The Role of Dub3-Snail1 in Metastasis of Breast Cancer

alters protein activity, interaction, ABSTRACT Nowadays, oncogenic proteins have been widely discovered and identified, scarcely ever oncogenic proteins can be well applied as drug targets, which is a difficult problem for translational medicine of breast cancer. Dub3, overexpressed in breast cancer, is a Snail1 deubiquitination enzyme that can interact with Snail1 and stabilize it. Snail1 is a key transcription factor in epithelial-mesenchymal transformation (EMT) and breast cancer metastasis and is prone to ubiquitination and degradation. Dysregulation of Dub3 can lead to Snail1 instability and inhibit the process of EMT, thereby reducing the migration, invasion and metastasis of tumor cells. Dub3 will provide potential of targeted therapies for breast cancer patients. This review expounds expression and mechanism of Dub3 and Snail1 in breast cancer and reviews the playing role of Dub3-Snail1 signaling axis in breast cancer.