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Poster Presentations - Proffered Abstracts最新文献

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Abstract P093: Proteomic analysis reveals a mechanism of resistance to radiation mediated by microvesicles in glioma 摘要:蛋白质组学分析揭示了胶质瘤中微囊泡介导的辐射抗性机制
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p093
E. Panizza, Brandon D. Regalado, Fangyu Wang, R. Munroe, Nathaniel M. Vacanti, M. Antonyak, R. Cerione
{"title":"Abstract P093: Proteomic analysis reveals a mechanism of resistance to radiation mediated by microvesicles in glioma","authors":"E. Panizza, Brandon D. Regalado, Fangyu Wang, R. Munroe, Nathaniel M. Vacanti, M. Antonyak, R. Cerione","doi":"10.1158/1535-7163.targ-21-p093","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p093","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82444976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract P215: The MDM2 inhibitor milademetan induces synthetic lethality in GATA3 mutant, ER positive breast cancer 摘要P215: MDM2抑制剂米拉德美坦诱导GATA3突变体ER阳性乳腺癌的合成致死性
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p215
V. Tirunagaru, Gaia Bianco, C. Ng, E. Marangoni, S. Piscuoglio, F. Bidard, R. Doebele
{"title":"Abstract P215: The MDM2 inhibitor milademetan induces synthetic lethality in GATA3 mutant, ER positive breast cancer","authors":"V. Tirunagaru, Gaia Bianco, C. Ng, E. Marangoni, S. Piscuoglio, F. Bidard, R. Doebele","doi":"10.1158/1535-7163.targ-21-p215","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p215","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81008164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract P018: Integrative proteomics of PARP1 protein complexes and post-translational modifications implicates DDR and AKT-mTOR signaling in mediating response or primary resistance of ovarian carcinoma cells to PARP1 inhibitors 摘要P018: PARP1蛋白复合物的整合蛋白质组学和翻译后修饰暗示DDR和AKT-mTOR信号传导介导卵巢癌细胞对PARP1抑制剂的反应或原发性耐药
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p018
Ou Deng, Sweta Dash, Thales C. Nepomuceno, B. Fang, D. Marchion, J. Koomen, A. Monteiro, U. Rix
{"title":"Abstract P018: Integrative proteomics of PARP1 protein complexes and post-translational modifications implicates DDR and AKT-mTOR signaling in mediating response or primary resistance of ovarian carcinoma cells to PARP1 inhibitors","authors":"Ou Deng, Sweta Dash, Thales C. Nepomuceno, B. Fang, D. Marchion, J. Koomen, A. Monteiro, U. Rix","doi":"10.1158/1535-7163.targ-21-p018","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p018","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"342 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82965086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract P026: NUC-7738 alters oxidative phosphorylation and causes terminal differentiation in acute myeloid leukemia cells 摘要P026: nucc -7738改变急性髓系白血病细胞的氧化磷酸化并导致终末分化
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p026
A. Shahid, I. Um, O. Read, D. Harrison
{"title":"Abstract P026: NUC-7738 alters oxidative phosphorylation and causes terminal differentiation in acute myeloid leukemia cells","authors":"A. Shahid, I. Um, O. Read, D. Harrison","doi":"10.1158/1535-7163.targ-21-p026","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p026","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90987840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract P202: Initial findings from an ongoing first-in-human phase 1 study of the CBP/p300 inhibitor FT-7051 in men with metastatic castration-resistant prostate cancer P202:一项正在进行的CBP/p300抑制剂FT-7051在转移性去势抵抗性前列腺癌患者中的首次人体i期研究的初步结果
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p202
A. Armstrong, M. Gordon, M. Reimers, A. Hussain, V. Patel, E. Lam, Alexander Sedkov, V. Potter, N. Shore
{"title":"Abstract P202: Initial findings from an ongoing first-in-human phase 1 study of the CBP/p300 inhibitor FT-7051 in men with metastatic castration-resistant prostate cancer","authors":"A. Armstrong, M. Gordon, M. Reimers, A. Hussain, V. Patel, E. Lam, Alexander Sedkov, V. Potter, N. Shore","doi":"10.1158/1535-7163.targ-21-p202","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p202","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"56 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79131703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Abstract P072: Combining ATR inhibitors with carboplatin in chemoresistant TNBC conditionally reprogrammed cells and patient-derived xenografts P072: ATR抑制剂联合卡铂治疗化疗耐药TNBC条件重编程细胞和患者来源的异种移植物
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p072
J. Guay
{"title":"Abstract P072: Combining ATR inhibitors with carboplatin in chemoresistant TNBC conditionally reprogrammed cells and patient-derived xenografts","authors":"J. Guay","doi":"10.1158/1535-7163.targ-21-p072","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p072","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"79 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87007943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract P089: Discovery of novel small-molecule inhibitors for an epigenetic modulator WDR5 P089:表观遗传调节剂WDR5新小分子抑制剂的发现
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p089
Cindy Huang, Shirley Guo, P. Cao
{"title":"Abstract P089: Discovery of novel small-molecule inhibitors for an epigenetic modulator WDR5","authors":"Cindy Huang, Shirley Guo, P. Cao","doi":"10.1158/1535-7163.targ-21-p089","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p089","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87114083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract P193: AMX-818, a novel prodrug HER2-XPAT T-cell engager (TCE) with potent T cell activation, proteolytic cleavage and efficacy in xenograft tumors, and wide safety margins in NHP (Non Human Primate) 摘要:AMX-818是一种新的前药HER2-XPAT T细胞接触剂(TCE)，具有有效的T细胞激活，蛋白水解裂解和在异种移植肿瘤中的有效性，并且在NHP(非人灵长类动物)中具有广泛的安全边际。
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p193
Milton To, P. Yeung, Michael Fox, M. Hammond, F. Cattaruzza, A. Nazeer, C. Koski, Lucas Y Liu, S. Khorsand, Deena A Rennerfeldt, K. Morrissey, Z. Lange, M. Dong, Sharon Lam, M. Derynck, B. Irving, V. Schellenberger
{"title":"Abstract P193: AMX-818, a novel prodrug HER2-XPAT T-cell engager (TCE) with potent T cell activation, proteolytic cleavage and efficacy in xenograft tumors, and wide safety margins in NHP (Non Human Primate)","authors":"Milton To, P. Yeung, Michael Fox, M. Hammond, F. Cattaruzza, A. Nazeer, C. Koski, Lucas Y Liu, S. Khorsand, Deena A Rennerfeldt, K. Morrissey, Z. Lange, M. Dong, Sharon Lam, M. Derynck, B. Irving, V. Schellenberger","doi":"10.1158/1535-7163.targ-21-p193","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p193","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"45 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90905649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract P111: Therapeutic KRASG12C inhibition alleviates KRAS-driven immunosuppression 治疗性KRASG12C抑制可缓解kras驱动的免疫抑制
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p111
E. Mugarza, F. van Maldegem, J. Boumelha, C. Moore, S. Rana, M. L. Sopena, P. East, M. M. Arcas, J. Downward
{"title":"Abstract P111: Therapeutic KRASG12C inhibition alleviates KRAS-driven immunosuppression","authors":"E. Mugarza, F. van Maldegem, J. Boumelha, C. Moore, S. Rana, M. L. Sopena, P. East, M. M. Arcas, J. Downward","doi":"10.1158/1535-7163.targ-21-p111","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p111","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"138 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73311219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Abstract P044: A phase 1 dose escalation study of protein arginine methyltransferase 5 (PRMT5) brain penetrant inhibitor PRT811 in patients with advanced solid tumors, including recurrent high-grade gliomas P044:蛋白精氨酸甲基转移酶5 (PRMT5)脑渗透抑制剂PRT811在晚期实体瘤(包括复发性高级别胶质瘤)患者中的一期剂量递增研究
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p044
G. Falchook, J. Glass, V. Monga, P. Giglio, D. Mauro, J. Viscusi, P. Scherle, N. Bhagwat, William Sun, R. Chiaverelli, Eric Mintah, L. Clements, T. Johanns, M. McKean
{"title":"Abstract P044: A phase 1 dose escalation study of protein arginine methyltransferase 5 (PRMT5) brain penetrant inhibitor PRT811 in patients with advanced solid tumors, including recurrent high-grade gliomas","authors":"G. Falchook, J. Glass, V. Monga, P. Giglio, D. Mauro, J. Viscusi, P. Scherle, N. Bhagwat, William Sun, R. Chiaverelli, Eric Mintah, L. Clements, T. Johanns, M. McKean","doi":"10.1158/1535-7163.targ-21-p044","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p044","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72697423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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