Psycho‐Oncology最新文献

{"title":"Digital Support for Cancer Caregivers in Latin America: Identifying Needs and Co-Designing a Culturally Adapted Resource.","authors":"Sonia Carreño-Moreno, Lorena Chaparro-Diaz, Carolyn Taylor, Olinda Santin","doi":"10.1002/pon.70609","DOIUrl":"10.1002/pon.70609","url":null,"abstract":"<p><strong>Objective: </strong>Cancer caregivers in low- and middle-income countries face substantial psychosocial and practical burdens. In Latin America, caregivers provide essential support under resource constrained conditions. This study aimed to co-design a transferable digital resource for Spanish-speaking caregivers that reflects their support and information needs.</p><p><strong>Methods: </strong>A three-phase co-design study engaged caregivers, healthcare professionals, academics, and policymakers across Latin America including Colombia, Argentina, Mexico and Peru. Phase 1 involved a hybrid workshop with oncology professionals to identify and prioritise caregiver needs. Phase 2 included verification workshops with professionals and an online caregiver survey to refine content and delivery. Phase 3 used think-aloud workshops to evaluate and finalise the prototype.</p><p><strong>Results: </strong>A total of 342 stakeholders contributed. Participants highlighted the need for accessible, structured support that addressed evolving caregiving needs. While information, practical support, and healthcare navigation were prioritised, participants also emphasised the importance of peer connection and maintaining opportunities for face-to-face engagement, positioning digital resources as a complement rather than a replacement for human support. Stakeholders highlighted the need for inclusive and accessible design, including simplified language, engaging multimedia content, caregiver narratives, and representation of diverse caregiving experiences. The resulting six-module prototype addressed the caregiver role, practical care and symptom support, navigating health and social care systems, palliative and end-of-life care, caregiver well-being, and locally adaptable supportive resources.</p><p><strong>Conclusions: </strong>This co-designed resource provides a foundation for developing culturally responsive caregiver support across Latin America. By combining digital delivery with opportunities for social connection, inclusive design, and local adaptation, the resource addresses key needs while supporting future implementation within existing care systems.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"35 9","pages":"e70609"},"PeriodicalIF":3.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13584649/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148991164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping Breast Cancer Screening Publications in Palestine: A Scoping Review of Barriers and Facilitators.","authors":"Mohammad Yaish, Ahmad Khursani, Ibrahim Althaher, Manar Hijazi, Hamzah Subeh, Ahmad Hanani","doi":"10.1002/pon.70589","DOIUrl":"10.1002/pon.70589","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to summarize literature about barriers and facilitators to participation in the breast cancer screening (BCS) activities among Palestinian women living in the West Bank or Gaza Strip to which could direct future research and guide policymakers and stakeholders for proper interventions.</p><p><strong>Methods: </strong>We conducted a literature review guided by the Arksey and O'Malley framework. PubMed, Scopus, and Google Scholar were searched from database inception to May 2025 without restrictions on language or publication date. Original studies examining barriers and/or facilitators related to breast cancer screening and early-detection practices among Palestinian women living in the West Bank or Gaza Strip were eligible. Two reviewers independently screened the records, and disagreements were resolved by a third reviewer. Data were charted using a predefined form. Without restrictions on language or publication date. After data extraction, reported barriers were grouped inductively into five overarching categories based on conceptual similarity. Facilitators were charted separately as factors associated with greater screening uptake or screening practice.</p><p><strong>Results: </strong>Low participation in BCS services was reported by several studies. Personal and cultural barriers such as embarrassment, fear of cancer diagnosis, not being a priority, and lack of time were highly reported. Other health care system, socioeconomic, knowledge-based, and geographical barriers such as male healthcare providers, perceived lower risk of cancer, unawareness of breast cancer screening services, cost, and difficulty reaching clinics were also reported by several studies. Meanwhile, good knowledge about BCS services, perceived benefit of early detection, receiving referrals from NGOs or hospitals, being employed or married, and living in a city were some of the reported facilitators.</p><p><strong>Conclusions: </strong>Health organizations, policymakers, and stakeholders can use this literature as a comprehensive source that summarizes the attitudes of Palestinian women toward BCS services, which could guide them in proper interventions, initiatives, and identifying opportunities for future research.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"35 9","pages":"e70589"},"PeriodicalIF":3.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149070126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing Self Care Among Oral Cancer Survivors Using a Digital Approach: The Empowered Survivor Trial.","authors":"Sharon L Manne, Shawna V Hudson, Janet H Van Cleave, Marissa Grosso, Sara Frederick, Morgan Pesanelli, Neetu Singh, Justin Solleder, Denalee M O'Malley, Elizabeth Handorf, Shou-En Lu","doi":"10.1002/pon.70579","DOIUrl":"10.1002/pon.70579","url":null,"abstract":"<p><strong>Background: </strong>Oral and oropharyngeal cancer survivors experience debilitating physical and psychosocial challenges. Little knowledge exists on the efficacy of interventions to enhance self-efficacy in managing these challenges, increase survivorship preparedness, and improve health-related quality of life (HRQoL).</p><p><strong>Methods: </strong>Individuals (n = 643) diagnosed with oral or oropharyngeal cancer diagnosed within past 3 years were randomized to a digital intervention, Empowered Survivor (ES) or a Generic Online Intervention (GO). Primary (self-efficacy, preparedness, HRQoL) and secondary outcomes (self-care activities) were measured at Baseline, 2-months, and 6-months.</p><p><strong>Results: </strong>Participants assigned to ES reported greater self-efficacy and increased self-care activities of oral self-exams, swallowing, and mobility exercises than those assigned to GO (self-efficacy: 2 months, p = 0.003, 6-months, p < 0.001; self-care activities).</p><p><strong>Conclusions: </strong>The ES enhanced self-efficacy and increased self-care activities. Further examinations of survivorship preparedness and HRQoL in oral and oropharyngeal cancer are warranted.</p><p><strong>Trial registration: </strong>Registered on clinicaltrials. gov as NCT04713449.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"35 9","pages":"e70579"},"PeriodicalIF":3.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13519139/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148831899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Not Too Young to Understand: Meaning Making From the Perspectives of School-Aged Children With Cancer-A Scoping Review.","authors":"Yixuan Wang, Cheng Jin, Jennifer Currin-McCulloch, David MacPhee, Abby R Rosenberg, Yijia Yang, Zhenrong Su, Peichen Liu, Jiameng Wang, Sydney Pryor","doi":"10.1002/pon.70592","DOIUrl":"10.1002/pon.70592","url":null,"abstract":"<p><strong>Background: </strong>Meaning making is increasingly recognized as an important determinant of psychosocial adjustment in adult oncology. However, how school-aged children make meaning of cancer and how developmental, relational, and sociocultural influences shape this process remain insufficiently characterized, particularly because frameworks are largely derived from adult research and centered on intrapersonal processes.</p><p><strong>Aims: </strong>To synthesize evidence on meaning making among school-aged children with cancer and examine these findings through Park's meaning-making model while identifying dimensions not fully captured by the model.</p><p><strong>Methods: </strong>A scoping review was conducted according to PRISMA-ScR guidelines. Four databases and reference lists were searched for peer-reviewed studies examining meaning making through direct reports from children aged 6-12 years with cancer. Park's meaning-making model informed study selection, data extraction, and deductive coding, while inductive coding identified dimensions not represented in the model.</p><p><strong>Results: </strong>Thirty-nine studies were included. Children's meaning making encompassed global beliefs and developmental and healthcare-related goals; appraisals of threats to the self, normalcy, relationships, and future; and cognitive, emotional, socially informed, spiritual, experiential, and avoidance-related processes. Meaning making emerged as a dynamic, developmentally grounded, and relational process shaped by caregivers, healthcare professionals, and sociocultural contexts across the cancer trajectory. Evidence regarding children's sense of meaning or purpose and meanings made was limited.</p><p><strong>Conclusions: </strong>School-aged children actively construct meaning throughout the cancer trajectory. Integrating interdisciplinary support for meaning making that is child-centered and developmentally and culturally responsive into psychosocial care, serious illness communication, and pediatric palliative care may strengthen children's participation, coping, and psychosocial-spiritual well-being.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"35 9","pages":"e70592"},"PeriodicalIF":3.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13537027/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148875875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Constrained Choices and Meaning-Making: A Qualitative Study of Caregivers of Children With Hematologic Malignancies.","authors":"Terigele, Shuyun Fan, Minglin Fan","doi":"10.1002/pon.70586","DOIUrl":"10.1002/pon.70586","url":null,"abstract":"<p><strong>Objective: </strong>Caregivers of children with hematologic malignancies experience prolonged treatment demands, uncertainty, and substantial psychosocial burden. This study explored how caregivers navigate everyday caregiving responsibilities, decision-making, and emotional endurance under conditions of uncertainty and constrained choice.</p><p><strong>Methods: </strong>A qualitative study informed by a descriptive phenomenological orientation was conducted with 15 primary caregivers recruited from a pediatric hematology unit in China using purposive sampling. Data were collected through semi-structured interviews and supplemented by non-participant observation. Data were analyzed using reflexive thematic analysis. An existential-oriented interpretive lens was introduced during later stages of analysis to deepen understanding of agency, responsibility, and meaning within caregiving experiences.</p><p><strong>Results: </strong>Caregivers described caregiving as an ongoing process of negotiating treatment demands, family responsibilities, financial pressures, and emotional strain under conditions of limited control. Everyday life became reorganized around the child's illness, with caregivers adopting present-oriented routines focused on symptom monitoring, treatment continuity, and maintaining immediate stability. Emotional endurance was sustained through regulation of distress, selective focus on incremental improvement, and maintenance of everyday relational continuity. Caregivers' experiences were also shaped by sociocultural expectations surrounding parental responsibility, emotional restraint, and family obligation.</p><p><strong>Conclusion: </strong>Caregiving in pediatric hematologic oncology involves continuous adaptation within conditions of uncertainty rather than discrete coping responses to stress. Psychosocial support may therefore benefit from approaches that help caregivers sustain everyday functioning, navigate ongoing decision-making, and maintain emotional continuity while living with unresolved uncertainty.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"35 9","pages":"e70586"},"PeriodicalIF":3.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13525232/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148851475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of a Nurse-Navigated Game-Based Program on Transition Readiness and Psychosocial Outcomes in Adolescents With Osteosarcoma: A Cluster-Nonrandomized Controlled Study.","authors":"Jun Ma, Xia Zhang, Jing Li, Fei Liu","doi":"10.1002/pon.70591","DOIUrl":"10.1002/pon.70591","url":null,"abstract":"<p><strong>Background: </strong>Adolescents with osteosarcoma face clinical and psychosocial challenges during the transition from adolescence to adulthood.</p><p><strong>Aims: </strong>This study examined the effects of a nurse-navigated game-based intervention (N²-GBI) on transition readiness in adolescents.</p><p><strong>Methods: </strong>Participants in the control group received usual care, whereas the intervention group received the N²-GBI programme alongside usual care. Transition readiness was assessed using the Self-Management and Transition to Adulthood with Rx = Treatment Questionnaire as the primary outcome. Secondary outcomes included cancer worry, transition expectation and patient activation, which were measured using the Cancer Worry Scale, Transition Expectation Scale, and Patient Activation Measure, respectively. Outcomes were assessed at baseline (T0), immediately after intervention (T1) and at 12-week follow-up (T2). Generalized estimating equations were used to estimate the intervention effects.</p><p><strong>Results: </strong>A total of 59 adolescents were enrolled. The intervention and control groups comprised 32 and 27 adolescents, respectively, with mean ages of 15 and 13 years, respectively. A total of 19 and 15 participants were male in the intervention and control groups, respectively. Compared with the control group, the N²-GBI group showed significantly greater improvement in transition readiness at T1 (β = 8.83, p < 0.001) and T2 (β = 7.97, p = 0.001). The N²-GBI programme also significantly reduced cancer worry (p = 0.009) and increased patient activation (p = 0.001), but had no significant effect on transition expectation (p = 0.056).</p><p><strong>Conclusions: </strong>The N²-GBI programme improved transition readiness, reduced cancer worry, and increased patient activation among adolescents with osteosarcoma, but did not significantly improve transition expectation. This intervention may be a useful nurse-led approach to transition preparation in pediatric oncology care. Future studies with larger sample sizes and prolonged follow-up durations are needed.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"35 9","pages":"e70591"},"PeriodicalIF":3.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13537029/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148875850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Young Women With Pancreatic Cancer: A High-Risk Group for Demoralization.","authors":"Abrahm Levi, Aryan Nasr, Yujie Cui, Anser A Abbas, Tara T Arouchian, Andrew L Coveler, Tracey L Pierce, Brian T Anderson, Eric Collisson, John Davelaar, Simon K Lo, Srinivas Gaddam, Jun Gong, Arsen Osipov, Andrew E Hendifar","doi":"10.1002/pon.70601","DOIUrl":"10.1002/pon.70601","url":null,"abstract":"<p><strong>Background: </strong>Demoralization is a maladaptive coping response to stressful situations, characterized by thoughts of hopelessness, helplessness, and loss of meaning and purpose. Demoralization is clinically measurable using the Demoralization Scale 2 (DS-II). Pancreatic cancer (PC) patients, who carry a notoriously poor prognosis, are hypothesized to be at higher risk of demoralization.</p><p><strong>Aims: </strong>This study uses the DS-II to gauge the impact of demoralization in PC patients compared to a heterogenous cancer population and establish its relation to depression.</p><p><strong>Methods: </strong>Patients completed the DS-II, PHQ-9, and a demographic survey. The mean DS-II score of PC patients was compared with that of a previously published heterogenous cancer cohort reported by Ignatius et al. using a one-sample t-test. The univariable association between DS-II scores and PHQ-9 scores was examined using linear regression models.</p><p><strong>Results: </strong>Of the 206 patients enrolled in the study, 47% were women and the mean age was 67 ± 10 years. The mean DS-II total score was 4.9 ± 5.2 points, significantly lower than the mean of 10.8 ± 8.0 previously reported by Ignatius and De La Garza II in a psychiatric oncology cohort (p < 0.001). There was no significant difference in demoralization scores across disease stages (p = 0.8). DS-II scores in univariable models were associated with depression (β = 0.79, p < 0.001), age (β = -0.09, p = 0.008), and women (p = 0.002).</p><p><strong>Conclusion: </strong>Demoralization in this cohort of patients with PC was lower than that reported by Ignatius et al., although differences in recruitment settings and patient characteristics limit direct comparisons. Though disease stage did not impact demoralization scores in PC, our study found demoralization was strongly associated with concurrent depression, young age, and women. Understanding the risk factors associated with demoralization in PC can help enhance the quality of psychosocial care in oncology.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"35 9","pages":"e70601"},"PeriodicalIF":3.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13557214/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148920926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Equipercentile Equating of Scores From Common Patient-Reported Outcome Measures of Role, Social, and Emotional Functioning in Patients With Cancer.","authors":"M Rothmund-Grenier, J M Pilz, L Schlosser, J I Arraras, M Groenvold, B Holzner, M Van Leeuwen, M A Petersen, H Schmidt, T Young, M Rose, D Cella, J M Giesinger","doi":"10.1002/pon.70595","DOIUrl":"10.1002/pon.70595","url":null,"abstract":"<p><strong>Background: </strong>Patient-reported outcome measures (PROMs) are fundamental in evaluating cancer treatments within clinical research and practice. The existence of various PROMs that assess similar health domains presents challenges for comparing or aggregating study results and data. Score linking is a well-established method for addressing this issue by converting scores from the metric of one PROM to another.</p><p><strong>Aims: </strong>To provide equipercentile equating of psychosocial scales from commonly used PROMs in cancer patients to facilitate data pooling and comparisons.</p><p><strong>Methods: </strong>Cancer patients with diverse diagnoses from five European countries completed the EORTC CAT Core, EORTC QLQ-C30, FACT-G, SF-36, and HADS Emotional, Role, and Social functioning (EF; RF; SF) scales. For scales with Spearman correlations exceeding 0.70, scores were linked using equipercentile equating as provided by the R package \"equate\". To evaluate linking precision, Standardized Mean Absolute Errors (SMAEs) were calculated.</p><p><strong>Results: </strong>A total of 945 cancer patients were included in the analysis (mean age 58.4 years; 54.7% male). Bidirectional conversion tables were established for three pairs of SF/RF scales and 10 pairs of EF scales. Overall, linking was possible for most scales from the EORTC Measures, SF-36, and HADS, whereas the FACT-G allowed linking only for its Emotional Well-Being (EWB) scale.</p><p><strong>Conclusions: </strong>The findings suggest greater linking ability for EF scales compared to RF and SF scales, which seem to be more heterogeneous in terms of content. The established crosswalks support the combined evaluation of data from different PROMs.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"35 9","pages":"e70595"},"PeriodicalIF":3.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13545499/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148892297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Mechanisms to Manifestations: A Scoping Review Exploring Cancer-Related Discrimination.","authors":"Oluwaseyifunmi Andi Agbejule, Fiona Crawford-Williams, Ria Joseph, Kim Hobbs, Carla Thamm, Sue Woodall, Ashleigh R Sharman, Joe Wing Pun, Monique Bareham, Jenny Richards, James Scheibner, Catherine Paterson, Raymond J Chan","doi":"10.1002/pon.70614","DOIUrl":"10.1002/pon.70614","url":null,"abstract":"<p><strong>Objective: </strong>This scoping review examines the available qualitative evidence from systematic and scoping reviews, and mixed-methods or qualitative studies on cancer-related discrimination.</p><p><strong>Methods: </strong>Cancer-related discrimination was defined as direct and recurring experiences of enacted stigma, behaviours, or unfair treatment based on an individual's cancer history, current cancer diagnosis, perceived cancer risk, or cancer caregiving role. A systematic search of ProQuest databases, Cochrane CENTRAL, Scopus, APA PsycINFO, MEDLINE, and Web of Science identified peer-reviewed research published before December 13, 2025. Two independent reviewers screened studies, and data were narratively synthesised using the Health Stigma and Discrimination Framework (i.e., drivers and system-level facilitators; discrimination experiences; impacts).</p><p><strong>Results: </strong>In total, 116 studies met inclusion criteria, comprising 83 qualitative studies, 23 mixed-method, nine systematic reviews, and one scoping review. Cancer-related discrimination was reported across four contexts: (1) familial and social; (2) hiring and workplace; (3) insurance and welfare; and (4) healthcare. Discrimination drivers included misconceptions that cancer is contagious, employer concerns about productivity and costs, rigid welfare regulations, and reduced public empathy for cancers perceived as 'self-inflicted'. Reported experiences ranged from social exclusion and bullying, to workplace dismissals, job rejections, and barriers to insurance or financial support. In healthcare contexts, provider blame, judgement, and strained patient-clinician interactions were reported. Impacts of discrimination included self-isolation, concealment of diagnosis, internalised stigma, psychological distress, financial burden, and delayed treatment-seeking.</p><p><strong>Conclusions: </strong>Cancer-related discrimination arises from cultural, institutional, and structural mechanisms, with significant impacts on quality of life and health. Coordinated policy, legal, institutional, and public education responses are required to address these challenges.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"35 9","pages":"e70614"},"PeriodicalIF":3.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13618453/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149070163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping Psychosocial Determinants for Cancer Onset: An Umbrella Review.","authors":"M Masiero, E Tomezzoli, C Marzorati, G Pagani, R Pietrobon, S Mattioli, L Teixeira, P Dorangricchia, M Serra-Blasco, A García-Serra, C Ochoa-Arnedo, D Monzani, B Caci, G Miale, G Pravettoni","doi":"10.1002/pon.70597","DOIUrl":"10.1002/pon.70597","url":null,"abstract":"<p><strong>Background: </strong>Despite the growing body of literature suggesting that psychosocial factors contribute to cancer susceptibility, the existing evidence remains heterogeneous, and it is unclear which domains show the most consistent associations. Systematically mapping this literature helps inform the integration of psychosocial factors into cancer risk assessment and management frameworks, alongside behavioural risk factors.</p><p><strong>Methods: </strong>To synthesise existing evidence on psychosocial factors associated with cancer onset, we conducted an umbrella review within the EU-funded iBeChange project (ID:101136840). Following Joanna Briggs Institute (JBI) methodology, PRISMA 2020 and SWiM guidelines, we included systematic reviews and meta-analyses examining psychosocial exposures in relation to cancer risk or incidence. Searches were conducted in PubMed, Embase, and Scopus, and methodological quality was assessed using ROBIS.</p><p><strong>Results: </strong>Forty-one reviews were included. Across psychosocial domains, the consistency of evidence varied considerably. Depression showed the most robust low-risk-of-bias evidence, particularly for lung and overall cancer risk. Adverse childhood experiences showed high concordance across reviews with a dose-response gradient, though all reviews were rated at high risk of bias. Urbanicity, composite socioeconomic status, and anxiety showed moderate or variable patterns, while stressful life events, socioeconomic indicators, and coping strategies were characterised by low consistency and very high heterogeneity. Evidence for psychiatric diagnoses and psychological distress was limited to single reviews. Approximately one third of the included reviews were rated at low risk of bias.</p><p><strong>Conclusions: </strong>This umbrella review identifies psychosocial domains that should be considered in relation to cancer risk, providing a foundation for expanding prevention models beyond traditional behavioural risk factors towards multidimensional, psychosocially informed approaches. Lower-consistency domains should not be prematurely dismissed, as current evidence gaps may reflect methodological limitations rather than true absence of effect. Further high-quality longitudinal studies are needed to clarify underlying mechanisms and support the integration of psychosocial factors into cancer prevention strategies.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"35 9","pages":"e70597"},"PeriodicalIF":3.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13570670/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148956389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}