Psycho‐Oncology最新文献

{"title":"Cognitive Behavioral Therapy for Cancer-Related Fatigue: A Comparison Between Patients Treated With Curative Intent and Patients With Advanced Cancer.","authors":"Hannah B van der Pas, Annemarie M J Braamse, Gijs Bleijenberg, Hanneke W M van Laarhoven, Pythia Nieuwkerk, Harm Westdorp, Lia van Zuylen, Fabiola Müller, Hans Knoop","doi":"10.1002/pon.70282","DOIUrl":"10.1002/pon.70282","url":null,"abstract":"<p><strong>Background: </strong>Cancer-related fatigue (CRF) is prevalent in patients who have been treated with curative intent and patients with advanced cancer. Cognitive behavioral therapy (CBT) has been shown effective in reducing CRF in both groups.</p><p><strong>Aims: </strong>To compare both groups with respect to: (1) pre-treatment levels of fatigue and fatigue-perpetuating cognitive-behavioral factors; (2) the magnitude of the effect of CBT on fatigue; and (3) mediators of the treatment response.</p><p><strong>Methods: </strong>Data of four randomized controlled trials testing the efficacy of CBT for CRF were pooled, three in patients treated with curative intent (n = 249), and one in patients with advanced cancer (n = 134). Baseline characteristics were compared with ANCOVAs. Moderation analysis was used to investigate whether the treatment effect differed between groups. With moderated mediation analyses differences in the mechanisms by which CBT reduces fatigue were evaluated.</p><p><strong>Results: </strong>The two groups differed significantly at baseline on fatigue-perpetuating factors, but not on fatigue severity. Patients with advanced cancer reported a smaller decrease in fatigue severity following CBT than patients treated with curative intent (p = 0.022). The multivariate moderated mediation analysis showed a larger decrease in fatigue catastrophizing in patients treated with curative intent than in patients with advanced cancer.</p><p><strong>Conclusion: </strong>CBT for CRF has less effect on catastrophizing, a known fatigue-perpetuating factor and mediator of the effect of CBT, and fatigue severity in patients with advanced cancer. Further research has to determine if the effectiveness of CBT for CRF in advanced cancer patients can be improved.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"34 9","pages":"e70282"},"PeriodicalIF":3.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449572/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Living With Advanced Pancreatic Cancer: Patients' Experiences of Daily Life.","authors":"Jenny Bergqvist, Johanna Hök Nordberg, Kathrin Wode, Berit Sunde, Per Fransson, Britt-Marie Bernhardson","doi":"10.1002/pon.70260","DOIUrl":"10.1002/pon.70260","url":null,"abstract":"<p><strong>Background: </strong>Pancreatic cancer is often diagnosed in late stages of the disease with only a 10% 5-year survival. The disease is associated with complex symptoms and psychological distress.</p><p><strong>Aims: </strong>The specific objective of this qualitative study was to explore patients' experiences of what symptoms and distress that had impact on their everyday life.</p><p><strong>Methods: </strong>We interviewed 31 patients with advanced pancreatic cancer nested within a randomized controlled study, called MISTRAL, about their everyday life using a semi structured interview guide. For data analysis we used interpretive description as described by S. Thorne to capture the subjective experiences of a population with the intention of improving clinical practice.</p><p><strong>Results: </strong>Three themes were identified from the interviews: \"Unpredictability\", \"Psychological and social distress\" and \"Strategies for hope and normalization\". Unpredictable and highly fluctuating levels of energy as well as psychological and social distress were reported as major concerns. Participants tried to normalize everyday life to maintain hope and cope with the situation.</p><p><strong>Conclusions: </strong>Unpredictable and highly fluctuating levels of energy and major psychological and social distress impact on patients' ability to cope with symptoms and treatment. Patient-centered care with interventions to reduce distress is important to improve quality of life among patients with advanced pancreatic cancer.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"34 9","pages":"e70260"},"PeriodicalIF":3.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12408248/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144993208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Dyadic Experience of a New Breast Cancer Diagnosis Into the Shared Decision-Making Process: A Qualitative Analysis.","authors":"Clizia Cincidda, Serena Oliveri, Valeria Sebri, Gabriella Pravettoni","doi":"10.1002/pon.70277","DOIUrl":"https://doi.org/10.1002/pon.70277","url":null,"abstract":"<p><strong>Objective: </strong>This study explores the dyadic experience of patients newly diagnosed with breast cancer and their caregivers, focusing on emotional responses, informational needs, and shared involvement in clinical decision-making.</p><p><strong>Methods: </strong>Twenty-three patient-caregiver dyads participated in semi-structured interviews conducted by psychologists specializing in clinical and health psychology. The interviews were analyzed using Qualitative Thematic Analysis to identify core themes reflecting the dyadic experience.</p><p><strong>Results: </strong>Findings highlighted the central role of the patient-caregiver relationship in coping with diagnosis and treatment planning. Both patients and caregivers valued sharing medical information, participating together in medical consultation and jointly engaging in treatment decisions, which fostered a sense of unity, reduced anxiety and improved understanding of treatment choice. Trust in healthcare providers, particularly their clarity, empathy, and expertise, emerged as a critical factor in alleviating patients' decisional regret and sustaining caregivers' confidence in supporting the patient. Although both patients and caregivers faced emotional challenges, their fears and concerns often differed, underscoring the need for individualized emotional support. Inclusion of caregivers in clinical discussions was considered essential for promoting a cohesive and supportive care experience.</p><p><strong>Conclusions: </strong>The study underscores the emotional complexity and interdependence of the patient-caregiver dynamic following a breast cancer diagnosis. Being the patient-caregiver relationship central to cancer care, it is important to encourage coordinated involvement of both parties in the clinical process may reduce psychological distress, alleviate decisional conflict, and enhance overall quality of life. These findings support the adoption of a person-centered, relational model of care that recognizes the dyad as a unit of support and decision-making.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"34 9","pages":"e70277"},"PeriodicalIF":3.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12398323/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144966359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Supportive Care Needs From Mid-to Long-Term Follow-Up Among Head and Neck Cancer Survivors: A Longitudinal Cohort Study.","authors":"Femke Jansen, Dominique Molenaar, Öykü Zarsat, Birgit I Lissenberg-Witte, Robert P Takes, Remco de Bree, Johannes A Langendijk, Jose A Hardillo, Femke Lamers, C René Leemans, Irma M Verdonck-de Leeuw","doi":"10.1002/pon.70276","DOIUrl":"10.1002/pon.70276","url":null,"abstract":"<p><strong>Background: </strong>There is limited knowledge on the supportive care needs (SCNs) of head and neck cancer (HNC) survivors during long-term survivorship.</p><p><strong>Aims: </strong>To investigate SCNs from 2 to 5 years after treatment among HNC survivors, and its association with demographic, personal, clinical, physical, psychological, social and lifestyle, and cancer-related quality of life factors.</p><p><strong>Methods: </strong>SCNs were measured at 2, 3, 4 and 5 years using the supportive care needs survey (SCNS-SF34 and SCNS-HNC) in 403 HNC survivors. Linear mixed model analyses were performed to investigate changes in SCNs (continuous outcome) over time and factors associated with SCNs (continuous). Also, the proportion of unmet moderate-high SCNs (dichotomous) was calculated.</p><p><strong>Results: </strong>SCNs on the health system, information and patient support and lifestyle domain decreased from 2 to 5 years, whereas physical and daily living, psychological, sexuality and HNC-function needs were stable. At 5 years, 33% of HNC survivors had unmet SCNs, in particular lack of energy/tiredness (9.2%) and dry mouth/sticky mucus (8.1%). Demographic (male, higher education), personal (personality, coping, self-efficacy), clinical (advanced tumor stage, tumor recurrence), physical (low handgrip strength), psychological (anxiety, depression, fear of cancer recurrence (FCR)), lifestyle (smoking, drinking, being underweight) and cancer-related factors (lower levels of functioning, lower levels of nausea and vomiting, higher levels of fatigue, constipation, financial, speech, social eating, dry mouth and sexuality problems, and painkiller usage) were associated with SCNs. Specifically FCR and painkillers usage were very consistently associated with higher SCNs.</p><p><strong>Conclusions: </strong>SCNs of HNC survivors decrease over time. A third experiences SCNs at long-term follow-up.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"34 9","pages":"e70276"},"PeriodicalIF":3.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12408419/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144993218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Together and Apart: A Gender-Informed Qualitative Analysis of Childhood Brain Tumour and the Parental Relationship.","authors":"Kate Young, Christina Malatzky, Natalie Bradford","doi":"10.1002/pon.70274","DOIUrl":"https://doi.org/10.1002/pon.70274","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to investigate the gendered impact of childhood cancer on the parental relationship, specifically on the work of parenting together.</p><p><strong>Methods: </strong>Parents/carers of a child diagnosed with a brain tumour and receiving care within a statewide hospital and health service in Australia were invited to participate in semi-structured interviews about their associated experiences. Data were collected from February 2021 to December 2022. Interview transcripts were analysed using reflexive thematic analysis.</p><p><strong>Results: </strong>Twenty-four parents/carers representing diverse socioeconomic backgrounds and brain tumour experiences were interviewed (mothers: n = 22). All parents in a relationship (n = 19) discussed the impact of their child's tumour on their relationship with their co-parent. Gendered patterns were identified in coping styles and family roles; some participants described these as a source of struggle. Mothers were more often reported as doing 'emotion work' for their family; fathers were more often reported engaging in 'emotion-avoidant' coping strategies. Parents consistently spoke of the need to be 'together' in the experience of their child's cancer, though this was rarely elaborated upon.</p><p><strong>Conclusion: </strong>Future research and clinical guidance must apply a gendered lens to highlight the ways that mothers are made responsible for the emotional wellbeing of others and support more equitable divisions for this responsibility, including ensuring fathers receive supportive care outside of the parental relationship amid childhood cancer.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"34 9","pages":"e70274"},"PeriodicalIF":3.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12383243/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144966349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Efficacy of Sub-Anesthesia S-Ketamine on Postoperative Depressive Symptoms in Patients Undergoing Abdominal Tumor Resection: A Randomized Controlled Trial.","authors":"Yi He, Jiaqi Yu, Jin Liu, Jia Cai, Zhi Li, Mingzhe Xu, Qian Li","doi":"10.1002/pon.70265","DOIUrl":"10.1002/pon.70265","url":null,"abstract":"<p><strong>Background: </strong>Cancer patients undergoing major surgery often have perioperative depression symptoms, and are associated with worsened outcomes.</p><p><strong>Aims: </strong>We aimed to evaluate the efficacy of S-ketamine in alleviating depressive symptoms after abdominal Tumor surgery.</p><p><strong>Methods: </strong>A prospective, double-blind, placebo-controlled randomized trial was conducted, enrolling 230 patients with newly screened mild-to-severe depressive symptoms scheduled for abdominal tumor resection. Participants were randomly assigned to receive either 0.4 mg/kg of S-ketamine or normal saline. The primary outcome was the difference in treatment response rates, which defined as a 50% decrease from baseline in Patient Health Questionnaire-9 (PHQ-9) on postoperative day (POD) 1. Secondary outcomes included global quality of recovery (QoR-15) scores and adverse events. Group-based trajectory modeling was used to identify the potential trajectories of depression severity over the postoperative 7-day and the risk factors were also analyzed.</p><p><strong>Results: </strong>On POD 1, the S-ketamine group demonstrated a slightly higher treatment response (odds ratio [OR], 1.4 [95% confidence interval (CI), 0.8 to 2.6], p = 0.017), a reduction in PHQ-9 scores (MD -1.0 [95% CI, -2.0 to 0]; p = 0.002) and higher QoR-15 scores (MD -2.2 [95% CI: -4.3 to -0.7]; p = 0.043). However, the treatment responses, PHQ-9 scores and QoR-15 scores were similar on POD 3 and 7. Adverse events were comparable between the two groups. Additionally, logistic regression did not indicate significant associations between treatment allocation.</p><p><strong>Conclusions: </strong>This study found the effects of sub-anesthesia S-ketamine on depressive symptoms in this patient population postoperatively were limited. The long-term efficacy needs to be explored.</p><p><strong>Trial registration: </strong>Chinese Clinical Trial Registry Identifier: ChiCTR 2200065298.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"34 8","pages":"e70265"},"PeriodicalIF":3.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144883547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychometric Properties of the Fear of Progression Questionnaire for Children in Two German Samples (Acute Treatment and Follow-Up Care).","authors":"Florian Schepper, Anja Santel, Jessy Herrmann, Kristina Herzog, Leonard Konstantin Kulisch, Jörn-Sven Kühl, Julia Martini","doi":"10.1002/pon.70254","DOIUrl":"10.1002/pon.70254","url":null,"abstract":"<p><strong>Background: </strong>Fear of progression (FoP) is among the most prevalent psychosocial burdens in paediatric oncology. Empirical evidence suggests that FoP is particularly pronounced during acute treatment and often persists into follow-up care. It is associated with heightened perception of physical symptoms, increased post-traumatic stress symptoms, more negative illness perceptions, and reduced quality of life (QoL). Consequently, a comprehensive diagnostic instrument is essential to assess FoP in children with cancer.</p><p><strong>Objective: </strong>This study aimed to prospectively validate the German self-report version of the Fear of Progression Questionnaire for Children (FoP-Q-SF/C) aged 7-18 years both during acute treatment and in follow-up care.</p><p><strong>Methods: </strong>A total of 116 children participated in the study, including 39 undergoing acute treatment and 77 in follow-up care. Participants completed the FoP-Q-SF/C. Factor analyses were conducted, and associations between FoP and QoL, illness perceptions, posttraumatic stress symptoms, time since diagnosis, cancer type and treatment modality were examined.</p><p><strong>Results: </strong>All items were applicable in children. The FoP-Q-SF/C demonstrated high internal consistency and good convergent, criterion and divergent validity. Consistent with previous research, factor analysis supported a one-factor structure, although findings suggest potential for structural refinement.</p><p><strong>Conclusions: </strong>The FoP-Q-SF/C is a reliable and valid questionnaire for assessing FoP in children with cancer across different treatment phases. It serves as a valuable screening instrument to identify children at risk for elevated psychosocial distress and to guide targeted psychosocial interventions.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"34 8","pages":"e70254"},"PeriodicalIF":3.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12350204/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144848515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"School Bullying of Childhood Leukemia Survivors.","authors":"Yaacov B Yablon, Sigal Eden, Michal Dayan-Sharabi, Yifat Ezer-Cohen, Dina Mazor-Yehezkel, Moria Charka, Sigal Dahan, Gali Avrahami, Shlomit Barzilai-Birenboim, Gil Gilad, Liron Martin, Irit Schwartz-Attias, Anat Yahel, Shai Izraeli, Naomi Litichever, Sarah Elitzur","doi":"10.1002/pon.70244","DOIUrl":"10.1002/pon.70244","url":null,"abstract":"<p><strong>Background: </strong>With improving childhood cancer cure rates, there is a growing focus on the long-term health and well-being of survivors. School reintegration is crucial for their rehabilitation and psychosocial adaptation, yet little is known about school violence and bullying faced by cancer survivors upon their return.</p><p><strong>Aims: </strong>This study aimed to investigate the prevalence and forms of school bullying against childhood acute lymphoblastic leukemia (ALL) survivors, identifying risk and protective factors.</p><p><strong>Methods: </strong>ALL survivors aged 6-18 years were assessed through interviews and questionnaires. A paired comparison group of healthy students was recruited from their classrooms.</p><p><strong>Results: </strong>The study included 70 students from grades 6-12 (mean age 14.9 ± 1.82 years), comprising 35 ALL survivors and a paired comparison group. ALL survivors endured more physical (M = 1.64, SD = 1.00) and relational bullying (M = 1.50, SD = 1.04) than their healthy classmates (M = 0.90, SD = 0.58; M = 0.90, SD = 0.51 respectively), while facing similar verbal bullying levels (M = 1.71, SD = 0.99 vs. M = 1.38, SD = 0.69). However, survivors reported less cyberbullying (M = 0.45, SD = 0.36) and severe bullying (M = 0.41, SD = 0.05) than their healthy classmates (M = 1.49, SD = 0.48; M = 0.66, SD = 0.53 respectively). Survivors who returned to a different school cohort post-remission faced higher bullying risks than those who rejoined their original cohort (-0.79 < β < -0.92; p < 0.001). Physical disfigurements following cancer treatment were a risk factor for victimization only among those who returned to their original cohort.</p><p><strong>Conclusions: </strong>The findings highlight the unique challenges faced by childhood leukemia survivors in school reintegration after cancer therapy, emphasizing the significant effect of the school cohort environment on their bullying experiences.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"34 8","pages":"e70244"},"PeriodicalIF":3.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12306848/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144744540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"If I Can't Live as a Man, I'd Rather Not Live at All\": Older Prostate Cancer Patients Discuss Doctors' Attitudes Toward Their Sexuality.","authors":"Shlomit Manor, Roy Holland","doi":"10.1002/pon.70263","DOIUrl":"10.1002/pon.70263","url":null,"abstract":"<p><strong>Objective: </strong>Prostate cancer is the most common cancer among men in the Western world and frequently requires treatment with androgen deprivation therapy (ADT), which carries significant side effects, including loss of sexual function. This study explores how older men with prostate cancer perceive physician communication about the sexual and emotional impact of ADT, and whether they feel their values, masculinity, and quality-of-life concerns are considered in treatment decisions.</p><p><strong>Methods: </strong>This qualitative study employed an interpretative phenomenological approach based on in-depth interviews with 25 men aged 60-80 undergoing or having completed ADT. Participants interviewed about their experiences with cancer treatment, physician communication, and their perceptions of how sexuality and masculinity were addressed. Interviews were transcribed and thematically analyzed.</p><p><strong>Results: </strong>Two central themes emerged: (i) physicians often minimized or overlooked the significance of sexual function and masculinity in older men, reflecting ageist and paternalistic assumptions; and (ii) information about ADT and its effects was frequently presented in generic or emotionally detached ways, with limited sensitivity to individual preferences or emotional readiness. While most patients received some information about side effects, many described the communication as dismissive or lacking in nuance. Several reported feeling excluded from shared decision-making.</p><p><strong>Conclusion: </strong>Older men undergoing ADT often feel that their sexuality and masculinity are undervalued in clinical care. Physician communication may reflect ageist assumptions and insufficient engagement with patient preferences. These findings underscore the need for more patient-centered, culturally competent, and age-sensitive approaches in prostate cancer care, particularly around sensitive issues such as sexual function.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"34 8","pages":"e70263"},"PeriodicalIF":3.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144874903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Effectiveness of Psychosocial Protective Factors for Prostate Cancer Survivorship - A UK Biobank Study.","authors":"Yan Yu, Olivia Miu Yung Ngan, Varut Vardhanabhuti, Xin-Yuan Guan, Fraide A Ganotice","doi":"10.1002/pon.70258","DOIUrl":"10.1002/pon.70258","url":null,"abstract":"<p><strong>Background: </strong>This study investigates psychosocial and lifestyle factors to improve survival outcomes in prostate cancer patients.</p><p><strong>Methods: </strong>From the UK Biobank cohort, 13,110 male prostate cancer subjects were analysed to examine the relationship between psychosocial and lifestyle factors and survival with a mean follow-up of 14.2 years from recruitment.</p><p><strong>Results: </strong>Participation in sports club or gym (HR = 0.82, 95% CI 0.74-0.91, p < 0.005), religious groups (HR = 0.83, 95% CI 0.73-0.94, p < 0.005) and other group activity (HR = 0.87, 95% CI 0.78-0.97, p = 0.01) were associated with lower mortality risk in our analysis, after adjusting for age, deprivation and comorbidities, followed by. In contrast, neither the pub or social club nor the adult education class demonstrated a statistically significant survival benefit. A modest dose-response relationship between the number of social activities engaged in and mortality risk reduction is observed. There were no differential benefits in alcohol intake, while smoking demonstrated a graded risk increase in mortality (HR = 1.74, 95% CI 1.51-2.0, p < 0.005 in current smokers; HR = 1.21, 95% CI 1.1-1.32, p < 0.005 in previous smokers) compared to never smokers. Having close and frequent confidants (HR = 0.83, 95% CI 0.75-0.92, p < 0.005 for daily) also confers benefits to survival.</p><p><strong>Conclusions: </strong>This study demonstrates that participation in sports club or gym, engaging in religious groups and other group activities, forming good health habits such as smoking cessation, and having people to confide in regularly is associated with reduced mortality risk in prostate cancer patients. These findings highlight the importance of integrating psychosocial resilience, health behaviour optimisation, and spiritual engagement into survivorship care. The hierarchical risk reduction profile supports prioritising interventions targeting modifiable health behaviours, spiritual/social support, and group activities. While religious participation is associated with notable survival benefits, this study recognises the complex interplay of cultural, social, and personal factors influencing engagement in such activities. These findings advocate for stratified survivorship care models prioritising engagement modalities with dual physiological, psychosocial, and spiritual benefits.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"34 8","pages":"e70258"},"PeriodicalIF":3.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12357647/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144859557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}