设计专家协助制剂,表征和优化瑞格列奈微乳液为基础的固体脂质纳米颗粒。

IF 4.4 3区 医学 Q2 ENGINEERING, BIOMEDICAL
Progress in Biomaterials Pub Date : 2021-12-01 Epub Date: 2021-11-23 DOI:10.1007/s40204-021-00174-3
Balaji Maddiboyina, Vikas Jhawat, Ramya Krishna Nakkala, Prasanna Kumar Desu, Sivaraman Gandhi
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引用次数: 8

摘要

瑞格列奈是一种新型的口服降糖药,属于美格列奈类药物。以单硬脂酸甘油酯、十六烷基棕榈酸酯和三硬脂酸为脂质,以波洛沙姆188为表面活性剂,制备了负载瑞格列奈的固体脂质纳米颗粒。利用o/w微乳液技术制备固体脂质纳米颗粒,其中包括脂质单硬脂酸甘油酯和三硬脂酸,蜡质如十六烷基棕榈酸酯和表面活性剂poloxam188。形成的固体脂质纳米颗粒的平均粒径约为339 nm,包封效率为82.20%。体外释放研究继续使用透析袋扩散技术进行。12 h内累积释药率为88.4%。结果表明,由三硬脂苷和单硬脂酸甘油酯按相同比例制成的固体脂质纳米颗粒释放瑞格列奈的速度较慢。三硬脂酸发现了其他脂质载体如单硬脂酸甘油和十六烷基棕榈酸酯的控制释放和极端捕获。差示扫描量热法表明,瑞格列奈在固体脂质纳米颗粒中以无定形或分子状态纠缠。SEM显微镜显示制备的瑞格列奈固体脂质纳米颗粒呈球形。在2-8°C下储存一个月后,短期稳定性测试显示无明显变化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Design expert assisted formulation, characterization and optimization of microemulsion based solid lipid nanoparticles of repaglinide.

Design expert assisted formulation, characterization and optimization of microemulsion based solid lipid nanoparticles of repaglinide.

Design expert assisted formulation, characterization and optimization of microemulsion based solid lipid nanoparticles of repaglinide.

Repaglinide, a member of the meglitinide class of drugs, is a new anti-diabetic agent that is utilized as an oral hypoglycemic agent. Using glyceryl monostearate, cetyl palmitate, and tristearin as lipids and poloxamer 188 as a surfactant, repaglinide-loaded solid lipid nanoparticles were created. Solid lipid nanoparticles were prepared utilizing an o/w microemulsion technique, which included the lipids glyceryl monostearate and tristearin, as well as waxes such as cetyl palmitate and the surfactant poloxamer 188. The mean particle size of the solid lipid nanoparticles formed was around 339 nm, with an entrapment efficiency of 82.20%. In-vitro release studies continued to be conducted using the dialysis bag diffusion technique. Within 12 h, the cumulative drug release was 88.4%. The results indicate that repaglinide was released more slowly from solid lipid nanoparticles made from tristearin and glyceryl monostearate in an equal ratio. Tristearin found the controlled release and extreme entrapment from other lipid carriers like glyceryl monostearate and cetyl palmitate. Differential scanning calorimetry demonstrates that repaglinide is entangled in amorphous or molecular state within solid lipid nanoparticles. SEM microscopy revealed that the produced repaglinide solid lipid nanoparticles had a spherical shape. After one month of storage at 2-8 °C, short-term stability testing revealed no significant alteration.

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来源期刊
Progress in Biomaterials
Progress in Biomaterials MATERIALS SCIENCE, BIOMATERIALS-
CiteScore
9.60
自引率
4.10%
发文量
35
期刊介绍: Progress in Biomaterials is a multidisciplinary, English-language publication of original contributions and reviews concerning studies of the preparation, performance and evaluation of biomaterials; the chemical, physical, biological and mechanical behavior of materials both in vitro and in vivo in areas such as tissue engineering and regenerative medicine, drug delivery and implants where biomaterials play a significant role. Including all areas of: design; preparation; performance and evaluation of nano- and biomaterials in tissue engineering; drug delivery systems; regenerative medicine; implantable medical devices; interaction of cells/stem cells on biomaterials and related applications.
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