Radiation protection dosimetry最新文献_第3页

Establishment and validation of a dose-response curve for semi-automated analysis of dicentric chromosomes induced by 60Co γ-rays. 60Co γ射线诱导双中心染色体半自动化分析剂量响应曲线的建立与验证。

IF 0.7 4区环境科学与生态学

Radiation protection dosimetry Pub Date : 2025-09-12 DOI: 10.1093/rpd/ncaf101

Qian-Qian Meng, Yue Ren, Zhong-Xin Zhang, Xiao-Zhen Li, Xiao-Quan Zhang, Hong-Yan Liu, Yu-Feng Guo, Rui-Feng Zhang

{"title":"Establishment and validation of a dose-response curve for semi-automated analysis of dicentric chromosomes induced by 60Co γ-rays.","authors":"Qian-Qian Meng, Yue Ren, Zhong-Xin Zhang, Xiao-Zhen Li, Xiao-Quan Zhang, Hong-Yan Liu, Yu-Feng Guo, Rui-Feng Zhang","doi":"10.1093/rpd/ncaf101","DOIUrl":"https://doi.org/10.1093/rpd/ncaf101","url":null,"abstract":"The dicentric chromosome assay serves as the \"gold standard\" for biodosimetry, playing a crucial role in rapid clinical decision-making during extensive nuclear radiation incidents. This study aimed to develop a semi-automated dose-response curve for the analysis of dicentric chromosomes induced by irradiation of human peripheral blood lymphocytes with 60Co gamma rays. Blood samples were collected from three healthy donors and subjected to irradiation, culture, and harvesting, following International Atomic Energy Agency standard protocols. The Metafer4 system, an automatic scoring system, was utilized to acquire images of the metaphase chromosome segregation phase, and the dose-response curve was constructed through automatic analysis of dicentric chromosomes supplemented by manual verification. The curve was subsequently validated through blind scoring. The results demonstrated that the semi-automated scoring method provides quick and precise dose estimations and offers a viable alternative to manual dicentric chromosome assay. This approach holds significant potential for application in the nuclear emergency management of large-scale radiological events.","PeriodicalId":20795,"journal":{"name":"Radiation protection dosimetry","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of neutron stray fields close to the two meson targets of the PSI proton accelerator facility. PSI质子加速器两个介子靶附近的中子杂散场研究。

IF 0.7 4区环境科学与生态学

Radiation protection dosimetry Pub Date : 2025-09-08 DOI: 10.1093/rpd/ncaf093

Eike Hohmann, Roman Galeev, Sophie Harzmann, Marcel Reginatto, Nick Walter, Sabine Mayer

{"title":"Investigation of neutron stray fields close to the two meson targets of the PSI proton accelerator facility.","authors":"Eike Hohmann, Roman Galeev, Sophie Harzmann, Marcel Reginatto, Nick Walter, Sabine Mayer","doi":"10.1093/rpd/ncaf093","DOIUrl":"https://doi.org/10.1093/rpd/ncaf093","url":null,"abstract":"The High-Intensity Proton Accelerator Facility at the Paul Scherrer Institute (PSI) accelerates protons to an energy of 590 MeV with currents up to 2.4 mA, i.e. 1.4 MW beam power. The beam feeds four main experiments using individual targets. The areas adjacent to these targets are heavily shielded by several meters of iron and concrete. The neutron stray field at different positions outside the shielding close to two of these targets has been investigated using the PSI extended range Bonner sphere spectrometer (ERBSS). It consists of 10 moderator spheres made of polyethylene and 4 spheres modified with metal shells, enhancing the sensitivity for neutrons with energies >20 MeV. The data was normalized to the proton current measured by a resonance chamber upstream of the first target. Two commercially available survey instruments for neutron radiation constantly monitored the stability of the field during the measurements. The spectral neutron distribution was determined by applying Bayesian methods, which were optimized for measurements of neutron stray fields behind shielding at high-energy accelerators. The measurements within restricted access areas resulted in ambient dose equivalent rates of 25-50 μSv (h mA)-1 with significant contributions of high-energy neutrons. The comparison to doses indicated by a commercially available survey instrument suitable for measurements in fields with a high-energy neutron component showed reasonable agreement with the dose values obtained from the ERBSS measurement. However, it is desirable to apply in-field calibration factors derived from spectrum measurements to reduce the uncertainty of dose values obtained with survey instruments.","PeriodicalId":20795,"journal":{"name":"Radiation protection dosimetry","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145016120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimization of beam quality for lumbar spine imaging with heavy metal filters: a phantom model study. 利用重金属滤光片优化腰椎成像的光束质量：一项幻影模型研究。

IF 0.7 4区环境科学与生态学

Radiation protection dosimetry Pub Date : 2025-09-04 DOI: 10.1093/rpd/ncaf100

Chihiro Koide, Seiichi Murakami

引用次数: 0

IF 0.7 4区环境科学与生态学

Radiation protection dosimetry Pub Date : 2025-08-28 DOI: 10.1093/rpd/ncaf098

Joëlle Ann Feghali, Jacques-Antoine Maisonobe, Bouchra Habib Geryes

{"title":"Recommended guidelines for choosing and optimizing surgical C-arms in pediatric surgery to minimize radiation exposure.","authors":"Joëlle Ann Feghali, Jacques-Antoine Maisonobe, Bouchra Habib Geryes","doi":"10.1093/rpd/ncaf098","DOIUrl":"https://doi.org/10.1093/rpd/ncaf098","url":null,"abstract":"Introduction: Surgical C-arms are essential tools in pediatric surgery in various specialties. The selection of an appropriate C-arm for pediatric use is critical, as manufacturers offer different balances between radiation dose and image quality.Objective: This study introduces a practical measurement protocol that enables straightforward comparison of C-arms using readily available tools in most facilities.Methods: A measurement protocol for evaluating radiation dose and image quality across different C-arm models for pediatric use is suggested. To illustrate this methodology, seven C-arm models from three manufacturers were assessed using a polymethyl methacrylate phantom to simulate pediatric patients. Dose and image quality were measured across various configurations, including fluoroscopy and low-dose modes, while considering features like additional copper filtration, anti-scatter grid removal, and field zoom.Results: Dose and image quality measurements on C-arms illustrate the methodology's application and the impact of fluoroscopy parameters and pediatric-specific features on dose and image quality. Recommendations are provided to guide the selection and optimization of C-arms for pediatric surgery, ensuring the best compromise between dose reduction and diagnostic image quality.Conclusion: This study introduces a practical method for evaluating C-arms in pediatric settings, helping to improve equipment selection and optimize imaging protocols for safer pediatric imaging practices.","PeriodicalId":20795,"journal":{"name":"Radiation protection dosimetry","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144966518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Short and long-term effects on the thyroid proteome after 131I exposure. 131I暴露后对甲状腺蛋白质组的短期和长期影响。

IF 0.7 4区环境科学与生态学

Radiation protection dosimetry Pub Date : 2025-08-26 DOI: 10.1093/rpd/ncaf073

Klara Insulander Björk, Britta Langen, Anja Schroff, Emman Shubbar, Khalil Helou, Johan Spetz, Eva Forssell-Aronsson

{"title":"Short and long-term effects on the thyroid proteome after 131I exposure.","authors":"Klara Insulander Björk, Britta Langen, Anja Schroff, Emman Shubbar, Khalil Helou, Johan Spetz, Eva Forssell-Aronsson","doi":"10.1093/rpd/ncaf073","DOIUrl":"https://doi.org/10.1093/rpd/ncaf073","url":null,"abstract":"131I is recognised, both for its significance in nuclear medicine, and for its association with a rise in paediatric but not adult thyroid cancer cases following the Chornobyl accident. However, the detailed radiobiological mechanisms underlying 131I effects on the thyroid remain unknown to date. In the present study, 1 kBq or 100 kBq 131I was administered to mice that were euthanised after 48 h, 3 weeks or 6 months. Thyroid glands were surgically removed, and proteins were extracted and analysed by tandem mass spectrometry. On a group-level, the results showed few alterations in protein abundance, mainly linked to RNA metabolism and DNA damage response. However, individual analysis of protein abundance changes in each animal showed distinct findings suggesting inhibited proliferation in a few individuals across various exposure levels and time points. Future studies should involve larger animal groups to better assess the frequency and variability of proteomic radiation responses.","PeriodicalId":20795,"journal":{"name":"Radiation protection dosimetry","volume":"201 13-14","pages":"919-933"},"PeriodicalIF":0.7,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12392893/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144966601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Age- and sex-specific cancer risk predictions for some important radionuclides in a Swedish population-use of the updated ORNL computation method for chronic exposure. 瑞典人群中一些重要放射性核素的年龄和性别特异性癌症风险预测-使用更新的ORNL慢性暴露计算方法。

IF 0.7 4区环境科学与生态学

Radiation protection dosimetry Pub Date : 2025-08-26 DOI: 10.1093/rpd/ncaf045

Martin Andersson, Richard W Leggett, Keith Eckerman, Sören Mattsson

{"title":"Age- and sex-specific cancer risk predictions for some important radionuclides in a Swedish population-use of the updated ORNL computation method for chronic exposure.","authors":"Martin Andersson, Richard W Leggett, Keith Eckerman, Sören Mattsson","doi":"10.1093/rpd/ncaf045","DOIUrl":"https://doi.org/10.1093/rpd/ncaf045","url":null,"abstract":"Radiation dosimetry and cancer risk estimations are central to virtually all radiation safety applications, optimization, and research. These estimates relate to various exposure situations including planned, existing, and emergency situations. The International Commission on Radiological Protection (ICRP) has developed a new methodology to handle the dosimetry of an acute/single intake of radionuclides. To expand this to a chronic exposure over a lifetime or during shorter periods, Oak Ridge National Laboratory (ORNL) applies a methodology based on the ICRP primary data with additional lifetime population-based radiogenic cancer risk estimations involving age- and gender-specific intake rates and organ specific cancer risk models. The releases of unwanted artificial radionuclides in the environment could have a big impact on society, both locally and globally. Such an exposure may occur over an extended time period, and the derived cancer risk coefficients should reflect that possibility. In the present study, cancer risk coefficients are calculated for the Swedish population for 14C, 137Cs, 90Sr, 131I, and 60Co, for internal exposure through air, food, and water and external exposure from air, water, surface, and soil.","PeriodicalId":20795,"journal":{"name":"Radiation protection dosimetry","volume":"201 13-14","pages":"966-973"},"PeriodicalIF":0.7,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12392900/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144966457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of coadministration schedules of rA1M for kidney protection after administration of 177Lu-octreotide. 177lu -奥曲肽给药后肾保护rA1M联合给药方案的评价。

IF 0.7 4区环境科学与生态学

Radiation protection dosimetry Pub Date : 2025-08-26 DOI: 10.1093/rpd/ncaf090

Nishte Rassol, Charlotte Ytterbrink, Daniella Pettersson, Amin Al-Awar, Hana Bakr, Magnus Gram, Johan Spetz, Eva Forssell-Aronsson

{"title":"Evaluation of coadministration schedules of rA1M for kidney protection after administration of 177Lu-octreotide.","authors":"Nishte Rassol, Charlotte Ytterbrink, Daniella Pettersson, Amin Al-Awar, Hana Bakr, Magnus Gram, Johan Spetz, Eva Forssell-Aronsson","doi":"10.1093/rpd/ncaf090","DOIUrl":"https://doi.org/10.1093/rpd/ncaf090","url":null,"abstract":"Late radiation-induced kidney toxicity limits molecular radionuclide therapy using radiopharmaceuticals such as 177Lu-octreotate and 177Lu-octreotide. Better kidney protection would allow higher amounts of radiopharmaceutical to be administered. Coadministration of recombinant human alpha-1-microglobulin (rA1M) has been suggested to protect kidneys from exposure from 177Lu-octreotate. Furthermore, early responding biomarkers are needed that identify patients that should or should not receive higher radiopharmaceutical activity. The aim of this study was to evaluate effects of different administration schedules of rA1M in combination with 177Lu-octreotide on urinary levels of retinol-binding protein 4 (RBP4) and creatinine (Cr). Mice received 60 MBq 177Lu-octreotide intravenously, plus none, one, or several rA1M injections. Urinary RBP4 and Cr concentrations were measured after 6-10 weeks. Urinary RBP4 was similar in all groups, but with large individual variations in some groups. RBP4/Cr may be a useful early-responding biomarker. Further investigations are needed to determine effects of long-term kidney protection by rA1M schedules.","PeriodicalId":20795,"journal":{"name":"Radiation protection dosimetry","volume":"201 13-14","pages":"995-1005"},"PeriodicalIF":0.7,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12392891/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144966451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early proteomic response in thyroid gland after 131I administration in female Balb/c mice. 雌性Balb/c小鼠注射131I后甲状腺早期蛋白质组学反应。

IF 0.7 4区环境科学与生态学

Radiation protection dosimetry Pub Date : 2025-08-26 DOI: 10.1093/rpd/ncaf057

Nils Rudqvist, Johan Spetz, Emil Schüler, Toshima Z Parris, Britta Langen, Carina Sihlbom Wallem, Khalil Helou, Eva Forssell-Aronsson

{"title":"Early proteomic response in thyroid gland after 131I administration in female Balb/c mice.","authors":"Nils Rudqvist, Johan Spetz, Emil Schüler, Toshima Z Parris, Britta Langen, Carina Sihlbom Wallem, Khalil Helou, Eva Forssell-Aronsson","doi":"10.1093/rpd/ncaf057","DOIUrl":"https://doi.org/10.1093/rpd/ncaf057","url":null,"abstract":"131I (iodide) accumulates in the thyroid and may affect thyroid tissue. Mechanisms behind such effects are not known. The aim was to investigate early changes in protein expression in thyroid and plasma from mice injected with 131I as iodide. Female Balb/c nude mice were i.v. injected with 0 or 490 kBq 131I and killed after 24 h. Thyroid and blood samples were collected from each animal. Protein levels were determined by mass spectrometry. Data are available via ProteomeXchange with identifier PXD062861. Altogether, 17 and 20 proteins showed statistically significant altered levels in thyroid gland and plasma, respectively, after 131I exposure. Most of these proteins had decreased and increased levels in thyroid and plasma, respectively. Few of them were previously proposed radiation responsive proteins. Functional annotation suggests impact on haematopoiesis, reduced oxygen levels, and hypothyroidism. The role of CHIA and PGAM2 in radiation-induced response should be further examined, together with identification and validation of biomarkers of 131I exposure.","PeriodicalId":20795,"journal":{"name":"Radiation protection dosimetry","volume":"201 13-14","pages":"887-898"},"PeriodicalIF":0.7,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12392886/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144966469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Economic aspects of evacuation and resettlement after a radioactive fallout in Sweden. 瑞典放射性沉降物后疏散和重新安置的经济方面。

IF 0.7 4区环境科学与生态学

Radiation protection dosimetry Pub Date : 2025-08-26 DOI: 10.1093/rpd/ncaf034

Reza Javid, Mats Isaksson, Robert Finck, Christopher L Rääf

引用次数: 0

Early apoptotic response in kidney after 177Lu-octreotate administration with or without potential radioprotector α1-microglobulin. 加或不加潜在放射保护剂α1微球蛋白的177lu - octreate给药后肾脏的早期凋亡反应

IF 0.7 4区环境科学与生态学

Radiation protection dosimetry Pub Date : 2025-08-26 DOI: 10.1093/rpd/ncaf055

Charlotte Ytterbrink, Klara Simonsson, Emman Shubbar, Magnus Gram, Khalil Helou, Eva Forssell-Aronsson

{"title":"Early apoptotic response in kidney after 177Lu-octreotate administration with or without potential radioprotector α1-microglobulin.","authors":"Charlotte Ytterbrink, Klara Simonsson, Emman Shubbar, Magnus Gram, Khalil Helou, Eva Forssell-Aronsson","doi":"10.1093/rpd/ncaf055","DOIUrl":"https://doi.org/10.1093/rpd/ncaf055","url":null,"abstract":"The antioxidant α1-microglobulin (A1M) has been suggested as kidney protector during 177Lu-octreotate treatment. The aim of this work was to evaluate apoptotic-related transcript expression in kidney cortex and medulla following injection of 177Lu-octreotate and/or A1M. Mice were injected with 177Lu-octreotate, A1M, or 177Lu-octreotate + A1M. Control groups received PBS or vehicle solution. Animals were killed after 24 hours or 7 d. mRNA was isolated from kidney medulla and cortex. Expression of 84 apoptosis-related genes was assessed by q-PCR. Gene expression profiles in kidney cortex were generally similar in the 177Lu-octreotate and 177Lu-octreotate + A1M groups. This was also seen in kidney medulla at 24 hours, but at 7 d anti-apoptotic response of A1M was observed. Altogether, 177Lu-octreotate exposure induced pro-apoptotic response (e.g. Apaf1, Bax, and Tnfrsf10b genes) in kidney medulla and cortex. A1M co-administration did not inhibit pro-apoptotic response in kidney cortex, while A1M initiated pro-survival mechanisms in kidney medulla.","PeriodicalId":20795,"journal":{"name":"Radiation protection dosimetry","volume":"201 13-14","pages":"877-886"},"PeriodicalIF":0.7,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12392902/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144966477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0