Psycho‐Oncology最新文献

{"title":"Correction to \"Exploring Hmong Shamans' Beliefs on Cancer\".","authors":"","doi":"10.1002/pon.70612","DOIUrl":"https://doi.org/10.1002/pon.70612","url":null,"abstract":"","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"35 9","pages":"e70612"},"PeriodicalIF":3.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148991232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effectiveness of a 6-Week Online Mindfulness-Based Intervention on Patients With Cervical Cancer or High-Grade Squamous Intraepithelial Lesion: A Randomized Controlled Trial Using Multimodal Data of Scales and Electroencephalogram.","authors":"Shu Jing, Zhenwei Dai, Xuelin Yang, You Xin, Rui Sun, Jing Wu, Yueyun Wang, Disi A, Xiaoyou Su","doi":"10.1002/pon.70610","DOIUrl":"10.1002/pon.70610","url":null,"abstract":"<p><strong>Background: </strong>Patients with cervical cancer or High-Grade Squamous Intraepithelial Lesion (HSIL) often experience mental problems such as anxiety and depression. Online mindfulness-based interventions offer accessible mental health support. However, evidence for cervical cancer or HSIL patients remains scarce, and evaluations often rely solely on self-reported scales, with a lack of neurophysiological assessments. This study aimed to assess the effectiveness of a 6-week online mindfulness-based intervention on mental health outcomes in this population by using scales, with exploratory frontal electroencephalogram (EEG) biomarkers as supplementary neurophysiological indicators.</p><p><strong>Methods: </strong>A single-center randomized controlled trial enrolling 151 cervical cancer or HSIL patients was conducted. The intervention group received a 6-week online mindfulness-based intervention, while the control group received general mental health education. Primary outcomes were depressive and anxiety symptoms assessed by validated scales. Frontal EEG metrics were collected as exploratory supplementary neurophysiological indicators. Assessments were conducted at baseline and post-intervention. Independent samples t-tests and Mann-Whitney U tests were used for intergroup comparisons, with Benjamini-Hochberg FDR correction applied to control for multiple testing.</p><p><strong>Results: </strong>A total of 149 patients completed the study. After the intervention, the intervention showed significantly lower symptoms of depression (t = 12.238, FDR-q < 0.001), anxiety (t = 11.150, FDR-q < 0.001), and higher levels of resilience, mindfulness, and perceived social support than the control group. Exploratory EEG analysis revealed that the intervention group exhibited higher relative theta and alpha power, higher time-domain standard deviation, and lower relative beta and gamma power than the control group.</p><p><strong>Conclusion: </strong>This study demonstrates that a 6-week online mindfulness-based intervention effectively alleviates depressive and anxiety symptoms among patients with cervical cancer or HSIL. Exploratory EEG findings provide preliminary neurophysiological support for these psychological benefits, though further validation with larger samples is warranted.</p><p><strong>Trial registration: </strong>The trial was prospectively registered on the Chinese Clinical Trial Registry (ID: ChiCTR2400087926, https://www.chictr.org.cn/) on August 07, 2024.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"35 9","pages":"e70610"},"PeriodicalIF":3.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149064220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Trial Perceptions Among Patients Enrolled in a Precision Oncology Protocol at an Appalachian-Serving Cancer Center.","authors":"Jerod L Stapleton, Allison Leip, Aurora Occa, Jill Kolesar, Elizabeth Belcher, Caitlin Deffendall, Taylor J Webb, Michael J Cavnar","doi":"10.1002/pon.70607","DOIUrl":"10.1002/pon.70607","url":null,"abstract":"<p><strong>Objective: </strong>Low rates of clinical trial participation, with notable disparities among rural populations, slow cancer treatment advances. Precision oncology protocols are designed to alleviate trial access barriers by consenting patients to sequencing with results matched to national databases of available trials. Precision oncology protocols represent a potential avenue for supporting patient informed trial decision-making before they are offered a specific trial but little is known about clinical trial perceptions and intentions of patients who join such protocols.</p><p><strong>Methods: </strong>We administered surveys to 116 patients with a cancer diagnosis enrolled in a precision oncology protocol at an Appalachia-serving, academic cancer center. Analyses tested associations between clinical trial perceptions (e.g., beliefs, attitudes, knowledge), sociodemographic covariates, and trial intentions.</p><p><strong>Results: </strong>Participants (mean age = 64.5; median education = high school; 97.4% white; 51.7% female; 60% Appalachian residence) held overall favorable clinical trial perceptions and overall positive intentions. Trial knowledge was significantly lower among participants with lower education, lower income, and those residing in Appalachian counties. Intentions were significantly associated with attitudes, beliefs around trying new treatments, and perceived family support for trial participation in both bivariate and multivariate regression analyses.</p><p><strong>Conclusions: </strong>This study contributes to the literature by describing clinical trial perceptions among patients in a precision oncology prospective cohort from a cancer center that serves a predominately white, Appalachian population. Addressing patients' perceptions and concerns related to trials and involving family or support networks in the decision making process is likely to be a key element of supporting informed patient decision-making for future trial opportunities.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"35 9","pages":"e70607"},"PeriodicalIF":3.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13580100/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148977787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Family Bonds at the End of Life: A Qualitative Study of Meaning Reconstruction Through Intergenerational Relationships Among Older Adults With Advanced Lung Cancer.","authors":"Qianyun Jiang, Jieru Yu, Chen Shen, Lingling Pan, Yumei Li","doi":"10.1002/pon.70602","DOIUrl":"10.1002/pon.70602","url":null,"abstract":"<p><strong>Background: </strong>Older adults with advanced lung cancer often face physical decline, changes in family roles, and existential distress, which may prompt their exploration of meaning in life. In the context of China's family-oriented culture, intergenerational relationships may play an important role in patients' meaning-making processes. Therefore, an in-depth exploration is needed to understand how older adults with advanced lung cancer construct meaning in life through intergenerational interactions with their children.</p><p><strong>Objective: </strong>This study aimed to explore the lived experiences of older adults with advanced lung cancer as they reconstruct meaning in life through intergenerational interactions and to understand the underlying psychosocial processes.</p><p><strong>Methods: </strong>This study used a descriptive phenomenological research design. Purposive sampling was used to recruit older adults with advanced lung cancer who were hospitalized in the Oncology Department of a tertiary Grade A hospital in Shanghai, China, from June through September 2025. Semi-structured interviews were conducted, and Colaizzi's phenomenological method was used to analyze the interview data and identify themes.</p><p><strong>Results: </strong>A total of 17 older adults with advanced lung cancer were interviewed, with a mean age of 69 years. Three themes were identified: (1) Triggers for the Search for Meaning in Life, comprising two subthemes: The Disruption of Established Life Routines and Existential Confusion; (2) Redefining Values in Relationships, comprising four subthemes: The Redefinition of Family Roles, The Psychological Tension Between Dependence and Self-Respect, Regaining Dignity and Worth Through Giving, and The Two-Way Experience of Giving and Receiving love; and (3) Integrating Meaning in Life, comprising two subthemes: Life Education Through Leading by Example, and The Continuation of the Spirit and the Passing Down of Responsibility.</p><p><strong>Conclusion: </strong>Meaning reconstruction among older adults with advanced lung cancer is not solely an individual psychological process but is continuously shaped and developed through intergenerational interactions. Family relationships provide not only emotional and caregiving support but also important psychological resources for maintaining patients' identity, dignity, and sense of continuity. In clinical practice, greater attention should be paid to family-centered psychosocial support to facilitate patients' meaningful role engagement and sense of value within intergenerational relationships and support positive psychological adaptation during the end-of-life stage.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"35 9","pages":"e70602"},"PeriodicalIF":3.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13575428/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148970855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Resilient Caregivers\"-A Randomized Trial of a Resilience-Based Intervention for Psychologically Distressed Partner Caregivers of Patients With Cancer.","authors":"Beverley Lim Høeg, Peter Genter, Camilla Jensen Hamre, Susanne Rosthøj, Lise Stampe Møller-Jørgensen, Susanne Oksbjerg Dalton, Pernille Envold Bidstrup","doi":"10.1002/pon.70603","DOIUrl":"10.1002/pon.70603","url":null,"abstract":"<p><strong>Background: </strong>Intimate partners of cancer patients often experience significant distress. We examined the effectiveness of the \"Resilient Caregivers\" group intervention for improving psychological outcomes among distressed partner caregivers in a randomized trial (Clinicaltrials.gov ID: NCT04610034).</p><p><strong>Methods: </strong>Participants were recruited through an oncology department and two cancer counseling centers in Denmark. Partners of patients receiving cancer treatment and experiencing distress (> 4 on the distress thermometer) were eligible and randomized 1:1 to either the intervention or usual care, stratified by sex and age (≤/> 50 years). \"Resilient Caregivers\" consists of seven manualized sessions developed according to a resilience framework focusing on meta-reflective skills, coping strategies and values clarification in relation to being a partner of a patient with cancer. Participants completed questionnaires at baseline, 3-, 6- and 12-months assessing anxiety (primary outcome) and depression, distress, stress, resilience, quality of life and sleep quality. Intervention effects were analyzed using mixed models for repeated measures.</p><p><strong>Results: </strong>Between April 2021 and May 2023, 79 partners were included (39 intervention, 40 control). Most were female (74%), above 50 years old (80%) and had at least a bachelor's degree (86%). There were significant improvements in anxiety at 12 months (mean difference: -2.5, 95% confidence interval: -4.6 to -0.4, p = 0.018), and depression and quality of life at 3 months. Between-group differences were not significant for other outcomes. Satisfaction was high and participants valued the group format.</p><p><strong>Conclusions: </strong>\"Resilient Caregivers\" showed encouraging findings and may be a potentially cost-effective approach to providing support to partner caregivers.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"35 9","pages":"e70603"},"PeriodicalIF":3.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13580108/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148977807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychological Readiness for Surgery Through Prehabilitation and Treatment: A Longitudinal Qualitative Study.","authors":"Aniqa Hussain, Thomas Schroder, Mike Rennoldson, Michael Baliousis","doi":"10.1002/pon.70594","DOIUrl":"10.1002/pon.70594","url":null,"abstract":"<p><strong>Background: </strong>Psychological prehabilitation aims to prepare patients for cancer treatment, yet psychological readiness is under-specified and distress during and after treatment is common. A patient-informed account of readiness is needed to guide readiness-focused, proactive psychological support in cancer care.</p><p><strong>Aims: </strong>To examine patients' experiences of psychological readiness for cancer surgery across the prehabilitation-treatment pathway.</p><p><strong>Methods: </strong>We used a longitudinal qualitative design. Ten adults enroled in a tertiary cancer prehabilitation service for major elective surgery completed semi-structured interviews before surgery (T1) and after surgery (T2). We analysed data using Reflexive Thematic Analysis with an inductive, semantic approach, and compared change and stability across time points using a longitudinal analytic matrix.</p><p><strong>Results: </strong>Participants described psychological readiness as developing a future-focused \"mindset to have surgery\", comprising three interrelated elements that were stable from T1 to T2: confidence, motivation, and contained anxiety, that is, anxiety that remained expected and manageable rather than absent or overwhelming. Three processes shaped this mindset. Reliable and complete information from professionals and credible peers supported clearer and more concrete expectations, increased confidence, and helped keep anxiety manageable. Participants preferred candid information about plausible difficulties over reassurance that downplayed them. Reciprocal support from family, peers, and professionals strengthened motivation and reduced loneliness. Readiness could be held back when participants found it difficult to tell loved ones about their diagnosis. Agency developed through drawing on personal resources and taking controllable steps, including making progress visible through prehabilitation activity and staff encouragement.</p><p><strong>Conclusions: </strong>These findings identify provisional, patient-informed targets for psychological preparation within multimodal prehabilitation. They provide a foundation to operationalise and measure readiness and, following work on transferability, co-production and feasibility, to test whether readiness-focused support in prehabilitation is associated with post-operative adjustment.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"35 9","pages":"e70594"},"PeriodicalIF":3.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13525233/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148851440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Effects of Various Delivery Methods of Cognitive Behavioral Therapy for Insomnia Among Patients With Cancers: Systematic Review and Network Meta-Analysis.","authors":"Chen-I Lee, Muhammad Amirul Mukminin, Ya-Wen Jan, Tzu-Hao Wang, Tsai-Wei Huang, Hsiao-Yean Chiu","doi":"10.1002/pon.70593","DOIUrl":"10.1002/pon.70593","url":null,"abstract":"<p><strong>Background: </strong>Insomnia affects 30%-60% of cancer survivors, with around 20% meeting criteria for insomnia disorder. Cognitive behavioral therapy for insomnia (CBTi) is the first-line treatment, but access is limited by cost and therapist availability, prompting exploration of alternative delivery modes, including digital interventions.</p><p><strong>Purpose: </strong>To systematically review and conduct a network meta-analysis (NMA) of the efficacy of different CBTi delivery methods for managing insomnia in cancer survivors.</p><p><strong>Methods: </strong>The PubMed, Embase, CINAHL and Cochrane Library were searched for relevant articles published before September 25, 2025. Only randomized controlled trials of adult cancer patients evaluating the effects of any CBTi delivery mode on subjective sleep outcomes were included. Primary outcome was insomnia severity index (ISI) score; secondary outcomes included sleep onset latency (SOL), wake after sleep onset (WASO), total sleep time (TST), and sleep efficiency (SE). A frequentist random-effects NMA was conducted.</p><p><strong>Results: </strong>Twenty-two trials involving 2040 participants were included. Compared with treatment as usual (TAU), digital CBTi (dCBTi) demonstrated the largest reduction in ISI scores (MD = -9.70, 95% CI = -10.80 to -8.61), followed by telephone CBTi (MD = -8.74). dCBTi also significantly improved SOL (-30.95 min), WASO (-25.62 min), TST (+31.67 min), and SE (+14.63%). Group CBTi significantly improved SOL (-11.60 min) and WASO (-22.03 min). Meta-regression analyses identified breast cancer diagnosis as a significant moderator of dCBTi effects on SOL (coefficient = 25.20, p = 0.015) and SE (coefficient = -16.17, p = 0.007). The certainty of evidence ranged from low to very low, primarily because of imprecision and network incoherence.</p><p><strong>Conclusions: </strong>dCBTi demonstrated the greatest potential for improving insomnia outcomes among the evaluated CBTi delivery modalities. However, given the low certainty of evidence and the presence of network inconsistency for selected outcomes, these findings should be interpreted cautiously. High-quality head-to-head trials are needed to confirm the comparative effectiveness of different CBTi delivery modalities in oncology populations.</p><p><strong>Trial registration: </strong>The study protocol was prospectively registered on PROSPERO (registration no. CRD42023429081).</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"35 9","pages":"e70593"},"PeriodicalIF":3.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13527890/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148866736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Referral and Utilization of Mental Health Services by Older Adults With Cancer and Factors Influencing Referral From Health Professionals.","authors":"Shuman Wang, Maria Ftanou, Lauren Pearson, Chloe Nicholas, Kylie King, Joshua F Wiley","doi":"10.1002/pon.70573","DOIUrl":"10.1002/pon.70573","url":null,"abstract":"<p><strong>Objective: </strong>Older adults with cancer commonly experience psychological distress. However, the rate at which they receive mental health services is low, and reasons are inconsistently documented. This study aims to characterize adults with cancer referred to mental health services, explore how age influences referrals, and examine factors influencing healthcare professionals' referrals within the Capability, Opportunity, Motivation, and Behavior (COM-B) model.</p><p><strong>Methods: </strong>We retrospectively collected data from 557 adults with cancer referred to the Clinical Psychology Department at Peter MacCallum Cancer Center in Melbourne, including demographics, clinical details, and referral information. Additionally, we surveyed 18 healthcare professionals using the General Help-Seeking Questionnaire, the Gatekeeper Behavior Scale, Mental Health Literacy Scale, and Attitude Questions, which assessed capability (e.g., knowledge), opportunity (e.g., resources), and motivation (e.g., beliefs) in the COM-B model.</p><p><strong>Results: </strong>Adults < 65 were more likely to be referred to mental health services than those ≥ 65 (p < 0.001), but among those referred there was no significant difference in referral acceptance/uptake rates (p = 0.25). Adults < 65 are more likely to be referred for adjustment reasons compared to those ≥ 65 (p < 0.05). Healthcare professionals endorse opportunity and motivation factors more when referring adults ≥ 65, but capability factors are a bigger barrier, with fewer than 60% of professionals endorsing nearly half of the capability items.</p><p><strong>Conclusions: </strong>Older adults with cancer may face inequities in mental health service referrals, but those referred were equally willing to engage. Capability factors present the greatest barrier for professionals referring for mental health, highlighting the need for training.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"35 9","pages":"e70573"},"PeriodicalIF":3.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13586635/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148991237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of Interest-Holder Perspectives Toward Post-Mortem Tissue Donation in Oncology: A Systematic Review.","authors":"Kaatje Goossens, Anaïs Anthierens, Caro Monteny, Catherine Dilewyns, Christine Desmedt, Hans Wildiers, Pascal Borry","doi":"10.1002/pon.70571","DOIUrl":"10.1002/pon.70571","url":null,"abstract":"<p><strong>Objective: </strong>Post-mortem tissue donation (PTD) is increasingly recognised as an important resource for advancing cancer research. Developing effective recruitment strategies for PTD programs requires a thorough understanding of interest-holder perspectives, which remain insufficiently explored. This systematic review examined factors influencing patients' willingness to participate in PTD, next-of-kin's willingness to support their relative's participation, and healthcare professionals willingness to recruit for PTD programs.</p><p><strong>Methods: </strong>A systematic literature search was conducted on 19 February 2026 to identify original research studies exploring self-reported factors influencing perspectives toward PTD. Study selection, data extraction, and quality appraisal were performed independently by four reviewers. Identified factors were synthesised and categorised into five domains: ethical/existential, emotional, practical, socio-demographic/socio-economic, and disease-related.</p><p><strong>Results: </strong>Fourteen studies were included from 11,986 records screened. Overall, attitudes toward PTD were generally favourable across interest-holders. Ethical, existential and emotional considerations, particularly altruism, reciprocity and the perceived impact on the patient-clinician relationship were associated with willingness to participate in, (support) consent to, or recruit for PTD. Reported barriers were predominantly practical, including logistical challenges, concerns regarding funeral arrangements, and limited knowledge of PTD procedures. Healthcare professionals additionally identified discomfort with end-of-life discussions and uncertainty about PTD processes as barriers to recruitment. Socio-demographic, socio-economic, and disease-related factors were reported inconsistently, with no clear pattern of association.</p><p><strong>Conclusions: </strong>Interest-holder attitudes toward PTD are primarily shaped by ethical, emotional, and practical considerations. The consistency of findings across interest-holder groups and cancer types supports the development of patient-centred communication strategies to facilitate the implementation of PTD programs.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"35 8","pages":"e70571"},"PeriodicalIF":3.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13453286/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148702197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Distress Thermometer in Pelvic Exenteration: Responsiveness-To-Change, Convergent Validity, and Clinical Cutoff.","authors":"Nicholas Melander, Claudia Rutherford, Daniel Steffens, Judith Fethney, Sascha Karunaratne, Kate Alexander, Cherry Koh, Michael Solomon, Bora Kim","doi":"10.1002/pon.70565","DOIUrl":"10.1002/pon.70565","url":null,"abstract":"<p><strong>Background: </strong>Pelvic exenteration (PE) is a radical surgery for advanced pelvic malignancies that carries substantial psychosocial impacts. Assessing distress is critical for timely support.</p><p><strong>Aims: </strong>To evaluate the responsiveness-to-change and convergent validity of the distress thermometer (DT), and to determine an optimal cutoff score for detecting clinically significant distress in a PE cohort.</p><p><strong>Methods: </strong>Secondary analyses of cohort study data involving adult patients who underwent PE at a quaternary referral hospital. Responsiveness was evaluated by determining whether the DT differentiated cases of decreased emotional well-being and health-related quality of life from pre- to post-surgery, using the Functional Assessment of Cancer Therapy-General (FACT-G), FACT-Colorectal, and Emotional Well-Being (EWB) subscale as external criteria. Convergent validity was evaluated using the correlation between the DT and the EWB subscale scores. Cutoff scores were examined by reviewing the following indices, using an existing EWB cutoff as an external anchor: sensitivity, specificity, positive/negative predictive values, and clinical utility index (CUI).</p><p><strong>Results: </strong>The analysis included 377 patients (mean age: 61 years, 56% male; 41% recurrent rectal cancer). The DT demonstrated responsiveness, with AUCs > 0.7 for detecting emotional and quality-of-life decline post-surgery. Convergent validity was demonstrated through a moderate correlation between the DT and the EWB subscale scores (r_s = -0.56, p < 0.001). The optimal DT cutoff score was 4: Sensitivity; 87.0%, Specificity; 52.7%, CUI- value; 0.49 (ruling out cases: satisfactory utility), CUI+ value; 0.33 (case finding: poor utility).</p><p><strong>Conclusion: </strong>The DT is a valid and responsive tool for detecting psychological distress in PE patients. Its high sensitivity supports its use in routine screening.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"35 8","pages":"e70565"},"PeriodicalIF":3.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13474108/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148761374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}