The interaction between prostaglandin E1 and delta 9-tetrahydrocannabinol on intestinal motility and on the abdominal constriction response in the mouse.

D M Jackson, R Malor, G B Chesher, G A Starmer, P J Welburn, R Bailey
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引用次数: 5

Abstract

The interaction between delta9-tetrahydrocannabinol (THC) and PGE1 was studied using two pharmacological parameters-the rate of passage of a charcoal meal through mouse small intestine and the abdominal constriction response in the mouse. PGE1 administered intraperitoneally produced a dose-dependent decrease in intestinal motility, and this effect was antagonized by low (0.25 mg/kg) doses of THC and potentiated by higher doses of THC (1 mg/kg). Kinetic analysis suggested that the interaction was of a mixed but predominantly competitive type. PGF2alpha produced an increase in intestinal motility but this was not dose-dependent. THC antagonized the effect of PGF2alpha in a dose-dependent manner suggestive of a physiological antagonism. THC (0.25-2 mg/kg) antagonized the dose-dependent PGE1 abdominal constriction response in a fashion which suggested a mixed (though mainly competitive) antagonism. It would ssem, therefore, that on the two pharmacological parameters studied THC appears to be interacting with PGE1 at the same receptor site. Although the doses of THC used are within the range of those used in man, it is not implied that these results are necessarily implicated in the psychoactivity of the drug.

前列腺素E1与δ 9-四氢大麻酚对小鼠肠道运动和腹部收缩反应的相互作用。
研究了四氢大麻酚(THC)与PGE1之间的相互作用,采用两个药理学参数——木炭粉通过小鼠小肠的速率和小鼠腹部收缩反应。腹腔给药PGE1产生剂量依赖性肠动力下降,这种作用被低剂量(0.25 mg/kg)的四氢大麻酚拮抗,并被高剂量(1 mg/kg)的四氢大麻酚增强。动力学分析表明,这种相互作用是混合的,但以竞争为主。PGF2alpha产生肠道蠕动的增加,但这不是剂量依赖性的。四氢大麻酚以剂量依赖的方式拮抗PGF2alpha的作用,提示一种生理拮抗作用。四氢大麻酚(0.25- 2mg /kg)以一种混合(尽管主要是竞争性)拮抗的方式拮抗剂量依赖性PGE1腹部收缩反应。因此,在研究的两个药理学参数上,THC似乎在同一受体位点与PGE1相互作用。虽然使用的四氢大麻酚剂量在人体使用的剂量范围内,但这并不意味着这些结果必然与药物的精神活性有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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