Psycho‐Oncology最新文献

{"title":"Early Palliative Care Team's Perception of Relational Work for Advanced Cancer Patients: A Qualitative Study.","authors":"C Bouleuc, L Thery, E Gilbert, A Burnod, C Laouisset, T Marchal, E Legrand, J C Mino","doi":"10.1002/pon.70283","DOIUrl":"10.1002/pon.70283","url":null,"abstract":"<p><strong>Background: </strong>In a day hospital stay, the palliative care (PC) delivery includes multi-disciplinary assessment of palliative care (PC) needs, with treating oncologist and supportive care professionals with a long time allocated for discussions with the patients and family. But little is known about the specificity of the relational work delivered by the PC team.</p><p><strong>Aims: </strong>The aim of this study was to explore the nature of the relational work carried out at the PC day hospital from the perspective of the PC team.</p><p><strong>Methods: </strong>This qualitative research used semi-structured open-ended interviews, conducted and analysed according to grounded theory. Twelve physicians and twelve nurses from PC team were interviewed over a period of 5 months to collect clinical cases.</p><p><strong>Results: </strong>The analysis resulted in three main categories that explain the processes of relational work during PC Day Hospital sessions: (1) Patient engagement is necessary to increase relational work and gain patients' confidence. This involves initiating medical exchanges from the patient's point of view to obtain their participation; (2) Raising awareness of irreversible decline and approaching death using interactive relational work tactics, in line with oncologists when making decisions and announcing the discontinuation of cancer treatment; (3) Managing the final phase of the cancer trajectory requires negotiating home care terms and being aware of the family's influence.</p><p><strong>Conclusions: </strong>PC day hospital in cancer centres allows a pluri-professional relational work including the oncologists which facilitates serious illness conversation, advance care planning and end-of-life care management for advanced cancer patients.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"34 9","pages":"e70283"},"PeriodicalIF":3.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12447257/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expanding Psycho-Oncology Services in India: Perspectives From Physicians in Cancer Care Centres.","authors":"Bincy Mathew, Wendy W T Lam, Saipriya Tiwari, Melissa Henry","doi":"10.1002/pon.70271","DOIUrl":"https://doi.org/10.1002/pon.70271","url":null,"abstract":"<p><strong>Background: </strong>Given the rising importance of mental health in current times, it also calls for attention to how cancer care services can be improved upon by integrating the emotional needs of patients and caregivers in India. The country's unique diversity and socio-cultural fabric presents unseen challenges; therefore, this study explores the enablers and barriers of integrating psycho-oncology services in India through the lens of physicians working in cancer care settings.</p><p><strong>Methods: </strong>Semi-structured interviews were conducted with 20 physicians (medical oncologists, surgical oncologists, radiation oncologists, and palliative physicians) who had worked in cancer care along with a psycho-oncologist, over the past 2 years. The data were analysed using thematic analysis.</p><p><strong>Results: </strong>Four major themes and 15 sub-themes emerged during the analysis. All physicians unanimously reported that psycho-oncology services have been an enabler in the cancer care continuum, as well as a key catalyst in improving their productivity, impacting the overall treatment outcome. However, the multifaceted problem space requires national-level interventions to streamline an equitable delivery of psycho-oncology services across India. Major and sub-themes were identified and documented along with the text excerpts in the table.</p><p><strong>Conclusion: </strong>This study highlighted the much-needed appreciation of the intangible value added by early interventions from psycho-oncology professionals in India, as expressed by the beneficiaries of this service. The study also revealed the potential challenges hindering its growth, and perspectives from professionals across the country reinforced the need for novel solutions that address unique challenges while embracing its diversity.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"34 9","pages":"e70271"},"PeriodicalIF":3.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144966441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of a Personal Cancer Diagnosis on the Psychological Health of Adolescent/Young Adult Cancer Survivors: A Mixed Methods Study.","authors":"Pooja Rao, Katie A Devine, Kristin Bingen, Allison M Scott, Laura M Koehly, Courtney L Rumbaugh, Emily Wasserman, Heather J Costigan, Smita Dandekar, Natthapol Songdej, George F Blackall, Eugene J Lengerich, Lauren J Van Scoy","doi":"10.1002/pon.70272","DOIUrl":"10.1002/pon.70272","url":null,"abstract":"<p><strong>Background: </strong>Adolescent/young adult cancer survivors (AYACS), describing people diagnosed with cancer between 15 and 39 years old across the cancer continuum, suffer from poor psychological health. Poor psychological health is associated with difficulty achieving professional goals, financial stress, and poorer health.</p><p><strong>Aims: </strong>The objective of this study was to use a mixed methods approach to understand AYACS' perspectives on how a personal cancer diagnosis impacts psychological health.</p><p><strong>Methods: </strong>In this convergent mixed methods study, data from 35 AYACS participants were collected consisting of Patient Reported Outcomes Measurement Information System Anxiety and Depression measures, a sociodemographic survey, and semi-structured interviews.</p><p><strong>Results: </strong>Mixed methods integration revealed the following for AYACS across the cancer continuum: (1) A need for proactive and longitudinal addressal of psychological health; (2) Promotion of social connectedness as a means of coping with illness; (3) A need for innovative and age-appropriate coping strategies; and (4) Promotion of resilience to help improve psychological health.</p><p><strong>Conclusions: </strong>This study provides direction for intervention development to improve psychological health.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"34 9","pages":"e70272"},"PeriodicalIF":3.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12433271/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145058412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Communication Skills Training on Cancer Patients' Outcomes: A Case-Control Study in Taiwan.","authors":"Thi Ngoc Pham, Ji-Tseng Fang, Shih-Ying Chen, Chun-Kai Fang, Maiko Fujimori, Woung-Ru Tang","doi":"10.1002/pon.70275","DOIUrl":"https://doi.org/10.1002/pon.70275","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the effectiveness of communication skill training (CST) from both physicians and patients' perspectives.</p><p><strong>Methods: </strong>This case-control study was conducted at five hospitals across Taiwan using purposive sampling. Physicians were matched by gender, seniority, and department; patients were matched by age, gender, cancer type, and stage. A total of 232 patients were included: 116 in the experimental group (physicians who received CST) and 116 in the control group (physicians without CST). Physicians' truth-telling practices were evaluated immediately after CST using a 70-item questionnaire. Patient emotional distress was assessed 3 months later using the Hospital Anxiety and Depression Scale and Distress Thermometer.</p><p><strong>Results: </strong>A statistically significant difference in physicians' truth-telling practices was found between the groups. Physicians in the experimental group demonstrated significantly better truth-telling practices than those in the control group (265.23 ± 26.57 vs. 257.81 ± 29.84, p = 0.047). Three months after receiving bad news, patients in the experimental group had lower levels of depression (5.98 ± 3.80 vs. 7.26 ± 4.90, p = 0.049), anxiety (5.84 ± 3.47 vs. 6.80 ± 4.02, p = 0.030), and emotional distress (3.39 ± 2.60 vs. 4.40 ± 2.97, p = 0.013) compared to those in the control group.</p><p><strong>Conclusion: </strong>CST can improve physicians' truth-telling practices and reduce emotional distress in cancer patients. Regular CST should be integrated into medical education and in -service training to sustain these skills. Further studies are needed to explore the long-term benefits of CST and its impact on healthcare utilization.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"34 9","pages":"e70275"},"PeriodicalIF":3.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144993233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding the Engagement Process of Prostate Cancer Patients in Physical Activity: A Qualitative Study Comparing Profiles of \"Inactive Patients\" With \"Active Patients\".","authors":"Baudot Amandine, Collange Fanny, Guyot Jessica, Bourmaud Aurélie, Chauvin Franck, Hupin David, Barth Nathalie","doi":"10.1002/pon.70256","DOIUrl":"10.1002/pon.70256","url":null,"abstract":"<p><strong>Objective: </strong>Despite the recognised benefits of physical activity in tertiary prevention, 60%-70% of patients with prostate cancer are insufficiently active. Therefore, it is important to understand the process of engagement in physical activity to develop an intervention that enables prostate cancer patients, treated in France, to engage in regular physical activity.</p><p><strong>Methods: </strong>This study was unique in that it compared active and inactive profiles using the concepts of 'disease trajectory' and 'career', borrowed from sociological interactionist theory. We interviewed 39 male participants who had been diagnosed with prostate cancer at least 1 year previously and were no longer receiving treatment other than hormone therapy.</p><p><strong>Results: </strong>Participants' engagement in PA after a prostate cancer diagnosis was shaped by emotional, social, and structural factors. Two main thematic axes emerged: (1) how participants made sense of PA within their illness trajectory, and (2) how past experiences and representations of sport influenced their motivation and perceived ability to engage in PA. While active participants integrated PA into a narrative of self-management and control, inactive participants valued it primarily for social support and needed more tailored, supportive approaches.</p><p><strong>Conclusion: </strong>These findings suggest that PA promotion and interventions should consider individuals' lived experiences, prior representations of PA. Personalizing support, particularly through PA promotion by healthcare professionals or peer-based strategies, may promote and sustainable PA engagement, ultimately improving quality of life and long-term health outcomes.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"34 9","pages":"e70256"},"PeriodicalIF":3.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12433256/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145058476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishing Diagnostic Cut-Off Scores for the Perceived Cognitive Impairment Subscale of the Functional Assessment of Cancer Therapy-Cognitive Function-Version 3 in Portuguese Cancer Survivors.","authors":"Ana F Oliveira, Sofia A Marques-Fernandes, Ana Bártolo, Pedro Bem-Haja, Ana Torres, Isabel M Santos","doi":"10.1002/pon.70278","DOIUrl":"10.1002/pon.70278","url":null,"abstract":"<p><strong>Objective: </strong>Cancer-related cognitive impairment (CRCI) negatively impacts the quality of life of non-central nervous system (non-CNS) cancer survivors. Detecting these cognitive changes remains challenging due to the lack of standardized CRCI classification and detection criteria. This study aimed to establish cut-off scores for the perceived cognitive impairment (CogPCI) subscale of the European Portuguese version of the Functional Assessment of Cancer Therapy-Cognitive Function-Version 3 (FACT-Cog-v3).</p><p><strong>Methods: </strong>We analyzed data from 266 Portuguese-speaking non-CNS cancer survivors and performed a receiver operating characteristic (ROC) curve analysis to evaluate the diagnostic validity of the CogPCI subscale of the FACT-Cog-v3 to detect meaningful perceived CRCI.</p><p><strong>Results: </strong>The CogPCI subscale demonstrated good screening performance in identifying individuals with and without clinically relevant CRCI, as indicated by a moderate-to-high area under the curve (AUC) score of 0.87. A suggested optimal cut-off score of < 51 provided good sensitivity (81.2%) and specificity (78.9%) for CogPCI to differentiate between the two groups. Over half of the participants reported significant cognitive complaints, highlighting the urgent need for standardized cognitive assessments in oncology.</p><p><strong>Conclusions: </strong>This study contributes valuable insights into the early and fast detection and intervention of CRCI in Portugal. Using a brief, validated, self-report cognitive assessment tool can enhance the management of cognitive symptoms in non-CNS cancer survivors.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"34 9","pages":"e70278"},"PeriodicalIF":3.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12436984/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145070368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Life Experiences of Women Diagnosed With Cervical Cancer in Sub-Saharan Africa: A Systematic Review of Qualitative Studies.","authors":"Emmanuel Z Chona, Rashid A Gosse, Emanueli Amosi Msengi, Therese Polin Aruldhas, Lutengano Mkonongo, Timotheo Meshark Matle, Masunga K Iseselo, Joel Seme Ambikile","doi":"10.1002/pon.70280","DOIUrl":"https://doi.org/10.1002/pon.70280","url":null,"abstract":"<p><strong>Background: </strong>Sub-Saharan Africa (SSA) bears the highest global burden of cervical cancer. Living with the disease is a complex experience, leading to significant changes across various biopsychosocial dimensions, which in turn affect the quality of life of affected women.</p><p><strong>Aims: </strong>This review aimed to synthesize available scientific evidence on the life experiences of women diagnosed with cervical cancer in SSA in order to generate valuable insights into the care of the affected population.</p><p><strong>Methods: </strong>Seven electronic databases were searched in August 2024, supplemented by manual reference list searching and snowballing to identify additional relevant studies. The eligibility criteria for inclusion were studies that sampled women (≥ 18 years) diagnosed with cervical cancer, used qualitative methodology, explored life experiences with cervical cancer as a primary aim, and were published between January 2015 and August 2024. The 10-item Critical Appraisal Skills Program (CASP) checklist was used to assess the methodological quality of individual studies. The findings of the studies were thematically synthesized to generate analytical themes.</p><p><strong>Results: </strong>A total of 14 studies were included, with the largest proportion of studies conducted in Ghana and South Africa. Four main themes highlighting the life experiences of women diagnosed with cervical cancer emerged from the synthesis: physical and psychosexual disruptions, knowledge of cervical cancer, socio-economic challenges, and treatment experiences.</p><p><strong>Conclusions: </strong>The findings highlight the profound physical, psychological, sexual, and socio-economic experiences of cervical cancer on women in SSA. To improve cervical cancer outcomes in the region, it is crucial to provide comprehensive, culturally sensitive care that emphasizes public awareness, early detection, psychological support, socio-economic interventions, and both curative and palliative treatment options.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"34 9","pages":"e70280"},"PeriodicalIF":3.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145034268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Randomized Controlled Trial of Group-Blended and Individual-Unguided Online Mindfulness-Based Cognitive Therapy to Reduce Psychological Distress in People With Cancer.","authors":"Nasim Badaghi, Linda Kwakkenbos, Judith Prins, Rogier Donders, Saskia Kelders, Anne Speckens","doi":"10.1002/pon.70286","DOIUrl":"10.1002/pon.70286","url":null,"abstract":"<p><strong>Objective: </strong>Online mindfulness-based cognitive therapy (eMBCT) can reduce psychological distress in people with cancer, but adherence and scalability could be improved. Through co-creation, we developed two eMBCT formats: group-blended and individual-unguided. This trial compared the effects of the two eMBCT to care as usual (CAU) on psychological distress and other mental health outcomes in people with cancer.</p><p><strong>Methods: </strong>In this parallel, three-armed randomized controlled trial, people with cancer were randomly allocated to group-blended eMBCT, individual-unguided eMBCT, or CAU. Participants completed baseline, mid-treatment, post-treatment, and 3 months follow-up assessments. The primary outcome analyzed in the intention-to-treat (ITT) population was psychological distress (Hospital Anxiety and Depression Scale) at post-treatment.</p><p><strong>Results: </strong>In total, 186 participants were randomized to group-blended eMBCT (N = 57), individual-unguided eMBCT (N = 75), or CAU (N = 54). Most participants were female (81%) with breast cancer (49%), and treated with curative intent (76%). In ITT analyses, group-blended eMBCT participants reported significantly lower levels of psychological distress at post-treatment (Cohen's d = 0.38) and follow-up (Cohen's d = 0.64) than those receiving CAU, while individual-unguided eMBCT participants only had significantly less psychological distress at follow-up (Cohen's d = 0.48). Additionally, participants in group-blended eMBCT had less rumination and greater mindfulness, decentering, and self-compassion than those in CAU at follow-up. Participants in individual-unguided eMBCT had greater decentering than those in CAU at post-treatment and follow-up, and less rumination and greater mindfulness skills than CAU at follow-up.</p><p><strong>Conclusions: </strong>Compared to CAU, both eMBCT conditions were effective in reducing psychological distress and could be an accessible, and potentially low-cost intervention to reduce distress in people with cancer.</p><p><strong>Trial registration: </strong>Dutch Registry CCMO, NL73117.091.20; clinicaltrials.gov, NCT05336916.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"34 9","pages":"e70286"},"PeriodicalIF":3.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12447259/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sun-Safety Knowledge, Attitudes and Behaviour in Western Saudi Arabia: Implications for Psycho-Oncology Prevention Services.","authors":"Arwa F Flemban, Saeed M Kabrah, Asmaa A Alabbadi, Noor M Alharbi, Abdulaziz A Alotaibi, Ragad A Baghdadi, Maryam K Alhawsawi, Bakr M Alharbi, Halah T Albar, Samar N Ekram, Hanan M Abd Elmoneim","doi":"10.1002/pon.70273","DOIUrl":"https://doi.org/10.1002/pon.70273","url":null,"abstract":"<p><strong>Background: </strong>Melanoma, a highly aggressive skin cancer, is strongly linked to ultraviolet (UV) exposure. Despite high UV levels in Saudi Arabia, public awareness and adherence to melanoma preventive behaviours remain underexplored. This study assessed knowledge (factual accuracy), attitudes, and sun-protective practices among adults in the western region of Saudi Arabia, investigating demographic and gender-specific differences.</p><p><strong>Methods: </strong>A cross-sectional online survey was conducted from April to May 2024, recruiting 553 participants aged 18-80 years through convenience sampling. A validated 46-item questionnaire assessed melanoma knowledge, risk perception, sun exposure patterns, and adherence to preventive behaviours. Descriptive statistics and one-way ANOVA were used to analyse differences based on age, gender, education, employment, and healthcare affiliation.</p><p><strong>Results: </strong>Moderate awareness of melanoma was observed (mean = 2.28, 5-point Likert scale), with 73.2% of participants recognising sunlight as a risk factor for skin cancer. However, misconceptions were widespread, including beliefs that short-term sun exposure is harmless (36%) and that sunscreen is unnecessary on cloudy days (43.8%). Females and younger participants (18-35 years) demonstrated significantly higher knowledge (p < 0.001 and p = 0.036, respectively) and risk perception; however, adherence to sun-protective behaviours (e.g., sunscreen re-application, protective clothing) was suboptimal across all groups (mean = 2.67). Education level influenced awareness (p = 0.031), but did not impact behaviour.</p><p><strong>Conclusion: </strong>Despite moderate awareness, significant knowledge gaps and a knowledge-action gap hinder melanoma prevention in this high-UV region. Culturally tailored interventions targeting misconceptions and behavioural barriers, particularly among males and individuals with lower educational attainment, are essential. These findings inform the development of evidence-based strategies to reduce melanoma risk in Saudi Arabia and similar high-UV settings.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"34 9","pages":"e70273"},"PeriodicalIF":3.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12396939/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144966378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive Behavioral Therapy for Cancer-Related Fatigue: A Comparison Between Patients Treated With Curative Intent and Patients With Advanced Cancer.","authors":"Hannah B van der Pas, Annemarie M J Braamse, Gijs Bleijenberg, Hanneke W M van Laarhoven, Pythia Nieuwkerk, Harm Westdorp, Lia van Zuylen, Fabiola Müller, Hans Knoop","doi":"10.1002/pon.70282","DOIUrl":"10.1002/pon.70282","url":null,"abstract":"<p><strong>Background: </strong>Cancer-related fatigue (CRF) is prevalent in patients who have been treated with curative intent and patients with advanced cancer. Cognitive behavioral therapy (CBT) has been shown effective in reducing CRF in both groups.</p><p><strong>Aims: </strong>To compare both groups with respect to: (1) pre-treatment levels of fatigue and fatigue-perpetuating cognitive-behavioral factors; (2) the magnitude of the effect of CBT on fatigue; and (3) mediators of the treatment response.</p><p><strong>Methods: </strong>Data of four randomized controlled trials testing the efficacy of CBT for CRF were pooled, three in patients treated with curative intent (n = 249), and one in patients with advanced cancer (n = 134). Baseline characteristics were compared with ANCOVAs. Moderation analysis was used to investigate whether the treatment effect differed between groups. With moderated mediation analyses differences in the mechanisms by which CBT reduces fatigue were evaluated.</p><p><strong>Results: </strong>The two groups differed significantly at baseline on fatigue-perpetuating factors, but not on fatigue severity. Patients with advanced cancer reported a smaller decrease in fatigue severity following CBT than patients treated with curative intent (p = 0.022). The multivariate moderated mediation analysis showed a larger decrease in fatigue catastrophizing in patients treated with curative intent than in patients with advanced cancer.</p><p><strong>Conclusion: </strong>CBT for CRF has less effect on catastrophizing, a known fatigue-perpetuating factor and mediator of the effect of CBT, and fatigue severity in patients with advanced cancer. Further research has to determine if the effectiveness of CBT for CRF in advanced cancer patients can be improved.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"34 9","pages":"e70282"},"PeriodicalIF":3.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449572/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}