Preventive Nutrition and Food Science最新文献

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Role of Lacticaseibacillus rhamnosus GG in the Management of Respiratory Diseases: A Systematic Review and Meta-Analysis. 鼠李糖乳杆菌GG在呼吸道疾病治疗中的作用:系统综述和荟萃分析。
IF 1.6
Preventive Nutrition and Food Science Pub Date : 2025-06-30 DOI: 10.3746/pnf.2025.30.3.222
Muhammad Naufal Zuhair, Edward Pandu Wiriansya, Ismail Masyhuri, Muhammad Fakhri, Mochammad Hatta, Irawaty Djaharuddin, Agussalim Bukhari
{"title":"Role of <i>Lacticaseibacillus rhamnosus</i> GG in the Management of Respiratory Diseases: A Systematic Review and Meta-Analysis.","authors":"Muhammad Naufal Zuhair, Edward Pandu Wiriansya, Ismail Masyhuri, Muhammad Fakhri, Mochammad Hatta, Irawaty Djaharuddin, Agussalim Bukhari","doi":"10.3746/pnf.2025.30.3.222","DOIUrl":"10.3746/pnf.2025.30.3.222","url":null,"abstract":"<p><p>Respiratory diseases represent a significant global health issue. Currently, there is growing interest in using probiotics [e.g., <i>Lacticaseibacillus rhamnosus</i> GG (LGG)] as adjunctive therapies for the management of respiratory diseases. However, the efficacy of LGG in respiratory diseases remains unknown. Therefore, this study aimed to evaluate the effectiveness of LGG in preventing and treating respiratory diseases. A comprehensive literature search was performed using the PubMed, Embase, Cochrane Library, and Scopus databases using keywords related to LGG and respiratory diseases. Studies were selected on the basis of predefined inclusion and exclusion criteria, and data were extracted for qualitative and quantitative analyses. The Cochrane Risk of Bias tool was used to assess the methodological quality of the included studies, and RevMan 5.4 was used to perform the meta-analysis. Out of 155 studies that were initially identified, 13 randomized controlled trials met the inclusion criteria. The meta-analysis showed that LGG intervention, both as a preventive and therapeutic strategy, significantly reduced the incidence of respiratory disease episodes (mean difference: -0.14, 95% confidence interval: -0.27 to -0.01, <i>P</i>=0.03) and mitigated associated symptoms compared with placebo or no intervention. The results of subgroup analyses indicated that LGG was particularly effective in reducing the duration and severity of respiratory infections in children and high-risk populations. However, heterogeneity (I<sup>2</sup>=62%) was observed, which was likely because of variations in the study design, dosage, and patient populations. These findings suggest that LGG may be a promising adjunctive therapy for respiratory diseases, particularly in preventive settings.</p>","PeriodicalId":20424,"journal":{"name":"Preventive Nutrition and Food Science","volume":"30 3","pages":"222-229"},"PeriodicalIF":1.6,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12213251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of Lutein with Cancer: A Systematic Review of the Lutein Effects on Cellular Processes Involved in Cancer Progression. 叶黄素与癌症的关系:叶黄素对参与癌症进展的细胞过程的影响的系统综述。
IF 1.6
Preventive Nutrition and Food Science Pub Date : 2025-06-30 DOI: 10.3746/pnf.2025.30.3.250
Fahmideh Bagrezaei, Sorayya Kheirouri, Mohammad Alizadeh
{"title":"Association of Lutein with Cancer: A Systematic Review of the Lutein Effects on Cellular Processes Involved in Cancer Progression.","authors":"Fahmideh Bagrezaei, Sorayya Kheirouri, Mohammad Alizadeh","doi":"10.3746/pnf.2025.30.3.250","DOIUrl":"10.3746/pnf.2025.30.3.250","url":null,"abstract":"<p><p>Lutein belongs to the carotenoid family of xanthophylls, which have antioxidant, anti-inflammatory, and anticancer properties. This study aimed to comprehensively review the interactions between lutein and critical cellular processes that influence cancer progression. A search of electronic databases, including PubMed, Science Direct, Cochrane Library, Web of Science, Scopus, Google Scholar, and Google, was conducted for the keywords \"cancer or tumor or neoplasm or carcinoma\" and \"lutein\" in the titles or abstracts of published research. A total of 47 studies were reviewed, and it was shown that lutein reduced estrogen receptors (2 out of 4 studies), DNA damage (4 out of 8 studies), cancer cell survival (1 out of 1 studies), growth (7 out of 7 studies), and proliferation (19 out of 19 studies) as well as cancer cell invasion, migration, metastasis, and adhesion (2 out of 2 studies), but induced apoptosis (17 out of 17 studies) and cell differentiation (1 out of 1 studies). According to this review, lutein may be effective in suppressing cellular processes involved in cancer progression through a variety of mechanisms.</p>","PeriodicalId":20424,"journal":{"name":"Preventive Nutrition and Food Science","volume":"30 3","pages":"250-262"},"PeriodicalIF":1.6,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12213252/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Kaempferol Inhibits Lipid Accumulation in HepG2 Cells through AMPK-Mediated Autophagy. 山奈酚通过ampk介导的自噬抑制HepG2细胞脂质积累。
IF 1.6
Preventive Nutrition and Food Science Pub Date : 2025-06-30 DOI: 10.3746/pnf.2025.30.3.242
Subin Park, Miey Park, Hae-Jeung Lee
{"title":"Kaempferol Inhibits Lipid Accumulation in HepG2 Cells through AMPK-Mediated Autophagy.","authors":"Subin Park, Miey Park, Hae-Jeung Lee","doi":"10.3746/pnf.2025.30.3.242","DOIUrl":"10.3746/pnf.2025.30.3.242","url":null,"abstract":"<p><p>Metabolic dysfunction-associated steatotic liver disease (MASLD) is closely associated with metabolic syndrome. Currently, it is considered as a global health concern. Kaempferol (a flavonoid) exhibits extensive pharmacological properties, including anti-inflammatory, antioxidant, anticancer, and neuroprotective effects. In the present study, we investigated the effects of kaempferol on free fatty acid (FFA)-induced lipid accumulation in HepG2 cells. To establish an <i>in vitro</i> model of MASLD, we treated the human hepatocellular carcinoma cell line HepG2 with FFAs. Subsequently, we performed Western blot analysis to analyze the expression levels of essential proteins associated with lipogenesis and autophagy. Vital lipogenesis-related proteins (e.g., acetyl-CoA carboxylase, fatty acid synthase, sterol regulatory element-binding protein-1c, CCAAT/enhancer-binding protein alpha, and peroxisome proliferator-activated receptor gamma) were downregulated by kaempferol treatment. Concurrently, the expression of proteins involved in fatty acid oxidation (e.g., carnitine palmitoyltransferase 1 and peroxisome proliferator-activated receptor alpha) was upregulated. These changes indicate that kaempferol promotes a shift toward enhanced fatty acid oxidation and reduced lipogenesis, thereby mitigating lipid accumulation in liver cells. Our findings suggest that kaempferol exerts a protective effect against MASLD by modulating lipid metabolism via autophagy activation.</p>","PeriodicalId":20424,"journal":{"name":"Preventive Nutrition and Food Science","volume":"30 3","pages":"242-249"},"PeriodicalIF":1.6,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12213249/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancing the Nutritional and Microbiological Properties of Fermented Melon Condiment (Ogiri) Using Newbouldia laevis and Icacina trichantha Leaves. 利用新叶和三叶提高甜瓜发酵调味品的营养和微生物特性。
IF 1.6
Preventive Nutrition and Food Science Pub Date : 2025-06-30 DOI: 10.3746/pnf.2025.30.3.285
Oluwatoyin Ajoke Oladeji, Clement Olusola Ogidi
{"title":"Enhancing the Nutritional and Microbiological Properties of Fermented Melon Condiment (<i>Ogiri</i>) Using <i>Newbouldia laevis</i> and <i>Icacina trichantha</i> Leaves.","authors":"Oluwatoyin Ajoke Oladeji, Clement Olusola Ogidi","doi":"10.3746/pnf.2025.30.3.285","DOIUrl":"10.3746/pnf.2025.30.3.285","url":null,"abstract":"<p><p>This study investigated the influence of incorporating <i>Newbouldia laevis</i> and <i>Icacina trichantha</i> leaves into fermented melon condiment using different wrapping materials for fermentation. Moreover, the resulting quality of the condiment was analyzed. The leaves were boiled with melon seeds after removing their pericarp. Subsequently, the boiled leaves were wrapped in <i>Thaumatococcus daniellii</i>. Other portions of the seeds that were not boiled with the leaves were wrapped in <i>T. danielli</i> leaves, aluminum foil paper, and airtight containers. The proximate, mineral, amino acid, microbiological quality, and antioxidant properties of the condiment were determined in accordance with standard procedures. The protein, ash, fat, and glutamic acid contents of the condiment ranged from 25.20% to 34.57%, 2.10% to 3.22%, 14.61% to 28.65%, and 12.30 mg/100 g protein to 13.80 mg/100 g protein, respectively. The incorporation of leaves and fermentation of melon in leaves significantly (<i>P</i>≤0.05) enhanced their antioxidant activities against 1,1-diphenyl-2-picrylhydrazyl (46.30%-65.60%) and ferric reducing antioxidant power (0.22-0.62 µmol/mL Fe<sup>2+</sup>). <i>Bacillus</i> <i>subtilis</i>, <i>Corynebacterium</i> spp., <i>Lactobacillus acidophilus</i>, and <i>Staphylococcus aureus</i> were isolated from the fermented condiment. The fermented condiment supported the growth of <i>Lactobacillus fermentum</i> with values of 1.80 to 2.80×10<sup>5</sup> colony-forming units/mL. Moreover, the fermented condiment showed improved microbiological quality, enhanced nutrient content, and profound antioxidant activities. Hence, the bioactive compounds in the leaves can be exploited and incorporated into food products for therapeutic purposes.</p>","PeriodicalId":20424,"journal":{"name":"Preventive Nutrition and Food Science","volume":"30 3","pages":"285-294"},"PeriodicalIF":1.6,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12213246/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Comprehensive Review of the Effects of Psidium guajava and Syzygium cumini Leaves on Diabetes Mellitus. 瓜石榴叶和茴香叶对糖尿病作用的研究综述。
IF 1.6
Preventive Nutrition and Food Science Pub Date : 2025-06-30 DOI: 10.3746/pnf.2025.30.3.209
Sukhmanpreet Kaur, Rohit Chaudhary
{"title":"A Comprehensive Review of the Effects of <i>Psidium guajava</i> and <i>Syzygium cumini</i> Leaves on Diabetes Mellitus.","authors":"Sukhmanpreet Kaur, Rohit Chaudhary","doi":"10.3746/pnf.2025.30.3.209","DOIUrl":"10.3746/pnf.2025.30.3.209","url":null,"abstract":"<p><p>Diabetes is a chronic metabolic disorder characterized by elevated blood sugar levels because of insulin resistance or insufficient insulin production. The early detection and management of diabetes are essential to control diabetes and prevent the progression of this disease. Natural remedies have attracted attention for their potential role in the treatment of diabetes. <i>Psidium guajava</i> and <i>Syzygium cumini</i> have shown significant hypoglycemic, antioxidant and anti-inflammatory properties because of the presence of quercetin, rutin and gallic acid. This review aims to provide evidence supporting the beneficial effects of <i>P. guajava</i> and <i>S. cumini</i> leaves as sustainable substitutes for synthetic drugs, highlighting their therapeutic potential in diabetes treatment.</p>","PeriodicalId":20424,"journal":{"name":"Preventive Nutrition and Food Science","volume":"30 3","pages":"209-221"},"PeriodicalIF":1.6,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12213247/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anti-Androgenic Effect of Soybean Tempeh Extract in the Treatment of Polycystic Ovary Syndrome. 大豆豆豉提取物治疗多囊卵巢综合征的抗雄激素作用。
IF 1.6
Preventive Nutrition and Food Science Pub Date : 2025-06-30 DOI: 10.3746/pnf.2025.30.3.263
Cut Raihanah, Yenni Karlina, Saleh Wikarsa, Neng Fisheri Kurniati, Sukrasno Sukrasno
{"title":"Anti-Androgenic Effect of Soybean Tempeh Extract in the Treatment of Polycystic Ovary Syndrome.","authors":"Cut Raihanah, Yenni Karlina, Saleh Wikarsa, Neng Fisheri Kurniati, Sukrasno Sukrasno","doi":"10.3746/pnf.2025.30.3.263","DOIUrl":"10.3746/pnf.2025.30.3.263","url":null,"abstract":"<p><p>Polycystic ovary syndrome (PCOS), also known as hyperandrogenic anovulation, has been linked to steroidogenic enzyme activity. Previous studies have reported that soybean isoflavones act as inhibitors of these enzymes due to their anti-androgenic properties. This study evaluated the potential anti-androgenic mechanism of soybean tempeh extract in PCOS through both <i>in vivo</i> and <i>in silico</i> approaches. Female Wistar rats were induced with letrozole to model PCOS, followed by treatments with tempeh extract and metformin as a positive control. Serum testosterone, estrous cycle patterns, and weight were assessed. In the <i>in silico</i> study, daidzein and genistein were docked to the androgen receptor (AR) and 17β-hydroxysteroid dehydrogenase (17β-HSD). Treatment with tempeh extract at 250 mg/kg body weight more effectively restored abnormal estrous cycles than metformin. Weight gain and testosterone levels also decreased in this group. Daidzein and genistein bound to AR inhibitor amino acids; however, only genistein showed high binding energy to 17β-HSD inhibitor amino acids. As an anti-androgen, the findings suggest that tempeh extract at 250 mg/kg body weight may serve as a dietary supplement for managing PCOS, potentially via AR inhibition.</p>","PeriodicalId":20424,"journal":{"name":"Preventive Nutrition and Food Science","volume":"30 3","pages":"263-273"},"PeriodicalIF":1.6,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12213253/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genomic Analysis and Metabolite Profiling of Three Probiotic Bacillus Strains for Potential Application in Aquaculture. 三种潜在应用于水产养殖的益生菌菌株的基因组分析和代谢物谱分析。
IF 1.6
Preventive Nutrition and Food Science Pub Date : 2025-06-30 DOI: 10.3746/pnf.2025.30.3.274
Evgeniya Valer'evna Prazdnova, Vladimir Anatolevich Chistyakov, Nikita Gennadjevich Vasilchenko, Radomir Viktorovich Skripnichenko, Alina Yurievna Gulyaeva, Anna Valentinovna Aleshukina, Iraida Sergeievna Berezinskaya, Dmitriy Vladimirovich Rudoy
{"title":"Genomic Analysis and Metabolite Profiling of Three Probiotic <i>Bacillus</i> Strains for Potential Application in Aquaculture.","authors":"Evgeniya Valer'evna Prazdnova, Vladimir Anatolevich Chistyakov, Nikita Gennadjevich Vasilchenko, Radomir Viktorovich Skripnichenko, Alina Yurievna Gulyaeva, Anna Valentinovna Aleshukina, Iraida Sergeievna Berezinskaya, Dmitriy Vladimirovich Rudoy","doi":"10.3746/pnf.2025.30.3.274","DOIUrl":"10.3746/pnf.2025.30.3.274","url":null,"abstract":"<p><p>In this study, we investigated the genomic characteristics and bioactive metabolite profiles of three novel <i>Bacillus</i> strains that were isolated from the intestinal tracts of healthy carp (<i>Cyprinus carpio</i>). Strain identification and whole-genome sequencing were performed before analysis. Among the three novel strains, R1 and R4 were classified as <i>Bacillus subtilis</i>, and strain R5 was classified as <i>Bacillus velezensis</i>. Genome mining revealed a repertoire of secondary metabolites, including bacillaene, bacillibactin, bacilysin, difficidin, and fengycin, which likely contribute to the probiotic potential of these strains. The metabolite profiles were further characterized using matrix-assisted laser desorption/ionisation time-of-flight (MALDI-TOF) mass spectrometry, with fengycins and bacillibactin specifically isolated and identified. Additionally, the presence of genetic markers associated with antimicrobial resistance was assessed, and these gene profiles were reconstructed. These <i>Bacillus</i> strains represent promising candidates for the development of novel feed additives for aquaculture.</p>","PeriodicalId":20424,"journal":{"name":"Preventive Nutrition and Food Science","volume":"30 3","pages":"274-284"},"PeriodicalIF":1.6,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12213248/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of High-Intensity Interval Training on Mitigating High-Fat Diet-Induced Damage in Rat Testicular Tissue. 高强度间歇训练对减轻高脂肪饮食引起的大鼠睾丸组织损伤的影响。
IF 1.6
Preventive Nutrition and Food Science Pub Date : 2025-06-30 DOI: 10.3746/pnf.2025.30.3.230
Faezeh Fayyazian, Marziyeh Saghebjoo, Mehdi Hedayati, Hadi Sarir
{"title":"Effect of High-Intensity Interval Training on Mitigating High-Fat Diet-Induced Damage in Rat Testicular Tissue.","authors":"Faezeh Fayyazian, Marziyeh Saghebjoo, Mehdi Hedayati, Hadi Sarir","doi":"10.3746/pnf.2025.30.3.230","DOIUrl":"10.3746/pnf.2025.30.3.230","url":null,"abstract":"<p><p>A high-fat diet (HFD) is a risk factor for infertility, and regular exercise has been considered as a nonpharmacological intervention in the treatment of infertility. This study examined how high-intensity interval training (HIIT) affects testicular levels of malondialdehyde, total antioxidant capacity, glutathione (GSH), GSH peroxidase, catalase (CAT), superoxide dismutase, glucose, lactate, total cholesterol (TC), and testicular and serum testosterone (TES) levels in rats fed with a HFD or normal diet (ND). Forty-four male Wistar rats were assigned to the ND control (NDC), HFD control (HFDC), HIIT+ND, and HIIT+HFD groups. The HIIT protocol involved treadmill running at an intensity of 85% to 90% maximal speed for 5 days weekly over 12 weeks. The results showed that the post-intervention GSH levels were lower in the HIIT+ND group than in the NDC and HFDC groups, and in the HIIT+HFD group than in the NDC group. The CAT activity and TC levels were lower in the HIIT+ND and HIIT+HFD groups than in the HFDC group. The glucose and lactate levels in the HIIT+ND and HIIT+HFD groups were lower than those in the NDC group. Moreover, the testicular TES levels in the HIIT+ND and HIIT+HFD groups were higher than those in the NDC and HFDC groups. No differences were observed in other biochemical variables among groups. HIIT could serve as a therapeutic approach to counteract HFD-induced testicular damage by modulating oxidative stress balance, potentially enhancing metabolic adaptation, and increasing testicular TES levels.</p>","PeriodicalId":20424,"journal":{"name":"Preventive Nutrition and Food Science","volume":"30 3","pages":"230-241"},"PeriodicalIF":1.6,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12213250/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antioxidative Action of Alpha-Linolenic Acid during Its Gastroprotective Effect in an Indomethacin-Induced Gastric Injury Model. -亚麻酸在吲哚美辛诱导胃损伤模型中的抗氧化作用及其胃保护作用。
IF 1.6
Preventive Nutrition and Food Science Pub Date : 2025-04-30 DOI: 10.3746/pnf.2025.30.2.132
Cristina Salinas-Nolasco, Elizabeth Pérez-Hernández, Secilia Garza, Hui Gyu Park, J Thomas Brenna, Gilberto Castañeda-Hernández, César A S Reyes-López, Nury Pérez-Hernández, Aracely Evangelina Chávez-Piña
{"title":"Antioxidative Action of Alpha-Linolenic Acid during Its Gastroprotective Effect in an Indomethacin-Induced Gastric Injury Model.","authors":"Cristina Salinas-Nolasco, Elizabeth Pérez-Hernández, Secilia Garza, Hui Gyu Park, J Thomas Brenna, Gilberto Castañeda-Hernández, César A S Reyes-López, Nury Pérez-Hernández, Aracely Evangelina Chávez-Piña","doi":"10.3746/pnf.2025.30.2.132","DOIUrl":"https://doi.org/10.3746/pnf.2025.30.2.132","url":null,"abstract":"<p><p>Polyunsaturated fatty acids (PUFAs) are known to have beneficial effects. In particular, the consumption of omega-3 PUFAs has recently increased because of their effects on human health. Previous studies have investigated the activity of alpha-linolenic acid (ALA; C:18 omega-3) in metabolism and inflammation models. In a murine model of colitis, treatment with ALA effectively reduced inflammation. Previously, our research group identified the protective action of docosahexaenoic acid against gastric damage caused by nonsteroidal anti-inflammatory drugs. The present study aimed to examine the impact of ALA in an indomethacin-induced gastric injury model and to determine its antioxidant activity in gastric tissue. Female Wistar rats were administered ALA over 10 days (20 mg/kg, orally). Two hours after the final ALA administration, the rats were given indomethacin (30 mg/kg, orally) to induce gastric injury. After 3 h, the rats were euthanized, and each stomach lesion was measured to determine the total damage. Stomach tissue samples were collected for the analysis of various antioxidant indicators. The results show ALA's gastroprotective effect following 10-day administration. ALA treatment significantly reduced gastric reactive oxygen species and malondialdehyde levels in the indomethacin-induced injury group. Moreover, ALA treatment decreased the levels of nitric oxide, myeloperoxidase, leukotriene B<sub>4</sub>, and increased glutathione following indomethacin administration. These results suggest that the gastroprotective effects of ALA are likely attributed to its role in the antioxidant pathway in indomethacin-induced gastric injury.</p>","PeriodicalId":20424,"journal":{"name":"Preventive Nutrition and Food Science","volume":"30 2","pages":"132-140"},"PeriodicalIF":1.6,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12061533/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quality Characteristics of Yogurt Fortified with Citrus sinensis L. Osbeck Powder. 柑桔粉强化酸奶的品质特性研究
IF 1.6
Preventive Nutrition and Food Science Pub Date : 2025-04-30 DOI: 10.3746/pnf.2025.30.2.196
Yerin Shim, Minji Cho, Misook Kim
{"title":"Quality Characteristics of Yogurt Fortified with <i>Citrus sinensis</i> L. Osbeck Powder.","authors":"Yerin Shim, Minji Cho, Misook Kim","doi":"10.3746/pnf.2025.30.2.196","DOIUrl":"https://doi.org/10.3746/pnf.2025.30.2.196","url":null,"abstract":"<p><p>In this study, functional yogurt enriched with <i>Citrus sinensis</i> L. Osbeck (CS) powder was prepared, and its fermentation characteristics, antioxidant activity, and inhibition properties against enzymes related to diabetes and obesity treatments, namely α-amylase, α-glucosidase, and lipase, were investigated. The yogurt was prepared by adding 1%, 3%, and 5% CS powder to skim milk, followed by sterilization and fermentation with a mixed starter culture for 6 h at 39°C. After fermentation, the yogurt had viable cell counts between 8.05 and 8.21 log colony-forming units/mL and a pH reduction to 4.54-4.63. The total anthocyanin content increased with increasing concentrations of CS powder. 1,1-Diphenyl-2-picrylhydrazyl radical scavenging activity and ferric reducing antioxidant power values also improved, with the highest antioxidant activity observed in the yogurt prepared with 5% CS powder. With regard to enzyme activity inhibition, CS addition significantly increased the α-glucosidase inhibitory activity, whereas the α-amylase inhibitory activity remained unchanged. These findings suggest that yogurt fortified with CS powder exhibits improved antioxidant activity and selective α-glucosidase inhibition, making it a promising candidate for the preparation of functional fermented beverages.</p>","PeriodicalId":20424,"journal":{"name":"Preventive Nutrition and Food Science","volume":"30 2","pages":"196-206"},"PeriodicalIF":1.6,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12061534/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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