Open Access Journal of Biomedical Science最新文献

{"title":"Satisfaction Assessment of Telephone Consultations among 270 Primary Health Care Physicians During the COVID-19 Pandemic in Qatar","authors":"Ahsan Ali Siddiqui","doi":"10.38125/oajbs.000364","DOIUrl":"https://doi.org/10.38125/oajbs.000364","url":null,"abstract":"","PeriodicalId":207626,"journal":{"name":"Open Access Journal of Biomedical Science","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133761058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Satisfaction Assessment of Telephone Consultations among 270 Primary Health Care Physicians During the COVID-19 Pandemic in Qatar\"","authors":"Moqthiar Sharief","doi":"10.38125/oajbs.000363","DOIUrl":"https://doi.org/10.38125/oajbs.000363","url":null,"abstract":"With over 270 million people worldwide infected with COVID-19 and over 5,3 million deaths since the pandemic began [1] the World Health Organization (WHO) has recommended the implementation of public health measures such as the quarantine of all individuals suspected of infection for 14 days [2-5]. Numerous countries have also implemented “social distancing” and “lock-downs” of varying degrees of severity for entire communities in an effort to contain the spread of COVID-19 [6-15]. ABSTRACT","PeriodicalId":207626,"journal":{"name":"Open Access Journal of Biomedical Science","volume":"140 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122920642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Dub3-Snail1 in Metastasis of Breast Cancer","authors":"Wenlin Chen","doi":"10.38125/oajbs.000362","DOIUrl":"https://doi.org/10.38125/oajbs.000362","url":null,"abstract":"alters protein activity, interaction, ABSTRACT Nowadays, oncogenic proteins have been widely discovered and identified, scarcely ever oncogenic proteins can be well applied as drug targets, which is a difficult problem for translational medicine of breast cancer. Dub3, overexpressed in breast cancer, is a Snail1 deubiquitination enzyme that can interact with Snail1 and stabilize it. Snail1 is a key transcription factor in epithelial-mesenchymal transformation (EMT) and breast cancer metastasis and is prone to ubiquitination and degradation. Dysregulation of Dub3 can lead to Snail1 instability and inhibit the process of EMT, thereby reducing the migration, invasion and metastasis of tumor cells. Dub3 will provide potential of targeted therapies for breast cancer patients. This review expounds expression and mechanism of Dub3 and Snail1 in breast cancer and reviews the playing role of Dub3-Snail1 signaling axis in breast cancer.","PeriodicalId":207626,"journal":{"name":"Open Access Journal of Biomedical Science","volume":"116 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124302410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent Advances in Biosensor Technology","authors":"A. Ahmadi","doi":"10.38125/oajbs.000361","DOIUrl":"https://doi.org/10.38125/oajbs.000361","url":null,"abstract":"Biosensors or biosensors are one of the most valuable and emerging technologies in recent years [1]. These sensors are installed on smart devices such as mobile phones, smart watches, smart bracelets, smart car steering wheels and more. The market for biosensors can be categorized by type (patch sensor and builtin device), product (wearable and non-wearable), technology (electrochemical and optical), application (POC, home diagnostics, research laboratory, food, and beverage) and geography. Global Forecast By 2024, the overall biosensor market is projected to grow from $21.2 billion in 2019 to $31.5 billion in 2024 with a combined annual growth rate of 8.3% over the forecast period. This growth is likely to be exacerbated by sustained technological advances in biosensor ecosystems, increased use of biosensors for non-medical applications, profitable growth in POC (clinical instant) diagnostics, and increased demand for glucose monitoring systems [2].","PeriodicalId":207626,"journal":{"name":"Open Access Journal of Biomedical Science","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125520735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of High Throughput Screening to Discover SARS-CoV-2 Main Protease Inhibitors with NanoBit Complementation","authors":"Jianxin Liu","doi":"10.38125/oajbs.000360","DOIUrl":"https://doi.org/10.38125/oajbs.000360","url":null,"abstract":"of High Throughput Screening to Discover SARS-CoV-2 Main Protease Inhibitors with NanoBit ABSTRACT SARS-CoV-2 has become a serious global public health problem and there is lack of effective drugs to fight it. Main protease (M pro ) of SARS-CoV-2 is an important antiviral drug target. We aim to establish a high-throughput screening (HTS) assay to identify inhibitors of SARS- CoV-2 M pro . A M pro NanoBiT assay for HTS was developed by using NanoBiT complementary strategy. M pro peptide substrate was flanked by subunits of Nano luciferase (NanoLuc), SmBiT and LgBiT respectively at the amino and carboxyl termini to obtain the structure M pro cleavage site-NanoBiT. M pro cleavage site-NanoBiT showed strong NanoLuc activity, which was modulated with M pro peptide digestion, indicating the inhibitory effect of compounds on M pro could be read out with NanoLuc activity. We optimized the experiment conditions including the quantity of M pro and M pro cleavage site-NanoBiT, DMSO tolerance, enzyme digestion time, and plate readout time after adding NanoLuc substrate. We further evaluated with two M pro reference inhibitors, GC376 and M pro inhibitor 11a, and found the assay was suitable for HTS of M pro inhibitors. The miniaturized 384-well plate format assay was further used to screen 6,400 compounds from FDA-approved Drug Library and Natural Bioactive Compound Library. Control experiments showed a significant separation of relative activity of the negative and positive controls leading to an acceptable HTS Z’ value of 0.67, indicating satisfactory assay performance. Our results demonstrated that our established M pro NanoBiT assay by inserting protease substrate peptides between SmBiT and LgBiT of NanoBiT could be applied for discovery of inhibitors of different proteases.","PeriodicalId":207626,"journal":{"name":"Open Access Journal of Biomedical Science","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123237254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Outcomes, Therapy Options and Risk Factor Impact Analysis on 1077 Patients Hospitalized for Covid-19","authors":"Š. Cimrman","doi":"10.38125/oajbs.000359","DOIUrl":"https://doi.org/10.38125/oajbs.000359","url":null,"abstract":"our cohort. ABSTRACT Purpose : In this retrospective study, a cohort of 1077 patients with covid-19 hospitalized in Masaryk hospital in Ústí nad Labem, Czech Republic, is examined. Several suggested risk factors for covid-19 are described and the impact of their presence on clinical outcome is explored. Treatment options for covid-19 are discussed. Methods : Using statistical analysis (Fisher’s exact test, logistic regression, induction of decision trees and random forests), the authors identify clinical and laboratory risk factors for mortality rate, development of severe disease and longer duration of hospitalization. Results : Age was confirmed to be the most impactful risk factor on mortality and length of hospitalization (95% CI 4.62-11.67, p =<0.00001). Obesity did not increase mortality but led to increased disease severity (95% CI 1.28-2.40, p =<0.00329). Diabetes (95% CI 1.68-3.17, p =<0.00001), heart disease (95% CI 2.85 -5.47, p =<0.00001), chronic kidney disease (95% CI 3.27-7.04, p =0.00001) and cancer (95% CI 1.36-3.55, p =0.00544) had an impact on mortality. Lung disease and immune system suppression were not established as significant risk factors. CRP (95% CI 2.7-5.61, p =<0.00001), D-dimer (95% CI 1.60-3.25, p =0.00002), procalcitonin (95% CI 4.24-11.95, p =<0.00001) and lymphocyte count (95% CI 2.11-4.03, p =<0.00001) are found to be significant early laboratory risk indicators in patients with covid-19. Conclusion : We suggest the presence of confirmed risk factors and laboratory markers to be evaluated and considered in determining initial treatment options provided to patients with covid-19.","PeriodicalId":207626,"journal":{"name":"Open Access Journal of Biomedical Science","volume":"242 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121167358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Multiple Sclerosis (MS) on Central Nervous System (CNS)","authors":"A. Ahmadi","doi":"10.38125/oajbs.000358","DOIUrl":"https://doi.org/10.38125/oajbs.000358","url":null,"abstract":"Multiple sclerosis (MS) is an autoimmune disorder of the CNS in which myelin components are specifically targeted by the immune system and lead to the destruction of myelin axons and associated debilitating symptoms [1-3]. Also, according to studies, no effective treatment for this disease has been found. Therefore, a safe and effective treatment option for MS is needed. Also, the central nervous system (CNS) is separated from the immune system by a blood-brain barrier and is traditionally considered “immune system protection”, and immune cells are also able to target the brain and lead to CNS autoimmune disorders Pahan et al. [4]. An article measuring the effects of cinnamon on MS mice used cinnamon and the brown bark of the cinnamon tree, which has been used as a spice or flavoring around the world for centuries. In addition, medieval physicians used cinnamon for medical purposes to treat a variety of disorders such as osteoarthritis, cough, hoarseness, sore throat, etc. Also, according to the findings of various articles, the results show that widespread inflammation, Loss of regulatory T cells (Tregs), autoimmune Th1 and Th17 cell hyperactivity, failure of the cerebral blood-brain barrier (BBB) and blood-spinal cord barrier (BSB), and loss of light-protective molecules in the CNS are some of the symptoms that Demystifying manifestations are required in MS [1-3]. Interestingly, NaB treatment is able to inhibit the expression of proinflammatory molecules in cultured astrocytes and microglia [4]. Reversal of NaB by inhibiting NF-κB activation and expression of nitric oxide synthase (iNOS) by mevalonate, 3-hydroxy-3methylglutaryl-coenzyme A and farnesyl pyrophosphate, mediators of the mevalonate pathway, in active astrocytes suggests that NaB. It has an inflammatory effect by inhibiting the cholesterolbiosynthesis pathway However, although NaB is able to lower cholesterol levels, cholesterol has no role in inhibiting NaBmediated iNOS [4]. Also, in an article by Brahmachari et al. [4], they measured the effects of cinnamon on mice with MS in which NaB reduced NF-κB activation and iNOS expression in glial cells by reducing p21ras activation, according to which oral administration of cinnamon powder [5] and drinking water containing NaB metabolite [4] suppresses iNOS and IL-1β expression in vivo in the spinal cord and cerebellum of EAE mice, these findings suggest that cinnamon is able to reduce in vivo inflammation in rat CNS EAE is also another feature of neurodegenerative disorders such as Alzheimer’s disease (AD) and Parkinson’s disease (PD), cinnamon and NaB. It also improves hippocampal function in an animal model of AD [6] and from nigrostriatum. Animal model PD Protects [7].","PeriodicalId":207626,"journal":{"name":"Open Access Journal of Biomedical Science","volume":"101 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124628395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What Do We Know About the Impacts of Novel Coronavirus (SARS-Cov-2) on Freshwater Ecosystems?","authors":"Didem Gökçe","doi":"10.38125/oajbs.000357","DOIUrl":"https://doi.org/10.38125/oajbs.000357","url":null,"abstract":"Epidemiological alterations in COVID-19 infection monitored for a long term the potential pathways of contagion, as well as the adaptation, evolution, and virus spread among humans and possible intermediate zoonotic hosts and reservoirs. In the present review, widespread transmission routes and pressures on water resources and freshwater ecosystems under the threat of COVID-19 with high mutation rate were evaluated. The climatic structure, aquatic ecosystem, water consumption, and wastewater ABSTRACT The coronavirus pandemic (COVID-19), which has numerous effects in the world, has crucial importance for water resources. The COVID-19 pandemic has had an unpredictable impact on worldwide societies and the economies. On the other hand, lockdown and isolation implemented due to pandemic have decreased environmental damage such as air pollution and gas emissions. However, its unexpected effect was the increase of plastic pollution, medical waste, and wastewater as well as the presence of SARS-CoV-2 in aquatic ecosystem. The present study discussed the potential of the COVID-19 on freshwater ecosystems contaminated by wastewater discharge. The effects of climate change and the use of contaminated waters on spread of COVID-19 were addressed and the related situation in Turkey was discussed.","PeriodicalId":207626,"journal":{"name":"Open Access Journal of Biomedical Science","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115312156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Related to Oral Care and Oral Health Education of Implant Patients","authors":"Hee Jn","doi":"10.38125/oajbs.000356","DOIUrl":"https://doi.org/10.38125/oajbs.000356","url":null,"abstract":"","PeriodicalId":207626,"journal":{"name":"Open Access Journal of Biomedical Science","volume":"74 6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130895382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vaccine Exemptions and Vaccination Coverage in the United States","authors":"A. Choudhury","doi":"10.38125/oajbs.000355","DOIUrl":"https://doi.org/10.38125/oajbs.000355","url":null,"abstract":"The creation of vaccines at the end of the 1700s has been one of the leading scientific advancements to improve public health. Diseases like smallpox and polio that once plagued humanity with devastating long-term health effects have been eradicated in most countries through the adoption of vaccines. However, despite developments in vaccines, the US has seen a decline in vaccination coverage in recent decades. This could be due to the presence of exemptions to vaccines that help prevent said outbreaks. In the United States there are three available exemptions to vaccination: medical, religious, and personal/philosophical.","PeriodicalId":207626,"journal":{"name":"Open Access Journal of Biomedical Science","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126954602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}