海洋天然产物与炎症相关疾病:机遇与挑战。

IF 10.9 1区 医学 Q1 CHEMISTRY, MEDICINAL
Tao Zhang, Zijun Ouyang, Yueran Zhang, Haiyan Sun, Lingdong Kong, Qiang Xu, Jiao Qu, Yang Sun
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引用次数: 0

摘要

近几十年来,海洋天然产物(MNPs)在医学领域的潜力日益得到认可。从海洋微生物、藻类和无脊椎动物中提取的天然化合物在治疗炎症相关疾病方面显示出巨大的希望。本文综述了MNPs的三种主要来源及其多样性和独特的化学结构和生物活性。本文综述了MNPs在抗炎症相关疾病中的研究进展。此外,我们还介绍了MNPs在疾病中的功能和机制,重点介绍了它们在调节炎症信号通路、细胞应激反应和肠道微生物群等方面的功能。同时,我们关注关键技术和科学方法,以解决当前MNPs的局限性和挑战。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Marine Natural Products in Inflammation-Related Diseases: Opportunities and Challenges.

In recent decades, the potentiality of marine natural products (MNPs) in the medical field has been increasingly recognized. Natural compounds derived from marine microorganisms, algae, and invertebrates have shown significant promise for treating inflammation-related diseases. In this review, we cover the three primary sources of MNPs and their diverse and unique chemical structures and bioactivities. This review aims to summarize the progress of MNPs in combating inflammation-related diseases. Moreover, we cover the functions and mechanisms of MNPs in diseases, highlighting their functions in regulating inflammatory signaling pathways, cellular stress responses, and gut microbiota, among others. Meanwhile, we focus on key technologies and scientific methods to address the current limitations and challenges in MNPs.

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来源期刊
CiteScore
29.30
自引率
0.00%
发文量
52
审稿时长
2 months
期刊介绍: Medicinal Research Reviews is dedicated to publishing timely and critical reviews, as well as opinion-based articles, covering a broad spectrum of topics related to medicinal research. These contributions are authored by individuals who have made significant advancements in the field. Encompassing a wide range of subjects, suitable topics include, but are not limited to, the underlying pathophysiology of crucial diseases and disease vectors, therapeutic approaches for diverse medical conditions, properties of molecular targets for therapeutic agents, innovative methodologies facilitating therapy discovery, genomics and proteomics, structure-activity correlations of drug series, development of new imaging and diagnostic tools, drug metabolism, drug delivery, and comprehensive examinations of the chemical, pharmacological, pharmacokinetic, pharmacodynamic, and clinical characteristics of significant drugs.
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