Open Access Journal of Biomedical Science最新文献

{"title":"Suggested Idea for Treatment of Virus Diseases","authors":"Samah Metwally Mahmoud Abd EL-Aziz","doi":"10.38125/oajbs.000406","DOIUrl":"https://doi.org/10.38125/oajbs.000406","url":null,"abstract":"","PeriodicalId":207626,"journal":{"name":"Open Access Journal of Biomedical Science","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129082096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Determination by Chromatographic Methods of Degradation Products of Thiamine 100mg Injection\"","authors":"José González","doi":"10.38125/oajbs.000405","DOIUrl":"https://doi.org/10.38125/oajbs.000405","url":null,"abstract":"is an essential nutrient that is involved in many physiological activities in the human body, including energy metabolism; synthesis of several ABSTRACT Injectable solution of Thiamine is a pharmaceutical prepared that participated in many chemical reactions of the body and is very use in vitamin and nutritional preparations. B 1 is a hydrosoluble (water-soluble) vitamin very sensitive to light, temperature, and oxidation increasing significantly its kinetic degradation when it is under exposure of those physic-chemical agents. Different studies of stability evidence that after 12 months the solution take a yellow light coloration, that intensify with the time, nonfulfillment the quality specifications as for organoleptic characteristics during the 24 months of validity. To improve the quality a redraw of formulation was done, changing the microbial preserver from Phenol to Chlorobutanol. Using different analytical techniques Thiamine storage stability in solution was monitored over time to determine the effect of different degradation agents like HCl, NaOH, H 2 O 2 , and thermolisis and photolysis. Degrading agents that more affect the used samples were NaOH and thermolisis.","PeriodicalId":207626,"journal":{"name":"Open Access Journal of Biomedical Science","volume":"23 3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121036549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Physical Activity Assessment in Tunisian Patients with Rheumatoid Arthritis Compared to Controls\"","authors":"Y. Makhlouf","doi":"10.38125/oajbs.000404","DOIUrl":"https://doi.org/10.38125/oajbs.000404","url":null,"abstract":"Physical activity (PA) is defined as “any movement produced by skeletal muscles responsible for increased energy expenditure” [2]. It is a major determinant of the health status of individuals in the general population and specifically in patients with rheumatic diseases (RD) including rheumatoid arthritis (RA). Nowadays, the health benefits of PA are well documented, and a positive effect is reported on the quality of life of RA patients [2]. Recently, recommendations for exercise prescription during RA have been announced [3]. However, physical inactivity appears to be more ABSTRACT","PeriodicalId":207626,"journal":{"name":"Open Access Journal of Biomedical Science","volume":"69 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124249031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Analgesia for Total Knee Arthroplasty: A Randomized Controlled Study Comparing Local Infusion Analgesia, Femoral Nerve Block and Intrathecal Morphine\"","authors":"Christopher J Wilson","doi":"10.38125/oajbs.000403","DOIUrl":"https://doi.org/10.38125/oajbs.000403","url":null,"abstract":"peripheral nerve blockade, ABSTRACT Introduction: The aim of this study was to compare the effectiveness of continuous intra-articular local infiltration analgesia, femoral nerve block and intrathecal morphine for the management of post-operative pain and early function following total knee arthroplasty. Methods: group, double blinded, randomized controlled pilot trial was undertaken. Patients were randomized to receive either local infiltration analgesia, femoral nerve block or intrathecal morphine for post-operative analgesia following total knee arthroplasty. The efficacy of analgesia was determined by recording post-operative pain visual analogue scores, opiate requirements and side effects, and functional scores at 24 hours, 48 hours, and 6 weeks post-operatively. Results: 45 patients were recruited to the study. 4 were excluded due to voluntary withdrawal and incomplete follow-up. The final analysis included 13 patients randomized to the local infiltration analgesia group, 14 patients to the femoral nerve block group and 14 patients to the intrathecal morphine group. There were no significant differences in post-operative pain scores, opiate requirements and associated side effects, or functional scores at any point during the study period. Conclusion: This study did not identify any significant differences between continuous intra-articular local infiltration analgesia, femoral nerve block and intrathecal morphine for delivering post-operative an-algesia following total knee arthroplasty.","PeriodicalId":207626,"journal":{"name":"Open Access Journal of Biomedical Science","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116999420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Facile Synthesis of Chitosan Nanoparticle with Different Features and Histopathological Ultrastructural Study on The Effect of Its Bio-complex with Bovine Serum Albumin in Mice Liver\"","authors":"M. El-Kemary","doi":"10.38125/oajbs.000402","DOIUrl":"https://doi.org/10.38125/oajbs.000402","url":null,"abstract":"Synthesis with Different Features and Histopathological Ultrastructural Study on The Effect of Its Bio-complex with Bovine Serum Albumin in Mice We have synthesized chitosan nanoparticles (CS-NPs) with different characteristics using ionic gelation method. Results showed that the synthesized CS-NPs with different concentrations of trisodium polyphosphate (TPP) are irregular - spherical shaped with narrow size distribution and high stability. The microporous chitosan was also synthesized with new features characterized with different techniques as SEM, EDX, FTIR and BET. The synthesized microporous chitosan has a surface area and pore volume of 245.571m 2 /g and 0.155cm 3 /g respectively. Its microporous surface is functionalized with carboxyl and amine groups. Histopathological and ultrastructural studies of mice liver were performed using optical and scanning electron microscopy (SEM) by intraperitoneal (IP) injection of male mice to evaluate toxicity of free and BSA-CS-NPs inside the body after three, six and nine days. However, no pathological or illness signs were observed in mice throughout the in vivo experiment with non-significant changes on body and relative weight of liver in compared to the negative control group. In addition, biochemical parameters exhibited a normal functionality of liver after BSA-CS-NPs administration. Accordingly, mild histopathological or ultrastructural alterations were observed in the liver of treated mice in all groups with respect with the negative controls. Activated Kupffer cells and leukocytes were observed due to the synergism of adjuvant effect of CS-NPs and antigenic peptides involved in BSA. Herein, we opened new direction for synthesis of different forms of CS-NPs and providing an obvious insight on histopathological and ultrastructural changes after administration of CS-NPs and its protein bio-complexes.","PeriodicalId":207626,"journal":{"name":"Open Access Journal of Biomedical Science","volume":"69 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131230848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Computation Deciphering the Mechanism of N-Glycan Processing α-Mannosidases","authors":"Santigo Alanso Gil","doi":"10.38125/oajbs.000401","DOIUrl":"https://doi.org/10.38125/oajbs.000401","url":null,"abstract":"During the last decade, computation has become a powerful tool to decipher the reaction mechanism of enzymes. In this mini-review, we summarize and highlight the achievements of computer science in modelling N-glycan processing enzymes.","PeriodicalId":207626,"journal":{"name":"Open Access Journal of Biomedical Science","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126091954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review on Analysis of Breast Tumor with Methods of Treatment","authors":"Nagham Mahmood Aljamali","doi":"10.38125/oajbs.000400","DOIUrl":"https://doi.org/10.38125/oajbs.000400","url":null,"abstract":"is the first step in helping doctors regulate the best suitable sequence of behavior. Malignance dramatization arrangement Classification for a tumor, nodes, and metastases is a measure of the animal amount and spread of a malignant growth [1-5]. ABSTRACT Breast malignance is the greatest public in ladies, with a high incidence in North America and Eastern Europe, medium in Southern Europe and the Middle East and low in the Far East. Breast malignance is the second most common malignance in the world after lung malignance, and since it happens a lot, the doctors asked the women to examine themselves by themselves, in order to discover the signs of the disease early before it spreads. It is possible that this disease can be treated after being diagnosed by a specialized doctor and determining the type of tumor in the breast, and the surgeon removes the breast completely and starts chemotherapy about 6 doses, then radiotherapy, how many sessions will be determined by the doctor, and then hormonal therapy, a medicine called Tamoxafin or any medicine determined by the doctor, and it is possible. This disease will not come back again if the eyes follow the instructions and do not tire themselves a lot, and remain calm, because malignance is one of the causes of its increased nervous appearance and you try to stop stimulants such as tea, coffee and chocolate because they increase the chance of injury. Also, stop cigarettes, even if drinks have a percentage A small amount of alcohol in response increases the chance of infection, and also exercise, if we practice it regularly, will benefit greatly and reduce the chances of contracting the disease.","PeriodicalId":207626,"journal":{"name":"Open Access Journal of Biomedical Science","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125726394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adoption of Digital Pen and Paper Technology (DPP) in Biomedical Technology","authors":"Dimitrios Zarakovitis","doi":"10.38125/oajbs.000399","DOIUrl":"https://doi.org/10.38125/oajbs.000399","url":null,"abstract":"In recent years, Health Information Management Systems are integrated in Information and Communication Technologies (ICT) in order to ensure that the effectiveness and efficiency of Health Units (H.Us) are improved. The use of major Medical Equipment (M/E) in Hospital Units is necessary for achieving the best possible treatment. Digital Pen and Paper technology (DPP) is a useful ICT tool that aims to enhance the electronic registration and management of Medical Equipment of Biomedical Technology (BIT) Departments. DPP application can help to upgrade the quality of public health services, reorganize and simplify the internal medical processes and save time and costs during the daily nursing practices. Furthermore, DPP technology also promotes a better assessment and management of public health services with full transparency of financial procedures by using real-time monitoring of Medical Equipment. It can also be used for the improvement of accountability procedures of both Health Professionals & Biomedical Engineers, as well as the design of effective health financial policies.","PeriodicalId":207626,"journal":{"name":"Open Access Journal of Biomedical Science","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134061585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Medication Errors in Emergency Ward at Nekemte Referral Hospital, West Ethiopia","authors":"Balisa Mosisa, Yeshi Mamo, Lemessa Berber","doi":"10.38125/oajbs.000398","DOIUrl":"https://doi.org/10.38125/oajbs.000398","url":null,"abstract":"Background: Medication error is defined as failure in the treatment process that leads to or has the potential to lead to harm to the patient. It may occur at each five stages of drug ordering and delivery including prescription, transcription, dispensing, and administration or monitoring. Prevalence of medication error in healthcare settings have been found that they were common in hospitals. A significant proportion of medication errors are associated with actual or potentially harmful effects. Objective: The major goal of this assessment was to figure out the actual practices on the ground in medications administered in NRH emergency ward, emphasizing on distribution and prevalence of errors. Methods: This study was a cross-sectional retrospective study conducted at medical and pediatrics wards of NRH. Results: To meet objectives, 768 prescription papers were used to collect necessary data within this study period. A total of 768 patient’s medical prescription orders, there were about 71.73% of at least one prescription error when it is compared to standard prescription order. Of this medication error prevalence, the number of prescriptions with low dose (35.93%) number of prescriptions without appropriate indication (26.43%) number of prescriptions with too high-dose (3.13%) number of prescriptions with inappropriate interval (2.73%) number of prescriptions with drug interaction (1.95%) number of prescriptions with contraindication (1.56%). Numbers of prescriptions with 1st line medicine indicated for diseases were 1.43%. Of total sampled prescriptions, the numbers of drugs order per the number of prescriptions were two. There were prescriptions without patient address (99.35%), prescriptions without card number (97.40%) prescriptions without date (60.94%) prescriptions without sex of patients, (13.02%) prescriptions without age of patients (8.85%). Conclusion and Recommendation: There were clear and large medication and prescription errors on medication prescribing and administration practices in NRH emergency ward. Every member of clinical team had better strive to perform sound performance standard to ensure maximum patient therapeutic outcome as long as negligence and carelessness must not make a patient life to be claimed.","PeriodicalId":207626,"journal":{"name":"Open Access Journal of Biomedical Science","volume":"61 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128877377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perioperative management of Adolescent Idiopathic Scoliosis: Posterior Spinal Fusion of 14 Segments with A Foreseen Blood Loss of 2000ml (57% of Total Blood Volume of the Patient) Without Transfusion","authors":"H. Pérez-Chrzanowska","doi":"10.38125/oajbs.000397","DOIUrl":"https://doi.org/10.38125/oajbs.000397","url":null,"abstract":"foreseen 57% total blood volume (TBV) (2000ml) loss, without recurring to allogenic blood product transfusion. Specific anesthetic and minimally invasive surgical techniques (MISS) were used [1-5]. We present 15 years old (50kg, 160cm, body mass index 19,5 kg/m2, total body surface 1.49m2), Latino male with AIS of the thoracolumbar spine (T2-L4) with curves of 78º and 42º ABSTRACT Adolescent Idiopathic Scoliosis (AIS) is a disease of the spinal column that affects up to 3% of pediatric patients at puberty. In most cases it can be managed conservatively and only a minority develop severe deformities which compromise neurological, pulmonary, cardiac and psychosocial function, requiring surgical management. The main complications of this highly complex operation, which needs careful planning and preparation, is excessive blood loss needing transfusion, and neurological injury. We present the case of a 15-year-old male who underwent a bloodless 14 spaces, instrumented posterior spinal fusion without any complications. All the pillars and means of patient blood management (PBM) and meticulous minimally invasive (MISS) surgical technique were applied to achieve a successful result. The dissemination of the management of complex cases like the one we describe, may help other teams worldwide when faced with similar challenges.","PeriodicalId":207626,"journal":{"name":"Open Access Journal of Biomedical Science","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131735952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}