The Quinoline Photoremovable Group (PPG) Platform-A Medicinal Chemist's Approach for Photocage Development and Applications.

IF 10.9 1区 医学 Q1 CHEMISTRY, MEDICINAL
Bence Kontra, Zoltán Mucsi, Janez Ilaš, Petra Dunkel
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引用次数: 0

Abstract

Photoremovable protecting groups (PPGs) offer a straightforward solution for the temporary inactivation of biologically active substrates and their subsequent controlled release by light irradiation. Their relatively easy design and mode of application have made them useful tools for studying dynamic biological processes in vitro and in vivo. Recently, there has been a growing body of data investigating their potential application in the development of drug delivery systems. Of the various PPG scaffolds in use, quinoline photocages have a history of about 20 years. The structure-property relationships of quinoline PPGs, as well as alternative multibranch designs based on quinoline monomers have been thoroughly studied both experimentally and theoretically. Therefore, quinoline PPGs serve as a representative study of PPG development, showing how the various applications of quinoline photocages followed the chemical optimization or how the applications drove the chemical design. Since the raison d'être of PPGs lies in their application for light-activated release of various substrates or performing light-activated structural changes in materials, it is crucial to understand how PPGs are selected and utilized by their end-users, who are often not chemists themselves. Therefore, we discuss whether the conclusions drawn from the selected quinoline PPG family could lead to more general insights for the field as whole. As PPG-related applications still rely heavily on a limited number of chemical scaffolds, it is worth considering, what could be the reasons for the slow uptake of novel chemical scaffolds.

喹啉光移除基(PPG)平台——药物化学家的光笼开发和应用方法。
光可移除保护基团(PPGs)为生物活性底物的暂时失活及其随后的光照射控制释放提供了一种直接的解决方案。它们相对容易的设计和应用模式使它们成为研究体内和体外动态生物过程的有用工具。最近,有越来越多的数据研究了它们在药物输送系统开发中的潜在应用。在目前使用的各种PPG支架中,喹啉光笼已有大约20年的历史。喹啉PPGs的结构-性能关系以及基于喹啉单体的多分支设计已经在实验和理论上得到了深入的研究。因此,喹啉光笼作为PPG发展的代表性研究,展示了喹啉光笼的各种应用如何遵循化学优化或应用如何驱动化学设计。由于PPGs的être的原因在于它们用于各种底物的光激活释放或在材料中进行光激活结构变化,因此了解PPGs如何被最终用户(通常不是化学家)选择和利用是至关重要的。因此,我们讨论从选定的喹啉PPG家族中得出的结论是否可以为整个领域带来更普遍的见解。由于ppg相关的应用仍然严重依赖于数量有限的化学支架,值得考虑的是,新型化学支架吸收缓慢的原因是什么?
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来源期刊
CiteScore
29.30
自引率
0.00%
发文量
52
审稿时长
2 months
期刊介绍: Medicinal Research Reviews is dedicated to publishing timely and critical reviews, as well as opinion-based articles, covering a broad spectrum of topics related to medicinal research. These contributions are authored by individuals who have made significant advancements in the field. Encompassing a wide range of subjects, suitable topics include, but are not limited to, the underlying pathophysiology of crucial diseases and disease vectors, therapeutic approaches for diverse medical conditions, properties of molecular targets for therapeutic agents, innovative methodologies facilitating therapy discovery, genomics and proteomics, structure-activity correlations of drug series, development of new imaging and diagnostic tools, drug metabolism, drug delivery, and comprehensive examinations of the chemical, pharmacological, pharmacokinetic, pharmacodynamic, and clinical characteristics of significant drugs.
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