Medicinal Research Reviews最新文献_第4页

Comparison of Radionuclide Drug Conjugates With Boron Neutron Capture Therapy: An Overview of Targeted Charged Particle Radiation Therapy 放射性核素药物偶联物与硼中子俘获治疗的比较：靶向带电粒子放射治疗综述。

IF 10.9 1区医学

Medicinal Research Reviews Pub Date : 2024-12-17 DOI: 10.1002/med.22093

Yingjun Zhang, Paolo Coghi, Zimo Ren, Narayan S. Hosmane, Yinghuai Zhu

{"title":"Comparison of Radionuclide Drug Conjugates With Boron Neutron Capture Therapy: An Overview of Targeted Charged Particle Radiation Therapy","authors":"Yingjun Zhang, Paolo Coghi, Zimo Ren, Narayan S. Hosmane, Yinghuai Zhu","doi":"10.1002/med.22093","DOIUrl":"10.1002/med.22093","url":null,"abstract":"<div>\u0000 \u0000 Targeted charged alpha- and beta-particle therapies are currently being used in clinical radiation treatments as newly developed methods for either killing or controlling tumor cell growth. The alpha particles can be generated either through a nuclear decay reaction or in situ by a nuclear fission reaction such as the boron neutron capture reaction. Different strategies have been employed to improve the selectivity and delivery of radiation dose to tumor cells based on the source of the clinically used alpha particles. As a result, the side effects of the treatment can be minimized. The increasing attention and research efforts on targeted alpha-particle therapy have been fueled by exciting results of both academic research and clinical trials. It is highly anticipated that alpha-particle therapy will improve the efficacy of treating malignant tumors. In this overview, we compare radionuclide drug conjugates (RDC) with boron neutron capture therapy (BNCT) to present recent developments in targeted alpha-particle therapy.</div>","PeriodicalId":207,"journal":{"name":"Medicinal Research Reviews","volume":"45 3","pages":"867-886"},"PeriodicalIF":10.9,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142845470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Front Cover Image, Volume 45, Issue 1 封面图像，第45卷，第1期

IF 10.9 1区医学

Medicinal Research Reviews Pub Date : 2024-12-13 DOI: 10.1002/med.22094

Jinyi Wang, Tingting Zhou

引用次数: 0

β3-Adrenoceptor Agonism to Mimic the Biological Effects of Intrauterine Hypoxia: Taking Great Strides Toward a Pharmacological Artificial Placenta β3-肾上腺素受体激动剂模拟宫内缺氧的生物效应：向药理人工胎盘迈出一大步。

IF 10.9 1区医学

Medicinal Research Reviews Pub Date : 2024-11-27 DOI: 10.1002/med.22092

Luca Filippi, Francesca Innocenti, Francesca Pascarella, Rosa Teresa Scaramuzzo, Riccardo Morganti, Paola Bagnoli, Maurizio Cammalleri, Massimo Dal Monte, Maura Calvani, Alessandro Pini

{"title":"β3-Adrenoceptor Agonism to Mimic the Biological Effects of Intrauterine Hypoxia: Taking Great Strides Toward a Pharmacological Artificial Placenta","authors":"Luca Filippi, Francesca Innocenti, Francesca Pascarella, Rosa Teresa Scaramuzzo, Riccardo Morganti, Paola Bagnoli, Maurizio Cammalleri, Massimo Dal Monte, Maura Calvani, Alessandro Pini","doi":"10.1002/med.22092","DOIUrl":"10.1002/med.22092","url":null,"abstract":"At different stages of life, from embryonic to postnatal, varying oxygen concentrations modulate cellular gene expression by enhancing or repressing hypoxia-inducible transcription factors. During embryonic/fetal life, these genes encode proteins involved in adapting to a low-oxygen environment, including the induction of specific enzymes related to glycolytic metabolism, erythropoiesis, angiogenesis, and vasculogenesis. However, oxygen concentrations fluctuate during intrauterine life, enabling the induction of tissue-specific differentiation processes. Fetal well-being is thus closely linked to the physiological benefits of a dynamically hypoxic environment. Premature birth entails the precocious exposure of the immature fetus to a more oxygen-rich environment compared to the womb. As a result, preterm newborns face a condition of relative hyperoxia, which alters the postnatal development of organs and contributes to prematurity-related diseases. However, until recently, the molecular mechanism by which high oxygen tension alters normal fetal differentiation remained unclear. In this review, we discuss the research trajectory followed by our research group, which suggests that early exposure to a relatively hyperoxic environment may impair preterm neonates due to reduced expression of the β3-adrenoceptor. Additionally, we explore how these impairments could be prevented through the pharmacological stimulation of the remaining β3-adrenoceptors. Recent preclinical studies demonstrate that pharmacological stimulation of the β3-adrenoceptor can decouple exposure to hyperoxia from its harmful effects, offering a glimpse of the possibility to recreating the conditions typical of intrauterine life, even after premature birth.","PeriodicalId":207,"journal":{"name":"Medicinal Research Reviews","volume":"45 3","pages":"842-866"},"PeriodicalIF":10.9,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/med.22092","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142737953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deciphering the landscape of triple negative breast cancer from microenvironment dynamics and molecular insights to biomarker analysis and therapeutic modalities 从微环境动力学和分子洞察到生物标记分析和治疗模式，解密三阴性乳腺癌的全貌。

IF 10.9 1区医学

Medicinal Research Reviews Pub Date : 2024-10-24 DOI: 10.1002/med.22090

Harshita Tiwari, Swati Singh, Sonal Sharma, Priyamvada Gupta, Ashish Verma, Amrit Chattopadhaya, Brijesh Kumar, Sakshi Agarwal, Rajiv Kumar, Sanjeev Kumar Gupta, Vibhav Gautam

{"title":"Deciphering the landscape of triple negative breast cancer from microenvironment dynamics and molecular insights to biomarker analysis and therapeutic modalities","authors":"Harshita Tiwari, Swati Singh, Sonal Sharma, Priyamvada Gupta, Ashish Verma, Amrit Chattopadhaya, Brijesh Kumar, Sakshi Agarwal, Rajiv Kumar, Sanjeev Kumar Gupta, Vibhav Gautam","doi":"10.1002/med.22090","DOIUrl":"10.1002/med.22090","url":null,"abstract":"Triple negative breast cancer (TNBC) displays a notable challenge in clinical oncology due to its invasive nature which is attributed to the absence of progesterone receptor (PR), estrogen receptor (ER), and human epidermal growth factor receptor (HER-2). The heterogenous tumor microenvironment (TME) of TNBC is composed of diverse constituents that intricately interact to evade immune response and facilitate cancer progression and metastasis. Based on molecular gene expression, TNBC is classified into four molecular subtypes: basal-like (BL1 and BL2), luminal androgen receptor (LAR), immunomodulatory (IM), and mesenchymal. TNBC is an aggressive histological variant with adverse prognosis and poor therapeutic response. The lack of response in most of the TNBC patients could be attributed to the heterogeneity of the disease, highlighting the need for more effective treatments and reliable prognostic biomarkers. Targeting certain signaling pathways and their components has emerged as a promising therapeutic strategy for improving patient outcomes. In this review, we have summarized the interactions among various components of the dynamic TME in TNBC and discussed the classification of its molecular subtypes. Moreover, the purpose of this review is to compile and provide an overview of the most recent data about recently discovered novel TNBC biomarkers and targeted therapeutics that have proven successful in treating metastatic TNBC. The emergence of novel therapeutic strategies such as chemoimmunotherapy, chimeric antigen receptor (CAR)-T cells-based immunotherapy, phytometabolites-mediated natural therapy, photodynamic and photothermal approaches have made a significant positive impact and have paved the way for more effective interventions.","PeriodicalId":207,"journal":{"name":"Medicinal Research Reviews","volume":"45 3","pages":"817-841"},"PeriodicalIF":10.9,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142491740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Front Cover Image, Volume 44, Issue 6 封面图片，第 44 卷第 6 期

IF 10.9 1区医学

Medicinal Research Reviews Pub Date : 2024-10-03 DOI: 10.1002/med.22089

Yunxiao Zhong, Xinya Zhang, Ruibing Feng, Yu Fan, Zhang Zhang, Qing-Wen Zhang, Jian-Bo Wan, Yitao Wang, Hua Yu, Guodong Li

引用次数: 0

Inside Front Cover Image, Volume 44, Issue 6 封面内页图片，第 44 卷第 6 期

IF 10.9 1区医学

Medicinal Research Reviews Pub Date : 2024-10-03 DOI: 10.1002/med.22088

Vijay K. Boda, Nelufar Yasmen, Jianxiong Jiang, Wei Li

引用次数: 0

An overview of the progress made in research into the Mpox virus Mpox 病毒研究进展概述。

IF 10.9 1区医学

Medicinal Research Reviews Pub Date : 2024-09-24 DOI: 10.1002/med.22085

Yansheng Li, Lianrong Wang, Shi Chen

引用次数: 0

A comprehensive review on the development of chiral Cu, Ni, and Zn complexes as pharmaceutical agents over the past decades: Synthesis, molecular structure and biological activity 全面回顾过去几十年来作为药剂的手性铜、镍和锌配合物的发展：合成、分子结构和生物活性

IF 10.9 1区医学

Medicinal Research Reviews Pub Date : 2024-09-19 DOI: 10.1002/med.22083

Zahra Kazemi, Nakisa Moini, Hadi Amiri Rudbari, Nicola Micale

{"title":"A comprehensive review on the development of chiral Cu, Ni, and Zn complexes as pharmaceutical agents over the past decades: Synthesis, molecular structure and biological activity","authors":"Zahra Kazemi, Nakisa Moini, Hadi Amiri Rudbari, Nicola Micale","doi":"10.1002/med.22083","DOIUrl":"10.1002/med.22083","url":null,"abstract":"Chirality is a fundamental and widespread geometric structural property in living organisms that most biomacromolecules including nucleic acids, proteins and enzymes, possess. Consequently, the development of chiral drugs capable of binding specific targets have gradually gained wide attention in recent decades due to their selective effects on a broad spectrum of biological events ranging from cell metabolism to cell fate. In this context, the synthesis of chiral compounds as promising therapeutic candidates has assumed a major role in drug discovery. Among them, chiral metal complexes have attracted considerable interest due to their unique and intriguing structural features that could enable overcoming side effects and drug-resistance phenomena of metal−based drugs currently in the market such as cisplatin. In the current scenario, an in-depth overview of non-platinum chiral complexes needs to be presented and carried forward. Therefore, in this perspective article, an update of the scientific development of bioactive chiral copper, zinc and nickel complexes have been reported since they have not been thoroughly reviewed so far. Specifically, we focused the article mainly on metal complexes containing chiral ligands (type 2 chirality) as in literature they are more numerous than those with chirality at the metal center (type 1 chirality). Herein, not only their biological activity but also their mechanism of action is summarized. Furthermore, in the final section of the article we have highlighted copper-based complexes as those with a superior biological activity profile and greater prospects for development as a drug.","PeriodicalId":207,"journal":{"name":"Medicinal Research Reviews","volume":"45 2","pages":"654-754"},"PeriodicalIF":10.9,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142269399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current emerging therapeutic targets and clinical investigational agents for schizophrenia: Challenges and opportunities 当前新出现的精神分裂症治疗靶点和临床研究药物：挑战与机遇

IF 10.9 1区医学

Medicinal Research Reviews Pub Date : 2024-09-19 DOI: 10.1002/med.22086

Na Ye, Qi Wang, Yue Li, Xuechu Zhen

{"title":"Current emerging therapeutic targets and clinical investigational agents for schizophrenia: Challenges and opportunities","authors":"Na Ye, Qi Wang, Yue Li, Xuechu Zhen","doi":"10.1002/med.22086","DOIUrl":"10.1002/med.22086","url":null,"abstract":"Since the first discovery of antipsychotics in the 1950s, targeting dopaminergic drugs has manifested to well manage the positive symptoms of schizophrenia with limited efficacy for the negative and cognitive symptoms. In past decades, extensive efforts have been undertaken towards the development of innovative agents that can effectively stabilize the dopamine and serotonin systems or target to nondopaminergic pathways, leading to various promising drug candidates entering into clinical trials. Notably, the sigma-2, 5-HT2A, and α1A receptor antagonist roluperidone, as well as a fixed-dose combination of the M1/4 receptor agonist KarXT, have been submitted for NDA applications. The dual agonist ulotaront, which targets TAAR1 and 5-HT1A receptors, and the GlyT1 inhibitor iclepertin have advanced into phase 3 clinical trials. Nevertheless, satisfactory therapeutic strategies for schizophrenia remain elusive. This review highlights current clinical endeavors in developing novel chemical small-molecule entities and fixed-dose combinations for the treatment of schizophrenia since 2017, thus facilitating the efficient development of the next generation of antipsychotics.","PeriodicalId":207,"journal":{"name":"Medicinal Research Reviews","volume":"45 2","pages":"755-787"},"PeriodicalIF":10.9,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142258277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current nanocomposite advances for biomedical and environmental application diversity 当前纳米复合材料在生物医学和环境应用多样性方面的进展

IF 10.9 1区医学

Medicinal Research Reviews Pub Date : 2024-09-17 DOI: 10.1002/med.22082

Narsimha Mamidi, Ramiro M. V. Delgadillo, Alan O. Sustaita, Karen Lozano, Murali M. Yallapu

{"title":"Current nanocomposite advances for biomedical and environmental application diversity","authors":"Narsimha Mamidi, Ramiro M. V. Delgadillo, Alan O. Sustaita, Karen Lozano, Murali M. Yallapu","doi":"10.1002/med.22082","DOIUrl":"10.1002/med.22082","url":null,"abstract":"Nanocomposite materials are emerging as key players in addressing critical challenges in healthcare, energy storage, and environmental remediation. These innovative systems hold great promise in engineering effective solutions for complex problems. Nanocomposites have demonstrated various advantages such as simplicity, versatility, lightweight, and potential cost-effectiveness. By reinforcing synthetic and natural polymers with nanomaterials, a range of nanocomposites have exhibited unique physicochemical properties, biocompatibility, and biodegradability. Current research on nanocomposites has demonstrated promising clinical and translational applications. Over the past decade, the production of nanocomposites has emerged as a critical nano-structuring methodology due to their adaptability and controllable surface structure. This comprehensive review article systematically addresses two principal domains. A comprehensive survey of metallic and nonmetallic nanomaterials (nanofillers), elucidating their efficacy as reinforcing agents in polymeric matrices. Emphasis is placed on the methodical design and engineering principles governing the development of functional nanocomposites. Additionally, the review provides an exhaustive examination of recent noteworthy advancements in industrial, environmental, biomedical, and clinical applications within the realms of nanocomposite materials. Finally, the review concludes by highlighting the ongoing challenges facing nanocomposites in a wide range of applications.","PeriodicalId":207,"journal":{"name":"Medicinal Research Reviews","volume":"45 2","pages":"576-628"},"PeriodicalIF":10.9,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142258279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0