羟基磷灰石涂层上功能性硅酸钙涂层的显微结构及体外特性研究。

IF 4.4 3区 医学 Q2 ENGINEERING, BIOMEDICAL
Progress in Biomaterials Pub Date : 2022-03-01 Epub Date: 2022-02-22 DOI:10.1007/s40204-022-00183-w
Jarnail Singh, Sukhpal Singh Chatha, Hazoor Singh
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引用次数: 7

摘要

羟基磷灰石(HA)涂层金属植入体中延迟组织与植入体的相互作用为开发替代生物活性涂层铺平了道路。本研究采用常压等离子喷涂(APS)工艺在Ti6Al4V合金表面制备了双层功能梯度(HA-CS)涂层。透明质酸层应用于金属界面以确保长期稳定性,而硅酸钙(CS)外层应用于实现快速组织-植入物相互作用。此外,还配制了单层HA和CS涂层进行对比分析。研究了涂层的相组成、微观结构、化学性能、显微硬度、孔隙率、表面粗糙度和体外生物活性。与内HA层相比,CS顶层具有较高的孔隙率和表面粗糙度,构成了促进生物活性的最佳微观结构。HA-CS的外CS层显微硬度为520.3±80.8 HV,内HA层显微硬度为291.7±45.7 HV。HA-CS和CS涂层比HA涂层表现出更高的体外生物活性。相反,HA涂层(3.76 mpy)的耐蚀性优于HA-CS涂层(4.17 mpy)和CS涂层(4.34 mpy)。体外实验结果表明,HA-CS涂层可促进成骨样MG-63的健康发育。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Microstructural and in-vitro characteristics of functional calcium silicate topcoat on hydroxyapatite coating for bio-implant applications.

Microstructural and in-vitro characteristics of functional calcium silicate topcoat on hydroxyapatite coating for bio-implant applications.

Microstructural and in-vitro characteristics of functional calcium silicate topcoat on hydroxyapatite coating for bio-implant applications.

The delayed tissue-implant interactions in metallic implants coated with hydroxyapatite (HA) paved the way for the development of alternative bioactive coatings. In this study, bi-layered functional gradient (HA-CS) coating was formulated by the atmospheric plasma spray (APS) process on Ti6Al4V alloy. The HA layer was applied at the metal interface to ensure long-term stability, while the calcium silicate (CS) outer layer was applied to achieve fast tissue-implant interactions. Moreover, single-layered HA and CS coating were also formulated for comparative analysis. The phase compositions, coating microstructure, chemical properties, microhardness, porosity, surface roughness, and in-vitro bioactivity were investigated. The CS top layer showed high porosity and surface roughness with respect to the inner HA layer, which constitutes an optimum microstructure to promote bioactivity. The microhardness of the outer CS layer of HA-CS was 520.3 ± 80.8 HV, while the corresponding value for the inner HA layer was 291.7 ± 45.7 HV. HA-CS and CS coatings demonstrated higher in-vitro bioactivity compared to HA coating. On the contrary, HA coating (3.76 mpy) displayed better corrosion resistance than the HA-CS (4.17 mpy) and CS coatings (4.34 mpy). The in-vitro results indicated that the HA-CS coating could promote the healthy development of osteoblast-like MG-63.

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来源期刊
Progress in Biomaterials
Progress in Biomaterials MATERIALS SCIENCE, BIOMATERIALS-
CiteScore
9.60
自引率
4.10%
发文量
35
期刊介绍: Progress in Biomaterials is a multidisciplinary, English-language publication of original contributions and reviews concerning studies of the preparation, performance and evaluation of biomaterials; the chemical, physical, biological and mechanical behavior of materials both in vitro and in vivo in areas such as tissue engineering and regenerative medicine, drug delivery and implants where biomaterials play a significant role. Including all areas of: design; preparation; performance and evaluation of nano- and biomaterials in tissue engineering; drug delivery systems; regenerative medicine; implantable medical devices; interaction of cells/stem cells on biomaterials and related applications.
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