Psychopharmacologia最新文献_第7页

Critical flicker frequency (CFF) and psychotropic drugs in normal human subjects-a review. 临界闪烁频率（CFF）与正常人的精神药物研究进展。

Psychopharmacologia Pub Date : 1976-05-28 DOI: 10.1007/BF00735818

J M Smith, H Misiak

引用次数: 0

Ethanol and isopropanol effects on schedule-controlled responding. 乙醇和异丙醇对进度控制反应的影响。

Psychopharmacologia Pub Date : 1976-05-28 DOI: 10.1007/BF00735815

J D Leander, D E Mcmillan, F W Ellis

{"title":"Ethanol and isopropanol effects on schedule-controlled responding.","authors":"J D Leander, D E Mcmillan, F W Ellis","doi":"10.1007/BF00735815","DOIUrl":"https://doi.org/10.1007/BF00735815","url":null,"abstract":"The effects of ethanol and isopropanol were studied on responding by pigeons under multiple fixed-ratio (FR), fixed-interval (FI) schedules of food presentation and under a fixed-interval (FI) schedule of food presentation where responding was decreased by punishment. The ethanol was rapidly absorbed into blood and decreased responding within 15 min after intubation to the opening of the proventriculus. Dose-effect determinations of the effects of ethanol showed that ethanol decreased responding in both the FR and FI components of the multiple schedules at similar doses, but there were increases in responding under an FR 100 schedule at lower doses. Isopropanol tended to decrease FR responding at doses that either increased FI responding or did not affect FI responding. Both ethanol and isopropanol (1 g/kg) produced effects on the local rates of responding within the FI which were rate-dependent in that they increased low rates while not affecting or actually decreasing the high rates of responding. Both ethanol and isopropanol increased punished responding if it was not severely suppressed by the punishment procedures.","PeriodicalId":20715,"journal":{"name":"Psychopharmacologia","volume":"47 2","pages":"157-64"},"PeriodicalIF":0.0,"publicationDate":"1976-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00735815","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12448202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Dystonic reactions following neuroleptics: time course and proposed mechanisms. 抗精神病药后的张力障碍反应：时间过程和可能的机制。

Psychopharmacologia Pub Date : 1976-05-28 DOI: 10.1007/BF00735822

D L Garver, D M Davis, H Dekirmenjian, S Ericksen, L Gosenfeld, J Haraszti

引用次数: 0

The effects of pre-exposure to scopolamine on subsequent drug state discrimination. 预暴露于东莨菪碱对随后药物状态歧视的影响。

Psychopharmacologia Pub Date : 1976-05-28 DOI: 10.1007/BF00735814

W A McKim

引用次数: 4

Effects of low and moderate doses of chlorpromazine on discrimination learning in the rat. 低、中剂量氯丙嗪对大鼠辨别学习的影响。

Psychopharmacologia Pub Date : 1976-05-28 DOI: 10.1007/BF00735824

J I Telner, V Vikis-Freibergs, F Lepore

引用次数: 3

Effects of caffeine consumption on nicotine consumption. 咖啡因摄入对尼古丁摄入的影响。

Psychopharmacologia Pub Date : 1976-05-28 DOI: 10.1007/BF00735816

L T Kozlowski

引用次数: 18

The interaction between prostaglandin E1 and delta 9-tetrahydrocannabinol on intestinal motility and on the abdominal constriction response in the mouse. 前列腺素E1与δ 9-四氢大麻酚对小鼠肠道运动和腹部收缩反应的相互作用。

Psychopharmacologia Pub Date : 1976-05-28 DOI: 10.1007/BF00735820

D M Jackson, R Malor, G B Chesher, G A Starmer, P J Welburn, R Bailey

{"title":"The interaction between prostaglandin E1 and delta 9-tetrahydrocannabinol on intestinal motility and on the abdominal constriction response in the mouse.","authors":"D M Jackson, R Malor, G B Chesher, G A Starmer, P J Welburn, R Bailey","doi":"10.1007/BF00735820","DOIUrl":"https://doi.org/10.1007/BF00735820","url":null,"abstract":"The interaction between delta9-tetrahydrocannabinol (THC) and PGE1 was studied using two pharmacological parameters-the rate of passage of a charcoal meal through mouse small intestine and the abdominal constriction response in the mouse. PGE1 administered intraperitoneally produced a dose-dependent decrease in intestinal motility, and this effect was antagonized by low (0.25 mg/kg) doses of THC and potentiated by higher doses of THC (1 mg/kg). Kinetic analysis suggested that the interaction was of a mixed but predominantly competitive type. PGF2alpha produced an increase in intestinal motility but this was not dose-dependent. THC antagonized the effect of PGF2alpha in a dose-dependent manner suggestive of a physiological antagonism. THC (0.25-2 mg/kg) antagonized the dose-dependent PGE1 abdominal constriction response in a fashion which suggested a mixed (though mainly competitive) antagonism. It would ssem, therefore, that on the two pharmacological parameters studied THC appears to be interacting with PGE1 at the same receptor site. Although the doses of THC used are within the range of those used in man, it is not implied that these results are necessarily implicated in the psychoactivity of the drug.","PeriodicalId":20715,"journal":{"name":"Psychopharmacologia","volume":"47 2","pages":"187-93"},"PeriodicalIF":0.0,"publicationDate":"1976-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00735820","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12448207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Effects of dopamine receptor stimulants on locomotor activity of rats with electrolytic or 6-hydroxydopamine-induced lesions of the nucleus accumbens. 多巴胺受体兴奋剂对电解或6-羟多巴胺诱导伏隔核损伤大鼠运动活动的影响。

Psychopharmacologia Pub Date : 1976-05-28 DOI: 10.1007/BF00735821

G N Woodruff, P H Kelly, A O Elkhawad

{"title":"Effects of dopamine receptor stimulants on locomotor activity of rats with electrolytic or 6-hydroxydopamine-induced lesions of the nucleus accumbens.","authors":"G N Woodruff, P H Kelly, A O Elkhawad","doi":"10.1007/BF00735821","DOIUrl":"https://doi.org/10.1007/BF00735821","url":null,"abstract":"Ergometrine (8 mg/kg) injected intraperitoneally into normal rats had little effect on locomotor activity. In contrast, rats with selective 6-hydroxydopamine-induced lesions of dopamine terminals in the nucleus accumbens showed a strong stimulation of locomotor activity following injection of this dose or ergometrine. The dopamine analogue 2-amino-6-7-dihydroxy-1, 2, 3, 4-tetrahydronaphthalene (ADTN) (150 mug), caused strong and long lasting stimulation of locomotor activity when injected intracerebroventricularly into rats. The ADTN response was markedly reduced in rats with bilateral electrolytic lesions of the nucleus accumbens, but unchanged in rats with bilateral electrolytic lesions of the caudate nucleus. At a lower dose level (50 mug) ADTN, injected intracerebroventricularly, had little effect on the locomotor activity of normal or sham-operated rats. This dose of ADTN was, however, effective in causing locomotor stimulation of rats with bilateral 6-hydroxydopamine-induced lesions of the nucleus accumbens. These results support the view that the dopamine receptors in the nucleus accumbens are involved in the actions of locomotor stimulant drugs.","PeriodicalId":20715,"journal":{"name":"Psychopharmacologia","volume":"47 2","pages":"195-8"},"PeriodicalIF":0.0,"publicationDate":"1976-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00735821","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12448208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Selective neuroendocrine effects of low-dose haloperidol in normal adult men. 低剂量氟哌啶醇对正常成年男性选择性神经内分泌的影响。

Psychopharmacologia Pub Date : 1976-05-28 DOI: 10.1007/BF00735811

R T Rubin, R E Poland, D O'Connor, P R Gouin, B B Tower

{"title":"Selective neuroendocrine effects of low-dose haloperidol in normal adult men.","authors":"R T Rubin, R E Poland, D O'Connor, P R Gouin, B B Tower","doi":"10.1007/BF00735811","DOIUrl":"10.1007/BF00735811","url":null,"abstract":"The neuroendocrine effects of haloperidol, usually reported as side effects of this drug when given in antipsychotic doses, have not been systematically investigated. In the present study five normal adult men were administered saline and two doses of of haloperidol (0.25 mg, 0.5 mg) intramuscularly in a double-blind randomized block design. The anterior pituitary hormones GH, LH, FSH, and PRL were measured in blood samples taken every 20 min for several hours thereafter. The low doses of haloperidol used have been shown by others to alter the human EEG; in our subjects these doses produced no objective or subjective clinical effects. There were no drug related changes in GH, LH, or FSH. PRL, however, showed a prompt, statistically significant, dose-related increase in plasma levels, with a return to baseline with 5 h. Haloperidol has strong dopamine-blocking effects, and the hypothalamic inhibitory mechanism for PRL release is believed to be dopamine-mediated. The results of this study suggest that haloperidol may have utility in low doses primarily for its hypothalamic neuroendocrine effects, and that dose-related PRL release may be a useful paradigm for comparing dopamine-blocking antipsychotic agents in humans.","PeriodicalId":20715,"journal":{"name":"Psychopharmacologia","volume":"47 2","pages":"135-40"},"PeriodicalIF":0.0,"publicationDate":"1976-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12448444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Persistence of relapse of morphine-seeking behavior in rats: the relative role of certain biological variables. 大鼠吗啡寻求行为复发的持久性:某些生物学变量的相对作用。

Psychopharmacologia Pub Date : 1976-05-28 DOI: 10.1007/BF00735813

A S Schwartz, P L Marchok

引用次数: 1