuresis.
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