Psycho‐Oncology最新文献

{"title":"A Multi-Level Analysis of Barriers and Promoting Factors to Cascade Screening Uptake Among Male Relatives of BRCA1/2 Carriers: A Qualitative Study.","authors":"G Ongaro, J G Hamilton, V Groner, J L Hay, M Calvello, S Oliveri, B Bonanni, I Feroce, G Pravettoni","doi":"10.1002/pon.70160","DOIUrl":"10.1002/pon.70160","url":null,"abstract":"<p><strong>Background: </strong>Pathogenic variants in the BRCA1/2 genes significantly elevate risks of breast, ovarian, prostate, and pancreatic cancer. Clinical guidelines recommend cascade screening (CS) to identify at-risk family members and advance genetically targeted disease prevention. However, despite the benefits of CS, testing uptake remains suboptimal, particularly among male first-degree relatives (FDRs) of female BRCA1/2 carriers.</p><p><strong>Aims: </strong>Little is known about factors that hinder or enhance the implementation of CS in at-risk men in BRCA-positive families. This qualitative study explored multifaceted barriers and promoting factors influencing CS in 11 untested male FDRs.</p><p><strong>Methods: </strong>Participants engaged in semi-structured interviews exploring their experiences and perspectives regarding CS uptake. Thematic analysis, guided by the Health Action Process Approach, revealed a complex interplay of barriers and promoting factors at individual, interpersonal, provider, and environmental levels.</p><p><strong>Results: </strong>Key barriers included limited awareness and communication, inaccurate knowledge regarding genetic testing, logistical constraints, and concerns regarding potential psychological outcomes. Potential promoting factors encompassed factors such as men's stage of life, actionability of genetic testing results, perceived benefit of prevention, familial cohesion, and provider direct recommendations.</p><p><strong>Conclusions: </strong>These findings contribute to a deeper understanding of the factors shaping CS uptake within BRCA-positive families and hold implications for targeted interventions to enhance CS uptake and improve the management of hereditary cancer syndromes. Gender-specific education and public awareness campaigns are crucial, highlighting male cancer risk and surveillance strategies. Exploring alternative delivery methods, such as direct provider engagement with at-risk males, can address challenges of low CS uptake, moving beyond traditional patient-mediated approaches.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"34 5","pages":"e70160"},"PeriodicalIF":3.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081208/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harnessing Social Media to Develop Conceptual Domains of Quality of Life for Adolescents With Advanced Cancer.","authors":"Andrea Johnson, Kimberley Widger","doi":"10.1002/pon.70155","DOIUrl":"https://doi.org/10.1002/pon.70155","url":null,"abstract":"<p><strong>Background: </strong>Many adolescents will not survive their cancer diagnosis and will live with advanced cancer (cancer i.e. difficult to cure). Due to the advancement of cancer therapies, many adolescents will live with advanced cancer for long periods of time. Enhancing QoL is a well-established goal of their clinical oncology and palliative care however, there has been little research to conceptualize QoL in ways meaningful to them. There has also been a lack of QoL research focused on the inclusion of their voices and experiences into QoL construct development.</p><p><strong>Objectives: </strong>The aim of this study was to develop proposed conceptual domains of QoL relevant to adolescents with advanced cancer.</p><p><strong>Methods: </strong>This study was a qualitative study grounded in Interpretive Description. We used social media content created by adolescents living with advanced cancer to inform the development of QoL domains. Adolescents are increasingly using social media to share their experiences and we believed social media would facilitate access to rich data.</p><p><strong>Results: </strong>235 social media posts recorded by 14 adolescents were included in the analysis. This analysis generated domains relevant to the QoL of adolescents with advanced cancer: (1) Perceived Health, (2) The Lived Body, (3) Emotional Wellbeing, (4) Normalcy, (5) Purpose and Direction and (6) Re-Orientation.</p><p><strong>Conclusions: </strong>The QoL of adolescents with advanced cancer is poorly understood. This research has generated unique conceptual domains of QoL relevant to this population of adolescents. These concepts will inform the future development of a patient-reported outcome measure (PROM) that can measure their QoL.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"34 5","pages":"e70155"},"PeriodicalIF":3.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12031689/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Nurse-Led Psychoeducation on Knowledge and Psychological Distress in Cancer Patients Undergoing Radiological Imaging: A Randomized Controlled Trial.","authors":"Anjali Dahiya, Poonam Joshi, Surya Kant Tiwari, Rakesh Garg, Sameer Rastogi, Kamlesh Kumari Sharma","doi":"10.1002/pon.70164","DOIUrl":"https://doi.org/10.1002/pon.70164","url":null,"abstract":"<p><strong>Background: </strong>Patients with cancer undergoing radiological imaging often experience psychological distress due to procedural uncertainty and fear of unfavorable diagnoses.</p><p><strong>Aims: </strong>This study aimed to evaluate the effectiveness of a nurse-led psychoeducational intervention on knowledge and psychological distress among cancer patients undergoing imaging in India.</p><p><strong>Methods: </strong>A randomized controlled trial was conducted with 120 adult cancer patients who underwent radiological imaging. Participants were randomly assigned to the intervention group, receiving nurse-led psychoeducation, or the control group, receiving standard care. The primary outcomes were knowledge of radiological imaging, assessed using a validated questionnaire, and psychological distress, measured using the Depression Anxiety Stress Scale-21. Data were collected at the baseline and immediately after imaging.</p><p><strong>Results: </strong>The post-intervention knowledge scores significantly improved in the intervention group compared to the control group (10.48 ± 1.99 vs. 8.51 ± 2.14; p < 0.001). Anxiety levels decreased significantly in the intervention group, with the proportion of participants experiencing no anxiety increasing from 67.74% to 93.55% (p = 0.001). After adjusting for baseline anxiety, the intervention group had significantly lower odds of anxiety than the control group (OR = 0.09, 95% CI: 0.02, 0.35; p = 0.001). No significant differences were observed in depression or stress levels between the groups.</p><p><strong>Conclusion: </strong>Nurse-led psychoeducation effectively improved knowledge and reduced anxiety in patients with cancer undergoing radiological imaging. Integrating such interventions into pre-imaging protocols can enhance patient preparedness and reduce psychological distress. Further research should explore the long-term effects and adaptability of this intervention in diverse healthcare settings.</p><p><strong>Trial registration: </strong>CTRI/2021/06/034458.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"34 5","pages":"e70164"},"PeriodicalIF":3.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cancer in Severe Mental Illness Patients: A Retrospective Study.","authors":"Théodore Vinais, Thibaut Gellé, Pierre-Marie Preux, Philippe Nubukpo, Aurélie Lacroix","doi":"10.1002/pon.70183","DOIUrl":"10.1002/pon.70183","url":null,"abstract":"<p><strong>Objective: </strong>Severe mental illness (SMI), including schizophrenia, bipolar disorder or depression, constitute a risk factor for premature death. SMI patients die more frequently and earlier of cancer than the general population. Chronic inflammation, lack of cancer screening and substance abuse could explain these premature deaths in SMI patients. The role of SMI in cancer incidence remains uncertain. This study aims to identify the temporal occurrence between SMI and cancer in the case of dual pathology, and to investigate possible associations between specific diagnoses of SMI and cancer locations.</p><p><strong>Methods: </strong>We retrieved medical data on more than 2000 SMI patients in care in 2022 with follow-up for up to 54 years and searched for cancer diagnoses and addictive comorbidities.</p><p><strong>Results: </strong>Most SMI patients with cancer had been diagnosed with SMI prior to cancer (85.8%). The most represented cancer was breast cancer (27.2%) followed by cutaneous cancer (16.6%) and prostate cancer (10.6%). No associations were found between pre-existing SMI and cancer diagnoses as a whole. No associations were found when considering specific psychiatric diagnoses of SMI and precise cancer locations. Psychoactive substance consumption was similar among the different SMI pathologies and were not associated with specific cancer except for alcohol and breast cancer as well as tobacco and lung cancer.</p><p><strong>Conclusion: </strong>This study highlights the need to reconsider the complex interaction between SMI and cancer, including their temporal relationship and mutual impact. The link between specific psychiatric diagnoses and cancers should be investigated in larger studies cross-referencing psychiatric files and cancer-specific database.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"34 5","pages":"e70183"},"PeriodicalIF":3.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12075676/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143994877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving Shared Decision-Making in Early Phase Clinical Trials and Palliative Care: A Prospective Study on the Impact of an Online Value Clarification Tool Intervention.","authors":"Liza G G van Lent, Julia C M van Weert, Maja J A de Jonge, Mirte van der Ham, Esther Oomen-de Hoop, Martijn P Lolkema, Marjolein van Mil, Eelke H Gort, Jelle van Gurp, Jeroen Hasselaar, Carin C D van der Rijt","doi":"10.1002/pon.70168","DOIUrl":"https://doi.org/10.1002/pon.70168","url":null,"abstract":"<p><strong>Objectives: </strong>This study evaluated the impact of the OnVaCT intervention, a narrative-based Online Value Clarification Tool (OnVaCT), combined with communication training for oncologists, on shared decision-making (SDM) in discussions on potential early phase clinical trial participation and palliative care. These high-stakes decisions often challenge patients and oncologists in addressing patient values, a crucial component of SDM. We hypothesized that the intervention would improve oncologist-patient communication, specifically SDM application, and (consequently) reduce patient decisional conflict.</p><p><strong>Methods: </strong>In this prospective, multicentre pre-post clinical study, patients completed two surveys, and their recorded consultations on early phase clinical trials and palliative care were assessed by independent coders. Pre-intervention patients received usual care, while post-intervention patients used the OnVaCT. Oncologists underwent communication training between study phases. Endpoints included decisional conflict (primary), the extent to which oncologists, patients and relatives participate in SDM, consultation length, and patient decisions (secondary).</p><p><strong>Results: </strong>Decisional conflict (p = 0.394) did not differ between pre-test (n = 116, M = 30.0, SD = 16.9) and post-test (n = 99, M = 29.4, SD = 15.2). Oncologists significantly increased their SDM application post-intervention (p < 0.001; n = 129, M = 38.5, SD = 12.6) compared to pre-intervention (n = 163, M = 28.8, SD = 9.2), particularly when the OnVaCT was discussed. Other outcomes, including consultation length, remained stable.</p><p><strong>Conclusions: </strong>The OnVaCT intervention enhanced SDM and supported value-based discussions, without prolonging consultations. Further research should explore whether additional implementation efforts could reduce decisional conflict and the intervention's potential impact on other patient-centred outcomes. Some decisions, however, may inherently involve unresolved conflict.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"34 5","pages":"e70168"},"PeriodicalIF":3.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12041624/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Psychological Impact of Sarcoma From Pre-Diagnosis to Post-Treatment, a Meta-Synthesis.","authors":"Christopher Meek, Michael Baliousis","doi":"10.1002/pon.70174","DOIUrl":"https://doi.org/10.1002/pon.70174","url":null,"abstract":"<p><strong>Objectives: </strong>Sarcoma is a rare form of cancer affecting soft tissue and bone. Previous research has highlighted psychological challenges associated with this subset of cancer. The purpose of this paper is to draw together existing qualitative research into the psychological experiences of sarcoma patients, and to identify any sarcoma-specific psychological needs.</p><p><strong>Methods: </strong>A systematic review was conducted with the question: 'What is the psychological impact of sarcoma?'. The protocol for the review was preregistered with PROSPERO (CRD42023439959). Thematic meta-synthesis (meta-ethnography) was used to consolidate a range of qualitative sources.</p><p><strong>Results: </strong>Screening of four relevant databases identified 43 studies for inclusion, with 40 contributing to the synthesis, post-quality assessment. Psychological experiences were split into two timepoints: Early Days (highlighting delays, shock, and immediate interpretations) and Living With and Beyond (encompassing relationships, anxieties and fears, sadness and loss, coping and growth). Many psychological impacts on general cancer populations are also applicable to sarcoma, such as fear of recurrence and progression of the disease. However, some have increased resonance in those with sarcoma, due in part to its rarity, disabling potential and its occurrence at younger age. Those with Kaposi's sarcoma face unique challenges around stigmatisation.</p><p><strong>Conclusions: </strong>Health professionals who work with sarcoma patients should be aware of the additional informational, relational, and emotional challenges faced by those with sarcoma. Further research could identify what interventions could meet these challenges.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"34 5","pages":"e70174"},"PeriodicalIF":3.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144036641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Psychological Intervention Based on Digital Health Technology on Psychological Outcomes in Cancer Survivors: Systematic Review and Meta-Analysis.","authors":"Mengyuan Dong, Yongqi Huang, Xuan Zhang, Liuliu Wu, Lubna Ghazal, Fenglin Cao","doi":"10.1002/pon.70166","DOIUrl":"https://doi.org/10.1002/pon.70166","url":null,"abstract":"<p><strong>Objectives: </strong>Digital health technology (DHT)-based psychological interventions are emerging as a means to enhance psychological outcomes for cancer survivors. This study aims to assess the effects of DHT-based psychological interventions on anxiety, depression, sleep disturbances, fatigue, and quality of life among cancer survivors.</p><p><strong>Methods: </strong>A systematic search was conducted in PubMed, Web of Science, the Cochrane Library, and Embase. The Cochrane risk-of-bias tool RoB 2 was used to evaluate the quality of the included studies. The Template for Intervention Description and Replication (TIDieR) checklist was used to check if the interventions reviewed were described in detail to be implemented in the clinical setting. Data synthesis was conducted in Review Manager (Version 5.4), and the effect size was calculated by the standardized mean difference and its 95% confidence interval. Sensitivity analysis and subgroup analysis were also conducted. The certainty of evidence was rated using the Grading of Recommendations, Assessment, Development and Evaluation approach.</p><p><strong>Results: </strong>This meta-analysis encompassed 46 randomized controlled trials, involving 5211 participants. DHT-based psychological interventions significantly reduced anxiety (SMD = -0.41, 95% CI -0.59/-0.24), depression (SMD = -0.26, 95% CI -0.39/-0.13), sleep disturbance (SMD = -0.39, 95% CI -0.64/-0.14), fatigue (SMD = -0.47, 95% CI -0.77/-0.17), and improved quality of life (SMD = 0.42, 95% CI 0.22/0.62). Subgroup analysis indicated that interventions lasting for a duration of ≥ 12 weeks, and integrated interventions might be the most effective in addressing adverse psychological outcomes. And cognitive-behavioral therapy interventions demonstrated significant effectiveness in managing sleep disturbance.</p><p><strong>Conclusion: </strong>DHT-based psychological interventions might be effective for improving anxiety, depression, sleep disturbances, fatigue, and quality of life in cancer survivors. We cannot draw definitive conclusions due to intervention and study design heterogeneity. Further rigorous trials are crucial to identify optimal interventions for different types of cancers, determine suitable durations, specify types of DHT-based psychological interventions and validate intervention therapies.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"34 5","pages":"e70166"},"PeriodicalIF":3.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143996214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploratory Analysis of Nationwide Japanese Patient Safety Reports on Suicide and Suicide Attempts Among Inpatients With Cancer Using Large Language Models.","authors":"Ken Kurisu, Maiko Fujimori, Saki Harashima, Masako Okamura, Kazuhiro Yoshiuchi, Yosuke Uchitomi","doi":"10.1002/pon.70150","DOIUrl":"https://doi.org/10.1002/pon.70150","url":null,"abstract":"<p><strong>Objective: </strong>Patients with cancer have a high risk of suicide. However, evidence-based preventive measures remain unclear. This study aimed to investigate suicide prevention strategies for hospitalized patients with cancer by analyzing nationwide patient safety reports using large language models.</p><p><strong>Methods: </strong>Data were drawn from patient safety reports collected by the Japan Council for Quality Health Care from 620 hospitals. Reports involving suicides or attempts among patients with cancer were analyzed. BERTopic was used to identify topics in free-text reports, and conditions such as depressive symptoms were labeled using the OpenAI API. Logistic regression was conducted to analyze the relationship between pre-incident conditions and proposed countermeasures.</p><p><strong>Results: </strong>Among 213 reports, key topics included mental and physical distress, symptom deterioration, nursing records, and post-incident documentation. Over 40% of patients exhibited depressive symptoms, and 30% expressed suicidal ideation. However, fewer received specialized mental care. Notably, over 10% appeared to experience delirium, potentially contributing to the incident. The most frequently suggested countermeasures were mental distress treatment, enhanced medical staff communication, and improved information sharing with families. Logistic regression revealed several associations between proposed countermeasures and pre-incident conditions, including mental health intervention for patients without prior treatment, physical interventions for those in severe pain, and improved staff communication for those with depressive symptoms.</p><p><strong>Conclusions: </strong>This study, based on nationwide patient safety reports, highlights critical suicide prevention strategies for hospitalized patients with cancer, many of which align with previously proposed strategies. Additionally, the study provides new insights, such as the need for preventive measures to manage delirium.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"34 5","pages":"e70150"},"PeriodicalIF":3.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12050354/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144045715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Memoriam Anthony R. Marchini, MA October 1936-March 2025.","authors":"Ivelisse Belardo","doi":"10.1002/pon.70169","DOIUrl":"https://doi.org/10.1002/pon.70169","url":null,"abstract":"","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"34 5","pages":"e70169"},"PeriodicalIF":3.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144042153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insomnia in Patients With Cancer: Challenges and Management Strategies.","authors":"Cristiane Decat Bergerot, Fernanda Cesar Oliveira, Benjamin Brewer, Matthew Loscalzo","doi":"10.1002/pon.70171","DOIUrl":"https://doi.org/10.1002/pon.70171","url":null,"abstract":"","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"34 5","pages":"e70171"},"PeriodicalIF":3.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}