Fabrication of porous TiO2 foams by powder metallurgy technique and study of bulk crushing strength for biomedical application.

IF 4.4 3区 医学 Q2 ENGINEERING, BIOMEDICAL
Progress in Biomaterials Pub Date : 2021-12-01 Epub Date: 2021-11-16 DOI:10.1007/s40204-021-00173-4
Farida Ahmed Koly, Md Arafat Rahman, Md Saiful Islam, Md Mizanur Rahman
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引用次数: 2

Abstract

Despite the importance of porous titanium oxide (PA-TiO2) in diverse functional applications, very little information is available on the compatible mechanical properties for potential biomedical applications. In this study, PA-TiO2 foam was synthesized using space-holding powder metallurgy and sintering methods to produce interconnected opened-cell structure with surface morphology of mountain-like features associated with the extensive rift valley system. Three different types of PA-TiO2 foams with porosities of 35-52% and mean pore diameter of 190-210 μm were fabricated for evaluating the effect of porosity on mechanical properties of bulk PA-TiO2. The modulus of elasticity of PA-TiO2 foams exhibited in the range of 45-262 MPa which was within the range of modulus of elasticity of human cancellous bone. Cytotoxicity test is performed in vitro analysis to observe the effect of cell toxicity to produce osteointegration when used as implantable materials. There was no cytotoxicity effect found and remarkable cell growth was observed for human cancerous (HeLa) cell line. However, there was no cytotoxicity effect found and cell growth was not observed for Vero cell line. This study suggested that PA-TiO2 facilitates cell growth without spreading toxicity and has mechanical properties of cancellous bone. Hence, it has potential application as implant and medical devices in biomedical applications.

Abstract Image

采用粉末冶金技术制备多孔TiO2泡沫,并研究其在生物医学应用中的整体抗压强度。
尽管多孔氧化钛(PA-TiO2)在各种功能应用中具有重要意义,但关于潜在生物医学应用的相容机械性能的信息很少。在本研究中,使用保空间粉末冶金和烧结方法合成了PA-TiO2泡沫,以生产具有与广泛裂谷系统相关的山状表面形貌的互连开孔结构。制备了孔隙率为35-52%、平均孔径为190-210μm的三种不同类型的PA-TiO2泡沫,以评估孔隙率对本体PA-TiO2-力学性能的影响。PA-TiO2泡沫的弹性模量在45-262MPa的范围内,这在人松质骨的弹性模量的范围内。细胞毒性试验是在体外分析中进行的,以观察细胞毒性在用作可植入材料时对产生骨整合的影响。没有发现细胞毒性作用,并且观察到人癌(HeLa)细胞系的显著细胞生长。然而,Vero细胞系没有发现细胞毒性作用,也没有观察到细胞生长。这项研究表明,PA-TiO2促进细胞生长而不扩散毒性,并且具有松质骨的力学性能。因此,它在生物医学应用中作为植入物和医疗器械具有潜在的应用前景。
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来源期刊
Progress in Biomaterials
Progress in Biomaterials MATERIALS SCIENCE, BIOMATERIALS-
CiteScore
9.60
自引率
4.10%
发文量
35
期刊介绍: Progress in Biomaterials is a multidisciplinary, English-language publication of original contributions and reviews concerning studies of the preparation, performance and evaluation of biomaterials; the chemical, physical, biological and mechanical behavior of materials both in vitro and in vivo in areas such as tissue engineering and regenerative medicine, drug delivery and implants where biomaterials play a significant role. Including all areas of: design; preparation; performance and evaluation of nano- and biomaterials in tissue engineering; drug delivery systems; regenerative medicine; implantable medical devices; interaction of cells/stem cells on biomaterials and related applications.
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