Effects of dopamine receptor stimulants on locomotor activity of rats with electrolytic or 6-hydroxydopamine-induced lesions of the nucleus accumbens.

Psychopharmacologia Pub Date : 1976-05-28 DOI:10.1007/BF00735821

G N Woodruff, P H Kelly, A O Elkhawad

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引用次数: 9

Abstract

Ergometrine (8 mg/kg) injected intraperitoneally into normal rats had little effect on locomotor activity. In contrast, rats with selective 6-hydroxydopamine-induced lesions of dopamine terminals in the nucleus accumbens showed a strong stimulation of locomotor activity following injection of this dose or ergometrine. The dopamine analogue 2-amino-6-7-dihydroxy-1, 2, 3, 4-tetrahydronaphthalene (ADTN) (150 mug), caused strong and long lasting stimulation of locomotor activity when injected intracerebroventricularly into rats. The ADTN response was markedly reduced in rats with bilateral electrolytic lesions of the nucleus accumbens, but unchanged in rats with bilateral electrolytic lesions of the caudate nucleus. At a lower dose level (50 mug) ADTN, injected intracerebroventricularly, had little effect on the locomotor activity of normal or sham-operated rats. This dose of ADTN was, however, effective in causing locomotor stimulation of rats with bilateral 6-hydroxydopamine-induced lesions of the nucleus accumbens. These results support the view that the dopamine receptors in the nucleus accumbens are involved in the actions of locomotor stimulant drugs.

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多巴胺受体兴奋剂对电解或6-羟多巴胺诱导伏隔核损伤大鼠运动活动的影响。

正常大鼠腹腔注射麦角新碱(8mg /kg)对运动活动影响不大。相比之下，6-羟多巴胺诱导的伏隔核多巴胺末端病变的大鼠在注射该剂量或麦角新碱后表现出强烈的运动活动刺激。多巴胺类似物2-氨基-6-7-二羟基- 1,2,3,4 -四氢萘(ADTN)(150马克杯)经脑室内注射后，对大鼠的运动活动产生强烈而持久的刺激。双侧伏隔核电损伤大鼠ADTN反应明显降低，双侧尾状核电损伤大鼠ADTN反应不变。在低剂量(50马克杯)下，ADTN脑室内注射对正常或假手术大鼠的运动活动几乎没有影响。然而，该剂量的ADTN对双侧6-羟多巴胺诱导的伏隔核损伤大鼠的运动刺激有效。这些结果支持伏隔核多巴胺受体参与运动兴奋剂作用的观点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Psychopharmacologia

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