Clinical Outcomes, Therapy Options and Risk Factor Impact Analysis on 1077 Patients Hospitalized for Covid-19

Abstract

our cohort. ABSTRACT Purpose : In this retrospective study, a cohort of 1077 patients with covid-19 hospitalized in Masaryk hospital in Ústí nad Labem, Czech Republic, is examined. Several suggested risk factors for covid-19 are described and the impact of their presence on clinical outcome is explored. Treatment options for covid-19 are discussed. Methods : Using statistical analysis (Fisher’s exact test, logistic regression, induction of decision trees and random forests), the authors identify clinical and laboratory risk factors for mortality rate, development of severe disease and longer duration of hospitalization. Results : Age was confirmed to be the most impactful risk factor on mortality and length of hospitalization (95% CI 4.62-11.67, p =<0.00001). Obesity did not increase mortality but led to increased disease severity (95% CI 1.28-2.40, p =<0.00329). Diabetes (95% CI 1.68-3.17, p =<0.00001), heart disease (95% CI 2.85 -5.47, p =<0.00001), chronic kidney disease (95% CI 3.27-7.04, p =0.00001) and cancer (95% CI 1.36-3.55, p =0.00544) had an impact on mortality. Lung disease and immune system suppression were not established as significant risk factors. CRP (95% CI 2.7-5.61, p =<0.00001), D-dimer (95% CI 1.60-3.25, p =0.00002), procalcitonin (95% CI 4.24-11.95, p =<0.00001) and lymphocyte count (95% CI 2.11-4.03, p =<0.00001) are found to be significant early laboratory risk indicators in patients with covid-19. Conclusion : We suggest the presence of confirmed risk factors and laboratory markers to be evaluated and considered in determining initial treatment options provided to patients with covid-19.