催眠药物的残留效应:警觉性个体差异的证据。

A W Peck, R Adams, C Bye, R T Wilkinson
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引用次数: 7

摘要

12名健康志愿者按照平衡设计和双盲条件,在每周23.00小时给予布托巴比酮100和200 mg,硝西泮5和10 mg以及2个乳糖假体治疗,持续6周。在第二天上午9点至下午17点之间研究它们的表现。敲击率和数字符号替换出现显著(P < 0.05)的损伤。两组在听觉警觉性和主观效应方面均无显著差异。观察被试对4种催眠药物治疗反应的个体差异,并与假人后的反应进行比较,发现被试可分为两组。一组人在催眠后一直认为自己更警觉,他们的警觉性也有所提高。另一组在接受催眠后一直更加困倦,他们的表现受到了损害。这表明,第一组的改善是由于睡眠质量的改善足以抵消催眠药的残留效应,而第二组仅仅显示药物的残留效应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Residual effects of hypnotic drugs: evidence for individual differences on vigilance.

Twelve healthy volunteers were given butobarbitone 100 and 200 mg, nitrazepam 5 and 10 mg and 2 lactose dummy treatments, at 23.00 hours at weekly intervals over 6 weeks according to a balanced design and using double blind conditions. Performance was studied between 09.00 hours and 17.00 hours the following day. Significant (P is less than 0.05) impairment of tapping rate and digit symbol substitution occurred. No significant differences occurred between performance after active drug and dummy in auditory vigilance, and subjective effects. Examination of individual differences in the response of subjects to the 4 hypnotic drug treatments, compared with their responses after dummy, indicated that subjects could be divided into two groups. One group consistently rated themselved as more alert after hypnotics and their vigilance performance improved. The other group consistently were more drowsy after hypnotics and their performance was impaired. It is suggested that the improvement in the first group resulted from improved sleep quality sufficient to counteract the residual effect of the hypnotic, whereas the second group merely showed the residual effects of the drugs.

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