低、中剂量氯丙嗪对大鼠辨别学习的影响。

J I Telner, V Vikis-Freibergs, F Lepore
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引用次数: 3

摘要

研究了氯丙嗪对食物奖励下明暗辨别获得的影响。实验前1 h, 4组7只Sprague-Dawley大鼠分别腹腔注射0.5、1.0或2.0 mg/kg CPZ和生理盐水。经过3周的适应期和预训练后,每周7天,每天20次。达到18/20连续正确反应标准的试验次数没有发现药物影响,这需要平均6.2天的培训。然而,准前潜伏期随着剂量水平的增加而增加。选择后潜伏期不受影响,排除了运动迟缓作为潜伏期效应的解释。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effects of low and moderate doses of chlorpromazine on discrimination learning in the rat.

The effects of chlorpromazine on the acquisition of a brightness discrimination with food reward were examined. Doses of 0.5, 1.0 or 2.0 mg/kg of CPZ as well as saline were administered intraperitoneally to 4 groups of 7 Sprague-Dawley rats, 1 h prior to testing. After a 3-week period of habituation and pre-training, rats were tested 20 trials a day, 7 days a week. No drug effect was found on the number of trials to reach a criterion of 18/20 successive correct responses, which required an average of 6.2 days of training. Precriterion latencies, however, showed an increase as a function of increasing dose level. Post-choice latencies were not affected, eliminating motor retardation as an explanation for the latency effect.

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