Psycho‐Oncology最新文献

{"title":"Optimal Exercise Modality and Dose to Alleviate Depressive and Anxiety Symptoms in Patients With Cancer: A Network Meta-Analysis and Dose-Response Study.","authors":"Bing Zeng, Jiu Chen, Hai Wang, Zhe Kong, Ni Dong, Jun Xie","doi":"10.1002/pon.70479","DOIUrl":"https://doi.org/10.1002/pon.70479","url":null,"abstract":"<p><strong>Objective: </strong>To compare the effects of different exercise modalities on depressive and anxiety symptoms in patients with cancer and to explore the exercise dose-response relationship to identify the optimal dose.</p><p><strong>Methods: </strong>Randomized controlled trials published from database inception to January 2026 were searched in PubMed, Web of Science, Embase, and the Cochrane Library. Risk of bias was assessed using the Cochrane Risk of Bias tool. Stata 17.0 and R 4.4.3 were used for data transformation and statistical analyses, including comparisons of exercise modalities and dose-response evaluation for depressive and anxiety outcomes.</p><p><strong>Results: </strong>Sixty-seven randomized controlled trials involving 5778 patients with cancer were included. Network meta-analysis showed that mind-body exercise (MBE), combined aerobic and resistance exercise (COM), and aerobic exercise (AE) significantly improved depressive symptoms, whereas resistance training (RT) did not. For anxiety, significant improvements were observed with MBE and AE, with MBE showing the greatest benefit for both outcomes. Dose-response analysis showed a nonlinear U-shaped association between total exercise dose and both depression and anxiety, with optimal doses of 770 and 700 MET-min/week, respectively.</p><p><strong>Conclusions: </strong>Different exercise modalities vary in their effects on depressive and anxiety symptoms in patients with cancer, with MBE showing the greatest overall benefit. The U-shaped dose-response relationship suggests that an appropriate exercise dose may help optimize improvements in depressive and anxiety symptoms and provide a basis for more precise exercise prescriptions based on exercise modality and dose.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"35 5","pages":"e70479"},"PeriodicalIF":3.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147819790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychological Distress Trajectories and Associated Factors in Patients With Breast Cancer: A Cohort Study.","authors":"Meidi Xiong, Wei Wei, Liangli Wang, Hongmei Yao, Fuxiang Zhou, Chunhua Zhang","doi":"10.1002/pon.70474","DOIUrl":"https://doi.org/10.1002/pon.70474","url":null,"abstract":"<p><strong>Purpose: </strong>Breast cancer patients often experience significant psychological distress. This study examined distress trajectories from diagnosis to 6 months post-treatment and explored differences across demographic, medical, and psychosocial subgroups.</p><p><strong>Methods: </strong>In this prospective cohort study, 528 patients with breast cancer were recruited between 1 December 2023 and 31 December 2024. Assessments were conducted at baseline (at diagnosis, T0), after the first treatment (T1), mid-treatment (T2), at treatment completion (T3), and at three (T4) and six months (T5) post-treatment. Growth mixture modeling (GMM) was used to identify distinct trajectories of psychological distress. Multinomial logistic regression analysis was performed to examine associations between patient-related factors and trajectory membership.</p><p><strong>Results: </strong>Three psychological distress trajectories were identified: a high-distress remission group (17.05%), a moderate-stable distress group (11.93%), and a low-fluctuating distress group (71.02%). Multivariable analyses showed that higher educational attainment, breast-conserving surgery, early disease stage, partial self-management ability, and strong social support were associated with membership in the moderate-stable or low-fluctuating groups (p < 0.05). Employment, health insurance coverage, avoidant medical coping style, and higher baseline anxiety and depression scores were concurrently associated with membership in the high-distress remission group (p < 0.05).</p><p><strong>Conclusions: </strong>Although psychological distress generally decreased over time, 71.02% of patients followed a low-fluctuating trajectory, 11.93% maintained moderate distress with potential risk of persistence, and 17.05% showed high initial distress that remitted substantially within 6 months. Continuous monitoring and early psychosocial support are recommended, particularly for patients with moderate- or high-risk trajectories.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"35 5","pages":"e70474"},"PeriodicalIF":3.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147819991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Proof-of-Concept Analysis of the Healthy Communication Practice Intervention to Enhance Adult-Child Caregivers' Psychosocial Well-Being: A Brief Report.","authors":"Carla L Fisher, Kevin B Wright, Easton N Wollney, Alyssa Crowe, Samantha R Paige, Maria Sae-Hau, Elisa S Weiss, Carma L Bylund","doi":"10.1002/pon.70478","DOIUrl":"https://doi.org/10.1002/pon.70478","url":null,"abstract":"<p><strong>Background: </strong>Caregivers manage complex demands with little support, contributing to significant psychological distress. Though caregiver-focused supportive care is scarce, this type of psychosocial support enhances well-being and caregiving ability. Given the caregiver support gap, we developed an online, self-directed intervention (Healthy Communication Practice) to reduce caregivers' distress by enhancing their online, clinical, and family communication skills. It was first developed for adult children of parents with blood cancer. We previously established the acceptability and feasibility of the intervention in partnership with Blood Cancer United (formerly The Leukemia & Lymphoma Society).</p><p><strong>Aim: </strong>This proof-of-concept analysis examined the impact of Healthy Communication Practice on adult-child caregivers' distress and secondary psychosocial outcomes.</p><p><strong>Methods: </strong>Participants were adult-child caregivers of parents with blood cancer diagnosed at least 3 months prior and in treatment or completed treatment within a year. Outcomes were assessed pre-, immediate-post, and 3-month post-intervention using paired t-tests to analyze pre- and post-intervention differences.</p><p><strong>Results: </strong>Participants (N = 55) were aged 18-59, mostly female (76%) and white (78%). Caregivers experienced reduced distress between pre-intervention and 3-month post completion as well as increased positive meaning associated with their caregiving role between pre-intervention to 3-month post completion. Communication skills in each care domain (online, clinical, and family communication) increased between pre- and 3-month post completion.</p><p><strong>Conclusions: </strong>Results provide proof-of-concept evidence that the Healthy Communication Practice can enhance caregivers' psychological well-being and caregiving communication skills. Results further demonstrate a sustainable, innovative communication-focused approach to providing caregiver-targeted supportive care that can also be widely disseminated, thus warranting further evaluation.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"35 5","pages":"e70478"},"PeriodicalIF":3.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147841986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methods of Suicide Used by People With Cancer: A Scoping Review.","authors":"Doireann Ni Dhalaigh, Zubair Kabir, Fahmi Ismail, Paul Corcoran, Daisy Wiggin, Eugene Cassidy","doi":"10.1002/pon.70476","DOIUrl":"10.1002/pon.70476","url":null,"abstract":"<p><strong>Background: </strong>Individuals diagnosed with cancer are at increased risk of suicide compared to the general population. Access to means is a key volitional risk factor for suicide and represents a modifiable target for prevention at a population level. Understanding the methods of suicide in this group is crucial to inform targeted prevention strategies.</p><p><strong>Aims: </strong>This scoping review aimed to examine the methods of suicide used by individuals with cancer, identify the types of study designs used to investigate this topic, and evaluate the feasibility of a future systematic review.</p><p><strong>Methods: </strong>This scoping review followed JBI methodology and the PRISMA-ScR checklist. A comprehensive search was conducted in five databases: Medline (EBSCO), PsycINFO (EBSCO), Embase (Elsevier), CINAHL Plus (EBSCO), and Web of Science (Clarivate) and gray literature. Studies were eligible if they quantitatively reported suicide methods in individuals with cancer. Studies of non-fatal self-harm, case reports, or those lacking method-specific data were excluded.</p><p><strong>Results: </strong>Twenty-seven studies from multiple countries were included. Method choice was influenced by geographical location, age, and sex. There was considerable heterogeneity in study design, cancer definitions, control groups used, and the characteristics of comparison samples reported.</p><p><strong>Conclusions: </strong>Due to substantial methodological variation, a systematic review is not currently feasible. Future research should, at a minimum, control for age and sex, include underrepresented populations, and adopt region-specific approaches.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"35 5","pages":"e70476"},"PeriodicalIF":3.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13136553/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147819760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Systematic Review and Meta-Analysis on the Levels of Supportive Care Needs in Adults With Cancer.","authors":"Caroline B Silveira, Anderson Rech, Maria Petropoulou, Pietro S Rössler, Francine F de Souza, Helena B Böhmer, Amanda L Giacomet, Richard Alejandro B de Barros, Lucélia de C de Barros, Vagner R Z B Pereira, Nanci da S T Junqueira, Pedro Lopez","doi":"10.1002/pon.70477","DOIUrl":"10.1002/pon.70477","url":null,"abstract":"<p><strong>Objective: </strong>To estimate the levels of supportive care needs among adults with cancer using the Supportive Care Needs Survey-Short Form 34 (SCNS-SF34) and to examine demographic, clinical, and treatment-related determinants.</p><p><strong>Methods: </strong>A systematic review and meta-analysis was conducted (CRD42024604977). Studies reporting SCNS-SF34 scores in adults with cancer were included. Searches were performed across six different databases (November 2024; updated August 2025). Random-effects meta-analyses were undertaken to estimate the pooled mean scores across the five SCNS-SF34 domains and total score. Subgroup and meta-regression analyses explored potential determinants.</p><p><strong>Results: </strong>Ninety-five studies (n = 32,493) were analysed. The unmet needs observed tended to be higher in the Health systems and information (Mean estimate [95% CI] = 38.4 [34.6-42.2]) and Psychological (Mean estimate [95% CI] = 35.9 [32.5-39.3]) domains, followed by Physical and daily living (Mean estimate [95% CI] = 31.2 [27.7-34.6]) and Patient care and support (Mean estimate [95% CI] = 30.0 [26.2-33.8]). The lowest needs were reported in the Sexuality domain (Mean estimate [95% CI] = 21.3 [18.1-24.5]). Cancer type influenced all domains, except for the psychological domain. Treatment status only influenced the health system and information domain. Older age was consistently associated with lower unmet needs in the health system and information, psychological and patient care and support domains, while surgical treatment was associated with lower needs in physical, patient care, and sexuality domains.</p><p><strong>Conclusions: </strong>The level of supportive care needs was identified, with informational and psychological domains representing the greatest burden. These needs vary according to cancer type, age, and treatment characteristics, supporting the need for tailored, multidisciplinary strategies to address unmet needs across the cancer continuum.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"35 5","pages":"e70477"},"PeriodicalIF":3.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13127244/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147779357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Feasibility of a Co-Designed Online Healthy Living Intervention for Cancer Survivors: Valuable Content, But Limited Engagement.","authors":"Morgan Leske, Bogda Koczwara, Jason Blunt, Camille E Short, Anthony Daly, Julia N Morris, Jon Degner, Lisa Beatty","doi":"10.1002/pon.70486","DOIUrl":"https://doi.org/10.1002/pon.70486","url":null,"abstract":"<p><strong>Introduction: </strong>Healthy Living after Cancer (HLaC) was an evidence-based, telephone-delivered lifestyle program for survivors. HLaC Online was co-designed with cancer survivors, healthcare professionals, and cancer support representatives to enhance sustainability and reach through a self-directed digital format, while incorporating both physical health and mental health content. This study examined HLaC Online's feasibility.</p><p><strong>Methods: </strong>Eleven Australian post-treatment cancer survivors participated in a 12-week, single-arm pilot with mixed-methods evaluation. Feasibility indicators included uptake, usage, attrition, usability, satisfaction, and indicators of preliminary efficacy.</p><p><strong>Results: </strong>Of 318 website visitors, 11 enrolled, with nearly half never logging in. Module usage was limited (M = 3.3 of 9 modules) and only 5 completed follow-up. Perceived usability of HLaC Online was varied (rated F- B+). Qualitative feedback highlighted the relevance of psychosocial modules, but engagement was hindered by technology barriers, cancer-related symptoms, and lack of guidance. Participants suggested human support for orientation, accountability, and motivation.</p><p><strong>Conclusions: </strong>While HLaC Online was valued for its co-designed mental health focus, feasibility was limited without guidance. Findings raise questions about which survivors can benefit from self-directed digital programs versus those requiring human support. Future work should explore referral pathways, scalable human support models, and tailoring by need.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"35 5","pages":"e70486"},"PeriodicalIF":3.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147841959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Metacognition, Intolerance of Uncertainty, and Cognitive-Attentional Syndrome in Differentiating Fear of Cancer Recurrence.","authors":"Wendy W T Lam, Danielle W L Ng, Ceci Guo, Rachel Ng, Richard Fielding, Chi Chung Foo, Ava Kwong, Siu-Man Simon Ng, Dacita Suen, Sara Fung, Oi Kwan Chun, Karen K L Chan, Wendy W L Chan, Amy T Y Chang","doi":"10.1002/pon.70475","DOIUrl":"10.1002/pon.70475","url":null,"abstract":"<p><strong>Objectives: </strong>This study tested (1) whether intolerance of uncertainty (IU) and negative metacognitive beliefs independently differentiate fear of cancer recurrence (FCR) status, and (2) whether mediation by cognitive-attentional syndrome (CAS) elements modify the relationships of IU and metacognitive beliefs with FCR status.</p><p><strong>Methods: </strong>Baseline data from 384 participants (collected ∼15.6 months post-diagnosis) pooled from a prospective longitudinal study and an FCR intervention trial were analyzed. Measures included FCRI-SF (FCR), MCQ-30 (metacognitive beliefs), IUS-12 (IU), and CAS-1 (CAS). FCR status was classified based on the FCRI-SF scores as non-clinical (< 13), subclinical (13-21), and clinically significant (≥ 22). Fully adjusted multinomial logistic regression examined direct effects of IU and metacognitive domains on FCR status and indirect effects via CAS.</p><p><strong>Results: </strong>Compared to the non-clinical group (n = 116), subclinical (n = 190) and clinically-significant (n = 78) FCR groups showed greater negative beliefs about worry (OR range 1.297-1.500, p < 0.001), higher IU (OR 1.050-1.066, p = 0.037), increased use of CAS metacognitive strategies (OR 1.077-1.108, p = 0.021-< 0.001), and less perceived need to control thoughts (OR 0.847-0.857, p = 0.003-0.027). Clinically-significant FCR was additionally associated with poorer cognitive confidence (OR 1.122, p = 0.030). CAS partially mediated associations of FCR status with negative beliefs about worry, cognitive confidence, and IU, and fully mediated the association with need to control thoughts.</p><p><strong>Conclusions: </strong>IU and negative metacognitive beliefs can characterize individuals vulnerable to differentially-elevated FCR. CAS centrally mediates the relationships between FCR, IU, and metacognition. Cognitive-behavioral interventions for FCR explicitly targeting CAS should disrupt the impact of IU and metacognitive beliefs on FCR.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"35 5","pages":"e70475"},"PeriodicalIF":3.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13127241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147779418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Out-of-Pocket Costs and Antidepressant Adherence in Head and Neck Cancer Survivors.","authors":"Gennaro Di Tosto, Neil K Mehta, Christopher W Noel, Ann Scheck McAlearney, Lauren E Miller","doi":"10.1002/pon.70473","DOIUrl":"https://doi.org/10.1002/pon.70473","url":null,"abstract":"<p><strong>Background: </strong>Head and neck cancer (HNC) survivors have a high burden of depression, yet real-world antidepressant adherence and the role of patient out-of-pocket (OOP) costs in this population remain poorly characterized.</p><p><strong>Methods: </strong>We analyzed a retrospective cohort of US adults with HNC and a new antidepressant prescription in Merative MarketScan databases (2016-2023). We measured 180-day adherence using the medication possession ratio (MPR; adherent if MPR ≥ 80%) and 180-day persistence as no pharmacy-claims gap > 15 days. We summarized antidepressant cost-sharing and used multivariable logistic regression to evaluate associations between index-fill OOP cost and adherence; Kaplan-Meier and Cox models assessed time to first therapy gap by antidepressant class.</p><p><strong>Results: </strong>Among 9267 HNC survivors (median age 61 years; 61% male), 42% were adherent and 80% were persistent over 180 days. Six-month antidepressant OOP spending was low (median $10; mean $18). Higher index-fill OOP cost was statistically associated with adherence (adjusted OR 1.02, 95% CI 1.02-1.03), but the magnitude was small over the observed cost range and was not clinically meaningful. Persistence did not differ by single antidepressant class; however, use of multiple antidepressant classes was associated with higher discontinuation risk (HR 2.08, 95% CI 1.84-2.34) relative to SSRI monotherapy.</p><p><strong>Conclusions: </strong>In this claims-based cohort of HNC survivors, antidepressant OOP costs were modest and did not appear to be a major barrier to adherence. Adherence remained suboptimal, and discontinuation risk was concentrated among patients receiving multiple antidepressant classes, suggesting the need to focus on nonfinancial and clinical drivers of medication continuity.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"35 5","pages":"e70473"},"PeriodicalIF":3.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13141665/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147842043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Healthcare Professionals' Perspectives on Unmet Needs and Service Provision for Patients With Cancer and Caregivers in Türkiye: An Exploratory Study.","authors":"Ozan Bahcivan, Mehmet Salduz, Levent Ertuna, Youngmee Kim","doi":"10.1002/pon.70481","DOIUrl":"https://doi.org/10.1002/pon.70481","url":null,"abstract":"<p><strong>Objective: </strong>Understanding the availability of various supportive care services for patients and caregivers is essential for informing national healthcare strategies and research priorities. Given the crucial role of healthcare professionals (HCPs) in delivering supportive care, this study examined their perspectives on assessing cancer-related unmet needs and differences in service provision for patients versus caregivers in Türkiye, a lower-middle-income country.</p><p><strong>Methods: </strong>Data were drawn from the Turkish subsample of the International Psycho-Oncology Society Survivorship Online Survey who provided valid responses (n = 52). Participants reported on institutional practices related to the assessment and service provision for 13 kinds of unmet needs for patients and caregivers.</p><p><strong>Results: </strong>Most institutions systematically assessed (≥ 50%) and provided services to address unmet needs (≥ 51.9%) for patients, whereas only few did so for caregivers (19.2%, ≤ 23.1%, respectively). Medical concerns for patients (78.8%) and psychosocial issues for caregivers (19.2%) were most frequently assessed, and services for emotional distress were most frequently provided for both patients and caregivers (82.7% and 23.1%, respectively). Sexuality/intimacy and financial concerns were least assessed and addressed (≤ 50.0% for patients, ≤ 15.4% for caregivers). Differences in assessments and service provision between patients and caregivers were significant across all unmet needs with large effect sizes (all p < 0.001, Cramer's V = 0.52 - 0.62).</p><p><strong>Conclusions: </strong>Findings highlight both strengths and gaps in supportive care service provision and guide the development of integrated, comprehensive, and equitable programs for populations affected by cancer in Türkiye. These results also provide an initial foundation for future large-scale and longitudinal studies aimed at addressing the unmet needs of individuals affected by cancer.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"35 5","pages":"e70481"},"PeriodicalIF":3.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147841997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding Physical Activity in Patients With Metastatic Breast Cancer: An Analysis Rooted in the Theory of Planned Behaviour.","authors":"Esther C E de Jongh, Johanna Depenbusch, Anne May, Anouk Hiensch, Yvonne Wengström, Jon Belloso, Milena Lachowicz, Lonneke van de Poll-Franse, Karen Steindorf, Martijn M Stuiver","doi":"10.1002/pon.70457","DOIUrl":"10.1002/pon.70457","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to improve understanding physical activity behaviour in patients with metastatic breast cancer, based broadly on Ajzen's Theory of Planned Behaviour (TPB). We assessed the role of different pathways in the TPB and of cancer specific barriers to find points of leverage for improving exercise support and behaviour in this vulnerable population. In addition, we explored international differences in the model's pathways.</p><p><strong>Methods: </strong>We conducted an international survey (n = 420) amongst patients with metastatic breast cancer, including items assessing attitude, injunctive subjective norm, intention, perceived behavioural control (PBC), and self-reported physical activity. Additionally, we examined the relative importance of health-related barriers on motivational pathways.</p><p><strong>Results: </strong>Model fit indices indicated a reasonable fit for the TPB (cfi = 0.98, rmsea = 0.08) with small (standardized absolute coefficients 0.13-0.30) but statistically significant associations in the expected directions according to the theoretical model, except for subjective norm (β = 0.05). The interaction of PBC with intention was statistically significant, but adding this term diminished overall model fit (cfi = 0.85, rmsea = 0.13). The presence of health-related barriers impacted behaviour (β = -0.19) whilst acting as a mediator for PBC on intention. International differences in the strength of model pathways suggest cultural variation.</p><p><strong>Conclusions: </strong>Findings support the applicability of the TPB for understanding and supporting physical activity behaviour in patients with MBC. Targeting perceived behavioural control may be especially effective in overcoming health-related barriers in this population. Additionally, improving affective and instrumental attitude towards physical activity could enhance intervention outcomes.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"35 4","pages":"e70457"},"PeriodicalIF":3.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13084298/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147691863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}