感觉,知觉,运动和认知功能和主观报告后口服德尔塔9-四氢大麻酚。

B A Peters, E G Lewis, R E Dustman, R C Straight, E C Beck
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引用次数: 20

摘要

对10名经常吸食大麻的人和10名偶尔吸食大麻的人口服三种剂量水平(0.2、0.4和0.6 mg/kg)的四氢大麻酚(THC)和安慰剂。在服用每种剂量和安慰剂后,从一系列常规用于评估住院患者脑功能障碍的感觉和知觉运动测试中选择客观测试。δ 9-四氢大麻酚对熟练程度和表现可变性的影响很小。然而,当将个人测试分数和可变性合并并转换为标准分数时,允许对整体表现进行分析,THC对表现的熟练程度和可变性都有很小但一致的有害影响。相比之下,四氢大麻酚对志愿者的主观体验有深刻的影响,通过主观药物效应问卷来评估。所有受试者都报告了情绪、感觉、知觉和躯体感觉的主观变化,但在偶尔使用的人群中更为明显。研究人员提出,与对主观反应的巨大影响相比,摄入delta - 9- thc后对客观测试成绩的轻微损害表明,大麻的主要影响是自主神经系统,而不是高级皮质功能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Sensory, perceptual, motor and cognitive functioning and subjective reports following oral administration of delta9-tetrahydrocannabinol.

Three dose levels, 0.2, 0.4, and 0.6 mg/kg, of delta9-tetrahydrocannabinol (THC) and a placebo were orally administered to 10 frequent and 10 occasional marijuana users. Following ingestion of each dose and the placebo, objective tests selected from a battery of sensory and perceptual motor tests routinely used to evaluate cerebral dysfunction in hospitalized patients were administered. The influence of delta9-THC on proficiency and variability of performance was minimal. However, when individual test scores and variabilities were combined and converted to standard scores, allowing for analysis of overall performance, THC had a small but consistent detrimental effect on both proficiency and variability of performance. In contrast, THC exerted profound effects on the subjective experiences of the volunteers as assessed by the Subjective Drug Effects Questionnaire. Subjective changes in mood, feeling, perception and somatic sensations were reported by all subjects but were more pronounced in the occasional user group. It was proposed that the small impairment noted in objective test performance after ingestion of delta9-THC as contrasted to the large effects on subjective responses suggests that the principal effects of marijuana are on the autonomic nervous system rather than on higher cortical functions.

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