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Poster Presentations - Proffered Abstracts最新文献

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Abstract P073: Pharmacological inhibition of IRAK4 with CA-4948 is beneficial in marginal zone lymphoma models with secondary resistance to PI3K and BTK inhibitors 摘要CA-4948药物抑制IRAK4对PI3K和BTK抑制剂继发性耐药的边缘区淋巴瘤模型有益
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p073
F. Guidetti, A. Arribas, F. Spriano, L. Barnabei, R. V. von Roemeling, E. Martinez, E. Zucca, F. Bertoni
{"title":"Abstract P073: Pharmacological inhibition of IRAK4 with CA-4948 is beneficial in marginal zone lymphoma models with secondary resistance to PI3K and BTK inhibitors","authors":"F. Guidetti, A. Arribas, F. Spriano, L. Barnabei, R. V. von Roemeling, E. Martinez, E. Zucca, F. Bertoni","doi":"10.1158/1535-7163.targ-21-p073","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p073","url":null,"abstract":"Francesca Guidetti 1, Alberto J. Arribas 1,2, Filippo Spriano 1, Laura Barnabei 1, Reinhard von Roemeling 3, Elizabeth Martinez 3, Emanuele Zucca 1,4, Francesco Bertoni 1,4 1 Institute of Oncology Research, Faculty of Biomedical Sciences, USI, Bellinzona, Switzerland; 2 SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland; 3 Curis, Inc, Lexington, MA, USA; 4 Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81228181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Abstract P059: Exploiting mutant PPM1D-induced metabolic defects with nanoparticle-encapsulated NAMPT inhibitors P059:利用纳米颗粒封装的NAMPT抑制剂研究突变型ppm1d诱导的代谢缺陷
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p059
Matthew A. Murray, Yazhe Wang, R. Sundaram, J. Beckta, M. Saltzman, R. Bindra
{"title":"Abstract P059: Exploiting mutant PPM1D-induced metabolic defects with nanoparticle-encapsulated NAMPT inhibitors","authors":"Matthew A. Murray, Yazhe Wang, R. Sundaram, J. Beckta, M. Saltzman, R. Bindra","doi":"10.1158/1535-7163.targ-21-p059","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p059","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75649458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract P069: GDF15 contributes to the maintenance of the drug-tolerant persister state in cells responding to eribulin P069: GDF15参与维持对伊瑞布林有反应的细胞的耐药持续状态
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p069
C. Bellio, Marta Emperador, E. Zamora, V. Serra, C. Saura, B. Littlefield, J. Villanueva
{"title":"Abstract P069: GDF15 contributes to the maintenance of the drug-tolerant persister state in cells responding to eribulin","authors":"C. Bellio, Marta Emperador, E. Zamora, V. Serra, C. Saura, B. Littlefield, J. Villanueva","doi":"10.1158/1535-7163.targ-21-p069","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p069","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83334980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract P149: Novel compounds to probe Hippo kinase STK3 noncanonical function in prostate cancer P149:新化合物探测Hippo激酶STK3在前列腺癌中的非规范功能
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p149
A. Schirmer, Lucy M. Driver, Megan T. Zhao, C. Wells, Xuan Yang, D. Drewry, I. Spasojević, Everardo Macias
{"title":"Abstract P149: Novel compounds to probe Hippo kinase STK3 noncanonical function in prostate cancer","authors":"A. Schirmer, Lucy M. Driver, Megan T. Zhao, C. Wells, Xuan Yang, D. Drewry, I. Spasojević, Everardo Macias","doi":"10.1158/1535-7163.targ-21-p149","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p149","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"82 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80150415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract P003: In vitro and in vivo characterization of CCR8 humanized mouse model (HuGEMM™) P003: CCR8人源化小鼠模型(HuGEMM™)的体内外特性
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p003
D. He, H. Li
{"title":"Abstract P003: In vitro and in vivo characterization of CCR8 humanized mouse model (HuGEMM™)","authors":"D. He, H. Li","doi":"10.1158/1535-7163.targ-21-p003","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p003","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80052944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract P042: Phase I/II first-in-human study of TT-10 (A2AB inhibitor) as a single agent in subjects with advanced selected solid tumors P042: TT-10 (A2AB抑制剂)作为单一药物在晚期选择性实体瘤患者中的I/II期首次人体研究
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p042
Sushant Kumar, K. Mookhtiar, Desa Rae Pastore, B. Schwartz, V. Reddy
{"title":"Abstract P042: Phase I/II first-in-human study of TT-10 (A2AB inhibitor) as a single agent in subjects with advanced selected solid tumors","authors":"Sushant Kumar, K. Mookhtiar, Desa Rae Pastore, B. Schwartz, V. Reddy","doi":"10.1158/1535-7163.targ-21-p042","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p042","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"51 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77963743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract P228: Preclinical pharmacokinetics and pharmacodynamics of KB-0742, a selective, oral CDK9 inhibitor P228:选择性口服CDK9抑制剂KB-0742的临床前药代动力学和药效学
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p228
M. Day, D. Saffran, N. Rioux, Tom Chen, Christina Lee, David B. Freeman, C. Mackenzie, J. Vacca, P. Rahl, B. Trotter, Charles Y. Lin, Pavan Kumar, J. Dimartino
{"title":"Abstract P228: Preclinical pharmacokinetics and pharmacodynamics of KB-0742, a selective, oral CDK9 inhibitor","authors":"M. Day, D. Saffran, N. Rioux, Tom Chen, Christina Lee, David B. Freeman, C. Mackenzie, J. Vacca, P. Rahl, B. Trotter, Charles Y. Lin, Pavan Kumar, J. Dimartino","doi":"10.1158/1535-7163.targ-21-p228","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p228","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78215281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract P248: The tyrosine kinase inhibitor XL092 promotes an immune-permissive tumor microenvironment and enhances the anti-tumor activity of immune checkpoint inhibitors in preclinical models P248:酪氨酸激酶抑制剂XL092在临床前模型中促进免疫允许的肿瘤微环境，增强免疫检查点抑制剂的抗肿瘤活性
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p248
J. Hsu, Coling Chong, J. Serrill, Sharon C. Wu, K. Leong, Ted Yun, L. Bannen, P. Lamb, Wei Xu, P. Yu
{"title":"Abstract P248: The tyrosine kinase inhibitor XL092 promotes an immune-permissive tumor microenvironment and enhances the anti-tumor activity of immune checkpoint inhibitors in preclinical models","authors":"J. Hsu, Coling Chong, J. Serrill, Sharon C. Wu, K. Leong, Ted Yun, L. Bannen, P. Lamb, Wei Xu, P. Yu","doi":"10.1158/1535-7163.targ-21-p248","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p248","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"136 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75518827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract P099: Radionuclide imaging of low-density-lipoprotein receptor (LDLR)-overexpressing glioblastoma: A preclinical study of Gallium-68 RMX-VH 低密度脂蛋白受体(LDLR)过表达胶质母细胞瘤的放射性核素成像:镓-68 RMX-VH的临床前研究
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p099
I. Tworowska, L. Flores, Xue-Li Qu, C. Malicet, N. Wagh, David Ranganathan, Jonathan Nowak, P. Lécorché, J. Temsamani, E. Delpassand
{"title":"Abstract P099: Radionuclide imaging of low-density-lipoprotein receptor (LDLR)-overexpressing glioblastoma: A preclinical study of Gallium-68 RMX-VH","authors":"I. Tworowska, L. Flores, Xue-Li Qu, C. Malicet, N. Wagh, David Ranganathan, Jonathan Nowak, P. Lécorché, J. Temsamani, E. Delpassand","doi":"10.1158/1535-7163.targ-21-p099","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p099","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"276 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77836370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract P043: A double-blind randomized, placebo-controlled trial of oral administration with human papillomavirus (HPV) type 16 E7-expressing Lactobacillus-based vaccine, BLS-ILB-E710c, for the treatment of cervical intraepithelial neoplasia (CIN2/3) P043:一项双盲随机、安慰剂对照试验:口服表达e7的人乳头瘤病毒(HPV) 16型乳酸菌基疫苗BLS-ILB-E710c治疗宫颈上皮内瘤变(CIN2/3)
Poster Presentations - Proffered Abstracts Pub Date : 2021-12-01 DOI: 10.1158/1535-7163.targ-21-p043
Jae Kwan Lee, S. Song, Young Tae Kim, C. Cho, C. Kim, Young-Chul Park
{"title":"Abstract P043: A double-blind randomized, placebo-controlled trial of oral administration with human papillomavirus (HPV) type 16 E7-expressing Lactobacillus-based vaccine, BLS-ILB-E710c, for the treatment of cervical intraepithelial neoplasia (CIN2/3)","authors":"Jae Kwan Lee, S. Song, Young Tae Kim, C. Cho, C. Kim, Young-Chul Park","doi":"10.1158/1535-7163.targ-21-p043","DOIUrl":"https://doi.org/10.1158/1535-7163.targ-21-p043","url":null,"abstract":"","PeriodicalId":20348,"journal":{"name":"Poster Presentations - Proffered Abstracts","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74305675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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