Progress in Biomaterials最新文献_第4页

Progress in manufacturing and processing of degradable Fe-based implants: a review. 可降解铁基植入物的制备和加工进展：综述。

IF 4.9 3区医学

Progress in Biomaterials Pub Date : 2022-06-01 Epub Date: 2022-05-18 DOI: 10.1007/s40204-022-00189-4

V P Muhammad Rabeeh, T Hanas

{"title":"Progress in manufacturing and processing of degradable Fe-based implants: a review.","authors":"V P Muhammad Rabeeh, T Hanas","doi":"10.1007/s40204-022-00189-4","DOIUrl":"https://doi.org/10.1007/s40204-022-00189-4","url":null,"abstract":"Biodegradable metals have gained vast attention as befitting candidates for developing degradable metallic implants. Such implants are primarily employed for temporary applications and are expected to degrade or resorbed after the tissue is healed. Fe-based materials have generated considerable interest as one of the possible biodegradable metals. Like other biometals such as Mg and Zn, Fe exhibits good biocompatibility and biodegradability. The versatility in the mechanical behaviour of Fe-based materials makes them a better choice for load-bearing applications. However, the very low degradation rate of Fe in the physiological environment needs to be improved to make it compatible with tissue growth. Several studies on tailoring the degradation behaviour of Fe in the human body are already reported. Majority of these works include studies on the effect of manufacturing and processing techniques on biocompatibility and biodegradability. This article focuses on a comprehensive review and analysis of the various manufacturing and processing techniques so far reported for developing biodegradable iron-based orthopaedic implants. The current status of research in the field is neatly presented, and a summary of the works is included in the article for the benefit of researchers in the field to contextualise their research and effectively find the lacunae in the existing scholarship.","PeriodicalId":20691,"journal":{"name":"Progress in Biomaterials","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9156655/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71426274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Fabrication of anti-bacterial cotton bandage using biologically synthesized nanoparticles for medical applications 医用生物合成纳米颗粒抗菌棉绷带的研制

IF 4.9 3区医学

Progress in Biomaterials Pub Date : 2022-05-27 DOI: 10.1007/s40204-022-00190-x

Monika Senthamarai Kannan, Ponlakshmi S Hari Haran, K. Sundar, Selvaraj Kunjiappan, Vanavil Balakrishnan

引用次数: 6

An aorta ECM extracted hydrogel as a biomaterial in vascular tissue engineering application 主动脉ECM提取水凝胶在血管组织工程中的应用

IF 4.9 3区医学

Progress in Biomaterials Pub Date : 2022-05-18 DOI: 10.1007/s40204-022-00186-7

Khadijeh Baaji, Mohamad Pezeshki‐Modaress, S. Rajabi

引用次数: 0

In vitro DNA plasmid condensation and transfection through pH-responsive nanohydrogel 通过ph反应纳米水凝胶进行体外DNA质粒浓缩和转染

IF 4.9 3区医学

Progress in Biomaterials Pub Date : 2022-05-09 DOI: 10.1007/s40204-022-00187-6

Fatemeh Farjadian, A. Behzad-Behbahani, S. Mohammadi-Samani, Soheila Ghasemi

引用次数: 1

Injectable hydrogels for bone and cartilage tissue engineering: a review 可注射水凝胶用于骨和软骨组织工程:综述

IF 4.9 3区医学

Progress in Biomaterials Pub Date : 2022-04-14 DOI: 10.1007/s40204-022-00185-8

N. Olov, S. Bagheri‐Khoulenjani, H. Mirzadeh

引用次数: 17

Graphene-tethered 5-fluorouracil-loaded ZnO nanocomposites for pH-responsive enhanced efficacy in drug delivery on MCF-7 cells 石墨烯系链负载5-氟尿嘧啶的ZnO纳米复合材料用于ph响应增强MCF-7细胞的药物递送效率

IF 4.9 3区医学

Progress in Biomaterials Pub Date : 2022-03-16 DOI: 10.1007/s40204-022-00184-9

V. Sawant, Bhausaheb V. Tawade, V. M. Desai, B. B. Dongare, S. Nipane

引用次数: 1

Multi-antibacterial agent-based electrospun polycaprolactone for active wound dressing. 多抗菌剂型静电纺聚己内酯活性创面敷料。

IF 4.9 3区医学

Progress in Biomaterials Pub Date : 2022-03-01 Epub Date: 2022-01-29 DOI: 10.1007/s40204-021-00176-1

Fatemeh Safdari, Maryam Darya Gholipour, Azam Ghadami, Mahdi Saeed, Mojgan Zandi

{"title":"Multi-antibacterial agent-based electrospun polycaprolactone for active wound dressing.","authors":"Fatemeh Safdari, Maryam Darya Gholipour, Azam Ghadami, Mahdi Saeed, Mojgan Zandi","doi":"10.1007/s40204-021-00176-1","DOIUrl":"https://doi.org/10.1007/s40204-021-00176-1","url":null,"abstract":"Today, due to the greater knowledge of the side effects of chemical drugs and the favorable pharmacological properties of herbal compounds, the use of these compounds is increasing. Since wounds need fast and efficient healing, wound dressing fabrication methods play an important role in wound healing. In this research, electrospinning process was used to prepare samples. Natural antibacterial compounds, such as curcumin, piperine, eugenol, and rutin were loaded in electrospun nano-fibrous based on polycaprolactone. Three-component novel systems of curcumin-piperine-eugenol (PCPiEu), and curcumin-piperine-rutin (PCPiR) were designed and prepared. Their synergistic effect was investigated and also compared with one- and two-component systems. The results showed that medium diameter nanofibers of PCPiEu and PCPiR samples was 198.38 and 142.60, respectively, and they were obtained in smooth, uniform and bead free morphology using optimization of process parameters. The amount of water absorption and water vapor permeability of the three-component samples were in the appropriate range (8.33-10.42 mg cm2 h-1) for wound dressings. The mechanical properties of samples were reduced compared to the control sample, which required further investigation. Antibacterial tests showed good results for partial toxicity of PCPiEu and PCPiR samples. Antibacterial tests showed minor toxicity in PCPiR samples and good results were obtained for PCPiEu samples. In addition, the results showed that PCPiEu and PCPiR samples exhibited antibacterial activity against Gram-positive bacterium Staphylococcus aureus and Gram-negative Enterococcus faecalis bacterium, so that killing ability of 74% and 75% against Gram-positive bacterium and 99.47% and 96.88% against Gram-negative bacterium were obtained for these three systems, respectively.","PeriodicalId":20691,"journal":{"name":"Progress in Biomaterials","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8927529/pdf/40204_2021_Article_176.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39570853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Drug infused Al₂O₃-bioactive glass coatings toward the cure of orthopedic infection. 药物灌注al2o3生物活性玻璃涂层在骨科感染治疗中的应用。

IF 4.9 3区医学

Progress in Biomaterials Pub Date : 2022-03-01 Epub Date: 2022-01-30 DOI: 10.1007/s40204-022-00181-y

P Bargavi, R Riju Chandran, D Durgalakshmi, P Rajashree, R Ramya, S Balakumar

{"title":"Drug infused Al2O3-bioactive glass coatings toward the cure of orthopedic infection.","authors":"P Bargavi, R Riju Chandran, D Durgalakshmi, P Rajashree, R Ramya, S Balakumar","doi":"10.1007/s40204-022-00181-y","DOIUrl":"https://doi.org/10.1007/s40204-022-00181-y","url":null,"abstract":"A unique implant coated substrate with dual-drug-eluting system exhibiting antibacterial, anti-inflammatory, and bone regenerative capacity has been fabricated using spray pyrolysis deposition (SPD) method. Bioglass (BG) and BG-alumina (BG-Al) composites coatings with different concentrations of Al incorporated on BG network over the Cp-Ti substrate were fabricated using SPD technique. Phase purity of BG and BG-Al composites were analyzed by XRD in which Na2Ca2Si3O9 and β-Na2Ca4(PO4)2SiO4) and Na7.15(Al7.2Si8.8O32) phases were formed. Surface morphology of the coated substrates was analyzed by SEM. Uniformity of the coatings were evaluated by surface profilometer and the uniform distribution the nanoparticles were confirmed with Elemental mapping. Systematically, each apatite layer formation on coated substrate was confirmed by immersing the samples for 1, 3, and 7 days in simulated body fluid and the needle-like structure was characterized using SEM. Cumulative release of Tetracycline hydrochloride (Tet) antibiotic and Dexamethasone (Dex) anti-inflammatory drug-loaded BG-Al and BG-Al composite-coated substrate were studied for 24 h. Antibacterial activity of the coated substrates were evaluated by time-dependent growth inhibition and minimal inhibitory concentration (MIC) assays in which BG-Al and BG-Al composite loaded with Tet showed considerable growth inhibition against S. aureus. Osteoblast-like cells (MG-63) exhibited profound proliferation with no cytotoxic effects which was due to release of Dex drug-coated substrates. Thus, surface modification of Cp-Ti substrate with BG, BG-Al composites coatings loaded with Tet and Dex drug can be considered for post-operative orthopedic implant infection application.","PeriodicalId":20691,"journal":{"name":"Progress in Biomaterials","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8927578/pdf/40204_2022_Article_181.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39733197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Microstructural and in-vitro characteristics of functional calcium silicate topcoat on hydroxyapatite coating for bio-implant applications. 羟基磷灰石涂层上功能性硅酸钙涂层的显微结构及体外特性研究。

IF 4.9 3区医学

Progress in Biomaterials Pub Date : 2022-03-01 Epub Date: 2022-02-22 DOI: 10.1007/s40204-022-00183-w

Jarnail Singh, Sukhpal Singh Chatha, Hazoor Singh

{"title":"Microstructural and in-vitro characteristics of functional calcium silicate topcoat on hydroxyapatite coating for bio-implant applications.","authors":"Jarnail Singh, Sukhpal Singh Chatha, Hazoor Singh","doi":"10.1007/s40204-022-00183-w","DOIUrl":"https://doi.org/10.1007/s40204-022-00183-w","url":null,"abstract":"The delayed tissue-implant interactions in metallic implants coated with hydroxyapatite (HA) paved the way for the development of alternative bioactive coatings. In this study, bi-layered functional gradient (HA-CS) coating was formulated by the atmospheric plasma spray (APS) process on Ti6Al4V alloy. The HA layer was applied at the metal interface to ensure long-term stability, while the calcium silicate (CS) outer layer was applied to achieve fast tissue-implant interactions. Moreover, single-layered HA and CS coating were also formulated for comparative analysis. The phase compositions, coating microstructure, chemical properties, microhardness, porosity, surface roughness, and in-vitro bioactivity were investigated. The CS top layer showed high porosity and surface roughness with respect to the inner HA layer, which constitutes an optimum microstructure to promote bioactivity. The microhardness of the outer CS layer of HA-CS was 520.3 ± 80.8 HV, while the corresponding value for the inner HA layer was 291.7 ± 45.7 HV. HA-CS and CS coatings demonstrated higher in-vitro bioactivity compared to HA coating. On the contrary, HA coating (3.76 mpy) displayed better corrosion resistance than the HA-CS (4.17 mpy) and CS coatings (4.34 mpy). The in-vitro results indicated that the HA-CS coating could promote the healthy development of osteoblast-like MG-63.","PeriodicalId":20691,"journal":{"name":"Progress in Biomaterials","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8927532/pdf/40204_2022_Article_183.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39942914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

A review of current challenges and prospects of magnesium and its alloy for bone implant applications 镁及其合金在骨种植体中的应用现状及展望

IF 4.9 3区医学

Progress in Biomaterials Pub Date : 2022-03-01 DOI: 10.1007/s40204-022-00182-x

Meysam Nasr Azadani, A. Zahedi, Oluwole K. Bowoto, Bankole I. Oladapo

引用次数: 36