Psychopharmacologia最新文献_第7页

Sensory, perceptual, motor and cognitive functioning and subjective reports following oral administration of delta9-tetrahydrocannabinol. 感觉，知觉，运动和认知功能和主观报告后口服德尔塔9-四氢大麻酚。

Psychopharmacologia Pub Date : 1976-05-28 DOI: 10.1007/BF00735812

B A Peters, E G Lewis, R E Dustman, R C Straight, E C Beck

{"title":"Sensory, perceptual, motor and cognitive functioning and subjective reports following oral administration of delta9-tetrahydrocannabinol.","authors":"B A Peters, E G Lewis, R E Dustman, R C Straight, E C Beck","doi":"10.1007/BF00735812","DOIUrl":"https://doi.org/10.1007/BF00735812","url":null,"abstract":"Three dose levels, 0.2, 0.4, and 0.6 mg/kg, of delta9-tetrahydrocannabinol (THC) and a placebo were orally administered to 10 frequent and 10 occasional marijuana users. Following ingestion of each dose and the placebo, objective tests selected from a battery of sensory and perceptual motor tests routinely used to evaluate cerebral dysfunction in hospitalized patients were administered. The influence of delta9-THC on proficiency and variability of performance was minimal. However, when individual test scores and variabilities were combined and converted to standard scores, allowing for analysis of overall performance, THC had a small but consistent detrimental effect on both proficiency and variability of performance. In contrast, THC exerted profound effects on the subjective experiences of the volunteers as assessed by the Subjective Drug Effects Questionnaire. Subjective changes in mood, feeling, perception and somatic sensations were reported by all subjects but were more pronounced in the occasional user group. It was proposed that the small impairment noted in objective test performance after ingestion of delta9-THC as contrasted to the large effects on subjective responses suggests that the principal effects of marijuana are on the autonomic nervous system rather than on higher cortical functions.","PeriodicalId":20715,"journal":{"name":"Psychopharmacologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1976-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00735812","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12448445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20

Dystonic reactions following neuroleptics: time course and proposed mechanisms. 抗精神病药后的张力障碍反应:时间过程和可能的机制。

Psychopharmacologia Pub Date : 1976-05-28 DOI: 10.1007/BF00735822

D L Garver, D M Davis, H Dekirmenjian, S Ericksen, L Gosenfeld, J Haraszti

引用次数: 24

Ethanol and isopropanol effects on schedule-controlled responding. 乙醇和异丙醇对进度控制反应的影响。

Psychopharmacologia Pub Date : 1976-05-28 DOI: 10.1007/BF00735815

J D Leander, D E Mcmillan, F W Ellis

引用次数: 17

The effects of pre-exposure to scopolamine on subsequent drug state discrimination. 预暴露于东莨菪碱对随后药物状态歧视的影响。

Psychopharmacologia Pub Date : 1976-05-28 DOI: 10.1007/BF00735814

W A McKim

引用次数: 4

Effects of low and moderate doses of chlorpromazine on discrimination learning in the rat. 低、中剂量氯丙嗪对大鼠辨别学习的影响。

Psychopharmacologia Pub Date : 1976-05-28 DOI: 10.1007/BF00735824

J I Telner, V Vikis-Freibergs, F Lepore

引用次数: 3

Effects of caffeine consumption on nicotine consumption. 咖啡因摄入对尼古丁摄入的影响。

Psychopharmacologia Pub Date : 1976-05-28 DOI: 10.1007/BF00735816

L T Kozlowski

引用次数: 18

The interaction between prostaglandin E1 and delta 9-tetrahydrocannabinol on intestinal motility and on the abdominal constriction response in the mouse. 前列腺素E1与δ 9-四氢大麻酚对小鼠肠道运动和腹部收缩反应的相互作用。

Psychopharmacologia Pub Date : 1976-05-28 DOI: 10.1007/BF00735820

D M Jackson, R Malor, G B Chesher, G A Starmer, P J Welburn, R Bailey

{"title":"The interaction between prostaglandin E1 and delta 9-tetrahydrocannabinol on intestinal motility and on the abdominal constriction response in the mouse.","authors":"D M Jackson, R Malor, G B Chesher, G A Starmer, P J Welburn, R Bailey","doi":"10.1007/BF00735820","DOIUrl":"https://doi.org/10.1007/BF00735820","url":null,"abstract":"The interaction between delta9-tetrahydrocannabinol (THC) and PGE1 was studied using two pharmacological parameters-the rate of passage of a charcoal meal through mouse small intestine and the abdominal constriction response in the mouse. PGE1 administered intraperitoneally produced a dose-dependent decrease in intestinal motility, and this effect was antagonized by low (0.25 mg/kg) doses of THC and potentiated by higher doses of THC (1 mg/kg). Kinetic analysis suggested that the interaction was of a mixed but predominantly competitive type. PGF2alpha produced an increase in intestinal motility but this was not dose-dependent. THC antagonized the effect of PGF2alpha in a dose-dependent manner suggestive of a physiological antagonism. THC (0.25-2 mg/kg) antagonized the dose-dependent PGE1 abdominal constriction response in a fashion which suggested a mixed (though mainly competitive) antagonism. It would ssem, therefore, that on the two pharmacological parameters studied THC appears to be interacting with PGE1 at the same receptor site. Although the doses of THC used are within the range of those used in man, it is not implied that these results are necessarily implicated in the psychoactivity of the drug.","PeriodicalId":20715,"journal":{"name":"Psychopharmacologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1976-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00735820","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12448207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Effects of dopamine receptor stimulants on locomotor activity of rats with electrolytic or 6-hydroxydopamine-induced lesions of the nucleus accumbens. 多巴胺受体兴奋剂对电解或6-羟多巴胺诱导伏隔核损伤大鼠运动活动的影响。

Psychopharmacologia Pub Date : 1976-05-28 DOI: 10.1007/BF00735821

G N Woodruff, P H Kelly, A O Elkhawad

{"title":"Effects of dopamine receptor stimulants on locomotor activity of rats with electrolytic or 6-hydroxydopamine-induced lesions of the nucleus accumbens.","authors":"G N Woodruff, P H Kelly, A O Elkhawad","doi":"10.1007/BF00735821","DOIUrl":"https://doi.org/10.1007/BF00735821","url":null,"abstract":"Ergometrine (8 mg/kg) injected intraperitoneally into normal rats had little effect on locomotor activity. In contrast, rats with selective 6-hydroxydopamine-induced lesions of dopamine terminals in the nucleus accumbens showed a strong stimulation of locomotor activity following injection of this dose or ergometrine. The dopamine analogue 2-amino-6-7-dihydroxy-1, 2, 3, 4-tetrahydronaphthalene (ADTN) (150 mug), caused strong and long lasting stimulation of locomotor activity when injected intracerebroventricularly into rats. The ADTN response was markedly reduced in rats with bilateral electrolytic lesions of the nucleus accumbens, but unchanged in rats with bilateral electrolytic lesions of the caudate nucleus. At a lower dose level (50 mug) ADTN, injected intracerebroventricularly, had little effect on the locomotor activity of normal or sham-operated rats. This dose of ADTN was, however, effective in causing locomotor stimulation of rats with bilateral 6-hydroxydopamine-induced lesions of the nucleus accumbens. These results support the view that the dopamine receptors in the nucleus accumbens are involved in the actions of locomotor stimulant drugs.","PeriodicalId":20715,"journal":{"name":"Psychopharmacologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1976-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00735821","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12448208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Selective neuroendocrine effects of low-dose haloperidol in normal adult men. 低剂量氟哌啶醇对正常成年男性选择性神经内分泌的影响。

Psychopharmacologia Pub Date : 1976-05-28 DOI: 10.1007/BF00735811

R T Rubin, R E Poland, D O'Connor, P R Gouin, B B Tower

{"title":"Selective neuroendocrine effects of low-dose haloperidol in normal adult men.","authors":"R T Rubin, R E Poland, D O'Connor, P R Gouin, B B Tower","doi":"10.1007/BF00735811","DOIUrl":"https://doi.org/10.1007/BF00735811","url":null,"abstract":"The neuroendocrine effects of haloperidol, usually reported as side effects of this drug when given in antipsychotic doses, have not been systematically investigated. In the present study five normal adult men were administered saline and two doses of of haloperidol (0.25 mg, 0.5 mg) intramuscularly in a double-blind randomized block design. The anterior pituitary hormones GH, LH, FSH, and PRL were measured in blood samples taken every 20 min for several hours thereafter. The low doses of haloperidol used have been shown by others to alter the human EEG; in our subjects these doses produced no objective or subjective clinical effects. There were no drug related changes in GH, LH, or FSH. PRL, however, showed a prompt, statistically significant, dose-related increase in plasma levels, with a return to baseline with 5 h. Haloperidol has strong dopamine-blocking effects, and the hypothalamic inhibitory mechanism for PRL release is believed to be dopamine-mediated. The results of this study suggest that haloperidol may have utility in low doses primarily for its hypothalamic neuroendocrine effects, and that dose-related PRL release may be a useful paradigm for comparing dopamine-blocking antipsychotic agents in humans.","PeriodicalId":20715,"journal":{"name":"Psychopharmacologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1976-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00735811","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12448444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Residual effects of hypnotic drugs: evidence for individual differences on vigilance. 催眠药物的残留效应:警觉性个体差异的证据。

Psychopharmacologia Pub Date : 1976-05-28 DOI: 10.1007/BF00735826

A W Peck, R Adams, C Bye, R T Wilkinson

{"title":"Residual effects of hypnotic drugs: evidence for individual differences on vigilance.","authors":"A W Peck, R Adams, C Bye, R T Wilkinson","doi":"10.1007/BF00735826","DOIUrl":"https://doi.org/10.1007/BF00735826","url":null,"abstract":"Twelve healthy volunteers were given butobarbitone 100 and 200 mg, nitrazepam 5 and 10 mg and 2 lactose dummy treatments, at 23.00 hours at weekly intervals over 6 weeks according to a balanced design and using double blind conditions. Performance was studied between 09.00 hours and 17.00 hours the following day. Significant (P is less than 0.05) impairment of tapping rate and digit symbol substitution occurred. No significant differences occurred between performance after active drug and dummy in auditory vigilance, and subjective effects. Examination of individual differences in the response of subjects to the 4 hypnotic drug treatments, compared with their responses after dummy, indicated that subjects could be divided into two groups. One group consistently rated themselved as more alert after hypnotics and their vigilance performance improved. The other group consistently were more drowsy after hypnotics and their performance was impaired. It is suggested that the improvement in the first group resulted from improved sleep quality sufficient to counteract the residual effect of the hypnotic, whereas the second group merely showed the residual effects of the drugs.","PeriodicalId":20715,"journal":{"name":"Psychopharmacologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1976-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00735826","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12448144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7