Progress in Biomaterials最新文献

筛选
英文 中文
Correction to: Characteristics of a decellularized human ovarian tissue created by combined protocols and its interaction with human endometrial mesenchymal cells. 更正:由联合方案产生的去细胞化人卵巢组织的特征及其与人子宫内膜间充质细胞的相互作用。
IF 4.9 3区 医学
Progress in Biomaterials Pub Date : 2022-03-01 DOI: 10.1007/s40204-021-00175-2
Maryam Nezhad Sistani, Saeed Zavareh, Mojtaba Rezazadeh Valojerdi, Mojdeh Salehnia
{"title":"Correction to: Characteristics of a decellularized human ovarian tissue created by combined protocols and its interaction with human endometrial mesenchymal cells.","authors":"Maryam Nezhad Sistani, Saeed Zavareh, Mojtaba Rezazadeh Valojerdi, Mojdeh Salehnia","doi":"10.1007/s40204-021-00175-2","DOIUrl":"https://doi.org/10.1007/s40204-021-00175-2","url":null,"abstract":"","PeriodicalId":20691,"journal":{"name":"Progress in Biomaterials","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8927483/pdf/40204_2021_Article_175.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39689566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Artificial neural network for optimizing the formulation of curcumin-loaded liposomes from statistically designed experiments. 从统计设计的实验中优化姜黄素脂质体配方的人工神经网络。
IF 4.9 3区 医学
Progress in Biomaterials Pub Date : 2022-03-01 Epub Date: 2022-01-18 DOI: 10.1007/s40204-022-00179-6
Ibilola M Cardoso-Daodu, Margaret O Ilomuanya, Andrew N Amenaghawon, Chukwuemeka P Azubuike
{"title":"Artificial neural network for optimizing the formulation of curcumin-loaded liposomes from statistically designed experiments.","authors":"Ibilola M Cardoso-Daodu,&nbsp;Margaret O Ilomuanya,&nbsp;Andrew N Amenaghawon,&nbsp;Chukwuemeka P Azubuike","doi":"10.1007/s40204-022-00179-6","DOIUrl":"https://doi.org/10.1007/s40204-022-00179-6","url":null,"abstract":"<p><p>Curcumin is a primary polyphenol of the rhizomatous perennial plant called Curcuma Longa. Curcumin interferes favorably with the cellular events that take place in the inflammatory and proliferative stages of wound healing, hence its importance in skin regeneration and wound healing. Curcumin is however lipophilic, and this must be considered in the choice of its drug delivery system. Liposomes are spherical vesicles with bi-lipid layers. Liposomes can encapsulate both lipophilic and hydrophilic drugs, hence their suitability as an ideal drug delivery system for curcumin. There is, nevertheless, a tendency for liposomes to be unstable and have low encapsulation efficiency if it is not formulated properly. Formulation optimization of curcumin-loaded liposomes was studied by the application of artificial neural network (ANN) to improve encapsulation efficiency and flux of the liposomes. The input factors selected for optimization of the formulation were sonication time, hydration volume, and lipid/curcumin ratio. The response variables were encapsulation efficiency and flux. The maximum encapsulation efficiency and flux were obtained using lipid/curcumin ratio of 4.35, sonicator time of 15 min, and hydration volume of 25 mL. The maximum encapsulation efficiency and flux predicted were 100% and 51.23 µg/cm<sup>2</sup>/h, respectively. The experimental values were 99.934% and 51.229 µg/cm<sup>2</sup>/h, respectively. Curcumin-loaded liposome formulation is a promising drug delivery system in the pharmaceutical industry when formulated using optimized parameters derived from ANN statistically designed models.</p>","PeriodicalId":20691,"journal":{"name":"Progress in Biomaterials","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8927551/pdf/40204_2022_Article_179.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39829338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Correction to: Injectable hyaluronic acid-based antibacterial hydrogel adorned with biogenically synthesized AgNPs-decorated multi-walled carbon nanotubes. 更正:可注射的透明质酸抗菌水凝胶,由生物合成的agnps装饰的多壁碳纳米管装饰。
IF 4.9 3区 医学
Progress in Biomaterials Pub Date : 2022-03-01 DOI: 10.1007/s40204-021-00177-0
Pooyan Makvandi, Milad Ashrafizadeh, Matineh Ghomi, Masoud Najafi, Hamid Heydari Sheikh Hossein, Ali Zarrabi, Virgilio Mattoli, Rajender S Varma
{"title":"Correction to: Injectable hyaluronic acid-based antibacterial hydrogel adorned with biogenically synthesized AgNPs-decorated multi-walled carbon nanotubes.","authors":"Pooyan Makvandi,&nbsp;Milad Ashrafizadeh,&nbsp;Matineh Ghomi,&nbsp;Masoud Najafi,&nbsp;Hamid Heydari Sheikh Hossein,&nbsp;Ali Zarrabi,&nbsp;Virgilio Mattoli,&nbsp;Rajender S Varma","doi":"10.1007/s40204-021-00177-0","DOIUrl":"https://doi.org/10.1007/s40204-021-00177-0","url":null,"abstract":"","PeriodicalId":20691,"journal":{"name":"Progress in Biomaterials","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8927476/pdf/40204_2021_Article_177.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39822669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fe3O4 nanoparticles coated with carboxymethyl chitosan containing curcumin in combination with hyperthermia induced apoptosis in breast cancer cells. 含有姜黄素的羧甲基壳聚糖包覆的 Fe3O4 纳米粒子与热疗结合可诱导乳腺癌细胞凋亡。
IF 4.4 3区 医学
Progress in Biomaterials Pub Date : 2022-03-01 Epub Date: 2022-01-13 DOI: 10.1007/s40204-021-00178-z
Negin Pazouki, Shiva Irani, Nafiseh Olov, Seyed Mohammad Atyabi, Shadab Bagheri-Khoulenjani
{"title":"Fe<sub>3</sub>O<sub>4</sub> nanoparticles coated with carboxymethyl chitosan containing curcumin in combination with hyperthermia induced apoptosis in breast cancer cells.","authors":"Negin Pazouki, Shiva Irani, Nafiseh Olov, Seyed Mohammad Atyabi, Shadab Bagheri-Khoulenjani","doi":"10.1007/s40204-021-00178-z","DOIUrl":"10.1007/s40204-021-00178-z","url":null,"abstract":"<p><p>Many studies have demonstrated that curcumin has potential anticancer properties. This research aims to study the effect of iron (II, III) oxide (Fe<sub>3</sub>O<sub>4</sub>) nanoparticles coated with carboxymethyl chitosan containing curcumin combination with hyperthermia on breast cancer cells. Magnetic nanoparticles coated with carboxymethyl chitosan containing curcumin (MNP-CMC-CUR) were prepared and specified. MCF-7, MDA-MB-231, and human fibroblast cells were treated with free curcumin and MNP-CMC-CUR at concentrations of 0-60 µM and at different time points. A combined therapy of MNP-CMC-CUR and hyperthermia was performed on MCF-7 cells. The cytotoxicity of curcumin and MNP-CMC-CUR combined with hyperthermia was assessed by MTT. The changes in TP53 and CASPASE3 gene expression were evaluated using real-time PCR. Both cell apoptosis and cell cycle were studied by Annexin/PI staining. The results of MTT showed that the IC<sub>50</sub> amount of MNP-CMC-CUR has significantly decreased compared to free curcumin (p < 0.05) and MNP-CMC-CUR in combination with the hyperthermia, and significantly reducing the metabolic activity of the cells (p < 0.05). Real-time PCR results revealed the up-regulation of TP53 and CASPASE3 (p < 0.05). The combinational therapy-induced cell apoptosis (64.51%) and sub-G1 cell cycle were arrested in MCF-7 cells. Based on these observations, a combination of MNP-CMC-CUR with hyperthermia could inhibit the proliferation of MCF-7 cells.</p>","PeriodicalId":20691,"journal":{"name":"Progress in Biomaterials","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8927563/pdf/40204_2021_Article_178.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39817456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A hyaluronic acid/PVA electrospun coating on 3D printed PLA scaffold for orthopedic application. 用于骨科3D打印PLA支架的透明质酸/PVA电纺丝涂层。
IF 4.9 3区 医学
Progress in Biomaterials Pub Date : 2022-03-01 Epub Date: 2022-01-22 DOI: 10.1007/s40204-022-00180-z
Mina Farsi, Azadeh Asefnejad, Hadi Baharifar
{"title":"A hyaluronic acid/PVA electrospun coating on 3D printed PLA scaffold for orthopedic application.","authors":"Mina Farsi,&nbsp;Azadeh Asefnejad,&nbsp;Hadi Baharifar","doi":"10.1007/s40204-022-00180-z","DOIUrl":"https://doi.org/10.1007/s40204-022-00180-z","url":null,"abstract":"<p><p>The need for bone tissue replacement, repair and regeneration for orthopedic application is constantly growing. Therefore, the application of cartilage substitute due to the lack of donors as well as biocompatibility leads to immune system rejection. In order to overcome these drawbacks, researchers have used porous scaffold as an option for bone transplantation. In this study, poly-lactic acid (PLA) scaffolds were prepared for cartilage application by fused deposition modeling (FDM) technique and then coated by electrospinning with polyvinyl alcohol (PVA) and hyaluronic acid (HLA) fibers. Hybrid electrospinning (ELS) method was used to produce porous scaffolds from HLA-PVA polymers. The printed scaffold was coated using FDM technique and the mechanical and biological investigation was performed on the polymeric composite specimen. The functional group and morphological behavior were investigated using Fourier-transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM) techniques. The obtained porous scaffold has hydrophilic properties as the PVA and HLA were coated on the PLA. The porous 3D-printed scaffold containing PLA/PVA/HLA scaffold does not show any toxicity in MTT evaluation after 1, 3 and 7 days. The SEM image confirmed the cell adhesion of the chondrite to the scaffold. Also, the mechanical performances of the sample, such as elastic modulus and compressive strength, were evaluated by compression test. By electro-spun coating, the elastic module of PVA/PLA and PLA/PVA/HLA scaffolds has increased to 18.31 ± 0.29 MPa and 19.25 ± 0.38 MPa. Also, the tensile strength of these two porous scaffolds has reached 6.11 ± 0.42 MPa and 6.56 ± 0.14 MPa, respectively. The failure strain of 3D printed PLA scaffold was reported to be 53 ± 0.21% and this value was reduced to 47 ± 0.62% and 42 ± 0.22% in PVA/PLA and PLA/PVA/HLA scaffolds. The cells' growth on the porous scaffolds showed a broad, spindle-shaped and regular shape. The obtained results of the chemical, physical and biological analyses showed that porous PLA/PVA/HLA scaffold has potential applications in cartilage construction.</p>","PeriodicalId":20691,"journal":{"name":"Progress in Biomaterials","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8927516/pdf/40204_2022_Article_180.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39938337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
Design expert assisted formulation, characterization and optimization of microemulsion based solid lipid nanoparticles of repaglinide. 设计专家协助制剂,表征和优化瑞格列奈微乳液为基础的固体脂质纳米颗粒。
IF 4.9 3区 医学
Progress in Biomaterials Pub Date : 2021-12-01 Epub Date: 2021-11-23 DOI: 10.1007/s40204-021-00174-3
Balaji Maddiboyina, Vikas Jhawat, Ramya Krishna Nakkala, Prasanna Kumar Desu, Sivaraman Gandhi
{"title":"Design expert assisted formulation, characterization and optimization of microemulsion based solid lipid nanoparticles of repaglinide.","authors":"Balaji Maddiboyina,&nbsp;Vikas Jhawat,&nbsp;Ramya Krishna Nakkala,&nbsp;Prasanna Kumar Desu,&nbsp;Sivaraman Gandhi","doi":"10.1007/s40204-021-00174-3","DOIUrl":"https://doi.org/10.1007/s40204-021-00174-3","url":null,"abstract":"<p><p>Repaglinide, a member of the meglitinide class of drugs, is a new anti-diabetic agent that is utilized as an oral hypoglycemic agent. Using glyceryl monostearate, cetyl palmitate, and tristearin as lipids and poloxamer 188 as a surfactant, repaglinide-loaded solid lipid nanoparticles were created. Solid lipid nanoparticles were prepared utilizing an o/w microemulsion technique, which included the lipids glyceryl monostearate and tristearin, as well as waxes such as cetyl palmitate and the surfactant poloxamer 188. The mean particle size of the solid lipid nanoparticles formed was around 339 nm, with an entrapment efficiency of 82.20%. In-vitro release studies continued to be conducted using the dialysis bag diffusion technique. Within 12 h, the cumulative drug release was 88.4%. The results indicate that repaglinide was released more slowly from solid lipid nanoparticles made from tristearin and glyceryl monostearate in an equal ratio. Tristearin found the controlled release and extreme entrapment from other lipid carriers like glyceryl monostearate and cetyl palmitate. Differential scanning calorimetry demonstrates that repaglinide is entangled in amorphous or molecular state within solid lipid nanoparticles. SEM microscopy revealed that the produced repaglinide solid lipid nanoparticles had a spherical shape. After one month of storage at 2-8 °C, short-term stability testing revealed no significant alteration.</p>","PeriodicalId":20691,"journal":{"name":"Progress in Biomaterials","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8633183/pdf/40204_2021_Article_174.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39651368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Effect of titanium dioxide intermediate layer on scratch and corrosion resistance of sol-gel-derived HA coating applied on Ti-6Al-4V substrate. 二氧化钛中间层对Ti-6Al-4V基板溶胶-凝胶型HA涂层划伤及耐蚀性能的影响
IF 4.9 3区 医学
Progress in Biomaterials Pub Date : 2021-12-01 Epub Date: 2021-11-06 DOI: 10.1007/s40204-021-00169-0
Rezvan Azari, Hamid Reza Rezaie, Alireza Khavandi
{"title":"Effect of titanium dioxide intermediate layer on scratch and corrosion resistance of sol-gel-derived HA coating applied on Ti-6Al-4V substrate.","authors":"Rezvan Azari,&nbsp;Hamid Reza Rezaie,&nbsp;Alireza Khavandi","doi":"10.1007/s40204-021-00169-0","DOIUrl":"https://doi.org/10.1007/s40204-021-00169-0","url":null,"abstract":"<p><p>Modification of dental and orthopedic implants' surface by coating them with bioactive materials, such as hydroxyapatite (HA), diminishes the implants' fixation time. Appropriate adhesion to the substrate and stability in biological conditions are essential requirements for these coatings. In this study, sol-gel-derived HA coating was applied on the Ti-6Al-4 V substrate, which is a high-performance alloy for manufacturing bone implants. Also, titanium dioxide (TiO<sub>2</sub>) which was prepared by the sol-gel method was used as an intermediate layer between HA coating and the substrate. The nano-scratch and potentiodynamic polarization tests were employed to evaluate the effectiveness of TiO<sub>2</sub> intermediate layer on improving the scratch resistance, as an indicator of coating adhesion strength, and the corrosion resistance of the coated samples. The quality of the coating bonded to the substrate was studied by cross-sectional SEM images. The XRD tests indicated that HA and TiO<sub>2</sub> coatings were formed with predetermined phase compositions. The biocompatibility of sol-gel-derived HA coating was established by simulated body fluid (SBF) immersion tests. The SEM images, along with the results of electrochemical and nano-scratch tests, proved the significant effect of a TiO<sub>2</sub> intermediate layer on improving the scratch resistance and stability of HA coating on titanium alloy substrate.</p>","PeriodicalId":20691,"journal":{"name":"Progress in Biomaterials","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8633272/pdf/40204_2021_Article_169.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39683408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Stimuli-responsive electrospun nanofibers based on PNVCL-PVAc copolymer in biomedical applications. 基于PNVCL-PVAc共聚物的电纺纳米纤维在生物医学中的应用。
IF 4.9 3区 医学
Progress in Biomaterials Pub Date : 2021-12-01 Epub Date: 2021-11-03 DOI: 10.1007/s40204-021-00168-1
Sogand Safari, Morteza Ehsani, Mojgan Zandi
{"title":"Stimuli-responsive electrospun nanofibers based on PNVCL-PVAc copolymer in biomedical applications.","authors":"Sogand Safari,&nbsp;Morteza Ehsani,&nbsp;Mojgan Zandi","doi":"10.1007/s40204-021-00168-1","DOIUrl":"https://doi.org/10.1007/s40204-021-00168-1","url":null,"abstract":"<p><p>Poly(N-vinylcaprolactam) (PNVCL) is a suitable alternative for biomedical applications due to its biocompatibility, biodegradability, non-toxicity, and showing phase transition at the human body temperature range. The purpose of this study was to synthesize a high molecular weight PNVCL-PVAc thermo-responsive copolymer with broad mass distribution suitable for electrospun nanofiber fabrication. The chemical structure of the synthesized materials was detected by FTIR and <sup>1</sup>HNMR spectroscopies. N-Vinyl caprolactam/vinyl acetate copolymers (159,680 molecular weight (g/mol) and 2.51 PDI) were synthesized by radical polymerization. The phase transition temperature of N-vinyl caprolactam/vinyl acetate copolymer was determined by conducting a contact angle test at various temperatures (25, 26, 28, and 30 [Formula: see text]). The biocompatibility of the nanofibers was also evaluated, and both qualitative and quantitative results showed that the growth and proliferation of 929L mouse fibroblast cells increased to 80% within 48 h. These results revealed that the synthesized nanofibers were biocompatible and not cytotoxic. The results confirmed that the synthesized copolymers have good characteristics for biomedical applications.</p>","PeriodicalId":20691,"journal":{"name":"Progress in Biomaterials","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8633178/pdf/40204_2021_Article_168.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39587291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Fabrication of porous TiO2 foams by powder metallurgy technique and study of bulk crushing strength for biomedical application. 采用粉末冶金技术制备多孔TiO2泡沫,并研究其在生物医学应用中的整体抗压强度。
IF 4.9 3区 医学
Progress in Biomaterials Pub Date : 2021-12-01 Epub Date: 2021-11-16 DOI: 10.1007/s40204-021-00173-4
Farida Ahmed Koly, Md Arafat Rahman, Md Saiful Islam, Md Mizanur Rahman
{"title":"Fabrication of porous TiO<sub>2</sub> foams by powder metallurgy technique and study of bulk crushing strength for biomedical application.","authors":"Farida Ahmed Koly,&nbsp;Md Arafat Rahman,&nbsp;Md Saiful Islam,&nbsp;Md Mizanur Rahman","doi":"10.1007/s40204-021-00173-4","DOIUrl":"10.1007/s40204-021-00173-4","url":null,"abstract":"<p><p>Despite the importance of porous titanium oxide (PA-TiO<sub>2</sub>) in diverse functional applications, very little information is available on the compatible mechanical properties for potential biomedical applications. In this study, PA-TiO<sub>2</sub> foam was synthesized using space-holding powder metallurgy and sintering methods to produce interconnected opened-cell structure with surface morphology of mountain-like features associated with the extensive rift valley system. Three different types of PA-TiO<sub>2</sub> foams with porosities of 35-52% and mean pore diameter of 190-210 μm were fabricated for evaluating the effect of porosity on mechanical properties of bulk PA-TiO<sub>2</sub>. The modulus of elasticity of PA-TiO<sub>2</sub> foams exhibited in the range of 45-262 MPa which was within the range of modulus of elasticity of human cancellous bone. Cytotoxicity test is performed in vitro analysis to observe the effect of cell toxicity to produce osteointegration when used as implantable materials. There was no cytotoxicity effect found and remarkable cell growth was observed for human cancerous (HeLa) cell line. However, there was no cytotoxicity effect found and cell growth was not observed for Vero cell line. This study suggested that PA-TiO<sub>2</sub> facilitates cell growth without spreading toxicity and has mechanical properties of cancellous bone. Hence, it has potential application as implant and medical devices in biomedical applications.</p>","PeriodicalId":20691,"journal":{"name":"Progress in Biomaterials","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8633157/pdf/40204_2021_Article_173.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39881782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Biological and bioactivity assessment of dextran nanocomposite hydrogel for bone regeneration. 葡聚糖纳米复合水凝胶骨再生生物学及生物活性评价。
IF 4.9 3区 医学
Progress in Biomaterials Pub Date : 2021-12-01 Epub Date: 2021-11-01 DOI: 10.1007/s40204-021-00171-6
Parisa Nikpour, Hamed Salimi-Kenari, Sayed Mahmood Rabiee
{"title":"Biological and bioactivity assessment of dextran nanocomposite hydrogel for bone regeneration.","authors":"Parisa Nikpour,&nbsp;Hamed Salimi-Kenari,&nbsp;Sayed Mahmood Rabiee","doi":"10.1007/s40204-021-00171-6","DOIUrl":"https://doi.org/10.1007/s40204-021-00171-6","url":null,"abstract":"<p><p>Insufficient biological and bioactive properties of dextran hydrogels limit their applications as promising scaffolds for tissue engineering. We developed nanocomposite dextran hydrogels comprised of bioactive glass (nBGC: 64% SiO2, 31% CaO, 5% P<sub>2</sub>O<sub>5</sub>) nanoparticles with an average particle size of 77 nm using a chemical crosslinking of dextran chains to form 3D hydrogel networks. In the current study; bioactivity of the obtained nanocomposite hydrogels was evaluated through the formation of apatite crystal structures after the incubation in simulated body fluid (SBF) at various submersion periods and nBGC content. The scanning electron microscopy (SEM) micrographs represented an enhanced hydroxyapatite formation on the cross section of nanocomposite comprising of nBGC content from 2 to 8 (% by wt). Biomineralization results of Dex-8 (% by wt) composite during 7, 14 and 28 days immersion indicated the apatite layer formation and the growth of apatite crystal size on the surface and cross section of the nanocomposite. Moreover, MTT assessments indicated that human osteosarcoma cells (SaOS-2) were able to adhere and spread within the dextran hydrogels reinforced with the bioactive glass nanoparticles. With regard to enhanced bioactivity and biocompatibility, the developed dextran-nBGC hydrogel could be considered as a suitable candidate for bone tissue engineering application.</p>","PeriodicalId":20691,"journal":{"name":"Progress in Biomaterials","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8633275/pdf/40204_2021_Article_171.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39581748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信