Preventive Nutrition and Food Science最新文献

Nutritional Composition and Effect of Loquat Fruit (Eriobotrya japonica L. var. Navela) on Lipid Metabolism and Liver Steatosis in High-Fat High-Sucrose Diet-Fed Mice. 枇杷果的营养成分及其对高脂高蔗糖饲料喂养小鼠脂质代谢和肝脏脂肪变性的影响

IF 1.6

Preventive Nutrition and Food Science Pub Date : 2024-09-30 DOI: 10.3746/pnf.2024.29.3.256

Imane Mokhtari, Mohammadine Moumou, Chakib Mokhtari, Mohamed Harnafi, Dragan Milenkovic, Souliman Amrani, Hicham Harnafi

{"title":"Nutritional Composition and Effect of Loquat Fruit (Eriobotrya japonica L. var. Navela) on Lipid Metabolism and Liver Steatosis in High-Fat High-Sucrose Diet-Fed Mice.","authors":"Imane Mokhtari, Mohammadine Moumou, Chakib Mokhtari, Mohamed Harnafi, Dragan Milenkovic, Souliman Amrani, Hicham Harnafi","doi":"10.3746/pnf.2024.29.3.256","DOIUrl":"10.3746/pnf.2024.29.3.256","url":null,"abstract":"Loquat (Eriobotrya japonica L.) is a popular fruit known for its sweet and slightly tangy flavor, which is widely consumed both fresh and in various processed forms. This study aimed to analyze the biochemical composition of loquat juice and investigate its metabolic benefits in mice fed a high-fat/high-sucrose diet (HFSD). Mice were fed either a standard diet or an HFSD and received or not the loquat juice at 4 or 8 mL/kg body weight for 8 weeks. Body weight, food efficiency ratio, plasma lipoprotein profile, plasma glucose, and lipid indices were monitored throughout the experiment. At the end of the experiment, additional assessments were performed, including lipid content measurements in liver, adipose tissue, bile, and feces; hepatic antioxidant enzyme activities (superoxide dismutase and catalase); hepatic malondialdehyde content; plasma biomarkers of liver injury; liver histology; and organ relative weight. Feeding mice with the HFSD resulted in a significant perturbation in lipid and glucose metabolism, obesity, liver steatosis, and oxidative stress-related enzymes. However, the concomitant administration of loquat juice significantly corrected this imbalance. Fresh loquat juice is low in fat and protein, moderately sugary, and energetically light; however, it is rich in minerals, vitamin C, and various phytochemicals compounds, such as phenolic acids, flavonoids, and carotenoids. The loquat juice could be considered a functional food and could be valorized through the extraction of active substances and their use as food supplements to prevent lipid metabolism disorders and the resulting health complications.","PeriodicalId":20424,"journal":{"name":"Preventive Nutrition and Food Science","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11450286/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Siegesbeckia glabrescens Extract on Foam Cell Formation in THP-1 Macrophages. 豨莶草提取物对 THP-1 巨噬细胞泡沫细胞形成的影响

IF 1.6

Preventive Nutrition and Food Science Pub Date : 2024-09-30 DOI: 10.3746/pnf.2024.29.3.288

Ha-Rin Moon, Jung-Mi Yun

{"title":"Effect of Siegesbeckia glabrescens Extract on Foam Cell Formation in THP-1 Macrophages.","authors":"Ha-Rin Moon, Jung-Mi Yun","doi":"10.3746/pnf.2024.29.3.288","DOIUrl":"10.3746/pnf.2024.29.3.288","url":null,"abstract":"The accumulation of cholesterol-bearing macrophage foam cells in the initial stages of atherosclerosis serves as a characteristic feature of atherosclerotic lesions. The inhibitory effect of Siegesbeckia glabrescens, a species of flowering plant in the Asteraceae family, on foam cell formation in THP-1 macrophages has not yet been elucidated. In this study, we explored the effect of S. glabrescens ethanol extract (SGEE) and hot water extract (SGWE) on foam cell formation via co-treatment with oxidized low density lipoprotein (ox-LDL) and lipopolysaccharide (LPS), mimicking the occurrence of atherosclerosis in vitro, and studied the regulation of its underlying mechanisms. THP-1 cells differentiated by PMA (1 μM) for 48 h were subsequently treated with/without SGWE and SGEE for 48 h. THP-1 macrophages were treated with ox-LDL (20 μg/mL) and LPS (500 ng/mL) for 24 h. Treatment with ox-LDL and LPS for 24 h enhanced the lipid accumulation in foam cells compared to in untreated cells, as determined by oil red O staining. In contrast, SGWE and SGEE treatment inhibited lipid accumulation in foam cells. Both extracts significantly upregulated ABCA1, LXRα, and PPARγ expression in ox-LDL- and LPS-treated cells (P<0.05). Moreover, both SGWE and SGEE decreased LOX-1, CD36, and SR-A1 expression. The co-treatment of ox-LDL and LPS increased NF-κB, COX-2, and pro-inflammatory activation and expression compared with untreated cells. However, this increase suppressed NF-κB, COX-2, and pro-inflammatory expression by SGWE and SGEE. The results indicated that both extracts can partially inhibit foam cell formation and contribute to protective effects by suppressing cholesterol accumulation during the onset of atherosclerosis.","PeriodicalId":20424,"journal":{"name":"Preventive Nutrition and Food Science","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11450289/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Precooked Jack Bean [Canavalia ensiformis (L.) DC] Sprout: Generation of Dipeptidyl Peptidase-IV Inhibitory Peptides during Simulated Digestion. 预煮蚕豆[Canavalia ensiformis (L.) DC]芽：模拟消化过程中二肽基肽酶-IV 抑制肽的生成。

IF 1.6

Preventive Nutrition and Food Science Pub Date : 2024-09-30 DOI: 10.3746/pnf.2024.29.3.345

Friska Citra Agustia, Dyah Umiyarni Purnamasari, Umi Faza Rokhmah

{"title":"Precooked Jack Bean [Canavalia ensiformis (L.) DC] Sprout: Generation of Dipeptidyl Peptidase-IV Inhibitory Peptides during Simulated Digestion.","authors":"Friska Citra Agustia, Dyah Umiyarni Purnamasari, Umi Faza Rokhmah","doi":"10.3746/pnf.2024.29.3.345","DOIUrl":"10.3746/pnf.2024.29.3.345","url":null,"abstract":"Bioactive peptides generated from jack bean sprouts are reported to function as dipeptidyl peptidase IV (DPP-IV) inhibitors. However, no studies have investigated the effect of precooking followed by simulated digestion using pepsin-pancreatin to increase DPP-IV inhibitory peptide generation in jack bean sprouts. Therefore, the present study aimed to explore the generation of DPP-IV inhibitory peptides from precooked jack bean [Canavalia ensiformis (L.) DC] sprouts during simulated digestion with pepsin-pancreatin. The results showed that peptide fractions of the sample hydrolysate with molecular weight <1 kDa exhibited the strongest DPP-IV inhibitory activity (84.77%±0.49%) after simulated digestion. This activity was slightly greater than that (74.12%±0.85%) observed prior to simulated digestion. These findings demonstrate that the DPP-IV inhibitory activity of precooked jack bean sprouts can be retained following simulated digestion. Moreover, our investigation revealed the sequences of two novel peptides following simulated digestion with critical amino acids. The presence of alanine and glycine at the penultimate N-terminus of AAGPKP and LGDLLK confirmed the presence of DPP-IV inhibitors. Both peptide sequences are nontoxic and interact with the catalytic sites of enzymes through hydrogen bonds.","PeriodicalId":20424,"journal":{"name":"Preventive Nutrition and Food Science","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11450285/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective Responses of Green Yuja Peel Extracts to Lipopolysaccharide-Induced Inflammation and Reactive Oxygen Species Production in RAW264.7 Cells. 绿柚子皮提取物对脂多糖诱导的 RAW264.7 细胞炎症和活性氧生成的保护作用

IF 1.6

Preventive Nutrition and Food Science Pub Date : 2024-09-30 DOI: 10.3746/pnf.2024.29.3.301

Sungjin Kim, Soo-Young Choi, Hae-In Lee, Mi-Kyung Lee

{"title":"Protective Responses of Green Yuja Peel Extracts to Lipopolysaccharide-Induced Inflammation and Reactive Oxygen Species Production in RAW264.7 Cells.","authors":"Sungjin Kim, Soo-Young Choi, Hae-In Lee, Mi-Kyung Lee","doi":"10.3746/pnf.2024.29.3.301","DOIUrl":"10.3746/pnf.2024.29.3.301","url":null,"abstract":"This study assessed the anti-inflammatory and antioxidant effects of green yuja peel hot water extract (GYW) and ethanol extract (GYE) on lipopolysaccharide (LPS)-stimulated RAW264.7 cells. GYW and GYE (50, 100, and 200 μg/mL) significantly reduced the LPS-induced production of nitric oxide (NO), interleukin (IL)-6, tumor necrosis factor-α (TNF-α), and reactive oxygen species in a concentration-dependent manner, without cytotoxicity. Compared with control cells, GYW and GYE significantly downregulated the protein levels of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) and the gene expression of iNOS, COX-2, TNF-α, and IL-6. Conversely, they upregulated the gene expression of IL-10. Moreover, GYW and GYE significantly suppressed NF-κB p65 and IκB-α phosphorylation and increased the protein levels of nuclear factor erythroid 2-related factor 2 (Nrf2) and its downstream target heme oxygenase-1 (HO-1) compared with control cells. These results suggest that GYW and GYE exhibit anti-inflammatory and antioxidative properties by downregulating the NF-κB signaling pathway and upregulating the Nrf2/HO-1 system in LPS-activated macrophages.","PeriodicalId":20424,"journal":{"name":"Preventive Nutrition and Food Science","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11450282/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective Effects of Purple Corn (Zea mays L.) Byproduct Extract on Blue Light-Induced Retinal Damage in A2E-Accumulated ARPE-19 Cells. 紫玉米（Zea mays L.）副产品提取物对蓝光诱导的 ARPE-19 细胞视网膜损伤的保护作用

IF 1.6

Preventive Nutrition and Food Science Pub Date : 2024-09-30 DOI: 10.3746/pnf.2024.29.3.376

Se Won Park, Hui Jeong Lee, Jimi Kim, Tae Yang Kim, Young Rok Seo, Gwang Il Kim, Sungeun Cho, Mi Jeong Kim

{"title":"Protective Effects of Purple Corn (Zea mays L.) Byproduct Extract on Blue Light-Induced Retinal Damage in A2E-Accumulated ARPE-19 Cells.","authors":"Se Won Park, Hui Jeong Lee, Jimi Kim, Tae Yang Kim, Young Rok Seo, Gwang Il Kim, Sungeun Cho, Mi Jeong Kim","doi":"10.3746/pnf.2024.29.3.376","DOIUrl":"10.3746/pnf.2024.29.3.376","url":null,"abstract":"This study investigated the antioxidative characteristics of Zea mays L. purple corn cob and husk extract (PCHE) and its potential protective effects against blue light (BL)-induced damage in N-retinylidene-N-retinylethanolamine (A2E)-accumulated ARPE-19 retinal pigment epithelial cells. PCHE had a 2,2-diphenyl-1-picrylhydrazyl radical-scavenging capacity and Trolox equivalent antioxidant capacity of 1.28±0.43 mM Trolox equivalents (TE)/g and 2,545.41±34.13 mM TE/g, respectively. Total content of anthocyanins, polyphenols, and flavonoids in the PCHE was 11.13±0.10 mg cyanidin-3-glucoside equivalents/100 g, 227.90±7.38 mg gallic acid equivalents/g, and 117.75±2.46 mg catechin equivalents/g, respectively. PCHE suppressed the accumulation of A2E and the photooxidation caused by BL in a dose-dependent manner. After initial treatment with 25 µM/mL A2E and BL, ARPE-19 cells showed increased cell viability following additional treatment with 15 µg/mL PCHE while the expression of the p62 sequestosome 1 decreased, whereas that of heme oxygenase-1 protein increased compared with that in cells without PCHE treatment. This suggests that PCHE may slow the autophagy induced by BL exposure in A2E-accumulated retinal cells and protect them against oxidative stress.","PeriodicalId":20424,"journal":{"name":"Preventive Nutrition and Food Science","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11450283/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erratum to: "Standardized Combined Plant Extract, RUG-com, Reduces Bacterial Levels and Suppresses Acute and Chronic Inflammation in Balb/c Mice Infected with CagA+ Helicobacter pylori." 勘误："标准化复合植物提取物 RUG-com 可降低感染 CagA+ 幽门螺杆菌的 Balb/c 小鼠体内的细菌水平，抑制急性和慢性炎症。

IF 1.6

Preventive Nutrition and Food Science Pub Date : 2024-09-30 DOI: 10.3746/pnf.2024.29.3.384

引用次数: 0

Probiotic Lactiplantibacillus plantarum subsp. plantarum Dad-13 Alleviates 2,4,6-Trinitrobenzene Sulfonic Acid-Induced Colitis Through Short-Chain Fatty Acid Production and Inflammatory Cytokine Regulation. 益生菌 Lactiplantibacillus plantarum subsp. plantarum Dad-13 通过产生短链脂肪酸和调节炎症细胞因子缓解 2,4,6-Trinitrobenzene Sulfonic Acid 诱发的结肠炎。

IF 1.6

Preventive Nutrition and Food Science Pub Date : 2024-09-30 DOI: 10.3746/pnf.2024.29.3.270

Rimba Bunga Pertiwi, Yosinta Christie Setiabudi, Yunika Mayangsari, Dian Anggraini Suroto, Endang Sutriswati Rahayu

{"title":"Probiotic Lactiplantibacillus plantarum subsp. plantarum Dad-13 Alleviates 2,4,6-Trinitrobenzene Sulfonic Acid-Induced Colitis Through Short-Chain Fatty Acid Production and Inflammatory Cytokine Regulation.","authors":"Rimba Bunga Pertiwi, Yosinta Christie Setiabudi, Yunika Mayangsari, Dian Anggraini Suroto, Endang Sutriswati Rahayu","doi":"10.3746/pnf.2024.29.3.270","DOIUrl":"10.3746/pnf.2024.29.3.270","url":null,"abstract":"The development of inflammatory bowel disease (IBD) is closely linked to inflammatory damage and dysbiosis. Recently, probiotics are being increasingly used to improve intestinal health. Probiotic-based therapies can prevent IBD by restoring the balance of gastrointestinal microbiota, reducing gut inflammation, and increasing the concentration of short-chain fatty acids (SCFAs). The present study aimed to investigate the protective effects of Lactiplantibacillus plantarum subsp. plantarum Dad-13, a novel probiotic strain derived from dadih (Indonesian curd from buffalo milk), on 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis in BALB/c mice. The results showed that probiotic Dad-13 supplementation at a dose of 107 or 109 CFU/mL improved the clinical symptoms of IBD and enhanced the production of SCFAs, particularly propionate and butyrate. Moreover, probiotic Dad-13 supplementation significantly decreased the levels of pro-inflammatory cytokines [tumor necrosis factor-α, interleukin (IL)-6, and IL-1β] and significantly increased the levels of anti-inflammatory cytokines (IL-10). These findings show that L. plantarum Dad-13 can effectively prevent TNBS-induced colitis by modulating SCFA production and inflammatory cytokines.","PeriodicalId":20424,"journal":{"name":"Preventive Nutrition and Food Science","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11450284/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antioxidant and Longevity-Related Properties of the Ethyl Acetate Fraction of Cnidium officinale Makino in Caenorhabditis elegans. Cnidium officinale Makino 的乙酸乙酯馏分在秀丽隐杆线虫体内的抗氧化和长寿特性

IF 1.6

Preventive Nutrition and Food Science Pub Date : 2024-09-30 DOI: 10.3746/pnf.2024.29.3.311

Hyeon-Ji Kim, Ji-Su Mun, Suk-Heung Oh, Jun-Hyeong Kim

{"title":"Antioxidant and Longevity-Related Properties of the Ethyl Acetate Fraction of Cnidium officinale Makino in Caenorhabditis elegans.","authors":"Hyeon-Ji Kim, Ji-Su Mun, Suk-Heung Oh, Jun-Hyeong Kim","doi":"10.3746/pnf.2024.29.3.311","DOIUrl":"10.3746/pnf.2024.29.3.311","url":null,"abstract":"Reactive oxygen species (ROS) are produced from energy metabolism and may cause diseases or cell death. Antioxidation refers to the suppression of ROS production and is considered beneficial in preventing diseases. This study aimed to examine the antioxidative effects of Cnidium officinale Makino (COM) extracts and fractions using Caenorhabditis elegans as an experimental model. The COM ethanol extract was fractionated according to polarity. The results showed that the ethyl acetate fraction of COM showed powerful radical scavenging activities and increased the activities of superoxide dismutase (SOD) and catalase in C. elegans in a concentration-dependent manner. Moreover, the ethyl acetate fraction reduced the ROS production rate in C. elegans and increased the cell survival rate, suggesting oxidative and thermal stress resistance. In addition, the SOD-3::green fluorescent protein (GFP) expression level in the transformed cells of C. elegans (CF1553) increased, suggesting oxidative stress resistance. Similarly, the HSP-16.2::GFP expression level increased, suggesting thermal stress resistance. In conclusion, the ethyl acetate fraction of COM demonstrated the strongest antioxidative effects, indicating that it may help extend longevity.","PeriodicalId":20424,"journal":{"name":"Preventive Nutrition and Food Science","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11450287/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inhibitory Effect of Phenolic Compounds on Vascular Endothelial Growth Factor-Induced Retinal Endothelial Permeability and Angiogenesis. 酚类化合物对血管内皮生长因子诱导的视网膜内皮渗透性和血管生成的抑制作用

IF 1.6

Preventive Nutrition and Food Science Pub Date : 2024-09-30 DOI: 10.3746/pnf.2024.29.3.321

Dong Yoon Kim, Seong-Min Hong, Jeong-Seok Cho, Sae-Byuk Lee, Hyun-Dong Cho

{"title":"Inhibitory Effect of Phenolic Compounds on Vascular Endothelial Growth Factor-Induced Retinal Endothelial Permeability and Angiogenesis.","authors":"Dong Yoon Kim, Seong-Min Hong, Jeong-Seok Cho, Sae-Byuk Lee, Hyun-Dong Cho","doi":"10.3746/pnf.2024.29.3.321","DOIUrl":"10.3746/pnf.2024.29.3.321","url":null,"abstract":"Age-related macular degeneration (AMD), often triggered by endothelial barrier disruption through vascular endothelial growth factor (VEGF), is a leading cause of blindness. This study investigated the inhibitory effects of phenolic compounds on VEGF-induced endothelial cell proliferation, migration, angiogenesis, and permeability using human retinal microvascular endothelial cells (hRECs). Thirty-seven polyphenolic compounds were selected from various databases based on their antioxidant properties, abundance in food, and solubility. These compounds significantly reduced migration, tube formation, and endothelial permeability in VEGF-stimulated hRECs. Notably, formononetin, eriodictyol, biochanin A, and p-coumaric acid were more effective in suppressing VEGF-induced angiogenesis and endothelial permeability than lutein. Molecular docking simulations revealed that formononetin, eriodictyol, and biochanin A had relatively lower binding energies with VEGF receptor 2 (VEGFR2) than lutein and sorafenib. These findings highlight the potential of phenolic compounds to be used as VEGFR2 inhibitors and an alternative strategy for preventing AMD.","PeriodicalId":20424,"journal":{"name":"Preventive Nutrition and Food Science","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11450277/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Efficacy of Probiotics Supplementation on the Quality of Life of Patients with Gastrointestinal Disease: A Systematic Review of Clinical Studies. 补充益生菌对胃肠道疾病患者生活质量的影响：临床研究系统回顾

IF 1.6

Preventive Nutrition and Food Science Pub Date : 2024-09-30 DOI: 10.3746/pnf.2024.29.3.237

Jalal Moludi, Amir Saber, Morteza Arab Zozani, Shima Moradi, Yasaman Azamian, Salimeh Hajiahmadi, Yahya Pasdar, Fardin Moradi

{"title":"The Efficacy of Probiotics Supplementation on the Quality of Life of Patients with Gastrointestinal Disease: A Systematic Review of Clinical Studies.","authors":"Jalal Moludi, Amir Saber, Morteza Arab Zozani, Shima Moradi, Yasaman Azamian, Salimeh Hajiahmadi, Yahya Pasdar, Fardin Moradi","doi":"10.3746/pnf.2024.29.3.237","DOIUrl":"10.3746/pnf.2024.29.3.237","url":null,"abstract":"Patients with gastrointestinal (GI) disorders might benefit from probiotic supplementation to resolve their bowel symptoms and enhance their quality of life (QoL). This systematic review aimed to evaluate the effects of oral probiotic supplementation on improving QoL. Relevant studies were systematically searched in online databases, including PubMed, Scopus, Embase, ProQuest, and Google Scholar up to September 2022 using relevant keywords. Studies that were conducted on GI patients and presented QoL outcomes were included. The Revised Cochrane Risk of Bias 2 tool and the Risk Of Bias In Non-randomized Studies of Intervention tool were used to assess the risk of bias. Of the 4,555 results found in the systematic search of databases, only 36 studies were eligible for evaluation. According to this systematic review, 24 studies reported improvements, whereas 12 studies reported no improvements on QoL in GI patients supplemented with probiotics. We found that probiotics may improve the QoL of patients with GI diseases and related metabolic complications. Therefore, probiotics can be a useful supportive treatment strategy in these patients.","PeriodicalId":20424,"journal":{"name":"Preventive Nutrition and Food Science","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11450280/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0