Medicinal Research Reviews最新文献_第5页

Advances in reversible covalent kinase inhibitors 可逆共价激酶抑制剂的研究进展

IF 10.9 1区医学

Medicinal Research Reviews Pub Date : 2024-09-17 DOI: 10.1002/med.22084

Zheng Zhao, Philip E. Bourne

引用次数: 0

Estrogen deficiency-mediated osteoimmunity in postmenopausal osteoporosis 绝经后骨质疏松症中雌激素缺乏介导的骨免疫。

IF 10.9 1区医学

Medicinal Research Reviews Pub Date : 2024-09-05 DOI: 10.1002/med.22081

Yao Yao, Xiaoyu Cai, Yue Chen, Meng Zhang, Caihong Zheng

引用次数: 0

Activation and inhibition of sirtuins: From bench to bedside 激活和抑制 sirtuins：从工作台到床边

IF 10.9 1区医学

Medicinal Research Reviews Pub Date : 2024-08-31 DOI: 10.1002/med.22076

Francesco Fiorentino, Emanuele Fabbrizi, Antonello Mai, Dante Rotili

{"title":"Activation and inhibition of sirtuins: From bench to bedside","authors":"Francesco Fiorentino, Emanuele Fabbrizi, Antonello Mai, Dante Rotili","doi":"10.1002/med.22076","DOIUrl":"10.1002/med.22076","url":null,"abstract":"The sirtuin family comprises seven NAD+-dependent enzymes which catalyze protein lysine deacylation and mono ADP-ribosylation. Sirtuins act as central regulators of genomic stability and gene expression and control key processes, including energetic metabolism, cell cycle, differentiation, apoptosis, and aging. As a result, all sirtuins play critical roles in cellular homeostasis and organism wellness, and their dysregulation has been linked to metabolic, cardiovascular, and neurological diseases. Furthermore, sirtuins have shown dichotomous roles in cancer, acting as context-dependent tumor suppressors or promoters. Given their central role in different cellular processes, sirtuins have attracted increasing research interest aimed at developing both activators and inhibitors. Indeed, sirtuin modulation may have therapeutic effects in many age-related diseases, including diabetes, cardiovascular and neurodegenerative disorders, and cancer. Moreover, isoform selective modulators may increase our knowledge of sirtuin biology and aid to develop better therapies. Through this review, we provide critical insights into sirtuin pharmacology and illustrate their enzymatic activities and biological functions. Furthermore, we outline the most relevant sirtuin modulators in terms of their modes of action, structure–activity relationships, pharmacological effects, and clinical applications.","PeriodicalId":207,"journal":{"name":"Medicinal Research Reviews","volume":"45 2","pages":"484-560"},"PeriodicalIF":10.9,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/med.22076","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142102701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A comprehensive overview on the crosstalk between microRNAs and viral pathogenesis and infection 全面概述 microRNA 与病毒发病和感染之间的相互关系。

IF 10.9 1区医学

Medicinal Research Reviews Pub Date : 2024-08-26 DOI: 10.1002/med.22073

Seyedeh Zahra Bahojb Mahdavi, Asiyeh Jebelli, Parisa Shiri Aghbash, Behzad Baradaran, Mohammad Amini, Fatemeh Oroojalian, Nasser Pouladi, Hossein Bannazadeh Baghi, Miguel de la Guardia, Amir Ali Mokhtarzadeh

{"title":"A comprehensive overview on the crosstalk between microRNAs and viral pathogenesis and infection","authors":"Seyedeh Zahra Bahojb Mahdavi, Asiyeh Jebelli, Parisa Shiri Aghbash, Behzad Baradaran, Mohammad Amini, Fatemeh Oroojalian, Nasser Pouladi, Hossein Bannazadeh Baghi, Miguel de la Guardia, Amir Ali Mokhtarzadeh","doi":"10.1002/med.22073","DOIUrl":"10.1002/med.22073","url":null,"abstract":"Infections caused by viruses as the smallest infectious agents, pose a major threat to global public health. Viral infections utilize different host mechanisms to facilitate their own propagation and pathogenesis. MicroRNAs (miRNAs), as small noncoding RNA molecules, play important regulatory roles in different diseases, including viral infections. They can promote or inhibit viral infection and have a pro-viral or antiviral role. Also, viral infections can modulate the expression of host miRNAs. Furthermore, viruses from different families evade the host immune response by producing their own miRNAs called viral miRNAs (v-miRNAs). Understanding the replication cycle of viruses and their relation with host miRNAs and v-miRNAs can help to find new treatments against viral infections. In this review, we aim to outline the structure, genome, and replication cycle of various viruses including hepatitis B, hepatitis C, influenza A virus, coronavirus, human immunodeficiency virus, human papillomavirus, herpes simplex virus, Epstein–Barr virus, Dengue virus, Zika virus, and Ebola virus. We also discuss the role of different host miRNAs and v-miRNAs and their role in the pathogenesis of these viral infections.","PeriodicalId":207,"journal":{"name":"Medicinal Research Reviews","volume":"45 2","pages":"349-425"},"PeriodicalIF":10.9,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/med.22073","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142054396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deciphering the enigmas of non-nucleoside reverse transcriptase inhibitors (NNRTIs): A medicinal chemistry expedition towards combating HIV drug resistance 破解非核苷类逆转录酶抑制剂（NNRTIs）之谜：对抗艾滋病抗药性的药物化学探险。

IF 10.9 1区医学

Medicinal Research Reviews Pub Date : 2024-08-26 DOI: 10.1002/med.22080

Kun Zhang, Yu-Jie Zhang, Min Li, Christophe Pannecouque, Erik De Clercq, Shuai Wang, Fen-Er Chen

{"title":"Deciphering the enigmas of non-nucleoside reverse transcriptase inhibitors (NNRTIs): A medicinal chemistry expedition towards combating HIV drug resistance","authors":"Kun Zhang, Yu-Jie Zhang, Min Li, Christophe Pannecouque, Erik De Clercq, Shuai Wang, Fen-Er Chen","doi":"10.1002/med.22080","DOIUrl":"10.1002/med.22080","url":null,"abstract":"The pivotal involvement of reverse transcriptase activity in the pathogenesis of the progressive HIV virus has stimulated gradual advancements in drug discovery initiatives spanning three decades. Consequently, nonnucleoside reverse transcriptase inhibitors (NNRTIs) have emerged as a preeminent category of therapeutic agents for HIV management. Academic institutions and pharmaceutical companies have developed numerous NNRTIs, an essential component of antiretroviral therapy. Six NNRTIs have received Food and Drug Administration approval and are widely used in clinical practice, significantly improving the quality of HIV patients. However, the rapid emergence of drug resistance has limited the effectiveness of these medications, underscoring the necessity for perpetual research and development of novel therapeutic alternatives. To supplement the existing literatures on NNRTIs, a comprehensive review has been compiled to synthesize this extensive dataset into a comprehensible format for the medicinal chemistry community. In this review, a thorough investigation and meticulous analysis were conducted on the progressions achieved in NNRTIs within the past 8 years (2016–2023), and the experiences and insights gained in the development of inhibitors with varying chemical structures were also summarized. The provision of a crucial point of reference for the development of wide-ranging anti-HIV medications is anticipated.","PeriodicalId":207,"journal":{"name":"Medicinal Research Reviews","volume":"45 2","pages":"426-483"},"PeriodicalIF":10.9,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142071603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling gut microbiota's role: Bidirectional regulation of drug transport for improved safety 揭示肠道微生物群的作用：双向调节药物运输，提高安全性。

IF 10.9 1区医学

Medicinal Research Reviews Pub Date : 2024-08-24 DOI: 10.1002/med.22077

Jinyi Wang, Tingting Zhou

{"title":"Unveiling gut microbiota's role: Bidirectional regulation of drug transport for improved safety","authors":"Jinyi Wang, Tingting Zhou","doi":"10.1002/med.22077","DOIUrl":"10.1002/med.22077","url":null,"abstract":"Drug safety is a paramount concern in the field of drug development, with researchers increasingly focusing on the bidirectional regulation of gut microbiota in this context. The gut microbiota plays a crucial role in maintaining drug safety. It can influence drug transport processes in the body through various mechanisms, thereby modulating their efficacy and toxicity. The main mechanisms include: (1) The gut microbiota directly interacts with drugs, altering their chemical structure to reduce toxicity and enhance efficacy, thereby impacting drug transport mechanisms, drugs can also change the structure and abundance of gut bacteria; (2) bidirectional regulation of intestinal barrier permeability by gut microbiota, promoting the absorption of nontoxic drugs and inhibiting the absorption of toxic components; (3) bidirectional regulation of the expression and activity of transport proteins by gut microbiota, selectively promoting the absorption of effective components or inhibiting the absorption of toxic components. This bidirectional regulatory role enables the gut microbiota to play a key role in maintaining drug balance in the body and reducing adverse reactions. Understanding these regulatory mechanisms sheds light on novel approaches to minimize toxic side effects, enhance drug efficacy, and ultimately improve drug safety. This review systematically examines the bidirectional regulation of gut microbiota in drug transportation from the aforementioned aspects, emphasizing their significance in ensuring drug safety. Furthermore, it offers a prospective outlook from the standpoint of enhancing therapeutic efficacy and reducing drug toxicity, underscoring the importance of further exploration in this research domain. It aims to provide more effective strategies for drug development and treatment.","PeriodicalId":207,"journal":{"name":"Medicinal Research Reviews","volume":"45 1","pages":"311-343"},"PeriodicalIF":10.9,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142046037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Indirect influence on the BDNF/TrkB receptor signaling pathway via GPCRs, an emerging strategy in the treatment of neurodegenerative disorders 通过 GPCRs 间接影响 BDNF/TrkB 受体信号通路，这是治疗神经退行性疾病的一种新兴策略。

IF 10.9 1区医学

Medicinal Research Reviews Pub Date : 2024-08-24 DOI: 10.1002/med.22075

Mirjana Antonijevic, Patrick Dallemagne, Christophe Rochais

引用次数: 0

The recent advance and prospect of poly(ADP-ribose) polymerase inhibitors for the treatment of cancer 聚（ADP-核糖）聚合酶抑制剂治疗癌症的最新进展和前景。

IF 10.9 1区医学

Medicinal Research Reviews Pub Date : 2024-08-24 DOI: 10.1002/med.22069

Yi-Ru Bai, Wei-Guang Yang, Rui Jia, Ju-Shan Sun, Dan-Dan Shen, Hong-Min Liu, Shuo Yuan

{"title":"The recent advance and prospect of poly(ADP-ribose) polymerase inhibitors for the treatment of cancer","authors":"Yi-Ru Bai, Wei-Guang Yang, Rui Jia, Ju-Shan Sun, Dan-Dan Shen, Hong-Min Liu, Shuo Yuan","doi":"10.1002/med.22069","DOIUrl":"10.1002/med.22069","url":null,"abstract":"Chemotherapies are commonly used in cancer therapy, their applications are limited to low specificity, severe adverse reactions, and long-term medication-induced drug resistance. Poly(ADP-ribose) polymerase (PARP) inhibitors are a novel class of antitumor drugs developed to solve these intractable problems based on the mechanism of DNA damage repair, which have been widely applied in the treatment of ovarian cancer, breast cancer, and other cancers through inducing synthetic lethal effect and trapping PARP-DNA complex in BRCA gene mutated cancer cells. In recent years, PARP inhibitors have been widely used in combination with various first-line chemotherapy drugs, targeted drugs and immune checkpoint inhibitors to expand the scope of clinical application. However, the intricate mechanisms underlying the drug resistance to PARP inhibitors, including the restoration of homologous recombination, stabilization of DNA replication forks, overexpression of drug efflux protein, and epigenetic modifications pose great challenges and desirability in the development of novel PARP inhibitors. In this review, we will focus on the mechanism, structure–activity relationship, and multidrug resistance associated with the representative PARP inhibitors. Furthermore, we aim to provide insights into the development prospects and emerging trends to offer guidance for the clinical application and inspiration for the development of novel PARP inhibitors and degraders.","PeriodicalId":207,"journal":{"name":"Medicinal Research Reviews","volume":"45 1","pages":"214-273"},"PeriodicalIF":10.9,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142046036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fenamates: Forgotten treasure for cancer treatment and prevention: Mechanisms of action, structural modification, and bright future 非那明酸盐：被遗忘的癌症治疗和预防宝藏：作用机制、结构改造和光明前景。

IF 10.9 1区医学

Medicinal Research Reviews Pub Date : 2024-08-22 DOI: 10.1002/med.22079

Junfang Li, Xiaodong Wang, Honghua Zhang, Xiaoling Hu, Xue Peng, Weifan Jiang, Linsheng Zhuo, Yan Peng, Guo Zeng, Zhen Wang

{"title":"Fenamates: Forgotten treasure for cancer treatment and prevention: Mechanisms of action, structural modification, and bright future","authors":"Junfang Li, Xiaodong Wang, Honghua Zhang, Xiaoling Hu, Xue Peng, Weifan Jiang, Linsheng Zhuo, Yan Peng, Guo Zeng, Zhen Wang","doi":"10.1002/med.22079","DOIUrl":"10.1002/med.22079","url":null,"abstract":"Fenamates as classical nonsteroidal anti-inflammatory agents are widely used for relieving pain. Preclinical studies and epidemiological data highlight their chemo-preventive and chemotherapeutic potential for cancer. However, comprehensive reviews of fenamates in cancer are limited. To accelerate the repurposing of fenamates, this review summarizes the results of fenamates alone or in combination with existing chemotherapeutic agents. This paper also explores targets of fenamates in cancer therapy, including COX, AKR family, AR, gap junction, FTO, TEAD, DHODH, TAS2R14, ion channels, and DNA. Besides, this paper discusses other mechanisms, such as regulating Wnt/β-catenin, TGF-β, p38 MAPK, and NF-κB pathway, and the regulation of the expressions of Sp, EGR-1, NAG-1, ATF-3, ErbB2, AR, as well as the modulation of the tumor immune microenvironment. Furthermore, this paper outlined the structural modifications of fenamates, highlighting their potential as promising leads for anticancer drugs.","PeriodicalId":207,"journal":{"name":"Medicinal Research Reviews","volume":"45 1","pages":"164-213"},"PeriodicalIF":10.9,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142015807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Canonical effects of cytokines on glomerulonephritis: A new outlook in nephrology 细胞因子对肾小球肾炎的典型影响：肾脏病学的新前景

IF 10.9 1区医学

Medicinal Research Reviews Pub Date : 2024-08-20 DOI: 10.1002/med.22074

Sepideh Zununi Vahed, Seyed Mahdi Hosseiniyan Khatibi, Mohammadreza Ardalan

引用次数: 0