Psycho‐Oncology最新文献

{"title":"Accepting to Participate in an Early-Phase Clinical Trial in Oncology: A Qualitative Study on the Patients' Experiences, Understanding, and Inner Motivations.","authors":"Estelle Guerdoux, Anne Stoebner, Louise Coutant, Marion Zamith-Chavant, Sylvie Dolbeault, Jessica Martinez, Marta Jarlier, Diego Tosi","doi":"10.1002/pon.70291","DOIUrl":"10.1002/pon.70291","url":null,"abstract":"<p><strong>Background: </strong>The clinical trial landscape in oncology has evolved, with shifting endpoints and increased emphasis on early-phase clinical trials (EPCTs) across European centers.</p><p><strong>Aims: </strong>This study aimed to update knowledge on the experiences of patients enrolling in EPCTs, focusing on the individual/contextual factors influencing decision-making, and how to improve ethical and psycho-oncological support.</p><p><strong>Methods: </strong>This qualitative single-center study was part of a broader multicenter project. Twenty-five patients with locally advanced or metastatic solid cancer, for whom standard therapies had failed, were interviewed face-to-face, at a French EPCT center. A reflexive thematic analysis of the transcripts was conducted, following Braun and Clarke's six-step approach.</p><p><strong>Results: </strong>Four overarching themes emerged: \"Experiencing the EPCT proposal\", \"Accepting the EPCT\", \"Ambivalent feelings\" and \"Coping strategies\", and several subthemes. Decisions were often made quickly in crisis situations and perceived as the only option. While patients reported receiving adequate information, their understanding of the trial's aims varied. Emotional distress and time pressure likely hindered full comprehension. Patients relied on trust in clinicians and reframed trial participation as a constructive goal, drawing on coping strategies to manage uncertainty and restore a sense of coherence.</p><p><strong>Conclusions: </strong>Patients were neither delusional nor misinformed, but their decisions were shaped by complex emotional and relational dynamics. The perception of being well informed does not ensure true understanding, especially in high-stress contexts. Ambivalent emotions, tensions between expectations and hopes, and constrained choices should be considered when tailoring supportive care. Evidence-based strategies are needed to enhance communication and shared decision-making in EPCT settings.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"34 10","pages":"e70291"},"PeriodicalIF":3.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12491123/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145213501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measurement Properties of Health Information-Seeking Behavior Assessment Tools in Cancer Patients: A Systematic Review.","authors":"Yun Li, Li Wang, Xiao-Yan Dong, Ya-Di Zhang, Shu-Jing Suo, Yan Zhang, La-Mei Liu, Yan-Fei Liu","doi":"10.1002/pon.70298","DOIUrl":"https://doi.org/10.1002/pon.70298","url":null,"abstract":"<p><strong>Aims: </strong>To undertake a comprehensive systematic review of currently available instruments designed to assess health information-seeking behaviors among cancer patients, appraising their psychometric properties and methodological rigor to identify the most robust instrument for clinical application.</p><p><strong>Design: </strong>A systematic review based on COSMIN methodology.</p><p><strong>Date sources: </strong>Nine electronic databases CNKI, Wanfang, VIP, SinoMed, PubMed, Embase, Web of Science, CINAHL, and APA PsycINFO were systematically searched from inception until February 2025.</p><p><strong>Review methods: </strong>Employing a rigorously validated search methodology developed by Terwee, we systematically interrogated nine multinational databases spanning Chinese and English publications from inception through February 20, 2025, and targeting cancer patient populations. Following independent dual screening by researchers, the psychometric characteristics of identified instruments were systematically assessed using COSMIN quality criteria for measurement tool evaluation.</p><p><strong>Results: </strong>From the initial 6545 studies, 16 met the eligibility criteria, involving 11 instruments for evaluating health information-seeking behaviors in cancer populations. High-quality evidence revealed insufficient content validity for the BIAS and structural validity deficiencies in the HIOS, PSM, and MBSS, all assigned a class C recommendation, while the remaining seven instruments received class B ratings.</p><p><strong>Conclusion: </strong>Compared to the other 10 instruments, the MHISBQ measurement attributes are relatively comprehensive and can be provisionally recommended for use. However, there is still a need for large-scale studies involving diverse cancer populations to directly or indirectly compare psychological attributes, such as the stability and responsiveness of the MHISBQ. Additionally, these studies should track changes in HISB and explore its impact on patients, so that they can help guide the delivery of accurate health information and support for cancer patients.</p><p><strong>Registration: </strong>PROSPERO (CRD42024606469).</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"34 10","pages":"e70298"},"PeriodicalIF":3.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145252230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"It's Normal. Untrustworthy Memorable Messages in Formal Caregiving for Breast Cancer Patients.","authors":"Emilia Mazurek, Renata Martinec, Brigita Vilč","doi":"10.1002/pon.70279","DOIUrl":"https://doi.org/10.1002/pon.70279","url":null,"abstract":"<p><strong>Background: </strong>The patient-doctor relationship, including communication, is recognised as a critical aspect of the patient experience. Memorable messages are a part of communication between patient and doctor. However, little is known which memorable messages reduce patients' trust in doctors or lead to distrust.</p><p><strong>Aims: </strong>To reconstruct memorable messages which breast cancer patients recalled while receiving care from their clinicians leads patients to distrust doctors.</p><p><strong>Methods: </strong>In-depth interviews were conducted with 24 breast cancer patients, in Poland and Croatia. Participants ranged in age from 34 to 76 years. Reflexive thematic analysis was used.</p><p><strong>Results: </strong>Breast cancer patients recalled many memorable messages that reduce trust in oncology care. The overarching theme of untrustworthy memorable messages was developed, and it embraces three themes: seemingly caring memorable messages, careless memorable messages, missing expected memorable messages. They come in verbal, nonverbal and absent forms. Patient's responses to them include drawing attention directly to inappropriate communication, changing the doctor, learning to be better prepared for medical encounters, or passive adaptation.</p><p><strong>Conclusions: </strong>These results enrich the studies on memorable messages, enhancing the understanding of communication behaviors in triggering distrust toward doctors. Although patients are aware that doctors are overworked, they expect care, attention, individual approach, understanding, and empathy. However, doctors sometimes give untrustworthy memorable messages - especially messages perceived as dismissive, harmful, inadequate, or absent although expected - throughout the cancer trajectory. Thus, greater attention should be given to eliminating untrustworthy memorable messages, improving the understanding of trust dynamics in oncology, psycho-oncology and health education.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"34 10","pages":"e70279"},"PeriodicalIF":3.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145233314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding the Trajectory of Depressive Symptoms in Newly Diagnosed High-Grade Glioma Patients-A Meta-Analysis.","authors":"Shayda M Abazari, Peter G Bota, Thomas H Taylor, Daniela A Bota","doi":"10.1002/pon.70296","DOIUrl":"https://doi.org/10.1002/pon.70296","url":null,"abstract":"<p><strong>Introduction: </strong>High-grade gliomas, the most common and aggressive brain cancer, are associated with significant neurological disability and are almost uniformly fatal. Though the diagnosis of brain cancer is represented as one of the most stressful life events for patients as well as for their caregivers, the prevalence of depression as a longitudinal event during and after the initial diagnosis and sequential lines of treatment is under-researched.</p><p><strong>Objectives: </strong>To inform clinical practice, we assembled published, time-specific estimates of the prevalence of depression in adult high-grade glioma patients to test the idea that depression prevalence varies across therapeutic trajectory milestones.</p><p><strong>Methods: </strong>We a priori defined five time points in the clinical course of first-line therapy. After an exhaustive search of the current literature, we extracted time point-specific estimates of depression prevalence, pooled the data by time point across studies, and constructed 95% confidence intervals on depression prevalence at each time point. A total of 822 patients were identified and entered into our analyses.</p><p><strong>Results: </strong>The prevalence of depression in adult high-grade glioma is about 16%-27% between surgery and the end of temozolomide maintenance therapy, which is higher than the 9% estimated for the general population. However, when assessed in the time interval between the initial diagnostic tumor imaging and the confirmatory surgery, at least 30% of these patients are depressed.</p><p><strong>Conclusions: </strong>Because depression worsens the patient's quality of life and is treatable, the multidisciplinary treatment teams involved in the care of high-grade glioma patients should assess depression throughout the disease trajectory, and especially immediately after the first imaging study showing a suspicious intracranial mass.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"34 10","pages":"e70296"},"PeriodicalIF":3.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Three Factor Model of Parental Coping With Childhood Cancer.","authors":"Oz Hamtzani, Michael J Dolgin, Talma Kushnir","doi":"10.1002/pon.70294","DOIUrl":"10.1002/pon.70294","url":null,"abstract":"<p><strong>Objectives: </strong>Parents of children with cancer are at increased risk for anxiety, depression, and post-traumatic stress, although wide variability among parents has been documented. This cross-sectional study was designed to examine the individual contributions and simultaneous interaction of three coping constructs-coping strategy, repertoire of coping techniques, and flexibility in applying these techniques-in parental distress related to childhood cancer.</p><p><strong>Methods: </strong>A sample of 88 mothers and 57 fathers (N = 145) of children undergoing active cancer treatment were recruited from a pediatric hematology-oncology department. Parents' ages ranged from 22 to 58 years. Parents completed standardized measures including the Brief COPE, Coping Flexibility Scale-Revised, the Pediatric Parenting Stress Inventory, and the Profile of Mood States.</p><p><strong>Results: </strong>Avoidance-focused coping strategy, repertoire of coping techniques, and coping flexibility were individually found to be significantly correlated with parental distress. Bootstrap mediation analysis revealed that the collective model explained 37%-43% of the variance in parental distress, with avoidance-focused coping strategy emerging as the most significant predictor, accounting for approximately 29% of the total variance.</p><p><strong>Conclusions: </strong>These results suggest that clinical interventions should prioritize identifying and reducing parental reliance on avoidance-focused coping techniques as a primary target. Subsequently, expanding parents' repertoire of problem- and emotion-focused coping techniques and enhancing flexibility in their application could lead to better distress reduction. However, the cross-sectional design limits causal interpretation, and future longitudinal studies employing larger sample sizes are needed to establish the relationships between these constructs.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"34 10","pages":"e70294"},"PeriodicalIF":3.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12503083/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145239440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Psychometric Testing of the Social Participation Scale for Pediatric Cancer Patients.","authors":"Wang Mengjia, Liu Guo, Li Dan, Ji Jinglan, Ma Zilong, Wang Qing, Guo Xinyan, Zhang Ruixing","doi":"10.1002/pon.70303","DOIUrl":"https://doi.org/10.1002/pon.70303","url":null,"abstract":"<p><strong>Objectives: </strong>Social participation plays a key role in the rehabilitation process, improving mental health, reducing isolation, and enhancing quality of life. Despite its importance, existing tools for assessing social participation in pediatric cancer patients are limited in comprehensiveness and specificity. The aim of this study was to develop and evaluate the psychometric properties of a Social Participation Scale for Pediatric Cancer Patients (SPS-PC).</p><p><strong>Methods: </strong>Items were created after an extensive literature review and evaluated through expert consultation and a pilot study. A convenience sampling approach was employed to recruit 420 pediatric cancer patients from pediatric departments of three tertiary grade-A hospitals in Zhengzhou for psychometric testing of the scale. Item selection was based on item analysis, exploratory factor analysis was conducted to extract factors, and confirmatory factor analysis was used to assess structural validity.</p><p><strong>Results: </strong>The final version of the SPS-PC includes 16 items across four dimensions: school participation, family participation, peer participation, and health management participation. The scale demonstrated excellent content and construct validity, with high internal consistency (Cronbach's α = 0.900) and strong reliability (test-retest reliability = 0.820). Exploratory and confirmatory factor analyses confirmed a robust four-factor structure.</p><p><strong>Conclusion: </strong>The SPS-PC is a reliable and valid instrument for assessing social participation in pediatric cancer patients. The scale's comprehensive approach makes it an essential tool for clinical practice and research in pediatric oncology, contributing to the social reintegration of these children.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"34 10","pages":"e70303"},"PeriodicalIF":3.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145286891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinguishing Mental From Physical Fatigue in Patients With Low-Grade Glioma.","authors":"Femke F Siebenga, Sandra E Rakers, Floor Gelmers, Hiska L van der Weide, Miranda C A Kramer, Anouk van der Hoorn, Roelien H Enting, Ingeborg Bosma, Rob J M Groen, Hanne-Rinck Jeltema, Michiel Wagemakers, Jacoba M Spikman, Anne M Buunk","doi":"10.1002/pon.70289","DOIUrl":"10.1002/pon.70289","url":null,"abstract":"<p><strong>Background: </strong>Fatigue is a common consequence of low-grade gliomas (LGG), but its specific nature has not been extensively studied. In particular, it remains unclear if the prevalence and determinants of mental fatigue differ from those of physical fatigue. Therefore, this study aimed to examine (1) whether the prevalence and severity of mental fatigue differ from physical fatigue in patients with LGG; (2) the specific determinants of mental and physical fatigue, including cognitive impairments, affective symptoms and radiological abnormalities.</p><p><strong>Methods: </strong>A total of 148 patients with LGG were included and assessed with the Dutch Multifactor Fatigue Scale (DMFS; mental and physical fatigue) and the Hospital Anxiety and Depression Scale (HADS; affective symptoms). Neuropsychological tests were administered to measure cognitive impairments, particularly in basic and complex information processing speed.</p><p><strong>Results: </strong>Severe mental fatigue affected 38% of patients, a significantly different prevalence than that of severe physical fatigue (22%), with an overlap of 15%. Patients with severe mental fatigue had significantly lower scores on a divided attention task, compared to patients with non-severe mental fatigue. In a hierarchical linear prediction model with demographical, radiological and psychological variables, different sets of determinants were found for mental fatigue (anxiety and depression) and physical fatigue (depression, educational level and tumor volume).</p><p><strong>Conclusions: </strong>Mental fatigue can be distinguished from physical fatigue in patients with LGG, characterized by a high prevalence and unique determinants. Therefore, mental fatigue should be considered as a distinct construct and presumably requires a different (neuro)psychological therapeutic approach compared to physical fatigue.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"34 10","pages":"e70289"},"PeriodicalIF":3.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12521796/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145293347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Associated With Fear of Cancer Recurrence in a Multiethnic Cohort of Patients With Breast Cancer.","authors":"Armaan Jamal, Fangyuan Zhao, Jincong Q Freeman, Yijia Sun, Marcia M Tan, Rita Nanda, Nan Chen, Olufunmilayo I Olopade, Dezheng Huo","doi":"10.1002/pon.70307","DOIUrl":"https://doi.org/10.1002/pon.70307","url":null,"abstract":"<p><strong>Background: </strong>Fear of cancer recurrence (FCR) is prevalent among patients with breast cancer, yet those at high risk are not well characterized.</p><p><strong>Aims: </strong>This study aimed to identify the patient characteristics associated with FCR after diagnosis.</p><p><strong>Methods: </strong>Between July and September 2023, participants in the Chicago Multiethnic Epidemiologic Breast Cancer Cohort completed the 9-item FCR-Short Form Inventory. A score of 22 or higher indicated clinically significant FCR (csFCR). Logistic and linear regression estimated associations between different risk factors and csFCR and FCR scores, respectively. Missing data were addressed using multiple imputation.</p><p><strong>Results: </strong>Among 1390 stage I-III patients (mean age 63.1 years and 9.1 [mean] years since diagnosis), 262 (18.8%) reported csFCR. In adjusted models, csFCR was associated with having another cancer excluding non-melanoma skin (adjusted odds ratio [aOR], 2.64; 95% CI, 1.66-4.21), greater levels of stress (aOR, 2.40 per 1-SD increment; 95% CI, 1.98-2.91), having a prior recurrence (aOR, 2.26; 95% CI, 1.14-4.47), and having estrogen receptor-positive tumors (aOR, 1.60; 95% CI, 1.06-2.40). Older age at diagnosis (aOR, 0.64 per 10-year increment; 95% CI, 0.56-0.73) was associated with lower odds of csFCR. Similar associations were observed with continuous FCR scores, along with advanced stage at diagnosis associated with higher FCR scores (p-trend = 0.001).</p><p><strong>Conclusions: </strong>Nearly 1 in 5 breast cancer patients reported csFCR. Key risk factors included younger age at diagnosis, history of recurrence or other malignancies, greater levels of stress, and estrogen receptor-positive breast cancer, which can inform targeted interventions to support survivorship.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"34 10","pages":"e70307"},"PeriodicalIF":3.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145308763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cancer in Poetry-Poetry in Cancer: A Linguistic Analysis of Poems by Poets on Their Own Cancer and on the Cancer of Their Loved Ones.","authors":"Ad A Kaptein, Waldie E Hanser, Jan W Schoones, Peter Boot, James W Pennebaker, Brian M Hughes","doi":"10.1002/pon.70297","DOIUrl":"https://doi.org/10.1002/pon.70297","url":null,"abstract":"<p><strong>Background: </strong>Poems related to cancer offer a rich perspective on the clinical reality of living with cancer. Therefore, in this paper, poems written by poets about their own cancer and about the cancer of loved ones are examined in the context of communal coping.</p><p><strong>Methods: </strong>We analyzed 123 poems by 14 poets writing about their own cancer, and 72 poems by 8 poets writing about the cancer of their loved ones, with Linguistic Inquiry and Word Count software (LIWC).</p><p><strong>Results: </strong>LIWC-scores drawn from poems about one's own cancer exhibited a limited use of \"third-person singular\", social words (\"family\", \"female\", \"male\"), and time orientation (\"focus past\"), and an increased focus on the present. Support for this observation comes from significant correlations between words related to the present, body, and health, with strong, negative emotions. Poems about loved ones who suffer cancer tend to focus on grief and mourning, and to exhibit melancholy and represent paternal, maternal, spousal, and filial elegies.</p><p><strong>Conclusions: </strong>The linguistic characteristics and content of poems by poets writing about their cancer or about the cancer of their loved ones provides rich insights. This linguistic analysis of poems regarding cancer can be used in the further development of theory and clinical application of self-management approaches for persons with cancer, in support of expressive writing interventions, bibliotherapy, photovoice, art therapy, and health humanities.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"34 10","pages":"e70297"},"PeriodicalIF":3.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145252218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychosocial Risk Factors and Perceived Well-Being in Survivors of Gastrointestinal Cancer.","authors":"Samuel D Butensky, Kurt S Schultz, Elizabeth L Godfrey, Jihoon Kim, Tara Sanft, Caroline H Johnson, Ira L Leeds, Sajid A Khan","doi":"10.1002/pon.70302","DOIUrl":"https://doi.org/10.1002/pon.70302","url":null,"abstract":"<p><strong>Background: </strong>There are 18 million cancer survivors in the United States; 10% have gastrointestinal (GI) cancer. Psychosocial risk factors (PSRF) and perceived health (PH) are important to their well-being.</p><p><strong>Aims: </strong>This study examines PSRF among survivors of GI cancer and evaluates their association with PH.</p><p><strong>Methods: </strong>A cross-sectional analysis of the All of Us Research Program included survivors of GI cancer who completed Social Determinants of Health and Overall Health surveys. PSRF were assessed using validated scales. Regression models evaluated associations between PSRF and PH.</p><p><strong>Results: </strong>13,813 patients with GI cancer were included. Female patients were more likely to perceive good physical health (OR 1.52 [95% CI: 1.30-1.79]) than male patients. Black patients reported higher discrimination (β 0.25 [95% CI: 0.20-0.31]) compared to white patients. Increased loneliness and stress decreased the odds of reporting good mental health by 53% (OR 0.47 [95% CI: 0.39-0.56]) and 39% (OR 0.61 [95% CI: 0.50-0.74]), respectively. Increased spirituality was associated with improved perceived mental health (OR 1.12 [95% CI: 1.06-1.17]). Healthcare discrimination (OR 0.87 [95% CI: 0.79-0.97]) and loneliness (OR 0.84 [95% CI: 0.73-0.97]) were negatively associated with perceived physical health. Social support (OR 1.16 [95% CI: 1.06-1.26]) and spirituality (OR 1.08 [95% CI: 1.02-1.14]) were positively associated with quality of life.</p><p><strong>Conclusion: </strong>Protective PSRF such as social support and spirituality are correlated with better perceived health in survivors of GI cancer. Tailoring supportive services based on patient-reported experience may help improve quality of life in cancer survivorship.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"34 10","pages":"e70302"},"PeriodicalIF":3.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145259059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}