Recent Developments in the Optical Control of Adrenergic Signaling.

IF 10.9 1区医学 Q1 CHEMISTRY, MEDICINAL

Medicinal Research Reviews Pub Date : 2025-04-03 DOI:10.1002/med.22110

Shuang Shi, Yangzhi Cao, Maikel Wijtmans, Henry F Vischer, Rob Leurs

引用次数: 0

Abstract

Adrenoceptors (ARs) play a vital role in various physiological processes and are key therapeutic targets. The advent of optical control techniques, including optogenetics and photopharmacology, offers the potential to modulate AR signaling with precise temporal and spatial resolution. In this review, we summarize the latest advancements in the optical control of AR signaling, encompassing optogenetics, photocaged compounds, and photoswitchable compounds. We also discuss the limitations of current tools and provide an outlook on the next generation of optogenetic and photopharmacological tools. These emerging optical technologies not only enhance our understanding of AR signaling but also pave the way for potential therapeutic developments.

查看原文本刊更多论文

肾上腺素能信号光调控的最新进展。

肾上腺素受体（ARs）在多种生理过程中发挥重要作用，是重要的治疗靶点。光控制技术的出现，包括光遗传学和光药理学，提供了以精确的时间和空间分辨率调制AR信号的潜力。本文综述了AR信号光调控的最新进展，包括光遗传学、光笼化化合物和光开关化合物。我们还讨论了现有工具的局限性，并对下一代光遗传学和光药理学工具进行了展望。这些新兴的光学技术不仅增强了我们对AR信号的理解，而且为潜在的治疗发展铺平了道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Medicinal Research Reviews 医学-药学

CiteScore

29.30

自引率

0.00%

发文量

审稿时长

2 months

期刊介绍： Medicinal Research Reviews is dedicated to publishing timely and critical reviews, as well as opinion-based articles, covering a broad spectrum of topics related to medicinal research. These contributions are authored by individuals who have made significant advancements in the field. Encompassing a wide range of subjects, suitable topics include, but are not limited to, the underlying pathophysiology of crucial diseases and disease vectors, therapeutic approaches for diverse medical conditions, properties of molecular targets for therapeutic agents, innovative methodologies facilitating therapy discovery, genomics and proteomics, structure-activity correlations of drug series, development of new imaging and diagnostic tools, drug metabolism, drug delivery, and comprehensive examinations of the chemical, pharmacological, pharmacokinetic, pharmacodynamic, and clinical characteristics of significant drugs.