Psycho‐Oncology最新文献

{"title":"Surgeon Perspectives on Addressing Mental Health Among Total Laryngectomy Patients.","authors":"Carlos X Castellanos, Matthew E Lin, Tyler J Gallagher, Mark S Swanson, Daniel I Kwon","doi":"10.1002/pon.70162","DOIUrl":"https://doi.org/10.1002/pon.70162","url":null,"abstract":"<p><strong>Objective: </strong>Head and neck cancer patients, particularly those undergoing total laryngectomy, exhibit high rates of depression and suicide, even compared to other cancer patients. Thus, this study seeks to understand head and neck surgeons' perceived roles in and treatment patterns regarding mental health sequelae among total laryngectomy patients.</p><p><strong>Methods: </strong>An anonymous survey regarding provider perspectives about the mental health experiences of total laryngectomy patients was designed and distributed via email to American Head and Neck Society members and academic otolaryngology head and neck surgery departments. Descriptive statistics were utilized to describe results.</p><p><strong>Results: </strong>Respondents (n = 63) reported frequently seeing mental health issues among total laryngectomy patients (on average, 48% of patients) and believed otolaryngologists should frequently screen for these conditions (85%). However, a significant subset of the sample (39%) reported feeling uncomfortable addressing mental health issues and cited factors such as lack of expertise (73%) or lack of resources to address mental health (73%). Overall, most respondents agreed that this population could receive better mental healthcare (88%). Referral to speech-language pathologists (80%), community-based support groups (54%), and referral to a mental health provider (n = 35, 54%) were frequently recommended post-operative prophylactic measures.</p><p><strong>Conclusion: </strong>This national cross-sectional survey of head and neck surgeons demonstrated that while physicians acknowledge and appreciate the need for mental health services among laryngectomy patients, a significant minority feel unprepared to address mental health due to a lack of training and resources. Additional research is needed to identify methods to effectively address this gap in care for laryngectomy patients.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"34 5","pages":"e70162"},"PeriodicalIF":3.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12032048/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Professional Grief in Cancer Care-A Scoping Review.","authors":"Svenja Wandke, Hannah Führes, Mareike Rutenkröger, Klaus Lang, Martin Härter, Karin Oechsle, Isabelle Scholl","doi":"10.1002/pon.70156","DOIUrl":"https://doi.org/10.1002/pon.70156","url":null,"abstract":"<p><strong>Objective: </strong>Healthcare professionals (HCPs) in cancer care often face patient deaths, yet there is a notable absence of comprehensive evidence regarding their grief. This scoping review seeks to identify key aspects of professional grief in cancer care and give an overview pertaining its' conceptualization and frequency and intensity.</p><p><strong>Methods: </strong>The primary search covered three databases (MEDLINE, PSYNDEX, and PsycINFO). Two independent reviewers assessed 2248 records, selecting 34 eligible articles.</p><p><strong>Results: </strong>Most studies originated from North America and Israel, with limited evidence from the global south, East Asia and Europe, as well as few quantitative studies. HCPs exhibit classic grief symptoms (such as sadness) and distinct features (e.g., feelings of guilt) in response to patient deaths, though a clear definition and measures of professional grief are lacking. Grief frequency varies highly (from 23% to 100%).</p><p><strong>Conclusions: </strong>Future research should refine definitions and measures to better support HCPs in effectively managing professional grief in cancer care.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"34 5","pages":"e70156"},"PeriodicalIF":3.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12031695/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144008416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Qualitative Findings From a Survey Measuring Informational Needs and Quality of Life of Women Living With Metastatic Breast Cancer.","authors":"Rachel Starkings, Lesley Fallowfield, Stephanie Russ, Valerie Jenkins","doi":"10.1002/pon.70177","DOIUrl":"https://doi.org/10.1002/pon.70177","url":null,"abstract":"<p><strong>Background: </strong>People living with metastatic breast cancer (MBC) may have different support requirements to those with early stage breast cancer (EBC). These differences can be substantial, particularly as care pathways and information are often designed around the latter. There is limited understanding of how these discrepancies impact patients with MBC.</p><p><strong>Aims: </strong>In the LIMBER study (Living with Metastatic Breast Cancer), we explored the distinct and unmet needs of people living with MBC.</p><p><strong>Methods: </strong>In collaboration with people living with MBC and healthcare professionals (HCPs), we developed an online survey comprising fixed and free text responses. Fixed responses and overall study demographics from the main LIMBER study have been published elsewhere. A framework analysis of the free text comments is reported here.</p><p><strong>Results: </strong>The resulting thematic map has seven main themes - friends and family, reactions of others, healthcare professionals, systems & processes, knowledge & information, outlook & goals and wellbeing. Participants reflected that comments made by friends and family were often well-meaning but showed misunderstanding of the disease. This was particularly noticeable in understanding the difference between MBC and EBC. There were references to the lack of support and information from HCPs.</p><p><strong>Conclusions: </strong>The analysis of free text comments from this survey demonstrates the impact that MBC can have, particularly without robust support or accessible information. Understanding areas where patients have outstanding needs provides insight into how best to promote coping strategies and improved quality of life, while informing those who provide informal and formal care.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"34 5","pages":"e70177"},"PeriodicalIF":3.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065527/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144008522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Co-Creating and Refining a Values Assessment Tool (VAsT) for Women With Metastatic Breast Cancer.","authors":"Lorinda A Coombs, Victoria Crowder, Madison Black, Kelly Tan, Emily M Ray, Renée M Ferrari, Erin E Kent, Daniel S Reuland, Ashley Leak Bryant","doi":"10.1002/pon.70173","DOIUrl":"https://doi.org/10.1002/pon.70173","url":null,"abstract":"<p><strong>Background and aims: </strong>Patients with metastatic breast cancer (mBC) and their families often have differing perspectives on treatment goals. This highlights the need for systematically eliciting patients' and care partners' values to ensure values-aligned treatment decisions. This study aimed to inform the development of a values assessment tool to facilitate communication of priorities and preferences with oncology clinicians.</p><p><strong>Methods: </strong>Two rounds of semi-structured interviews were conducted with women with mBC from the Southeastern and Northeastern U.S. Recruitment included at least 50% of participants identifying as African American/Black, Latinx, Asian, American Indian, or Native American.</p><p><strong>Results: </strong>The initial round of 13 interviews yielded eight candidate domains. After confirmatory interviews with additional participants, the researchers identified nine final domains relevant to treatment decisions for mBC: desire not to appear sick; desire to help other women with breast cancer by participating in clinical research; financial concerns; living to care for a loved one; maintaining sexuality; maintaining quality of life; maximizing time away from medical appointments; minimizing and managing side effects; and slowing disease progression with an effective treatment.</p><p><strong>Conclusion: </strong>Eliciting treatment decision values across multiple domains and effectively communicating them with clinicians is a crucial aspect of patient-centered care to align values with care goals. To help patients identify and express their values to clinicians, we are developing a values assessment tool specifically for mBC. Future research will pilot this tool to assess its impact on communication between clinicians and patients and health outcomes for women with mBC.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"34 5","pages":"e70173"},"PeriodicalIF":3.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12061624/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143980998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concordance of Cancer Screening Attendance Among Spouse Couples: A Cross-Sectional Survey of the Tohoku Medical Megabank Project.","authors":"Naoki Nakaya, Kumi Nakaya, Toshimasa Sone, Mana Kogure, Rieko Hatanaka, Ippei Chiba, Sayuri Tokioka, Masato Takase, Yoko Izumi, Nobuo Fuse, Atsushi Hozawa","doi":"10.1002/pon.70158","DOIUrl":"https://doi.org/10.1002/pon.70158","url":null,"abstract":"<p><strong>Objectives: </strong>Owing to spousal pairs often exhibiting similar health behaviors, this study examined the concordance of cancer screening attendance between spouses using cross-sectional data from a large biobank study in Japan, which included 2022 spousal pairs.</p><p><strong>Study design: </strong>Cross-sectional study.</p><p><strong>Methods: </strong>Self-administered data were collected to determine whether participants had undergone screening for colorectal, gastric, and lung cancers in the past year. The following two analyses were conducted: the exposure was whether the husband attended cancer screening, and the outcome was whether the wife attended; the exposure was whether the wife attended, and the outcome was whether the husband attended. Multiple logistic regression analyses were performed, adjusting for confounding factors in the exposed individuals.</p><p><strong>Results: </strong>The multivariate odds ratio (95% confidence interval, p-value) for wives attending colorectal cancer screening when their husbands had attended was 2.7 (2.2-3.3, p < 0.0001), indicating a significant positive association. Similarly, when wives were the exposure and husbands were the outcomes, the odds ratio was 2.6 (2.2-3.2, p < 0.0001). Notably, these associations were consistent across colorectal, gastric, and lung cancer screenings.</p><p><strong>Conclusions: </strong>The findings of this study support the hypothesis that the attendance of one spouse at cancer screening significantly positively influences that of the other spouse, regardless of the type of cancer screening or the age of the spouses. Novel intervention strategies can be developed that specifically target spousal pairs and potentially enhance the effectiveness of cancer prevention initiatives compared to those targeting individuals alone.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"34 5","pages":"e70158"},"PeriodicalIF":3.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12031694/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Barriers to Inclusivity: Systematic Analysis of Exclusion Criteria and Potential Bias in Clinical Cancer Trials for Psychiatric and Neurological Conditions in European Protocols.","authors":"Margherita Dahò, Veronica Coppini, Maria Vittoria Ferrari, Giulia Ferraris, Virginia Sanchini, Dario Monzani, Roberto Grasso, Chiara Agnello, Giuseppe Badalamenti, Laura Algeri, Gabriella Pravettoni","doi":"10.1002/pon.70182","DOIUrl":"https://doi.org/10.1002/pon.70182","url":null,"abstract":"<p><strong>Background: </strong>Cancer clinical trials often employ exclusion criteria that can impact vulnerable populations, particularly individuals with psychological, psychiatric, or neurological conditions.</p><p><strong>Aims: </strong>This study aimed to analyze the prevalence and nature of exclusion criteria in clinical trials for prostate, breast, and lung cancers.</p><p><strong>Methods: </strong>The EU Clinical Trials Register identified 51 protocols uploaded between 2022 and 2024. Thematic content analysis categorized exclusion criteria, and the justifications provided, while frequency analysis quantified their prevalence.</p><p><strong>Results: </strong>After excluding five protocols (two non-English and three inaccessible), the final dataset comprised 46 protocols: 13 for prostate cancer (22.8%), 24 for breast cancer (42.1%), and 9 for lung cancer (15.8%). Exclusion criteria targeting vulnerable populations were present in 78.3% of protocols, categorized into five themes: psychiatric conditions (24.6%), neurological conditions (22.8%), other psychological conditions (22.8%), legal/guardianship status (5.3%), and unspecified conditions (24.6%). Compliance concerns (39.1%) were the most common justification, followed by informed consent challenges (32.6%), safety risks (13%), drug interference (10.9%), and not in the best interest (4.3%). Notably, 29.1% of protocols lacked justification for exclusions, raising ethical and transparency concerns.</p><p><strong>Conclusions: </strong>The exclusion of vulnerable populations may limit the inclusivity and generalizability of cancer research. Heuristic biases and systemic practices can potentially influence this. Exploring the role of these factors and considering adaptive trial designs, along with providing detailed justifications for exclusion criteria, could support more equitable and representative clinical research.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"34 5","pages":"e70182"},"PeriodicalIF":3.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068421/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"'Finding Comfort in Discomfort': A Qualitative Study of Cancer Clinicians and Researchers' Experiences of Conducting a Cancer Rapid Autopsy Program.","authors":"Erin Tutty, Philomena Horsley, Rowan Forbes Shepherd, Laura Forrest","doi":"10.1002/pon.70175","DOIUrl":"https://doi.org/10.1002/pon.70175","url":null,"abstract":"<p><strong>Background: </strong>Rapid autopsy offers a tantalising opportunity to better characterise metastatic disease and determine how malignancies evade treatment. The CASCADE (CAncer tiSsue Collection After DEath) rapid autopsy program at the Peter MacCallum Cancer Centre, established in 2012, has conducted more than 100 autopsies. The experiences of clinicians and researchers who conduct this program can offer insight into how a unique program can be conducted sensitively and how their involvement impacts them personally and professionally.</p><p><strong>Purpose: </strong>To explore experiences of the clinicians and researchers involved in the CASCADE cancer rapid autopsy program.</p><p><strong>Materials and methods: </strong>A qualitative approach employing semi-structured interviews was used to collect data from clinicians and researchers working at the Peter MacCallum Cancer Centre. Inductive thematic analysis with team-based codebook development was used to generate findings.</p><p><strong>Results: </strong>Participants (N = 20) described the benefits and burdens of involvement in a cancer rapid autopsy program, including strategies used to 'find comfort in discomfort'. Offering participation in CASCADE enhanced patient-clinician rapport. The goals of the CASCADE program helped participants overcome confronting experiences in the autopsy room and use of autopsy-derived tissue in the laboratory. Peer-support is essential to avoid burnout.</p><p><strong>Conclusion: </strong>The benefits outweighed the burdens of delivering a cancer rapid autopsy program, however, it is important that staff are well supported in their roles.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"34 5","pages":"e70175"},"PeriodicalIF":3.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144036640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Music Therapy on Quality of Life in Cancer Patients: A Systematic Review and Meta-Analysis.","authors":"Ting Luo, Suting Zhang, Mi Zhao, Hong Song, Shuo Wang, Jing Han","doi":"10.1002/pon.70165","DOIUrl":"https://doi.org/10.1002/pon.70165","url":null,"abstract":"<p><strong>Objective: </strong>This meta-analysis aims to evaluate the efficacy of music therapy on quality of life (QoL), anxiety, and depression in cancer patients.</p><p><strong>Methods: </strong>Nine electronic databases, encompassing six English and three Chinese databases were systematically searched for randomized controlled trials (RCTs) from the date of database inception to September 1, 2024. All RCTs that involved participants aged at least 18 years with any type of cancer, who received music therapy and had QoL as an outcome measure, were screened. The revised Cochrane's risk of bias tool was applied to evaluate the risk of bias. The Review Manager software was applied to execute this meta-analysis. Subgroup analyses were performed based on the type and duration of the music therapy.</p><p><strong>Results: </strong>Fourteen RCTs involving 1104 patients were included in this meta-analysis. The results showed that compared with usual care, wait list or health education, music therapy could significantly improve the QoL of cancer patients (standardized mean difference (SMD = 1.36); 95% confidence interval (CI: 0.77-1.96); p < 0.01; Grading of Recommendations Assessment, Development, and Evaluation assessment [GRADE]: moderate), with passive music therapy being superior to active-passive music therapy, can be protective against anxiety (SMD = -1.37; 95% CI:-2.29 to -0.45; p < 0.01; GRADE: moderate) and depression (SMD = -1.86; 95% CI:-3.65 to -0.08; p = 0.04; GRADE: low).</p><p><strong>Conclusion: </strong>Music therapy was effective in improving the QoL of patients with cancer, with passive music therapy being superior to active-passive music therapy. Meanwhile, anxiety and depression were relieved as well. Further studies with rigorous study designs are needed to verify our conclusions.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"34 5","pages":"e70165"},"PeriodicalIF":3.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Web-Based Interventions on Anxiety and Depression in Patients With Breast Cancer: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.","authors":"Myoungsuk Kim, Kyung Ja Kang, Seang Ryu","doi":"10.1002/pon.70167","DOIUrl":"https://doi.org/10.1002/pon.70167","url":null,"abstract":"<p><strong>Objective: </strong>This study evaluated the effects of web-based interventions on anxiety and depression in patients with breast cancer by conducting a meta-analysis of relevant randomized controlled trials (RCTs).</p><p><strong>Methods: </strong>We searched the PubMed, Web of Science, Cochrane Library, Cumulated Index to Nursing and Allied Health Literature, Embase, and PsycINFO databases from their inception to January 5, 2024. When substantial heterogeneity was observed among the studies, a random-effects model was applied to calculate effect sizes in terms of the standardized mean difference (SMD) and assessed the quality of the included studies using the updated Cochrane risk-of-bias tool for RCTs.</p><p><strong>Results: </strong>Fourteen RCTs were included in this study. The meta-analysis indicated that web-based intervention alleviated anxiety (SMD = -0.26, 95% CI = -0.44 to -0.07, p < 0.01, I² = 68%) and depression (SMD = -0.15, 95% CI = -0.25 to -0.06, p = 0.19, I² = 26%) in patients with breast cancer. There was substantial heterogeneity in anxiety, and the analysis of potential causes revealed that the intervention method was a factor influencing the variability in the actual effect size.</p><p><strong>Conclusions: </strong>This study showed that web-based interventions may help reduce anxiety and depression in patients with breast cancer. It also suggested the potential of these interventions as a strategy for alleviating symptoms in non-face-to-face settings. However, the limited number of studies and high heterogeneity in the subgroup analysis made it difficult to assess the effects of different intervention methods. Further high-quality research is needed to provide more reliable data on the effectiveness of various intervention methods.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"34 5","pages":"e70167"},"PeriodicalIF":3.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12061795/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144044814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationships Between Insomnia and Quality of Life in Patients With Advanced Liver Cancer: A Secondary Analysis of a Multicenter Cross-Sectional Study.","authors":"Zimeng Li, Lili Song, Jiahua Leng, Ying Pang, Yi He, Zhongge Su, Yu Wang, Yuhe Zhou, Yongkui Lu, Yu Jiang, Xinkun Han, Lihua Song, Liping Wang, Xiaojun Lv, Yan Wang, Juntao Yao, Xiaohong Liu, Xiaoyi Zhou, Shuangzhi He, Yening Zhang, Jinjiang Li, Bingmei Wang, Lili Tang","doi":"10.1002/pon.70157","DOIUrl":"https://doi.org/10.1002/pon.70157","url":null,"abstract":"<p><strong>Background: </strong>This study aims to evaluate the symptom burden of advanced liver cancer, explore factors related to quality of life (QoL), and investigate the relationship between insomnia and QoL.</p><p><strong>Methods: </strong>This is a secondary analysis of a multicenter cross-sectional study that included data from patients with advanced liver cancer (n = 364) recruited from 10 cancer centers across China. Participants were required to complete Patient Health Questionnaire-9 (PHQ-9), MD Anderson Symptom Inventory (MDASI), Insomnia Severity Index (ISI), 5-level EQ-5D (EQ-5D-5L). Factors associated with QoL were identified through a multiple stepwise linear regression model and the LASSO regression approach. The mediating effect between insomnia and quality of life was tested using the bootstrap method.</p><p><strong>Results: </strong>The three most prevalent symptoms were fatigue (17.0%), sleep disturbance (16.2%), and pain (15.8%). Insomnia, depression, and the 13 core symptoms in the MDASI were strongly correlated with reduced QoL (all p < 0.001). The mediating effect analysis showed that depression, dry mouth, pain, forgetfulness and fatigue were partial mediating variables between insomnia and QoL.</p><p><strong>Conclusion: </strong>Various physical and psychological symptoms could affect the QoL in patients with advanced liver cancer. Insomnia and related symptoms such as depression, dry mouth, pain, forgetfulness and fatigue should be identified and appropriately addressed to improve QoL for this population.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"34 5","pages":"e70157"},"PeriodicalIF":3.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144041992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}