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Poster Presentations - Proffered Abstracts最新文献

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Abstract P192: Comprehensive preclinical characterization of the mechanism of action of EPI-7386, an androgen receptor N-terminal domain inhibitor 摘要P192:雄激素受体n端结构域抑制剂EPI-7386作用机制的临床前综合表征
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p192
N. Hong, Shihua Sun, P. Virsik, A. Cesano, E. Mostaghel, S. Plymate, B. Biannic, Han-Jie Zhou, R. Le Moigne
{"title":"Abstract P192: Comprehensive preclinical characterization of the mechanism of action of EPI-7386, an androgen receptor N-terminal domain inhibitor","authors":"N. Hong, Shihua Sun, P. Virsik, A. Cesano, E. Mostaghel, S. Plymate, B. Biannic, Han-Jie Zhou, R. Le Moigne","doi":"10.1158/1535-7163.targ-21-p192","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p192","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"69 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74770975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract P256: Pan-ErbB inhibition enhances activity of KRASG12C inhibitors in preclinical models of KRASG12C mutant cancers P256: Pan-ErbB抑制增强KRASG12C抑制剂在KRASG12C突变癌临床前模型中的活性
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p256
J. Robichaux, Ana Galán‐Cobo, R. Powell, Kelly Gale, Junquin He, Fahao Zhang, M. Nilsson, Xiang Zhang, Mary Sobieski, Nghi D. Nguyen, S. C. Clifford, J. Heymach
{"title":"Abstract P256: Pan-ErbB inhibition enhances activity of KRASG12C inhibitors in preclinical models of KRASG12C mutant cancers","authors":"J. Robichaux, Ana Galán‐Cobo, R. Powell, Kelly Gale, Junquin He, Fahao Zhang, M. Nilsson, Xiang Zhang, Mary Sobieski, Nghi D. Nguyen, S. C. Clifford, J. Heymach","doi":"10.1158/1535-7163.targ-21-p256","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p256","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"69 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89452768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract P118: Analysis of macrophage function and histone deacetylase inhibition in neuroblastoma P118:神经母细胞瘤巨噬细胞功能及组蛋白去乙酰化酶抑制分析
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p118
Gabrielle L. Brumfield, S. Knoche, Alaina C. Larson, B. Poelaert, Benjamin T. Goetz, P. Pandey, D. Coulter, J. Solheim
{"title":"Abstract P118: Analysis of macrophage function and histone deacetylase inhibition in neuroblastoma","authors":"Gabrielle L. Brumfield, S. Knoche, Alaina C. Larson, B. Poelaert, Benjamin T. Goetz, P. Pandey, D. Coulter, J. Solheim","doi":"10.1158/1535-7163.targ-21-p118","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p118","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80407551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract P178: RBM39 degradation leads to exceptional responses in high-risk neuroblastoma by targeting the spliceosome P178: RBM39降解通过靶向剪接体导致高危神经母细胞瘤的异常反应
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p178
Jun Yang
{"title":"Abstract P178: RBM39 degradation leads to exceptional responses in high-risk neuroblastoma by targeting the spliceosome","authors":"Jun Yang","doi":"10.1158/1535-7163.targ-21-p178","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p178","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80751384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract P158: Phenotypic analysis of myeloid cells in a 3D image-based repolarization assay with tumor spheroids P158:骨髓细胞的表型分析在三维图像为基础的肿瘤球体复极化试验
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p158
G. Goverse, N. Beztsinna, B. Visser, T. Veenendaal, Marjan van de Merbel, E. Spanjaard, Ashgard Weterings, K. Yan, L. Price, L. Daszkiewicz
{"title":"Abstract P158: Phenotypic analysis of myeloid cells in a 3D image-based repolarization assay with tumor spheroids","authors":"G. Goverse, N. Beztsinna, B. Visser, T. Veenendaal, Marjan van de Merbel, E. Spanjaard, Ashgard Weterings, K. Yan, L. Price, L. Daszkiewicz","doi":"10.1158/1535-7163.targ-21-p158","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p158","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75517589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract P206: AB521 potently and selectively inhibits pro-tumorigenic gene transcription by Hypoxia-Inducible Factor (HIF)-2α in vitro and in vivo 摘要P206: AB521在体外和体内通过缺氧诱导因子(HIF)-2α有效和选择性地抑制促肿瘤基因转录
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p206
K. Gauthier, D. Piovesan, Soonweng Cho, K. Lawson, P. Schweickert, Alejandra López, Suan Liu, Tim Park, A. Mailyan, J. Fournier, J. Beatty, S. Drew, J. Kalisiak, Balint Gal, Guillaume Mata, Zhang Wang, Brandon R. Rosen, Clayton T. Hardman, Matthaw P. Epplin, K. Yu, Karl T. Haelsig, Lixia Jin, E. Ginn, J. Au, C. Meleza, Joel Tencer, Amber T. Pham, H. Kwon, S. W. Young, M. Leleti, J. Powers, M. Walters
{"title":"Abstract P206: AB521 potently and selectively inhibits pro-tumorigenic gene transcription by Hypoxia-Inducible Factor (HIF)-2α in vitro and in vivo","authors":"K. Gauthier, D. Piovesan, Soonweng Cho, K. Lawson, P. Schweickert, Alejandra López, Suan Liu, Tim Park, A. Mailyan, J. Fournier, J. Beatty, S. Drew, J. Kalisiak, Balint Gal, Guillaume Mata, Zhang Wang, Brandon R. Rosen, Clayton T. Hardman, Matthaw P. Epplin, K. Yu, Karl T. Haelsig, Lixia Jin, E. Ginn, J. Au, C. Meleza, Joel Tencer, Amber T. Pham, H. Kwon, S. W. Young, M. Leleti, J. Powers, M. Walters","doi":"10.1158/1535-7163.targ-21-p206","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p206","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72969883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract P114: Engineered hydrogel elucidates contributions of matrix mechanics to esophageal adenocarcinoma and identify matrix-activated therapeutic targets 摘要:工程水凝胶阐明了基质力学在食管癌中的作用，并确定了基质激活的治疗靶点
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p114
Ricardo Cruz-Acuña, Claudia Loebel, J. Burdick, A. Rustgi
{"title":"Abstract P114: Engineered hydrogel elucidates contributions of matrix mechanics to esophageal adenocarcinoma and identify matrix-activated therapeutic targets","authors":"Ricardo Cruz-Acuña, Claudia Loebel, J. Burdick, A. Rustgi","doi":"10.1158/1535-7163.targ-21-p114","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p114","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"22 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72570697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract P263: Interaction between CD36 and FABP4 regulates the import and metabolism of fatty acid in breast cancer cells P263: CD36和FABP4的相互作用调节乳腺癌细胞中脂肪酸的输入和代谢
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p263
Jones Gyamfi, Junjeong Choi, D. Kwon, J. Koo
{"title":"Abstract P263: Interaction between CD36 and FABP4 regulates the import and metabolism of fatty acid in breast cancer cells","authors":"Jones Gyamfi, Junjeong Choi, D. Kwon, J. Koo","doi":"10.1158/1535-7163.targ-21-p263","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p263","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74929339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract P170: SpliceCore® a platform for identifying aberrant alternative splicing in triple negative breast cancer for novel therapeutic development P170: SpliceCore®是一个识别三阴性乳腺癌异常选择性剪接的平台，用于新的治疗开发
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p170
M. Manzanares, Dhingra Priyanka, K. Anderson, Vanessa Frederick, A. Geier, A. Casill, Martin Akerman, G. Arun
{"title":"Abstract P170: SpliceCore® a platform for identifying aberrant alternative splicing in triple negative breast cancer for novel therapeutic development","authors":"M. Manzanares, Dhingra Priyanka, K. Anderson, Vanessa Frederick, A. Geier, A. Casill, Martin Akerman, G. Arun","doi":"10.1158/1535-7163.targ-21-p170","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p170","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"72 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73879355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract P216: IK-930 mediated TEAD inhibition decreases and delays tumor growth and enhances targeted apoptosis in lung and colon cancer xenografts when combined with MEK or EGFR inhibitors 摘要P216: IK-930介导的TEAD抑制与MEK或EGFR抑制剂联合使用时，可降低和延迟肺癌和结肠癌异种移植物的肿瘤生长，并增强靶向凋亡
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p216
B. Amidon, Hyejin Frosch, Sakeena Syed, Jillian D. Cavanaugh, Chelsea Turcotte, Katie O'Callaghan, P. Natarajan, J. Ecsedy, Karen McGovern, Alfredo C Castro
{"title":"Abstract P216: IK-930 mediated TEAD inhibition decreases and delays tumor growth and enhances targeted apoptosis in lung and colon cancer xenografts when combined with MEK or EGFR inhibitors","authors":"B. Amidon, Hyejin Frosch, Sakeena Syed, Jillian D. Cavanaugh, Chelsea Turcotte, Katie O'Callaghan, P. Natarajan, J. Ecsedy, Karen McGovern, Alfredo C Castro","doi":"10.1158/1535-7163.targ-21-p216","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p216","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75968357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
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