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Poster Presentations - Proffered Abstracts最新文献

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Abstract P165: MRTX1719: A first-in-class MTA-cooperative PRMT5 inhibitor that selectively elicits antitumor activity in MTAP/CDKN2A deleted cancer models P165: MRTX1719:一种mta协同PRMT5抑制剂，在MTAP/CDKN2A缺失的癌症模型中选择性地激发抗肿瘤活性
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p165
Christopher R. Smith, Lars D. Engstrom, S. Kulyk, Ruth Aranda, Laurie Waters, K. Moya, Vickie Bowcut, Allan Hebbert, David Trinh, David M Briere, J. Lawson, Jeff Clarine, L. Rahbaek, J. Christensen, M. Marx, P. Olson
{"title":"Abstract P165: MRTX1719: A first-in-class MTA-cooperative PRMT5 inhibitor that selectively elicits antitumor activity in MTAP/CDKN2A deleted cancer models","authors":"Christopher R. Smith, Lars D. Engstrom, S. Kulyk, Ruth Aranda, Laurie Waters, K. Moya, Vickie Bowcut, Allan Hebbert, David Trinh, David M Briere, J. Lawson, Jeff Clarine, L. Rahbaek, J. Christensen, M. Marx, P. Olson","doi":"10.1158/1535-7163.targ-21-p165","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p165","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74510898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract P025: NUC-3373 is a more potent inhibitor of thymidylate synthase than 5-FU and reduces generation of toxic metabolites 摘要P025: NUC-3373是一种比5-FU更有效的胸苷酸合成酶抑制剂，可减少有毒代谢物的产生
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p025
J. Bré, A. Dickson, O. Read, Ying Zhang, P. Mullen, C. Czekster, D. Harrison
{"title":"Abstract P025: NUC-3373 is a more potent inhibitor of thymidylate synthase than 5-FU and reduces generation of toxic metabolites","authors":"J. Bré, A. Dickson, O. Read, Ying Zhang, P. Mullen, C. Czekster, D. Harrison","doi":"10.1158/1535-7163.targ-21-p025","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p025","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84313784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract P240: Benchmarking the novel dual-MEK inhibitor, IMM-1-104, head-to-head and in combination with sotorasib (AMG-510) in the MIA PaCa-2 (KRAS-G12C) pancreatic cancer xenograft model P240:在MIA PaCa-2 (KRAS-G12C)胰腺癌异种移植模型中，对新型双mek抑制剂IMM-1-104进行头对头和与sotorasib (AMG-510)联合的基准测试
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p240
Peter J. King, A. Axel, Kevin D. Fowler, S. Kolitz, S. Barrett, B. Zeskind, B. Hall
{"title":"Abstract P240: Benchmarking the novel dual-MEK inhibitor, IMM-1-104, head-to-head and in combination with sotorasib (AMG-510) in the MIA PaCa-2 (KRAS-G12C) pancreatic cancer xenograft model","authors":"Peter J. King, A. Axel, Kevin D. Fowler, S. Kolitz, S. Barrett, B. Zeskind, B. Hall","doi":"10.1158/1535-7163.targ-21-p240","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p240","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84942551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract P229: Pre-clinical evaluation of next-generation inhibitor targeting a wide spectrum of oncogenic BRAF dimers P229:针对广谱致癌BRAF二聚体的下一代抑制剂的临床前评估
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p229
Yoon-Chi Han, Pui Yee Ng, Ryan Schulz, S. Yang, A. Lelo, Luisa Shin, M. O’Connor, I. Jewett, N. Ishiyama, D. Romashko, S. Thakur, A. Salomatov, S. Smith, E. Buck, Christopher Roberts, M. Lucas, Tai-an Lin
{"title":"Abstract P229: Pre-clinical evaluation of next-generation inhibitor targeting a wide spectrum of oncogenic BRAF dimers","authors":"Yoon-Chi Han, Pui Yee Ng, Ryan Schulz, S. Yang, A. Lelo, Luisa Shin, M. O’Connor, I. Jewett, N. Ishiyama, D. Romashko, S. Thakur, A. Salomatov, S. Smith, E. Buck, Christopher Roberts, M. Lucas, Tai-an Lin","doi":"10.1158/1535-7163.targ-21-p229","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p229","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"419 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77776511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract P180: Genetic screen identifies PDPK1 as a synergistic target to enhancing the efficacy of MEK1/2 inhibitors in NRAS mutant melanoma P180:基因筛选发现PDPK1是一个协同靶点，可增强MEK1/2抑制剂在NRAS突变型黑色素瘤中的疗效
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p180
Weijia Cai, Mai Q. Nguyen, Nicole A. Wilski, Timothy J. Purwin, Manoela TiagodosSantos, A. Aplin
{"title":"Abstract P180: Genetic screen identifies PDPK1 as a synergistic target to enhancing the efficacy of MEK1/2 inhibitors in NRAS mutant melanoma","authors":"Weijia Cai, Mai Q. Nguyen, Nicole A. Wilski, Timothy J. Purwin, Manoela TiagodosSantos, A. Aplin","doi":"10.1158/1535-7163.targ-21-p180","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p180","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"134 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77982675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract P142: Preclinical characterization of LOX-22783, a highly potent, mutant-selective and brain-penetrant allosteric PI3Kα H1047R inhibitor 摘要:LOX-22783是一种高效、突变选择性和脑渗透的变构PI3Kα H1047R抑制剂
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p142
A. Klippel, Rui Wang, L. Puca, Andrew L. Faber, W. Shen, S. Bhagwat, Kannan R. Karukurichi, Feiyu Zhang, C. Pérez, Ramón Rama, Ana Ramos, Yi Zheng, Z. Bonday, James Thomas, H. Brooks, Lisa J. Kindler, Sarah M. Bogner, Parisa Zolfaghari, M. Ii, S. Callies, B. Mattioni, L. LeBrun, J. Durbin, E. Anderson, Chris Mayne, E. Kesicki, Gabrielle R. Kolakowski, S. Andrews, B. Brandhuber
{"title":"Abstract P142: Preclinical characterization of LOX-22783, a highly potent, mutant-selective and brain-penetrant allosteric PI3Kα H1047R inhibitor","authors":"A. Klippel, Rui Wang, L. Puca, Andrew L. Faber, W. Shen, S. Bhagwat, Kannan R. Karukurichi, Feiyu Zhang, C. Pérez, Ramón Rama, Ana Ramos, Yi Zheng, Z. Bonday, James Thomas, H. Brooks, Lisa J. Kindler, Sarah M. Bogner, Parisa Zolfaghari, M. Ii, S. Callies, B. Mattioni, L. LeBrun, J. Durbin, E. Anderson, Chris Mayne, E. Kesicki, Gabrielle R. Kolakowski, S. Andrews, B. Brandhuber","doi":"10.1158/1535-7163.targ-21-p142","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p142","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76457811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Abstract P140: Chromomycin A5, a marine-derived antibiotic, targets the oncogenic TBX2 in breast cancer 摘要:海洋来源的抗生素Chromomycin A5靶向乳腺癌的致癌基因TBX2
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p140
C. Bellis, S. Chakraborty, Mihlali Mlaza, Bianca Del Bianco Sahm, Paula Rezende Teixeira, L. Costa‐Lotufo, S. Prince
{"title":"Abstract P140: Chromomycin A5, a marine-derived antibiotic, targets the oncogenic TBX2 in breast cancer","authors":"C. Bellis, S. Chakraborty, Mihlali Mlaza, Bianca Del Bianco Sahm, Paula Rezende Teixeira, L. Costa‐Lotufo, S. Prince","doi":"10.1158/1535-7163.targ-21-p140","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p140","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88285496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract P078: Aurora A kinase inhibition with VIC-1911 overcomes intrinsic and acquired resistance to KRASG12C inhibition in KRAS(G12C)-mutated lung cancer 摘要:在KRAS(G12C)突变的肺癌中，VIC-1911抑制Aurora A激酶克服了对KRASG12C抑制的内在和获得性耐药
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p078
J. W. Lee, Sundong Kim, C. Yang, B. Burtness
{"title":"Abstract P078: Aurora A kinase inhibition with VIC-1911 overcomes intrinsic and acquired resistance to KRASG12C inhibition in KRAS(G12C)-mutated lung cancer","authors":"J. W. Lee, Sundong Kim, C. Yang, B. Burtness","doi":"10.1158/1535-7163.targ-21-p078","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p078","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"20 4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86755969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Abstract P125: Combined inhibition of SHP2 and CDK4/6 is active in NF1-associated malignant peripheral nerve sheath tumor P125: SHP2和CDK4/6联合抑制在nf1相关的恶性周围神经鞘肿瘤中是活跃的
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p125
Jiawan Wang, A. Calizo, K. Pollard, A. Hirbe, C. Pratilas
{"title":"Abstract P125: Combined inhibition of SHP2 and CDK4/6 is active in NF1-associated malignant peripheral nerve sheath tumor","authors":"Jiawan Wang, A. Calizo, K. Pollard, A. Hirbe, C. Pratilas","doi":"10.1158/1535-7163.targ-21-p125","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p125","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"180 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88969314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Abstract P143: Development of siRNA-loaded lipid nanoparticles targeting long non-coding RNA LINC01257 as a novel and safe therapeutic approach for paediatric acute myeloid leukaemia P143: sirna负载脂质纳米颗粒靶向长链非编码RNA LINC01257作为一种新的安全治疗儿科急性髓性白血病的方法
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p143
Patrick Connerty, Ernest Moles, Charles E. deBock, Nisitha Jayatilleke, Jenny L. Smith, S. Meshinchi, C. Mayoh, M. Kavallaris, R. Lock
{"title":"Abstract P143: Development of siRNA-loaded lipid nanoparticles targeting long non-coding RNA LINC01257 as a novel and safe therapeutic approach for paediatric acute myeloid leukaemia","authors":"Patrick Connerty, Ernest Moles, Charles E. deBock, Nisitha Jayatilleke, Jenny L. Smith, S. Meshinchi, C. Mayoh, M. Kavallaris, R. Lock","doi":"10.1158/1535-7163.targ-21-p143","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p143","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"20 1 Part 2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89193213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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